| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperpigmentation | D017495 | 11 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
| Hypertrophy, Left Ventricular | D017379 | 12 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Helicobacter Infections | D016481 | 21 associated lipids |
| Mammary Neoplasms, Animal | D015674 | 27 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Vitamin D Deficiency | D014808 | 13 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Callaghan R et al. | Increased accumulation of drugs in a multidrug resistant cell line by alteration of membrane biophysical properties. | 1993 | Biochim. Biophys. Acta | pmid:8435444 |
| Reaven P et al. | Effects of oleate-rich and linoleate-rich diets on the susceptibility of low density lipoprotein to oxidative modification in mildly hypercholesterolemic subjects. | 1993 | J. Clin. Invest. | pmid:8432867 |
| Deigner HP and Dresel HA | Effect of platelet activating factor on the kinetics of LDL oxidation in vitro. | 1993 | FEBS Lett. | pmid:8425606 |
| Oliw EH et al. | Bis-allylic hydroxylation of polyunsaturated fatty acids by hepatic monooxygenases and its relation to the enzymatic and nonenzymatic formation of conjugated hydroxy fatty acids. | 1993 | Arch. Biochem. Biophys. | pmid:8424677 |
| Blair IA et al. | Dietary modification of omega 6 fatty acid intake and its effect on urinary eicosanoid excretion. | 1993 | Am. J. Clin. Nutr. | pmid:8424383 |
| Cominacini L et al. | Determination of lipid hydroperoxides in native low-density lipoprotein by a chemiluminescent flow-injection assay. | 1993 | Biochim. Biophys. Acta | pmid:8418885 |
| de Waard P et al. | Heteronuclear NMR analysis of unsaturated fatty acids in poly(3-hydroxyalkanoates). Study of beta-oxidation in Pseudomonas putida. | 1993 | J. Biol. Chem. | pmid:8416939 |
| Seidelin KN et al. | Percentage distribution of fatty acids in subcutaneous adipose tissue of patients with peptic ulcer disease. | 1993 | Am. J. Clin. Nutr. | pmid:8416668 |
| Keler T and Sorof S | Growth promotion of transfected hepatoma cells by liver fatty acid binding protein. | 1993 | J. Cell. Physiol. | pmid:8408240 |
| Kleinveld HA et al. | Oxidation resistance, oxidation rate, and extent of oxidation of human low-density lipoprotein depend on the ratio of oleic acid content to linoleic acid content: studies in vitamin E deficient subjects. | 1993 | Free Radic. Biol. Med. | pmid:8406127 |
| Toborek M and Hennig B | Vitamin E attenuates induction of elastase-like activity by tumor necrosis factor-alpha, cholestan-3 beta,5 alpha,6 beta-triol and linoleic acid in cultured endothelial cells. | 1993 | Clin. Chim. Acta | pmid:8403435 |
| Hatala MA et al. | Characterization of phospholipase A2 activity in MDA-MB-435 human breast cancer cells. | 1993 | Cancer Lett. | pmid:8402571 |
| Baykousheva S | Metabolism of [1-14C]linoleic acid in human promyelocytic leukemia HL-60 cells grown and differentiated in serum-free medium. | 1993 | Cancer Lett. | pmid:8402565 |
| Emken EA et al. | Influence of linoleic acid on desaturation and uptake of deuterium-labeled palmitic and stearic acids in humans. | 1993 | Biochim. Biophys. Acta | pmid:8399342 |
| Reid G | Metabolic disorders of cattle. | 1993 | Med. Hypotheses | pmid:8394500 |
| Laihia JK et al. | Lucigenin and linoleate enhanced chemiluminescent assay for superoxide dismutase activity. | 1993 | Free Radic. Biol. Med. | pmid:8394267 |
| Turley CP and Brewster MA | Alpha-tocopherol protects against a reduction in adenosylcobalamin in oxidatively stressed human cells. | 1993 | J. Nutr. | pmid:8391565 |
| Horrobin DF | Fatty acid metabolism in health and disease: the role of delta-6-desaturase. | 1993 | Am. J. Clin. Nutr. | pmid:8386433 |
| Soliven B et al. | Arachidonic acid and its metabolites increase Cai in cultured rat oligodendrocytes. | 1993 | Am. J. Physiol. | pmid:8384786 |
| Poisson JP et al. | Effect of salt-loading and spontaneous hypertension on in vitro metabolism of [1-14C]linoleic and [2-14C]dihomo-gamma-linolenic acids. | 1993 | Biochem. Med. Metab. Biol. | pmid:8382502 |
| Brinkmeier H et al. | Specific modifications of the membrane fatty acid composition of human myotubes and their effects on the muscular sodium channels. | 1993 | Biochim. Biophys. Acta | pmid:8380720 |
| James MJ et al. | Simple relationships exist between dietary linoleate and the n-6 fatty acids of human neutrophils and plasma. | 1993 | Am. J. Clin. Nutr. | pmid:8379505 |
| Feunekes GI et al. | Relative and biomarker-based validity of a food-frequency questionnaire estimating intake of fats and cholesterol. | 1993 | Am. J. Clin. Nutr. | pmid:8379504 |
