Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Maheswari SU et al. | Inhibition of Fe(II) catalyzed linoleic acid oxidation and DNA damage by phosvitin. | 1997 | Mol. Cell. Biochem. | pmid:9450644 |
Colquhoun A and Curi R | Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. | 1997 | Biochem. Soc. Trans. | pmid:9450108 |
Hamberg M | Stereochemistry of oxygenation of linoleic acid catalyzed by prostaglandin-endoperoxide H synthase-2. | 1998 | Arch. Biochem. Biophys. | pmid:9448728 |
Berry H et al. | Oxygen concentration determines regiospecificity in soybean lipoxygenase-1 reaction via a branched kinetic scheme. | 1998 | J. Biol. Chem. | pmid:9446584 |
Kaur K et al. | (Carboxyalkyl)pyrroles in human plasma and oxidized low-density lipoproteins. | 1997 | Chem. Res. Toxicol. | pmid:9437530 |
Bylund J et al. | Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes. | 1998 | J. Pharmacol. Exp. Ther. | pmid:9435160 |
Zhou L et al. | Tissue uptake and interconversion of plasma unesterified 14C linoleic acid in the guinea pig. | 1997 | Biochim. Biophys. Acta | pmid:9434134 |
Renaud SC | Dietary management of cardiovascular diseases. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430390 |
Kritchevsky D | Trans fatty acids and cardiovascular risk. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430386 |
van Niel MH and Beynen AC | The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue. | 1997 | Vet Q | pmid:9413110 |
Gniwotta C et al. | Prostaglandin F2-like compounds, F2-isoprostanes, are present in increased amounts in human atherosclerotic lesions. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409317 |
Ali I and Steele JE | Evidence that free fatty acids in trophocytes of Periplaneta americana fat body may be regulated by the activity of phospholipase A2 and cyclooxygenase. | 1997 | Insect Biochem. Mol. Biol. | pmid:9404012 |
Willett WC | Specific fatty acids and risks of breast and prostate cancer: dietary intake. | 1997 | Am. J. Clin. Nutr. | pmid:9394715 |
Ip C | Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids, and conjugated linoleic acid on mammary carcinogenesis in animals. | 1997 | Am. J. Clin. Nutr. | pmid:9394710 |
Rose DP | Effects of dietary fatty acids on breast and prostate cancers: evidence from in vitro experiments and animal studies. | 1997 | Am. J. Clin. Nutr. | pmid:9394709 |
Dullaart RP et al. | Cholesteryl ester transfer protein gene polymorphism is a determinant of HDL cholesterol and of the lipoprotein response to a lipid-lowering diet in type 1 diabetes. | 1997 | Diabetes | pmid:9392500 |
Priyadarsini KI | Free radical reactions of curcumin in membrane models. | 1997 | Free Radic. Biol. Med. | pmid:9378362 |
Guidot DM et al. | Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs. | 1997 | Am. J. Physiol. | pmid:9374722 |
Liu F et al. | Permeability properties of monolayers of the human trophoblast cell line BeWo. | 1997 | Am. J. Physiol. | pmid:9374645 |
Toborek M et al. | Linoleic acid potentiates TNF-mediated oxidative stress, disruption of calcium homeostasis, and apoptosis of cultured vascular endothelial cells. | 1997 | J. Lipid Res. | pmid:9374137 |