Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Authors Title Published Journal PubMed Link
Houtsmuller UM and van der Beek A Effects of topical application of fatty acids. 1981 Prog. Lipid Res. pmid:6804961
Mercuri O and De Tomás ME Early steps on the in vivo incorporation of [1-14C]linoleic acid into liver lipids of protein deficient pregnant rats. 1981 Prog. Lipid Res. pmid:6804968
Watkins BA et al. Linoleate impairs collagen synthesis in primary cultures of avian chondrocytes. 1996 Proc. Soc. Exp. Biol. Med. pmid:8650253
Wieland E et al. Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation? 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8327462
Levay-Young BK et al. Linoleic acid, but not cortisol, stimulates accumulation of casein by mouse mammary epithelial cells in serum-free collagen gel culture. 1987 Proc. Natl. Acad. Sci. U.S.A. pmid:3317407
Yehuda S and Carasso RL Modulation of learning, pain thresholds, and thermoregulation in the rat by preparations of free purified alpha-linolenic and linoleic acids: determination of the optimal omega 3-to-omega 6 ratio. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:7901853
Baker PR et al. Red cell membrane and plasma linoleic acid nitration products: synthesis, clinical identification, and quantitation. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15273286
Whittle EJ et al. Revealing the catalytic potential of an acyl-ACP desaturase: tandem selective oxidation of saturated fatty acids. 2008 Proc. Natl. Acad. Sci. U.S.A. pmid:18796606
Jiang Q et al. gamma-Tocopherol or combinations of vitamin E forms induce cell death in human prostate cancer cells by interrupting sphingolipid synthesis. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15596715
Asaoka Y et al. Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation. 1993 Proc. Natl. Acad. Sci. U.S.A. pmid:8099446
Saeki K et al. Functional expression of a Delta12 fatty acid desaturase gene from spinach in transgenic pigs. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15067141
Kliewer SA et al. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8041794
Chu S et al. Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7624373
Wright JR et al. Essential fatty acid deficiency prevents multiple low-dose streptozotocin-induced diabetes in CD-1 mice. 1988 Proc. Natl. Acad. Sci. U.S.A. pmid:3045812
Newman MJ Inhibition of carcinoma and melanoma cell growth by type 1 transforming growth factor beta is dependent on the presence of polyunsaturated fatty acids. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2371287
Kang JX et al. Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7732020
Stocker R et al. Antioxidant activity of albumin-bound bilirubin. 1987 Proc. Natl. Acad. Sci. U.S.A. pmid:3475708
Hill EG et al. Perturbation of the metabolism of essential fatty acids by dietary partially hydrogenated vegetable oil. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6951178
Lange LG Nonoxidative ethanol metabolism: formation of fatty acid ethyl esters by cholesterol esterase. 1982 Proc. Natl. Acad. Sci. U.S.A. pmid:6955782
Keler T et al. Specific growth stimulation by linoleic acid in hepatoma cell lines transfected with the target protein of a liver carcinogen. 1992 Proc. Natl. Acad. Sci. U.S.A. pmid:1594582
Blaul B and Ruther J How parasitoid females produce sexy sons: a causal link between oviposition preference, dietary lipids and mate choice in Nasonia. 2011 Proc. Biol. Sci. pmid:21429922
Utermohlen V and Tucker MA Possible effects of dietary n-6 series polyunsaturated fatty acids on the development of immune dysfunction and infection. 1986 Proc Nutr Soc pmid:3797410
Betteridge J Nutrition and platelet function in atherogenesis. 1987 Proc Nutr Soc pmid:2893383
Dupont J Essential fatty acids and prostaglandins. 1987 Prev Med pmid:3628199
Cohen LA Fat and endocrine-responsive cancer in animals. 1987 Prev Med pmid:3476922
Wadekar SD et al. Microbial synthesis of rhamnolipids by Pseudomonas aeruginosa (ATCC 10145) on waste frying oil as low cost carbon source. 2012 Prep. Biochem. Biotechnol. pmid:22509850
