Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Aortic Diseases D001018 11 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Glucose Intolerance D018149 13 associated lipids
Alopecia D000505 14 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Olfaction Disorders D000857 17 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Tuberculosis D014376 20 associated lipids
Helicobacter Infections D016481 21 associated lipids
Birth Weight D001724 23 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Kidney Diseases D007674 29 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Granot E et al. Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. 2000 Am. J. Clin. Nutr. pmid:11063450
Hayes KC The linoleic acid content of test diets must be carefully monitored in cholesterol studies. 1997 Am. J. Clin. Nutr. pmid:9094899
Jeppesen PB et al. Differences in essential fatty acid requirements by enteral and parenteral routes of administration in patients with fat malabsorption. 1999 Am. J. Clin. Nutr. pmid:10393142
Erickson KL Is there a relation between dietary linoleic acid and cancer of the breast, colon, or prostate? 1998 Am. J. Clin. Nutr. pmid:9665090
Zock PL and Katan MB Linoleic acid intake and cancer risk: a review and meta-analysis. 1998 Am. J. Clin. Nutr. pmid:9665108
Cleland LG et al. Linoleate inhibits EPA incorporation from dietary fish-oil supplements in human subjects. 1992 Am. J. Clin. Nutr. pmid:1310374
Jiang J et al. Relation between the intake of milk fat and the occurrence of conjugated linoleic acid in human adipose tissue. 1999 Am. J. Clin. Nutr. pmid:10393134
Cosgrove MC et al. Dietary nutrient intakes and skin-aging appearance among middle-aged American women. 2007 Am. J. Clin. Nutr. pmid:17921406
Thijssen MA and Mensink RP Small differences in the effects of stearic acid, oleic acid, and linoleic acid on the serum lipoprotein profile of humans. 2005 Am. J. Clin. Nutr. pmid:16155261
Asciutti-Moura LS et al. Fatty acid composition of serum lipids and its relation to diet in an elderly institutionalized population. 1988 Am. J. Clin. Nutr. pmid:3421207
Djoussé L et al. Relation between dietary linolenic acid and coronary artery disease in the National Heart, Lung, and Blood Institute Family Heart Study. 2001 Am. J. Clin. Nutr. pmid:11684529
Venäläinen TM et al. Effect of a 2-y dietary and physical activity intervention on plasma fatty acid composition and estimated desaturase and elongase activities in children: the Physical Activity and Nutrition in Children Study. 2016 Am. J. Clin. Nutr. pmid:27581473
Oosthuizen W et al. Polyunsaturated fatty acid intake is adversely related to liver function in HIV-infected subjects: the THUSA study. 2006 Am. J. Clin. Nutr. pmid:16685065
Chan JK et al. Dietary alpha-linolenic acid is as effective as oleic acid and linoleic acid in lowering blood cholesterol in normolipidemic men. 1991 Am. J. Clin. Nutr. pmid:1673589
Andersen LF et al. Evaluation of a food frequency questionnaire with weighed records, fatty acids, and alpha-tocopherol in adipose tissue and serum. 1999 Am. J. Epidemiol. pmid:10400557
Brosnan MJ and Carkner RD Hepatic effects of a fructose diet in the stroke-prone spontaneously hypertensive rat. 2008 Am. J. Hypertens. pmid:18437120
Taylor EN et al. Fatty acid intake and incident nephrolithiasis. 2005 Am. J. Kidney Dis. pmid:15685503
Ascherio A Epidemiologic studies on dietary fats and coronary heart disease. 2002 Am. J. Med. pmid:12566133
Weiss LA et al. The omega-6 fatty acid linoleic acid is associated with risk of gastroschisis: a novel dietary risk factor. 2012 Am. J. Med. Genet. A pmid:22315197
SCHWARTZ S et al. LIPID THROMBOPLASTINS AND MYOCARDIAL INFARCTION. 1965 Am. J. Med. Sci. pmid:14254823
Brush MG et al. Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. 1984 Am. J. Obstet. Gynecol. pmid:6091462
Kääpä P et al. Dietary fatty acids and platelet thromboxane production in puerperal women and their offspring. 1986 Am. J. Obstet. Gynecol. pmid:3089014
MacKenzie LW et al. Prostacyclin biosynthesis by cultured human myometrial smooth muscle cells: dependency on arachidonic or linoleic acid in the culture medium. 1988 Am. J. Obstet. Gynecol. pmid:3144917
Vaughan JE and Walsh SW Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-alpha in response to linoleic acid and oxidative stress. 2005 Am. J. Obstet. Gynecol. pmid:16150282
Liu H et al. Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease. 2015 Am. J. Pathol. pmid:25447051
McEntee MF et al. Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer. 2008 Am. J. Pathol. pmid:18556778
Pandey NR et al. An induction in hepatic HDL secretion associated with reduced ATPase expression. 2009 Am. J. Pathol. pmid:19717637
Thomson AB et al. A high linoleic acid diet diminishes enhanced intestinal uptake of sugars in diabetic rats. 1987 Am. J. Physiol. pmid:3826353
Düsing R et al. Dietary linoleic acid deprivation: effects on blood pressure and PGI2 synthesis. 1983 Am. J. Physiol. pmid:6337507
Murray MJ et al. Effects of endotoxin on pigs prefed omega-3 vs. omega-6 fatty acid-enriched diets. 1993 Am. J. Physiol. pmid:8279548
