Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypertension D006973 115 associated lipids
Hypertension, Renal D006977 9 associated lipids
Inflammation D007249 119 associated lipids
Insulin Resistance D007333 99 associated lipids
Kidney Diseases D007674 29 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Lactose Intolerance D007787 2 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Liver Diseases D008107 31 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphopenia D008231 2 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Melanosis D008548 4 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Codde JP et al. Dissociation of effects of dietary fatty acids on blood pressure and prostanoid metabolism in Goldblatt hypertensive rats. 1984 J. Hypertens. pmid:6099384
Chen TC et al. Modulation of 1,25-dihydroxyvitamin D3 receptor by phospholipids and fatty acids. 1984 J. Lipid Res. pmid:6099395
Laakso S Inhibition of lipid peroxidation by casein. Evidence of molecular encapsulation of 1,4-pentadiene fatty acids. 1984 Biochim. Biophys. Acta pmid:6419780
Grossman S et al. Methylmercuric iodide modification of lipoxygenase-1. Effects on the anaerobic reaction and pigment bleaching. 1984 Biochim. Biophys. Acta pmid:6424722
Sanders TA et al. The influence of a maternal diet rich in linoleic acid on brain and retinal docosahexaenoic acid in the rat. 1984 Br. J. Nutr. pmid:6228249
Baba A et al. Modulation by unsaturated fatty acids of norepinephrine- and adenosine-induced formation of cyclic AMP in brain slices. 1984 J. Neurochem. pmid:6315886
Kitagawa S et al. Effects of four types of reagents on ADP-induced aggregation and Ca2+ mobilization of bovine blood platelets. 1984 Biochim. Biophys. Acta pmid:6324876
Simon I et al. Electron-spin resonance studies of lipid-modified microsomes from Friend erythroleukemia cells. 1984 Biochim. Biophys. Acta pmid:6326852
Manku MS et al. Essential fatty acids in the plasma phospholipids of patients with atopic eczema. 1984 Br. J. Dermatol. pmid:6329254
Reeves VB et al. Variations in plasma fatty acid concentrations during a one-year self-selected dietary intake study. 1984 Am. J. Clin. Nutr. pmid:6507356
Rogiers V et al. Abnormal fatty acid turnover in the phospholipids of the red blood cell membranes of cystic fibrosis patients (in vitro study). 1984 Pediatr. Res. pmid:6472942
Sánchez J and Stumpf PK The effect of hypolipidemic drugs WY14643 and DH990, and lysophospholipids on the metabolism of oleate in plants. 1984 Arch. Biochem. Biophys. pmid:6696430
Chu CH et al. The activity of 3-hydroxyacyl-CoA epimerase is insufficient to account for the rate of linoleate oxidation in rat heart mitochondria. Evidence for a modified pathway of linoleate degradation. 1984 Biochem. Biophys. Res. Commun. pmid:6696754
Cherayil GD Sialic acid and fatty acid concentrations in lymphocytes, red blood cells and plasma from patients with multiple sclerosis. 1984 J. Neurol. Sci. pmid:6699649
Alao SJ and Balnave D Growth and carcass composition of broilers fed sunflower oil and olive oil. 1984 Br. Poult. Sci. pmid:6733552
Cunnane SC et al. Linoleic acid and arachidonic acid metabolism in human peripheral blood leucocytes: comparison with the rat. 1984 Br. J. Nutr. pmid:6422980
Curnutte JT et al. Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate. 1984 J. Biol. Chem. pmid:6090448
Koo SI and Ramlet JS Effect of dietary linoleic acid on the tissue levels of zinc and copper, and serum high density lipoprotein cholesterol. 1984 Atherosclerosis pmid:6712766
Harada H et al. Enhanced suppression of myocardial slow action potentials during hypoxia by free fatty acids. 1984 J. Mol. Cell. Cardiol. pmid:6716492
McMurchie EJ et al. Dietary-induced changes in the fatty acid composition of human cheek cell phospholipids: correlation with changes in the dietary polyunsaturated/saturated fat ratio. 1984 Am. J. Clin. Nutr. pmid:6720626
Schafer E and Arnrich L Effects of dietary vitamin E on serum and pulmonary fatty acids and prostaglandins in rats fed excess linoleic acid. 1984 J. Nutr. pmid:6726476
Singer P et al. Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. 1984 Prostaglandins pmid:6328578
