Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Ingkaninan K et al. | Interference of linoleic acid fraction in some receptor binding assays. | 1999 | J. Nat. Prod. | pmid:10395519 |
Andersen LF et al. | Evaluation of a food frequency questionnaire with weighed records, fatty acids, and alpha-tocopherol in adipose tissue and serum. | 1999 | Am. J. Epidemiol. | pmid:10400557 |
O'Donnell VB et al. | 15-Lipoxygenase catalytically consumes nitric oxide and impairs activation of guanylate cyclase. | 1999 | J. Biol. Chem. | pmid:10400618 |
Dontsov AE et al. | Retinal pigment epithelium pigment granules stimulate the photo-oxidation of unsaturated fatty acids. | 1999 | Free Radic. Biol. Med. | pmid:10401607 |
Murakami K et al. | Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10403814 |
Ding XZ et al. | Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10405349 |
Kim S et al. | C/EBPbeta (NF-M) is essential for activation of the p20K lipocalin gene in growth-arrested chicken embryo fibroblasts. | 1999 | Mol. Cell. Biol. | pmid:10409760 |
Sammon AM | Maize meal, non-esterified linoleic acid, and endemic cancer of the esophagus--preliminary findings. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410386 |
Demmelmair H et al. | Comparison of bolus versus fractionated oral applications of [13C]-linoleic acid in humans. | 1999 | Eur. J. Clin. Invest. | pmid:10411666 |
Calvo AM et al. | Sporogenic effect of polyunsaturated fatty acids on development of Aspergillus spp. | 1999 | Appl. Environ. Microbiol. | pmid:10427064 |