Sarel I and Widmaier EP Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. 1995 Am. J. Physiol. pmid:7611525
Rosenblum WI Unsaturated fatty acids and cyclooxygenase inhibitors: effects on pial arterioles. 1982 Am. J. Physiol. pmid:6801999
Meikle AW et al. Nonesterified fatty acids modulate steroidogenesis in mouse Leydig cells. 1989 Am. J. Physiol. pmid:2558577
West DB et al. Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. 1998 Am. J. Physiol. pmid:9728060
Jensen MD et al. Measurement of non-steady-state free fatty acid turnover. 1990 Am. J. Physiol. pmid:2405695
GOLD M and SPITZER JJ METABOLISM OF FREE FATTY ACIDS BY MYOCARDIUM AND KIDNEY. 1964 Am. J. Physiol. pmid:14111431
SPITZER JJ and GOLD M FREE FATTY ACID METABOLISM BY SKELETAL MUSCLE. 1964 Am. J. Physiol. pmid:14111432
Kerner J et al. Impaired gut lipid absorptive capacity after trauma-hemorrhage and resuscitation. 1995 Am. J. Physiol. pmid:7485605
ERWIN ES and STERNER W DIETARY LIPIDS AND FATTY ACID DEPOSITION IN VARIOUS CALF TISSUES. 1963 Am. J. Physiol. pmid:14084975
Emmison N et al. Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. 1995 Am. J. Physiol. pmid:7631907
Thomas ME et al. Metabolic effects of fatty acid-bearing albumin on a proximal tubule cell line. 1995 Am. J. Physiol. pmid:7611458
Spalinger JH et al. Uptake and metabolism of structured triglyceride by Caco-2 cells: reversal of essential fatty acid deficiency. 1998 Am. J. Physiol. pmid:9756493
Chen ZY et al. Depletion of linoleate induced by weight cycling is independent of extent of calorie restriction. 1997 Am. J. Physiol. pmid:9038989
WILSON JD Relation between dietary cholesterol and bile acid excretion in the rat. 1962 Am. J. Physiol. pmid:14001040
Nilsson A et al. Absorption and lymphatic transport of exogenous and endogenous arachidonic and linoleic acid in the rat. 1987 Am. J. Physiol. pmid:3109253
Reddy SR et al. Effect of linoleic acid infusion on blood pressure in normotensive and hypertensive rats. 1989 Am. J. Physiol. pmid:2764141
Le Petit-Thevenin J et al. Changes in pattern of phospholipid acylation during in vivo aging of rat red blood cells. 1991 Am. J. Physiol. pmid:1887869
Jayawickreme SP et al. Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells. 1999 Am. J. Physiol. pmid:10198357
DeLany JP et al. Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. 1999 Am. J. Physiol. pmid:10198400
Bogdanov KY et al. Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids. 1998 Am. J. Physiol. pmid:9486261
Chen ZY and Cunnane SC Preferential retention of linoleic acid-enriched triacylglycerols in liver and serum during fasting. 1992 Am. J. Physiol. pmid:1510164
Aw TY et al. Absorption and lymphatic transport of peroxidized lipids by rat small intestine in vivo: role of mucosal GSH. 1992 Am. J. Physiol. pmid:1733274
Liu F et al. Permeability properties of monolayers of the human trophoblast cell line BeWo. 1997 Am. J. Physiol. pmid:9374645
Guidot DM et al. Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs. 1997 Am. J. Physiol. pmid:9374722
Devor DC and Frizzell RA Modulation of K+ channels by arachidonic acid in T84 cells. II. Activation of a Ca(2+)-independent K+ channel. 1998 Am. J. Physiol. pmid:9458723
Shasby DM et al. Oxidants and conductance of cultured epithelial cell monolayers: inositol phospholipid hydrolysis. 1988 Am. J. Physiol. pmid:3144179
Chen ZY et al. Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats. 1995 Am. J. Physiol. pmid:7864247
Hjelte L et al. Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats. 1990 Am. J. Physiol. pmid:2115302
Phifer CB and Berthoud HR Duodenal nutrient infusions differentially affect sham feeding and Fos expression in rat brain stem. 1998 Am. J. Physiol. pmid:9841547
Meyer C et al. Human kidney free fatty acid and glucose uptake: evidence for a renal glucose-fatty acid cycle. 1997 Am. J. Physiol. pmid:9316458
Soliven B et al. Arachidonic acid and its metabolites increase Cai in cultured rat oligodendrocytes. 1993 Am. J. Physiol. pmid:8384786
Sebokova E et al. Modulation of receptor-mediated gonadotropin action in rat testes by dietary fat. 1988 Am. J. Physiol. pmid:2897795
Ookhtens M and Baker N Incomplete free fatty acid oxidation by ascites tumor cells under low oxygen tension. 1983 Am. J. Physiol. pmid:6295191
Delhanty PJ et al. Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization. 2010 Am. J. Physiol. Endocrinol. Metab. pmid:20587751
Ross RA et al. Differential effects of hypothalamic long-chain fatty acid infusions on suppression of hepatic glucose production. 2010 Am. J. Physiol. Endocrinol. Metab. pmid:20647558
López-Luna P et al. Fate of orally administered radioactive fatty acids in the late-pregnant rat. 2016 Am. J. Physiol. Endocrinol. Metab. pmid:26714850
Henriksen EJ et al. Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat. 2003 Am. J. Physiol. Endocrinol. Metab. pmid:12618357
Hodson L et al. Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate. 2009 Am. J. Physiol. Endocrinol. Metab. pmid:18940935
Dailey MJ et al. Jejunal linoleic acid infusions require GLP-1 receptor signaling to inhibit food intake: implications for the effectiveness of Roux-en-Y gastric bypass. 2011 Am. J. Physiol. Endocrinol. Metab. pmid:21917638
