Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ghebremeskel K et al. | Maternal diet high in fat reduces docosahexaenoic acid in liver lipids of newborn and sucking rat pups. | 1999 | Br. J. Nutr. | pmid:10615212 |
Matsusue K et al. | A highly toxic coplanar polychlorinated biphenyl compound suppresses Delta5 and Delta6 desaturase activities which play key roles in arachidonic acid synthesis in rat liver. | 1999 | Chem. Res. Toxicol. | pmid:10604864 |
Klein J et al. | Fatty acid ethyl esters: a novel biologic marker for heavy in utero ethanol exposure: a case report. | 1999 | Ther Drug Monit | pmid:10604826 |
Sprinz H et al. | Mechanism of thiyl radical-catalyzed isomerization of unsaturated fatty acid residues in homogeneous solution and in liposomes. | 2000 | Biochim. Biophys. Acta | pmid:10601698 |
Pirich C et al. | Effects of fish oil supplementation on platelet survival and ex vivo platelet function in hypercholesterolemic patients. | 1999 | Thromb. Res. | pmid:10588465 |
Velēna A et al. | Derivatives of 1,4-dihydropyridines as modulators of ascorbate-induced lipid peroxidation and high-amplitude swelling of mitochondria, caused by ascorbate, sodium linoleate and sodium pyrophosphate. | 1999 | Cell Biochem. Funct. | pmid:10587611 |
Hsu AF et al. | Immobilized lipoxygenase in a packed-bed column bioreactor: continuous oxygenation of linoleic acid. | 1999 | Biotechnol. Appl. Biochem. | pmid:10574694 |
Arun Kumar C and Das UN | Lipid peroxides, nitric oxide and essential fatty acids in patients with Plasmodium falciparum malaria. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10574650 |
Gelderblom WC et al. | Regulation of fatty acid biosynthesis as a possible mechanism for the mitoinhibitory effect of fumonisin B1 in primary rat hepatocytes. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10574646 |
Kamlage B et al. | Intestinal microorganisms do not supply associated gnotobiotic rats with conjugated linoleic acid. | 1999 | J. Nutr. | pmid:10573552 |
Ip C et al. | Conjugated linoleic acid-enriched butter fat alters mammary gland morphogenesis and reduces cancer risk in rats. | 1999 | J. Nutr. | pmid:10573540 |
Masuda T et al. | Evaluation of the antioxidant activity of environmental plants: activity of the leaf extracts from seashore plants. | 1999 | J. Agric. Food Chem. | pmid:10564049 |
Jung MY and Ha YL | Conjugated linoleic acid isomers in partially hydrogenated soybean oil obtained during nonselective and selective hydrogenation processes. | 1999 | J. Agric. Food Chem. | pmid:10563957 |
López-Nicolás JM et al. | Rapid reversed-phase high-performance liquid chromatographic determination of the regiospecificity of lipoxygenase products on linoleic acid. | 1999 | J Chromatogr A | pmid:10563421 |
Du M et al. | Effect of dietary conjugated linoleic acid on the composition of egg yolk lipids. | 1999 | Poult. Sci. | pmid:10560841 |
Grobas S et al. | Laying hen productivity as affected by energy, supplemental fat, and linoleic acid concentration of the diet. | 1999 | Poult. Sci. | pmid:10560827 |
Kuo JM et al. | Rapid photometric assay evaluating antioxidative activity in edible plant material. | 1999 | J. Agric. Food Chem. | pmid:10552632 |
Henderson DE et al. | Quantitative HPLC determination of the antioxidant activity of capsaicin on the formation of lipid hydroperoxides of linoleic acid: a comparative study against BHT and melatonin. | 1999 | J. Agric. Food Chem. | pmid:10552527 |
Budi Santosa FX and Padua GW | Tensile properties and water absorption of zein sheets plasticized with oleic and linoleic acids. | 1999 | J. Agric. Food Chem. | pmid:10552498 |
Angerosa F et al. | Virgin olive oil volatile compounds from lipoxygenase pathway and characterization of some italian cultivars. | 1999 | J. Agric. Food Chem. | pmid:10552376 |
Sánchez-Vioque R et al. | Interaction of chickpea (Cicer arietinum L.) legumin with oxidized linoleic acid. | 1999 | J. Agric. Food Chem. | pmid:10552371 |
Domingo N et al. | Effects of dexamethasone and linoleic acid on hepatic secretion of biliary lipids and anionic polypeptide factor: In vivo and in vitro studies. | 1999 Nov-Dec | Digestion | pmid:10545720 |
Kulkarni AP and Sajan M | Lipoxygenase-another pathway for glutathione conjugation of xenobiotics: A study with human term placental lipoxygenase and ethacrynic acid. | 1999 | Arch. Biochem. Biophys. | pmid:10545208 |
