Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Fu X et al. | Regulation of formation of volatile compounds of tea (Camellia sinensis) leaves by single light wavelength. | 2015 | Sci Rep | pmid:26567525 |
Mabalirajan U et al. | Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. | 2013 | Sci Rep | pmid:23443229 |
Fala AM et al. | Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α. | 2015 | Sci Rep | pmid:26237540 |
Wu MH et al. | A novel sodium N-fatty acyl amino acid surfactant using silkworm pupae as stock material. | 2014 | Sci Rep | pmid:24651079 |
Thomas EA and Yao JK | Clozapine specifically alters the arachidonic acid pathway in mice lacking apolipoprotein D. | 2007 | Schizophr. Res. | pmid:17011169 |
Medema S et al. | Levels of Red Blood Cell Fatty Acids in Patients With Psychosis, Their Unaffected Siblings, and Healthy Controls. | 2016 | Schizophr Bull | pmid:26385764 |
Peters BD et al. | Polyunsaturated fatty acid concentration predicts myelin integrity in early-phase psychosis. | 2013 | Schizophr Bull | pmid:22927668 |
Leskinen MH et al. | Serum fatty acids in postinfarction middle-aged men. | 2005 | Scand. J. Clin. Lab. Invest. | pmid:16179281 |
Kummerow FA et al. | Effects of trans fats on prostacyclin production. | 2013 | Scand. Cardiovasc. J. | pmid:24228623 |
Wolańska D and Kłosiewicz-Latoszek L | [Fatty acids intake and serum lipids profile in overweighted and obese adults]. | 2012 | Rocz Panstw Zakl Hig | pmid:22928362 |
Spaide RF et al. | Characterization of peroxidized lipids in Bruch's membrane. | 1999 | Retina (Philadelphia, Pa.) | pmid:10213241 |
Kim JY et al. | Lipid and fatty acid analysis of fresh and frozen-thawed immature and in vitro matured bovine oocytes. | 2001 | Reproduction | pmid:11425337 |
Zachut M et al. | Dietary unsaturated fatty acids influence preovulatory follicle characteristics in dairy cows. | 2008 | Reproduction | pmid:18296508 |
Robinson RS et al. | Effects of dietary polyunsaturated fatty acids on ovarian and uterine function in lactating dairy cows. | 2002 | Reproduction | pmid:12090925 |
Marei WF et al. | Impact of linoleic acid on bovine oocyte maturation and embryo development. | 2010 | Reproduction | pmid:20215338 |
Castellanos P et al. | Changes in fatty acid profiles in testis and spermatozoa of red deer exposed to metal pollution. | 2010 | Reprod. Toxicol. | pmid:20096347 |
Troegeler-Meynadier A et al. | Rates and efficiencies of reactions of ruminal biohydrogenation of linoleic acid according to pH and polyunsaturated fatty acids concentrations. | 2006 Nov-Dec | Reprod. Nutr. Dev. | pmid:17169317 |
Kiernan M et al. | The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. | 2013 | Reprod. Fertil. Dev. | pmid:23036717 |
Marei WF et al. | Differential effects of linoleic and alpha-linolenic fatty acids on spatial and temporal mitochondrial distribution and activity in bovine oocytes. | 2012 | Reprod. Fertil. Dev. | pmid:22697118 |
Renaville B et al. | Plasma and follicular fluid fatty acid profiles in dairy cows. | 2010 | Reprod. Domest. Anim. | pmid:19055554 |
Takahashi T et al. | Effect of linoleic acid albumin in a dilution solution and long-term equilibration for freezing of bovine spermatozoa with poor freezability. | 2012 | Reprod. Domest. Anim. | pmid:21635578 |
Salehi R et al. | A prepartum diet supplemented with oilseeds high in oleic or linoleic acid reduced GnRH-induced LH release in dairy cows during second week postpartum. | 2015 | Reprod. Biol. Endocrinol. | pmid:26138920 |
Godkin JD et al. | Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin production. | 2008 | Reprod. Biol. Endocrinol. | pmid:18811942 |
Walsh SW | Plasma from preeclamptic women stimulates transendothelial migration of neutrophils. | 2009 | Reprod Sci | pmid:19087976 |
Rittmann BE and Schloendorn J | Engineering away lysosomal junk: medical bioremediation. | 2007 | Rejuvenation Res | pmid:17708688 |
Zhu X and Sayre LM | Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal. | 2007 | Redox Rep. | pmid:17263908 |