Carpentier AC et al. Mechanism of insulin-stimulated clearance of plasma nonesterified fatty acids in humans. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17062840
Bézaire V et al. Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. 2001 Am. J. Physiol. Endocrinol. Metab. pmid:11595653
Guo W et al. Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17519282
Payet MD et al. An oxidized metabolite of linoleic acid increases intracellular calcium in rat adrenal glomerulosa cells. 2006 Am. J. Physiol. Endocrinol. Metab. pmid:16822961
Subauste AR and Burant CF Role of FoxO1 in FFA-induced oxidative stress in adipocytes. 2007 Am. J. Physiol. Endocrinol. Metab. pmid:17374693
de Vogel-van den Bosch HM et al. A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18356535
Kim EJ et al. Trans-10,cis-12-conjugated linoleic acid inhibits Caco-2 colon cancer cell growth. 2002 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12121883
Running CA and Mattes RD Humans are more sensitive to the taste of linoleic and α-linolenic than oleic acid. 2015 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:25540234
Lukovac S et al. Essential fatty acid deficiency in mice impairs lactose digestion. 2008 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:18653724
Mattes RD Effects of linoleic acid on sweet, sour, salty, and bitter taste thresholds and intensity ratings of adults. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17290007
Chalé-Rush A et al. Multiple routes of chemosensitivity to free fatty acids in humans. 2007 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:17234892
Cho HJ et al. Conjugated linoleic acid inhibits cell proliferation and ErbB3 signaling in HT-29 human colon cell line. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12571082
Friesen R and Innis SM Maternal dietary fat alters amniotic fluid and fetal intestinal membrane essential n-6 and n-3 fatty acids in the rat. 2006 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:16282365
Minich DM et al. Intestinal absorption and postabsorptive metabolism of linoleic acid in rats with short-term bile duct ligation. 2000 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11093947
Alzoghaibi MA et al. Linoleic acid induces interleukin-8 production by Crohn's human intestinal smooth muscle cells via arachidonic acid metabolites. 2004 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:14656710
McHowat J and Creer MH Selective plasmalogen substrate utilization by thrombin-stimulated Ca(2+)-independent PLA(2) in cardiomyocytes. 2000 Am. J. Physiol. Heart Circ. Physiol. pmid:10843891
Zaman MM et al. Linoleic acid supplementation results in increased arachidonic acid and eicosanoid production in CF airway cells and in cftr-/- transgenic mice. 2010 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:20656894
Mizuta K et al. Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle. 2015 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:26342087
Vij N Linoleic acid supplement in cystic fibrosis: friend or foe? 2010 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:20709729
Heeley EL et al. Phospholipid molecular species of bronchoalveolar lavage fluid after local allergen challenge in asthma. 2000 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:10666114
Randich A et al. Jejunal administration of linoleic acid increases activity of neurons in the paraventricular nucleus of the hypothalamus. 2004 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:14660477
Whigham LD et al. CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig tracheae. 2001 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:11171673
Matravadia S et al. LA and ALA prevent glucose intolerance in obese male rats without reducing reactive lipid content, but cause tissue-specific changes in fatty acid composition. 2016 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:26764053
Bruder ED et al. An oxidized metabolite of linoleic acid stimulates corticosterone production by rat adrenal cells. 2003 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:12689852
Sclafani A et al. CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:17804586
Stratford JM et al. Linoleic acid increases chorda tympani nerve responses to and behavioral preferences for monosodium glutamate by male and female rats. 2008 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:18635450
Al-Khalifa A et al. Effect of dietary hempseed intake on cardiac ischemia-reperfusion injury. 2007 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:17122327
Chen CS et al. Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue. 2013 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24154509
Dailey MJ et al. Nutrient-specific feeding and endocrine effects of jejunal infusions in obese animals. 2014 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24452547
Whigham LD et al. Decreased antigen-induced eicosanoid release in conjugated linoleic acid-fed guinea pigs. 2002 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:11893615
Darling RA et al. Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors. 2014 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24760994