| Sigurdson SL and Ip MM | Casein accumulation by rat mammary epithelial cells grown within a reconstituted basement membrane is modulated by fatty acids in a hormone- and time-dependent manner. | 1993 | Exp. Cell Res. | pmid:8375465 |
| van Zoeren-Grobben D et al. | Lipid peroxidation in human milk and infant formula: effect of storage, tube feeding and exposure to phototherapy. | 1993 | Acta Paediatr. | pmid:8374211 |
| Black JM and Kinsella JE | Dietary n-3 fatty acids alter murine peritoneal macrophage cytotoxicity. | 1993 | Ann. Nutr. Metab. | pmid:8373135 |
| Hong CY et al. | Linoleate-rich triacylglycerol in Panax pseudo-ginseng improves erythrocyte deformability in vitro. | 1993 | Planta Med. | pmid:8372148 |
| Rabinowitch HD et al. | Escherichia coli produces linoleic acid during late stationary phase. | 1993 | J. Bacteriol. | pmid:8366020 |
| Davis PA et al. | A linoleate-enriched cheese product reduces low-density lipoprotein in moderately hypercholesterolemic adults. | 1993 | Ann. Intern. Med. | pmid:8363165 |
| Chang WC et al. | Induction of arachidonate 12-lipoxygenase mRNA by epidermal growth factor in A431 cells. | 1993 | J. Biol. Chem. | pmid:8360167 |
| Zheng RL et al. | Inhibition of the autoxidation of linoleic acid by phenylpropanoid glycosides from Pedicularis in micelles. | 1993 | Chem. Phys. Lipids | pmid:8358852 |
| Buchanan MR and Brister SJ | Altering vessel wall fatty acid metabolism: a new strategy for antithrombotic treatment. | 1993 | Semin. Thromb. Hemost. | pmid:8356461 |
| Mao-Qiang M et al. | Inhibition of cholesterol and sphingolipid synthesis causes paradoxical effects on permeability barrier homeostasis. | 1993 | J. Invest. Dermatol. | pmid:8345219 |
| Roy R and Bélanger A | ZR-75-1 breast cancer cells generate nonconjugated steroids from low density lipoprotein-incorporated lipoidal dehydroepiandrosterone. | 1993 | Endocrinology | pmid:8344206 |
| Guha SN et al. | Free radical reductive degradation of vic-dibromoalkanes and reaction of bromine atoms with polyunsaturated fatty acids: possible involvement of Br(.) in the 1,2-dibromoethane-induced lipid peroxidation. | 1993 | Arch. Biochem. Biophys. | pmid:8342946 |
| Kühn H et al. | Overexpression, purification and characterization of human recombinant 15-lipoxygenase. | 1993 | Biochim. Biophys. Acta | pmid:8334154 |
| Dutta-Roy AK et al. | Purification and characterization of fatty acid-binding proteins from brown adipose tissue of the rat. | 1993 | Biochim. Biophys. Acta | pmid:8334153 |
| Rich MR | Conformational analysis of arachidonic and related fatty acids using molecular dynamics simulations. | 1993 | Biochim. Biophys. Acta | pmid:8329458 |
| Hansen HS | Linoleic acid as a precursor for acylation of transducin, a retinol G protein? | 1993 | Trends Biochem. Sci. | pmid:8328015 |
| Wieland E et al. | Peroxidase-dependent metal-independent oxidation of low density lipoprotein in vitro: a model for in vivo oxidation? | 1993 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8327462 |
| Kaneko T et al. | Protective effect of lipophilic derivatives of ascorbic acid on lipid peroxide-induced endothelial injury. | 1993 | Arch. Biochem. Biophys. | pmid:8323284 |
| Louw L and van der Westhuizen JP | Correlation between histopathology and linoleic acid levels in five meningioma types. | 1993 | Pathol. Res. Pract. | pmid:8321745 |
| Hernell O et al. | Does the bile salt-stimulated lipase of human milk have a role in the use of the milk long-chain polyunsaturated fatty acids? | 1993 | J. Pediatr. Gastroenterol. Nutr. | pmid:8315552 |
| Larner JM et al. | The isolation and characterization of estradiol-fatty acid esters in human ovarian follicular fluid. Identification of an endogenous long-lived and potent family of estrogens. | 1993 | J. Biol. Chem. | pmid:8314757 |
| Yamaguchi Y et al. | Enhancement of aortic cholesterol deposition by dietary linoleic acid in cholesterol-fed mice: an animal model for primary screening of antiatherosclerotic agents. | 1993 | J Pharmacol Toxicol Methods | pmid:8305719 |
| Marcelo CL and Dunham WR | Fatty acid metabolism studies of human epidermal cell cultures. | 1993 | J. Lipid Res. | pmid:8301228 |
| Ramasamy S et al. | Proteoglycans and endothelial barrier function: effect of linoleic acid exposure to porcine pulmonary artery endothelial cells. | 1993 | Atherosclerosis | pmid:8292102 |
| Li Y et al. | Chemical and alpha-chymotrypsin-mediated proteolytic degradation of insulin in bile salt-unsaturated fatty acid mixed micellar systems. | 1993 | Pharm. Res. | pmid:8290478 |
| Sanjurjo P et al. | Cross-sectional study of percentual changes in total plasmatic fatty acids during pregnancy. | 1993 | Horm. Metab. Res. | pmid:8288163 |
| Sunzeri FJ and Buehring GC | Lipids alter the level and distribution of mouse mammary tumor virus gp52 in vitro. | 1993 | Cancer Lett. | pmid:8287372 |