Murphy J et al. | Fat malabsorption in cystic fibrosis patients. | 1999 | Am. J. Clin. Nutr. | pmid:10539762 |
Rose DP and Connolly JM | Antiangiogenicity of docosahexaenoic acid and its role in the suppression of breast cancer cell growth in nude mice. | 1999 | Int. J. Oncol. | pmid:10536186 |
Dhiman TR et al. | Conjugated linoleic acid content of milk from cows fed different diets. | 1999 | J. Dairy Sci. | pmid:10531600 |
Howard FA and Henderson C | Hydrogenation of polyunsaturated fatty acids by human colonic bacteria. | 1999 | Lett. Appl. Microbiol. | pmid:10530040 |
Filley SJ et al. | Prostaglandin f(2alpha) concentrations, fatty acid profiles, and fertility in lipid-infused postpartum beef heifers. | 1999 | Biol. Reprod. | pmid:10529280 |
Dauchy RT et al. | Dim light during darkness stimulates tumor progression by enhancing tumor fatty acid uptake and metabolism. | 1999 | Cancer Lett. | pmid:10529012 |
Minich DM et al. | Biliary phospholipid secretion is not required for intestinal absorption and plasma status of linoleic acid in mice. | 1999 | Biochim. Biophys. Acta | pmid:10526224 |
Arutselvan N et al. | Antioxidative activity of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid. | 1999 | Arzneimittelforschung | pmid:10514898 |
Xu M and Dashwood RH | Chemoprevention studies of heterocyclic amine-induced colon carcinogenesis. | 1999 | Cancer Lett. | pmid:10503900 |
Masella R et al. | Antioxidant activity of 3,4-DHPEA-EA and protocatechuic acid: a comparative assessment with other olive oil biophenols. | 1999 | Redox Rep. | pmid:10496414 |
Tamatani T et al. | Neoplastic conversion of human urothelial cells in vitro by overexpression of H2O2-generating peroxisomal fatty acyl CoA oxidase. | 1999 | Int. J. Oncol. | pmid:10493957 |
Rickert KW and Klinman JP | Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects. | 1999 | Biochemistry | pmid:10493789 |
Blask DE et al. | Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events. | 1999 | Cancer Res. | pmid:10493527 |
Sauer LA et al. | 13-Hydroxyoctadecadienoic acid is the mitogenic signal for linoleic acid-dependent growth in rat hepatoma 7288CTC in vivo. | 1999 | Cancer Res. | pmid:10493526 |
Precht D and Molkentin J | C18:1, C18:2 and C18:3 trans and cis fatty acid isomers including conjugated cis delta 9, trans delta 11 linoleic acid (CLA) as well as total fat composition of German human milk lipids. | 1999 | Nahrung | pmid:10481820 |
Kankaanpää P et al. | Dietary fatty acids and allergy. | 1999 | Ann. Med. | pmid:10480759 |
Lin MY and Yen CL | Reactive oxygen species and lipid peroxidation product-scavenging ability of yogurt organisms. | 1999 | J. Dairy Sci. | pmid:10480088 |
Chamruspollert M and Sell JL | Transfer of dietary conjugated linoleic acid to egg yolks of chickens. | 1999 | Poult. Sci. | pmid:10472840 |
Meek S et al. | Microcystin affinity purification of plant protein phosphatases: PP1C, PP5 and a regulatory A-subunit of PP2A. | 1999 | FEBS Lett. | pmid:10471836 |
Park JY et al. | Role of hyperpolarization attained by linoleic acid in chick myoblast fusion. | 1999 | Exp. Cell Res. | pmid:10471316 |
Helge JW et al. | Regular exercise modulates muscle membrane phospholipid profile in rats. | 1999 | J. Nutr. | pmid:10460197 |
Warnotte C et al. | Unbound rather than total concentration and saturation rather than unsaturation determine the potency of fatty acids on insulin secretion. | 1999 | Mol. Cell. Endocrinol. | pmid:10459862 |
Lipkin M et al. | Dietary factors in human colorectal cancer. | 1999 | Annu. Rev. Nutr. | pmid:10448536 |
Sammon AM | Dietary linoleic acid, immune inhibition and disease. | 1999 | Postgrad Med J | pmid:10448487 |
Lundell KH et al. | Plasma metabolites after a lipid load in infants with congenital heart disease. | 1999 | Acta Paediatr. | pmid:10447129 |
Freese R et al. | Green tea extract decreases plasma malondialdehyde concentration but does not affect other indicators of oxidative stress, nitric oxide production, or hemostatic factors during a high-linoleic acid diet in healthy females. | 1999 | Eur J Nutr | pmid:10443337 |
Jarmuszkiewicz W et al. | Identification and characterization of a protozoan uncoupling protein in Acanthamoeba castellanii. | 1999 | J. Biol. Chem. | pmid:10438491 |