| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperpigmentation | D017495 | 11 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Hypertrophy, Left Ventricular | D017379 | 12 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Mammary Neoplasms, Animal | D015674 | 27 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Vitamin D Deficiency | D014808 | 13 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Grechkin AN et al. | The lipoxygenase pathway in garlic (Allium sativum L.) bulbs: detection of the novel divinyl ether oxylipins. | 1995 | FEBS Lett. | pmid:7672118 |
| Sakai T et al. | A lipid peroxidation-derived aldehyde, 4-hydroxy-2-nonenal and omega 6 fatty acids contents in meats. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7670203 |
| van Tol A et al. | Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man. | 1995 | Atherosclerosis | pmid:7669083 |
| Romon M et al. | Comparison between fat intake assessed by a 3-day food record and phospholipid fatty acid composition of red blood cells: results from the Monitoring of Cardiovascular Disease-Lille Study. | 1995 | Metab. Clin. Exp. | pmid:7666786 |
| Abdel-Fattah G et al. | Regulation of guinea pig very low density lipoprotein secretion rates by dietary fat saturation. | 1995 | J. Lipid Res. | pmid:7665997 |
| Mize CE et al. | Lipoprotein-cholesterol responses in healthy infants fed defined diets from ages 1 to 12 months: comparison of diets predominant in oleic acid versus linoleic acid, with parallel observations in infants fed a human milk-based diet. | 1995 | J. Lipid Res. | pmid:7665996 |
| Khan MF et al. | Hematopoietic toxicity of linoleic acid anilide: importance of aniline. | 1995 | Fundam Appl Toxicol | pmid:7665006 |
| Tezabwala BU et al. | Immunotoxicity of polyunsaturated fatty acids in serum-free medium. | 1995 | Immunopharmacol Immunotoxicol | pmid:7650296 |
| Laneuville O et al. | Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid. | 1995 | J. Biol. Chem. | pmid:7642610 |
| Rao GN et al. | Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells. | 1995 | J. Clin. Invest. | pmid:7635978 |
| Appel MJ and Woutersen RA | Effects of dietary fish oil (MaxEPA) on N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic carcinogenesis in hamsters. | 1995 | Cancer Lett. | pmid:7634246 |
| Leichsenring M et al. | Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. | 1995 | Acta Paediatr. | pmid:7633146 |
| Emmison N et al. | Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. | 1995 | Am. J. Physiol. | pmid:7631907 |
| Guo L et al. | Preferential formation of the hydroperoxide of linoleic acid in choline glycerophospholipids in human erythrocytes membrane during peroxidation with an azo initiator. | 1995 | Free Radic. Biol. Med. | pmid:7628726 |
| Krugliak M et al. | Antimalarial effects of C18 fatty acids on Plasmodium falciparum in culture and on Plasmodium vinckei petteri and Plasmodium yoelii nigeriensis in vivo. | 1995 | Exp. Parasitol. | pmid:7628573 |
| Chen CC and Chen CS | Brugia pahangi: effects of melanization on the uptake of nutrients by microfilariae in vitro. | 1995 | Exp. Parasitol. | pmid:7628569 |
| van der Heijdt LM et al. | Changes in the iron coordination sphere of Fe(II) lipoxygenase-1 from soybeans upon binding of linoleate or oleate. | 1995 | Eur. J. Biochem. | pmid:7628469 |
| Rudel LL et al. | Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness. | 1995 | Am. J. Clin. Nutr. | pmid:7625361 |
| Chu S et al. | Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7624373 |
| Camacho M et al. | Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. | 1995 | J. Biol. Chem. | pmid:7615528 |
| Norman HA et al. | Licorice-derived compounds inhibit linoleic acid (C:18:2 omega 6) desaturation in soybean chloroplasts. | 1995 | FEBS Lett. | pmid:7615067 |
| Sarel I and Widmaier EP | Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. | 1995 | Am. J. Physiol. | pmid:7611525 |
| Thomas ME et al. | Metabolic effects of fatty acid-bearing albumin on a proximal tubule cell line. | 1995 | Am. J. Physiol. | pmid:7611458 |
| Pyles LA et al. | Plasma antioxidant depletion after cardiopulmonary bypass in operations for congenital heart disease. | 1995 | J. Thorac. Cardiovasc. Surg. | pmid:7609540 |
| Jenkins TC | Butylsoyamide protects soybean oil from ruminal biohydrogenation: effects of butylsoyamide on plasma fatty acids and nutrient digestion in sheep. | 1995 | J. Anim. Sci. | pmid:7608016 |