Wood DA et al. Adipose tissue and platelet fatty acids and coronary heart disease in Scottish men. 1984 Lancet pmid:6146032
Hennig B et al. Exposure to free fatty acid increases the transfer of albumin across cultured endothelial monolayers. 1984 Sep-Oct Arteriosclerosis pmid:6477300
Buchanan MR et al. 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX. 1985 J. Biol. Chem. pmid:3934168
Salafsky B and Fusco AC Schistosoma mansoni: cercarial eicosanoid production and penetration response inhibited by esculetin and ibuprofen. 1985 Exp. Parasitol. pmid:2990990
Kharasch ED and Novak RF Mitoxantrone and ametantrone inhibit hydroperoxide-dependent initiation and propagation reactions in fatty acid peroxidation. 1985 J. Biol. Chem. pmid:2993283
Claeys M et al. Metabolic profile of linoleic acid in porcine leukocytes through the lipoxygenase pathway. 1985 Biochim. Biophys. Acta pmid:2996610
Charnock JS et al. Changes in fatty acid composition of the cardiac phospholipids of the cotton-eared marmoset (Callithrix jacchus) after feeding different lipid supplements. 1985 Ann. Nutr. Metab. pmid:3922279
Hansen HS and Jensen B Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate. 1985 Biochim. Biophys. Acta pmid:3922424
Nugteren DH et al. Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat. 1985 Biochim. Biophys. Acta pmid:3922425
Margetts BM et al. Blood pressure and dietary polyunsaturated and saturated fats: a controlled trial. 1985 Clin. Sci. pmid:3905211
Bowser PA et al. Identification, isolation and characterization of epidermal lipids containing linoleic acid. 1985 Biochim. Biophys. Acta pmid:3995076
Jett M et al. Metabolic fate of liposomal phosphatidylinositol in murine tumor cells: implications for the mechanism of tumor cell cytotoxicity. 1985 Cancer Res. pmid:4027970
Becker W and MÃ¥nsson JE Incorporation of 14C into tissue lipids after oral administration of [1-14C]linoleic acid in rats fed different levels of essential fatty acids. 1985 J. Nutr. pmid:4045568
Takahashi K et al. Ester-exchange catalyzed by lipase modified with polyethylene glycol. 1985 Biochem. Biophys. Res. Commun. pmid:4052065
Hennig B et al. Exposure to fatty acid increases human low density lipoprotein transfer across cultured endothelial monolayers. 1985 Circ. Res. pmid:4053308
Barclay LR et al. The antioxidant activity of alpha-tocopherol-bovine serum albumin complex in micellar and liposome autoxidations. 1985 J. Biol. Chem. pmid:4066696
Clark DL and Queener SF Effects of diabetes mellitus on renal fatty acid activation and desaturation. 1985 Biochem. Pharmacol. pmid:4074391
Giamalva D et al. A comparison of the rates of ozonation of biological antioxidants and oleate and linoleate esters. 1985 Biochem. Biophys. Res. Commun. pmid:4084297
Rebello T and Watts DC Gastrocnemius muscle lipids in relation to diet in two mouse mutants, 129Re-dy and A2G-adr, with abnormal muscle function. 1985 J. Neurochem. pmid:3158720
Pascaud M and Strouve-Vallet C Desaturation of 14C linoleic acid by the rat fetus. 1985 Ann. Nutr. Metab. pmid:2983600
Nordøy A et al. Effect of dietary (n--3) fatty acids on platelet function and lipid metabolism in rats. 1985 Biochim. Biophys. Acta pmid:2861854
Jones PJ et al. Whole body oxidation of dietary fatty acids: implications for energy utilization. 1985 Am. J. Clin. Nutr. pmid:3933323
Cooke RJ et al. Safflower oil emulsion administration during parenteral nutrition in the preterm infant. 1. Effect on essential fatty acid status. 1985 J. Pediatr. Gastroenterol. Nutr. pmid:3930688
Smith MT and Thompson S Free radicals and alcoholics. 1985 Lancet pmid:2864501
Fink R et al. Increased free-radical activity in alcoholics. 1985 Lancet pmid:2862465
Banerjee N and Rosenthal MD High-affinity incorporation of 20-carbon polyunsaturated fatty acids by human skin fibroblasts. 1985 Biochim. Biophys. Acta pmid:2990563
Crutchley DJ Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. 1985 Biochem. Biophys. Res. Commun. pmid:2865954
Salzmann-Reinhardt U et al. Metabolism of polyunsaturated fatty acids by rabbit reticulocytes. 1985 Eur. J. Biochem. pmid:3933978