Applegate TJ and Sell JL Effect of dietary linoleic to linolenic acid ratio and vitamin E supplementation on vitamin E status of poults. 1996 Poult. Sci. pmid:8966177
Shin D et al. Dietary combination effects of conjugated linoleic acid and flaxseed or fish oil on the concentration of linoleic and arachidonic acid in poultry meat. 2011 Poult. Sci. pmid:21597077
Parmentier HK et al. Dietary unsaturated fatty acids affect antibody responses and growth of chickens divergently selected for humoral responses to sheep red blood cells. 1997 Poult. Sci. pmid:9251147
Keshavarz K Further investigations on the effect of dietary manipulations of nutrients on early egg weight. 1995 Poult. Sci. pmid:7899214
Sirri F et al. Fatty acid composition and productive traits of broiler fed diets containing conjugated linoleic acid. 2003 Poult. Sci. pmid:12943310
Carrillo-Domínguez S et al. Cholesterol and n-3 and n-6 fatty acid content in eggs from laying hens fed with red crab meal (Pleuroncodes planipes). 2005 Poult. Sci. pmid:15685957
Badinga L et al. Dietary conjugated linoleic acid alters hepatic lipid content and fatty acid composition in broiler chickens. 2003 Poult. Sci. pmid:12580252
Engberg RM et al. Inclusion of oxidized vegetable oil in broiler diets. Its influence on nutrient balance and on the antioxidative status of broilers. 1996 Poult. Sci. pmid:8829233
Ding ST and Lilburn MS Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. 1997 Poult. Sci. pmid:9181615
Lee BD et al. Nutritive and economic values of high oil corn in layer diet. 2001 Poult. Sci. pmid:11732667
Puthpongsiriporn U and Scheideler SE Effects of dietary ratio of linoleic to linolenic acid on performance, antibody production, and in vitro lymphocyte proliferation in two strains of leghorn pullet chicks. 2005 Poult. Sci. pmid:15971520
Ferrini G et al. Dietary polyunsaturated fat reduces skin fat as well as abdominal fat in broiler chickens. 2008 Poult. Sci. pmid:18281580
Ain Baziz H et al. Chronic heat exposure enhances fat deposition and modifies muscle and fat partition in broiler carcasses. 1996 Poult. Sci. pmid:8786940
Sijben JW et al. Interactions and antigen dependence of dietary n-3 and n-6 polyunsaturated fatty acids on antibody responsiveness in growing layer hens. 2001 Poult. Sci. pmid:11469650
Potter LM and McCarthy JP Varying fat and protein in diets of growing large white turkeys. 1985 Poult. Sci. pmid:4070128
Wang YW et al. Maternal dietary ratio of linoleic acid to alpha-linolenic acid affects the passive immunity of hatching chicks. 2004 Poult. Sci. pmid:15615018
Du M and Ahn DU Effect of dietary conjugated linoleic acid on the growth rate of live birds and on the abdominal fat content and quality of broiler meat. 2002 Poult. Sci. pmid:11902422
Vilchez C et al. Effect of feeding palmitic, oleic, and linoleic acids to Japanese quail hens (Coturnix coturnix japonica). 1. Reproductive performance and tissue fatty acids. 1991 Poult. Sci. pmid:1784570
Du M et al. Quality characteristics of irradiated ready-to-eat breast rolls from turkeys fed conjugated linoleic acid. 2002 Poult. Sci. pmid:12269620
Cherian G et al. Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked, and irradiated eggs. 2002 Poult. Sci. pmid:12412926
Vilchez C et al. Effect of feeding palmitic, oleic, and linoleic acids to Japanese quail hens (Coturnix coturnix japonica). 2. Maternal diets and stage of incubation on the lipid metabolism of quail embryos. 1992 Poult. Sci. pmid:1614943
Aletor VA et al. The effects of conjugated linoleic acids or an alpha-glucosidase inhibitor on tissue lipid concentrations and fatty acid composition of broiler chicks fed a low-protein diet. 2003 Poult. Sci. pmid:12762403
Kim JH et al. Effect of dietary supplementation with conjugated linoleic acid, with oleic, linoleic, or linolenic acid, on egg quality characteristics and fat accumulation in the egg yolk. 2007 Poult. Sci. pmid:17495090
Shin D et al. Effects of dietary combination of n-3 and n-9 fatty acids on the deposition of linoleic and arachidonic acid in broiler chicken meats. 2012 Poult. Sci. pmid:22399741