Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Coronary Disease D003327 70 associated lipids
Colitis D003092 69 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Pain D010146 64 associated lipids
Weight Loss D015431 56 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Thrombosis D013927 49 associated lipids
Precancerous Conditions D011230 48 associated lipids
Fatty Liver D005234 48 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Heart Failure D006333 36 associated lipids
Liver Diseases D008107 31 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Kidney Diseases D007674 29 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Bretillon L et al. Desaturation and chain elongation of [1-14C]mono-trans isomers of linoleic and alpha-linolenic acids in perfused rat liver. 1998 J. Lipid Res. pmid:9799809
Turpeinen AM et al. Replacement of dietary saturated by unsaturated fatty acids: effects of platelet protein kinase C activity, urinary content of 2,3-dinor-TXB2 and in vitro platelet aggregation in healthy man. 1998 Thromb. Haemost. pmid:9798986
Hu ZY et al. cAMP inhibits linoleic acid-induced growth by antagonizing p27(kip1) depletion, but not interfering with the extracellular signal-regulated kinase or AP-1 activities. 1998 Biochim. Biophys. Acta pmid:9784625
Iwamoto S et al. Effects of fatty acids on liver metastasis of ACL-15 rat colon cancer cells. 1998 Nutr Cancer pmid:9770727
Obukowicz MG et al. Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. 1998 J. Pharmacol. Exp. Ther. pmid:9765335
Spalinger JH et al. Uptake and metabolism of structured triglyceride by Caco-2 cells: reversal of essential fatty acid deficiency. 1998 Am. J. Physiol. pmid:9756493
Kuratko CN and Constante BJ Linoleic acid and tumor necrosis factor-alpha increase manganese superoxide dismutase activity in intestinal cells. 1998 Cancer Lett. pmid:9751273
Kanazawa K and Ashida H Dietary hydroperoxides of linoleic acid decompose to aldehydes in stomach before being absorbed into the body. 1998 Biochim. Biophys. Acta pmid:9748650
Kanazawa K and Ashida H Catabolic fate of dietary trilinoleoylglycerol hydroperoxides in rat gastrointestines. 1998 Biochim. Biophys. Acta pmid:9748647
Berdeaux O et al. In vitro desaturation or elongation of monotrans isomers of linoleic acid by rat liver microsomes. 1998 Mol. Cell. Biochem. pmid:9746207