| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioma | D005910 | 112 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Okui T et al. | Cis-9,trans-11-conjugated linoleic acid promotes neuronal differentiation through regulation of Hes6 mRNA and cell cycle in cultured neural stem cells. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21723718 |
| Mujtaba SF et al. | Production of ROS by photosensitized anthracene under sunlight and UV-R at ambient environmental intensities. | 2011 Sep-Oct | Photochem. Photobiol. | pmid:21668866 |
| Ramandi NF et al. | Central composite design for the optimization of supercritical carbon dioxide fluid extraction of fatty acids from Borago officinalis L. flower. | 2011 Nov-Dec | J. Food Sci. | pmid:22416687 |
| Olszewska MA | Variation in the phenolic content and in vitro antioxidant activity of Sorbus aucuparia leaf extracts during vegetation. | 2011 Nov-Dec | Acta Pol Pharm | pmid:22125960 |
| Olszewska MA | In vitro antioxidant activity and total phenolic content of the inflorescences, leaves and fruits of Sorbus torminalis (L.) Crantz. | 2011 Nov-Dec | Acta Pol Pharm | pmid:22125961 |
| Kezutyte T et al. | Study of tolnaftate release from fatty acids containing ointment and penetration into human skin ex vivo. | 2011 Nov-Dec | Acta Pol Pharm | pmid:22125963 |
| China R et al. | In vitro antioxidant activity of different cultivars of banana flower (Musa paradicicus L.) extracts available in India. | 2011 Nov-Dec | J. Food Sci. | pmid:22416691 |
| Qu WX et al. | Analysis of fatty acids in A. szechenyianum Gay. by microwave-assisted extraction and gas chromatography-mass spectrometry. | 2011 May-Jun | Phytochem Anal | pmid:20848395 |
| Lam YY et al. | Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. | 2011 Jul-Aug | Biochim. Biophys. Acta | pmid:21570480 |
| de Luis DA et al. | Double blind randomized clinical trial controlled by placebo with an alpha linoleic acid and prebiotic enriched cookie on risk cardiovascular factor in obese patients. | 2011 Jul-Aug | Nutr Hosp | pmid:22470031 |
| Aluf Y et al. | Alterations in striatal oxidative stress level produced by pharmacological manipulation of dopamine as shown by a novel synthetic marker molecule. | 2011 Jul-Aug | Neuropharmacology | pmid:21414328 |
| Lasa A et al. | Effects of trans-10,cis-12 CLA on liver size and fatty acid oxidation under energy restriction conditions in hamsters. | 2011 | Nutrition | pmid:20619605 |
| Tan B et al. | Dietary L-arginine supplementation differentially regulates expression of lipid-metabolic genes in porcine adipose tissue and skeletal muscle. | 2011 | J. Nutr. Biochem. | pmid:20619625 |
| Kishino S et al. | Linoleic acid isomerase in Lactobacillus plantarum AKU1009a proved to be a multi-component enzyme system requiring oxidoreduction cofactors. | 2011 | Biosci. Biotechnol. Biochem. | pmid:21307591 |
| Retamal MA et al. | Biphasic effect of linoleic acid on connexin 46 hemichannels. | 2011 | Pflugers Arch. | pmid:21360038 |
| Maqbool A et al. | The skinny on tuna fat: health implications. | 2011 | Public Health Nutr | pmid:21324226 |
| Popescu FD et al. | Effects of season and reproductive state on lipid intake and fatty acid composition of gastrointestinal tract contents in the European hare. | 2011 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:21328065 |
| Lee MJ et al. | The effects of hempseed meal intake and linoleic acid on Drosophila models of neurodegenerative diseases and hypercholesterolemia. | 2011 | Mol. Cells | pmid:21331775 |
| Lebold KM et al. | Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). | 2011 | J. Nutr. | pmid:22013196 |
| Nishioka N et al. | Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1. | 2011 | Br. J. Cancer | pmid:22015554 |
| Strandvik B | The omega-6/omega-3 ratio is of importance! | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21945460 |
| Espinosa-Neira R et al. | Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A. | 2011 | Int. J. Biochem. Cell Biol. | pmid:21945809 |
| Sousa A et al. | Chemical characterization of "alcaparras" stoned table olives from northeast Portugal. | 2011 | Molecules | pmid:22031066 |
| Danish HH et al. | Hydrogen tunneling steps in cyclooxygenase-2 catalysis. | 2011 | J. Am. Chem. Soc. | pmid:21902213 |
| Shchepinov MS et al. | Isotopic reinforcement of essential polyunsaturated fatty acids diminishes nigrostriatal degeneration in a mouse model of Parkinson's disease. | 2011 | Toxicol. Lett. | pmid:21906664 |
