| MeSH term | MeSH ID | Detail |
|---|---|---|
| Glioma | D005910 | 112 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Grech ED et al. | Differential free-radical activity after successful and unsuccessful thrombolytic reperfusion in acute myocardial infarction. | 1993 | Coron. Artery Dis. | pmid:8287210 |
| Hrboticky N et al. | Lovastatin increases arachidonic acid levels and stimulates thromboxane synthesis in human liver and monocytic cell lines. | 1994 | J. Clin. Invest. | pmid:8282787 |
| Murray MJ et al. | Effects of endotoxin on pigs prefed omega-3 vs. omega-6 fatty acid-enriched diets. | 1993 | Am. J. Physiol. | pmid:8279548 |
| Bronstein JC and Bull AW | The correlation between 13-hydroxyoctadecadienoate dehydrogenase (13-HODE dehydrogenase) and intestinal cell differentiation. | 1993 | Prostaglandins | pmid:8278616 |
| Lamb RG et al. | An in vitro model of ethanol-dependent liver cell injury. | 1994 | Hepatology | pmid:8276354 |
| Ettinger WH et al. | Cytokines decrease apolipoprotein accumulation in medium from Hep G2 cells. | 1994 | Arterioscler. Thromb. | pmid:8274481 |
| Dehaut F et al. | n-6 polyunsaturated fatty acids increase the neurite length of PC12 cells and embryonic chick motoneurons. | 1993 | Neurosci. Lett. | pmid:8272254 |
| Sullivan JL et al. | Performance of dairy cows fed short staple, Pima, and cracked Pima cottonseed and feed characteristics. | 1993 | J. Dairy Sci. | pmid:8270698 |
| Blee E et al. | Regio- and stereoselectivity of cytochrome P-450 and peroxygenase-dependent formation of cis-12,13-epoxy-9(Z)-octadecenoic acid (vernolic acid) in Euphorbia lagascae. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8267615 |
| Whelan J et al. | Dietary arachidonate enhances tissue arachidonate levels and eicosanoid production in Syrian hamsters. | 1993 | J. Nutr. | pmid:8263613 |
| Viola G et al. | Absorption and distribution of arachidonate in rats receiving lysophospholipids by oral route. | 1993 | J. Lipid Res. | pmid:8263409 |
| Jones AL et al. | Rapid induction of microsomal delta 12(omega 6)-desaturase activity in chilled Acanthamoeba castellanii. | 1993 | Biochem. J. | pmid:8250841 |
| Vargas F et al. | Photodegradation and in vitro phototoxicity of fenofibrate, a photosensitizing anti-hyperlipoproteinemic drug. | 1993 | Photochem. Photobiol. | pmid:8248320 |
| Darmani H et al. | Interferon-gamma-stimulated uptake and turnover of linoleate and arachidonate in macrophages: a possible pathway for hypersensitivity to endotoxin. | 1993 | Cell. Immunol. | pmid:8242772 |
| Biagi PL et al. | Erythrocyte membrane fatty acid composition in children with atopic dermatitis compared to age-matched controls. | 1993 | Acta Paediatr. | pmid:8241678 |
| Markovic DZ and Patterson LK | Benzophenone-sensitized lipid peroxidation in linoleate micelles. | 1993 | Photochem. Photobiol. | pmid:8234464 |
| Daret D et al. | Synthesis of monohydroxylated fatty acids from linoleic acid by rat aortic smooth muscle cells and tissues: influence on prostacyclin production. | 1993 | J. Lipid Res. | pmid:8228632 |
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| Viscardi RM and Max SR | Unsaturated fatty acid modulation of glucocorticoid receptor binding in L2 cells. | 1993 | Steroids | pmid:8212085 |
| Sakuma S et al. | Effect of 13-hydroperoxyoctadecadienoic acid on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex. | 1993 | Prostaglandins | pmid:8210445 |
| Grammatopoulos D et al. | The human myometrial CRH receptor: G proteins and second messengers. | 1994 | Mol. Cell. Endocrinol. | pmid:8206332 |
| Glasgow WC and Eling TE | Structure-activity relationship for potentiation of EGF-dependent mitogenesis by oxygenated metabolites of linoleic acid. | 1994 | Arch. Biochem. Biophys. | pmid:8203891 |
| Yamashiro Y et al. | Effects of ursodeoxycholic acid treatment on essential fatty acid deficiency in patients with biliary atresia. | 1994 | J. Pediatr. Surg. | pmid:8201513 |
| Andrassy RJ et al. | Linoleic acid enhances mitogen response and survival of septic weanling rats. | 1994 | J. Pediatr. Surg. | pmid:8201499 |
| Truswell AS | Can linoleic acid contribute to coronary artery disease? | 1994 | Am. J. Clin. Nutr. | pmid:8198070 |