| Kurushima H et al. | Comparison of hypocholesterolemic effects induced by dietary linoleic acid and oleic acid in hamsters. | 1995 | Atherosclerosis | pmid:7605390 |
| van de Sandt JJ et al. | Release of arachidonic and linoleic acid metabolites in skin organ cultures as characteristics of in vitro skin irritancy. | 1995 | Fundam Appl Toxicol | pmid:7601324 |
| Blée E and Schuber F | Stereocontrolled hydrolysis of the linoleic acid monoepoxide regioisomers catalyzed by soybean epoxide hydrolase. | 1995 | Eur. J. Biochem. | pmid:7601104 |
| Engman L et al. | Organotellurium compounds as efficient retarders of lipid peroxidation in methanol. | 1995 | Free Radic. Biol. Med. | pmid:7590393 |
| Rodier M et al. | Effects of insulin therapy upon plasma lipid fatty acids and platelet aggregation in NIDDM with secondary failure to oral antidiabetic agents. | 1995 | Diabetes Res. Clin. Pract. | pmid:7587908 |
| Greco AV et al. | Free fatty acid analysis in ascitic fluid improves diagnosis in malignant abdominal tumors. | 1995 | Clin. Chim. Acta | pmid:7586583 |
| Jiang WG et al. | Regulation of the expression of E-cadherin on human cancer cells by gamma-linolenic acid (GLA). | 1995 | Cancer Res. | pmid:7585549 |
| Nakayama T et al. | Visible spectrophotometric assay, purification, and molecular properties of a lipoxygenase from eggplant (Solanum melongena Linne) fruits. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7575511 |
| Pietsch A et al. | N-3 but not N-6 fatty acids reduce the expression of the combined adhesion and scavenger receptor CD36 in human monocytic cells. | 1995 | Cell Biochem. Funct. | pmid:7554100 |
| Shintani T et al. | Recognition system for dietary fatty acids in the rat small intestine. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7549092 |
| Yamamoto A et al. | Absorption enhancement of intrapulmonary administered insulin by various absorption enhancers and protease inhibitors in rats. | 1994 | J. Pharm. Pharmacol. | pmid:7515417 |
| Teboul L et al. | Thiazolidinediones and fatty acids convert myogenic cells into adipose-like cells. | 1995 | J. Biol. Chem. | pmid:7499310 |
| Campbell FM and Dutta-Roy AK | Plasma membrane fatty acid-binding protein (FABPpm) is exclusively located in the maternal facing membranes of the human placenta. | 1995 | FEBS Lett. | pmid:7498505 |
| Bondy SC and Marwah S | Stimulation of synaptosomal free radical production by fatty acids: relation to esterification and to degree of unsaturation. | 1995 | FEBS Lett. | pmid:7498480 |
| Decsi T et al. | Long-chain polyunsaturated fatty acids in children with severe protein-energy malnutrition with and without human immunodeficiency virus-1 infection. | 1995 | Am. J. Clin. Nutr. | pmid:7491893 |
| Groscolas R et al. | Developing Yoshida sarcoma does not influence the fatty acid composition of adipose tissues in the rat. | 1995 | Nutr Cancer | pmid:7491300 |
| Johanning GL and Lin TY | Unsaturated fatty acid effects on human breast cancer cell adhesion. | 1995 | Nutr Cancer | pmid:7491298 |
| Rose DP et al. | Effects of linoleic acid and gamma-linolenic acid on the growth and metastasis of a human breast cancer cell line in nude mice and on its growth and invasive capacity in vitro. | 1995 | Nutr Cancer | pmid:7491296 |
| Iwase H et al. | pH dependent alterations of monoepoxides and monochlorohydrins of linoleic acid, and their existence in vivo. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488065 |
| Kerner J et al. | Impaired gut lipid absorptive capacity after trauma-hemorrhage and resuscitation. | 1995 | Am. J. Physiol. | pmid:7485605 |
| Noguchi M et al. | Effects of eicosapentaenoic and docosahexaenoic acid on cell growth and prostaglandin E and leukotriene B production by a human breast cancer cell line (MDA-MB-231). | 1995 Nov-Dec | Oncology | pmid:7478431 |
| Christen MO et al. | Use of linoleic acid radiolysis for assay of antioxidant action of anethole dithiolethione. | 1995 | Meth. Enzymol. | pmid:7476369 |
| Al MD et al. | Some aspects of neonatal essential fatty acid status are altered by linoleic acid supplementation of women during pregnancy. | 1995 | J. Nutr. | pmid:7472662 |
| Cho Y and Ziboh VA | Nutritional modulation of guinea pig skin hyperproliferation by essential fatty acid deficiency is associated with selective down regulation of protein kinase C-beta. | 1995 | J. Nutr. | pmid:7472653 |
| Kitada S et al. | Characterization of a lipid mobilizing factor from tumors. | 1981 | Prog. Lipid Res. | pmid:7342133 |