Masella R et al. | Antioxidant activity of 3,4-DHPEA-EA and protocatechuic acid: a comparative assessment with other olive oil biophenols. | 1999 | Redox Rep. | pmid:10496414 |
Kritharides L | Ascorbic acid and copper in linoleate oxidation--Dunkley revisited. | 1999 | Redox Rep. | pmid:10772064 |
Asselin C et al. | Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure. | 2014 | Redox Biol | pmid:24494189 |
Ladeira MM et al. | Lipids in the diet and the fatty acid profile in beef: a review and recent patents on the topic. | 2012 | Recent Pat Food Nutr Agric | pmid:22702746 |
Combet E et al. | Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation. | 2010 | Rapid Commun. Mass Spectrom. | pmid:20112267 |
Gakwaya R et al. | Examining the collision-induced decomposition spectra of ammoniated triglycerides. III. The linoleate and arachidonate series. | 2007 | Rapid Commun. Mass Spectrom. | pmid:17893948 |
Lee KW and Lip GY | The role of omega-3 fatty acids in the secondary prevention of cardiovascular disease. | 2003 | QJM | pmid:12881589 |
Griffin ME et al. | Non-insulin-dependent diabetes mellitus: dietary monounsaturated fatty acids and low-density lipoprotein composition and function. | 1996 | QJM | pmid:8731565 |
Cheng G et al. | Relative validity of a 3 d estimated food record in German toddlers. | 2013 | Public Health Nutr | pmid:22874634 |
Segovia-Siapco G et al. | Validation of a food-frequency questionnaire for measurement of nutrient intake in a dietary intervention study. | 2007 | Public Health Nutr | pmid:17261227 |
Petrogianni M et al. | Additional benefit in CVD risk indices derived from the consumption of fortified milk when combined with a lifestyle intervention. | 2014 | Public Health Nutr | pmid:23249766 |
Cantwell MM et al. | Development and validation of a food-frequency questionnaire for the determination of detailed fatty acid intakes. | 2005 | Public Health Nutr | pmid:15705250 |
Maqbool A et al. | The skinny on tuna fat: health implications. | 2011 | Public Health Nutr | pmid:21324226 |
Fremann D et al. | Dietary conjugated linoleic acid (CLA) intake assessment and possible biomarkers of CLA intake in young women. | 2002 | Public Health Nutr | pmid:12001981 |
Ghisolfi J et al. | Nutrient intakes of children aged 1-2 years as a function of milk consumption, cows' milk or growing-up milk. | 2013 | Public Health Nutr | pmid:23098567 |
Vinceti M et al. | A population-based case-control study of diet and melanoma risk in northern Italy. | 2005 | Public Health Nutr | pmid:16372927 |
Bazinet RP et al. | Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat. | 2005 | Psychopharmacology (Berl.) | pmid:15986187 |
Buydens-Branchey L et al. | Polyunsaturated fatty acid status and relapse vulnerability in cocaine addicts. | 2003 | Psychiatry Res | pmid:14500111 |
Verlotta A and Trono D | Expression, purification and refolding of active durum wheat (Triticum durum Desf.) secretory phospholipase A2 from inclusion bodies of Escherichia coli. | 2014 | Protein Expr. Purif. | pmid:24925645 |
Rose DP and Connolly JM | Effects of fatty acids and eicosanoid synthesis inhibitors on the growth of two human prostate cancer cell lines. | 1991 | Prostate | pmid:2020620 |
Cohen LA et al. | Effect of soy protein isolate and conjugated linoleic acid on the growth of Dunning R-3327-AT-1 rat prostate tumors. | 2003 | Prostate | pmid:12518321 |
Griffiths G et al. | Effect of n-6 polyunsaturated fatty acids on growth and lipid composition of neoplastic and non-neoplastic canine prostate epithelial cell cultures. | 1997 | Prostate | pmid:9108883 |
Connolly JM and Rose DP | Interactions between epidermal growth factor-mediated autocrine regulation and linoleic acid-stimulated growth of a human prostate cancer cell line. | 1992 | Prostate | pmid:1549552 |
Sammon AM | Maize meal, non-esterified linoleic acid, and endemic cancer of the esophagus--preliminary findings. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410386 |