| Hodgson JM et al. | Can linoleic acid contribute to coronary artery disease? | 1993 | Am. J. Clin. Nutr. | pmid:8192728 |
| Cronan JE and Rock CO | The presence of linoleic acid in Escherichia coli cannot be confirmed. | 1994 | J. Bacteriol. | pmid:8188608 |
| Belluzzi A et al. | Short report: zinc sulphate supplementation corrects abnormal erythrocyte membrane long-chain fatty acid composition in patients with Crohn's disease. | 1994 | Aliment. Pharmacol. Ther. | pmid:8186338 |
| Jakobsen K et al. | Heat production and quantitative oxidation of nutrients by physical activity in pigs. | 1994 | Ann. Nutr. Metab. | pmid:8185282 |
| Appel MJ et al. | Effects of dietary linoleic acid on pancreatic carcinogenesis in rats and hamsters. | 1994 | Cancer Res. | pmid:8174115 |
| Cho Y and Ziboh VA | Incorporation of 13-hydroxyoctadecadienoic acid (13-HODE) into epidermal ceramides and phospholipids: phospholipase C-catalyzed release of novel 13-HODE-containing diacylglycerol. | 1994 | J. Lipid Res. | pmid:8169529 |
| Fuchs GJ et al. | Effect of dietary fat on cardiovascular risk factors in infancy. | 1994 | Pediatrics | pmid:8165074 |
| Araki K et al. | Reduced cytotoxicity of a root canal sealer through eugenol substitution. | 1993 | J Endod | pmid:8151243 |
| Kanekal S and Kehrer JP | Metabolism of cyclophosphamide by lipoxygenases. | 1994 Jan-Feb | Drug Metab. Dispos. | pmid:8149893 |
| Reaven PD et al. | Effects of linoleate-enriched and oleate-enriched diets in combination with alpha-tocopherol on the susceptibility of LDL and LDL subfractions to oxidative modification in humans. | 1994 | Arterioscler. Thromb. | pmid:8148354 |
| Jenkins TC et al. | Dietary soybean oil changes lipolytic rate and composition of fatty acids in plasma membranes of ovine adipocytes. | 1994 | J. Nutr. | pmid:8145079 |
| Paiement J et al. | Modulation of GTP-dependent fusion by linoleic and arachidonic acid in derivatives of rough endoplasmic reticulum from rat liver. | 1994 | Biochim. Biophys. Acta | pmid:8142417 |
| Shiina T et al. | Eicosapentaenoic acid and docosahexaenoic acid suppress the proliferation of vascular smooth muscle cells. | 1993 | Atherosclerosis | pmid:8141854 |
| Calder PC et al. | Triacylglycerol metabolism by lymphocytes and the effect of triacylglycerols on lymphocyte proliferation. | 1994 | Biochem. J. | pmid:8141773 |
| Ip C et al. | Potential of food modification in cancer prevention. | 1994 | Cancer Res. | pmid:8137319 |
| Chopra M et al. | Free radical scavenging of lutein in vitro. | 1993 | Ann. N. Y. Acad. Sci. | pmid:8129303 |
| Castell JV et al. | Photodynamic lipid peroxidation by the photosensitizing nonsteroidal antiinflammatory drugs suprofen and tiaprofenic acid. | 1994 | Photochem. Photobiol. | pmid:8127938 |
| Rao SI et al. | The lipoxygenase activity of myoglobin. Oxidation of linoleic acid by the ferryl oxygen rather than protein radical. | 1994 | J. Biol. Chem. | pmid:8125933 |
| Liu XH and Rose DP | Stimulation of type IV collagenase expression by linoleic acid in a metastatic human breast cancer cell line. | 1994 | Cancer Lett. | pmid:8124668 |
| Schürer NY et al. | Evidence for a novel keratinocyte fatty acid uptake mechanism with preference for linoleic acid: comparison of oleic and linoleic acid uptake by cultured human keratinocytes, fibroblasts and a human hepatoma cell line. | 1994 | Biochim. Biophys. Acta | pmid:8123682 |
| Hernández-Muñoz I et al. | Toxic oil stimulates collagen synthesis acting at a pretranslational level in cultured fat-storing cells. | 1994 | Gastroenterology | pmid:8119541 |
| Loidl-Stahlhofen A and Spiteller G | alpha-Hydroxyaldehydes, products of lipid peroxidation. | 1994 | Biochim. Biophys. Acta | pmid:8117742 |
| Hamberg M et al. | Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions. | 1994 | Arch. Biochem. Biophys. | pmid:8117115 |
| DeWille JW and Farmer SJ | Linoleic acid controls neonatal tissue-specific stearoyl-CoA desaturase mRNA levels. | 1993 | Biochim. Biophys. Acta | pmid:8105893 |
| Spady DK | Regulatory effects of individual n-6 and n-3 polyunsaturated fatty acids on LDL transport in the rat. | 1993 | J. Lipid Res. | pmid:8105015 |