| Lee YJ and Jenkins TC | Identification of enriched conjugated linoleic acid isomers in cultures of ruminal microorganisms after dosing with 1-(13)C-linoleic acid. | 2011 | J. Microbiol. | pmid:21887646 |
| Beker BY et al. | Antioxidant protective effect of flavonoids on linoleic acid peroxidation induced by copper(II)/ascorbic acid system. | 2011 | Chem. Phys. Lipids | pmid:21925488 |
| Zhou XR et al. | Caenorhabditis elegans Delta12-desaturase FAT-2 is a bifunctional desaturase able to desaturate a diverse range of fatty acid substrates at the Delta12 and Delta15 positions. | 2011 | J. Biol. Chem. | pmid:22041902 |
| Akrout A et al. | Antioxidant and antitumor activities of Artemisia campestris and Thymelaea hirsuta from southern Tunisia. | 2011 | Food Chem. Toxicol. | pmid:21075159 |
| Hubert DJ et al. | In vitro hepatoprotective and antioxidant activities of crude extract and isolated compounds from Ficus gnaphalocarpa. | 2011 | Inflammopharmacology | pmid:21088994 |
| Jin G et al. | Crude lipoxygenase from pig muscle: partial characterization and interactions of temperature, NaCl and pH on its activity. | 2011 | Meat Sci. | pmid:21093161 |
| Du YZ et al. | Linoleic acid-grafted chitosan oligosaccharide micelles for intracellular drug delivery and reverse drug resistance of tumor cells. | 2011 | Int. J. Biol. Macromol. | pmid:21093477 |
| Huang YS et al. | Eicosadienoic acid differentially modulates production of pro-inflammatory modulators in murine macrophages. | 2011 | Mol. Cell. Biochem. | pmid:21688154 |
| Chen Q et al. | Delta-6 desaturase from borage converts linoleic acid to gamma-linolenic acid in HEK293 cells. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21679695 |
| Blaul B and Ruther J | How parasitoid females produce sexy sons: a causal link between oviposition preference, dietary lipids and mate choice in Nasonia. | 2011 | Proc. Biol. Sci. | pmid:21429922 |
| Briend A et al. | Fatty acid status in early life in low-income countries--overview of the situation, policy and research priorities. | 2011 | Matern Child Nutr | pmid:21366873 |
| Blasbalg TL et al. | Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. | 2011 | Am. J. Clin. Nutr. | pmid:21367944 |
| Rybicka M et al. | Comparative effects of conjugated linoleic acid (CLA) and linoleic acid (LA) on the oxidoreduction status in THP-1 macrophages. | 2011 | J. Agric. Food Chem. | pmid:21391598 |
| Rakib MA et al. | Preventive effect of t,t-conjugated linoleic acid on 12-O-tetradecanoylphorbol-13-acetate-induced inhibition of gap junctional intercellular communication in human mammary epithelial MCF-10A cells. | 2011 | J. Agric. Food Chem. | pmid:21391601 |
| Tuei VC et al. | Effects of human serum albumin complexed with free fatty acids on cell viability and insulin secretion in the hamster pancreatic β-cell line HIT-T15. | 2011 | Life Sci. | pmid:21396379 |
| Conforti F et al. | Correlation between environmental factors, chemical composition, and antioxidative properties of caper species growing wild in Calabria (South Italy). | 2011 | Chem. Biodivers. | pmid:21404435 |
| Edris AE | The chemical composition and the content of volatile oil: potential factors that can contribute to the oxidative stability of Nigella sativa L. crude oil. | 2011 | J Diet Suppl | pmid:22432633 |
| Parra-Cabrera S et al. | Dietary intakes of polyunsaturated fatty acids among pregnant Mexican women. | 2011 | Matern Child Nutr | pmid:21410881 |
| Litinas KE et al. | Synthesis and biological evaluation of fused oxepinocoumarins as free radicals scavengers. | 2011 | J Enzyme Inhib Med Chem | pmid:21381887 |
| Min Y et al. | Relationship between red cell membrane fatty acids and adipokines in individuals with varying insulin sensitivity. | 2011 | Eur J Clin Nutr | pmid:21386858 |
| Wong WT et al. | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. | 2011 | Nutr Metab Cardiovasc Dis | pmid:20005687 |
| Mariutto M et al. | The elicitation of a systemic resistance by Pseudomonas putida BTP1 in tomato involves the stimulation of two lipoxygenase isoforms. | 2011 | BMC Plant Biol. | pmid:21294872 |
| White HM et al. | Differential regulation of bovine pyruvate carboxylase promoters by fatty acids and peroxisome proliferator-activated receptor-α agonist. | 2011 | J. Dairy Sci. | pmid:21700028 |
| Siddique BM et al. | Chemical composition and antioxidant properties of candlenut oil extracted by supercritical CO2. | 2011 | J. Food Sci. | pmid:22417332 |
| Chen HH and Chiu TH | Phytochemicals characterization of solvent extracts from taro-scented japonica rice bran. | 2011 | J. Food Sci. | pmid:22417350 |