Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Kim SY et al. | S-adenosyl methionine prevents endothelial dysfunction by inducing heme oxygenase-1 in vascular endothelial cells. | 2013 | Mol. Cells | pmid:24046187 |
Otte KB et al. | Synthesis of 9-oxononanoic acid, a precursor for biopolymers. | 2013 | ChemSusChem | pmid:23934656 |
Nakashima R et al. | Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice. | 2013 | Toxicology | pmid:23619606 |
Huang X et al. | Targeted delivery of microRNA-29b by transferrin-conjugated anionic lipopolyplex nanoparticles: a novel therapeutic strategy in acute myeloid leukemia. | 2013 | Clin. Cancer Res. | pmid:23493348 |
Sy C et al. | Inhibition of iron-induced lipid peroxidation by newly identified bacterial carotenoids in model gastric conditions: comparison with common carotenoids. | 2013 | Food Funct | pmid:23411789 |
Tarawneh AH et al. | Fatty acids with in vitro binding affinity for human opioid receptors from the fungus Emericella nidulans. | 2013 | J. Agric. Food Chem. | pmid:24147790 |
Mabalirajan U et al. | Linoleic acid metabolite drives severe asthma by causing airway epithelial injury. | 2013 | Sci Rep | pmid:23443229 |
Tokede OA et al. | Plasma phospholipid trans fatty acids and risk of heart failure. | 2013 | Am. J. Clin. Nutr. | pmid:23446892 |
Kirpich IA et al. | Ethanol and dietary unsaturated fat (corn oil/linoleic acid enriched) cause intestinal inflammation and impaired intestinal barrier defense in mice chronically fed alcohol. | 2013 | Alcohol | pmid:23453163 |
Emery JA et al. | Δ-6 Desaturase substrate competition: dietary linoleic acid (18:2n-6) has only trivial effects on α-linolenic acid (18:3n-3) bioconversion in the teleost rainbow trout. | 2013 | PLoS ONE | pmid:23460861 |
Bartók T et al. | ESI-MS and MS/MS identification of the first ceramide analogues of fumonisin B₠mycotoxin from a Fusarium verticillioides culture following RP-HPLC separation. | 2013 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:23837460 |
Okada Y et al. | Wing (Ib) cells in frog taste discs detect dietary unsaturated fatty acids. | 2013 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:23872318 |
Van Ba H et al. | Significant influence of particular unsaturated fatty acids and pH on the volatile compounds in meat-like model systems. | 2013 | Meat Sci. | pmid:23632107 |
Al-Taan O et al. | Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. | 2013 | Lipids Health Dis | pmid:23648075 |
Nakagawa Y | [Metabolism and biological function of cardiolipin]. | 2013 | Yakugaku Zasshi | pmid:23649397 |
Fairfield K | ACP Journal Club. Review: replacing dietary saturated fatty acids with n-6 polyunsaturated fatty acids does not reduce mortality. | 2013 | Ann. Intern. Med. | pmid:23689785 |
Khalil WA et al. | Protective effects of antioxidants on linoleic acid-treated bovine oocytes during maturation and subsequent embryo development. | 2013 | Theriogenology | pmid:23683689 |
Le Maux S et al. | β-Lactoglobulin-linoleate complexes: In vitro digestion and the role of protein in fatty acid uptake. | 2013 | J. Dairy Sci. | pmid:23684041 |
SaÃn J et al. | Effects of trans-fatty acids on liver lipid metabolism in mice fed on diets showing different fatty acid composition. | 2013 | Ann. Nutr. Metab. | pmid:23594856 |
Nørskov NP et al. | Multicompartmental nontargeted LC-MS metabolomics: explorative study on the metabolic responses of rye fiber versus refined wheat fiber intake in plasma and urine of hypercholesterolemic pigs. | 2013 | J. Proteome Res. | pmid:23596967 |
Jung CH et al. | The preventive effect of uncarboxylated osteocalcin against free fatty acid-induced endothelial apoptosis through the activation of phosphatidylinositol 3-kinase/Akt signaling pathway. | 2013 | Metab. Clin. Exp. | pmid:23639572 |
Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
Carro M et al. | Linoleic acid stimulates neutral lipid accumulation in lipid droplets of maturing bovine oocytes. | 2013 | Theriogenology | pmid:23273433 |
Mena J et al. | Linoleic acid increases adhesion, chemotaxis, granule release, intracellular calcium mobilisation, MAPK phosphorylation and gene expression in bovine neutrophils. | 2013 | Vet. Immunol. Immunopathol. | pmid:23267746 |
Li L et al. | A novel galanin receptor 1a gene in zebrafish: tissue distribution, developmental expression roles in nutrition regulation. | 2013 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:23268327 |
Zeng G et al. | Kinetics of heterogeneous reaction of ozone with linoleic acid and its dependence on temperature, physical state, RH, and ozone concentration. | 2013 | J Phys Chem A | pmid:23347186 |
Soto-Guzman A et al. | Role of arachidonic acid metabolism in Stat5 activation induced by oleic acid in MDA-MB-231 breast cancer cells. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23332799 |
Poudyal H et al. | Responses to oleic, linoleic and α-linolenic acids in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. | 2013 | J. Nutr. Biochem. | pmid:23333092 |
Khan AA et al. | Anticancer efficacy of a novel propofol-linoleic acid-loaded escheriosomal formulation against murine hepatocellular carcinoma. | 2013 | Nanomedicine (Lond) | pmid:23311988 |
Carey AN et al. | The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. | 2013 | Nutr Neurosci | pmid:23321679 |
Calder PC | Old study sheds new light on the fatty acids and cardiovascular health debate. | 2013 | BMJ | pmid:23386269 |
Bin Q et al. | The caspase pathway of linoelaidic acid (9t, 12t-c18:2)-induced apoptosis in human umbilical vein endothelial cells. | 2013 | Lipids | pmid:23065354 |
Guo J et al. | Selective transport of long-chain fatty acids by FAT/CD36 in skeletal muscle of broilers. | 2013 | Animal | pmid:23031491 |
Kiernan M et al. | The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. | 2013 | Reprod. Fertil. Dev. | pmid:23036717 |
D'Angeli S et al. | Cold perception and gene expression differ in Olea europaea seed coat and embryo during drupe cold acclimation. | 2013 | New Phytol. | pmid:23078289 |
Loizzo MR et al. | Phenolics, aroma profile, and in vitro antioxidant activity of Italian dessert passito wine from Saracena (Italy). | 2013 | J. Food Sci. | pmid:23574495 |
Bassett JK et al. | Plasma phospholipid fatty acids, dietary fatty acids and prostate cancer risk. | 2013 | Int. J. Cancer | pmid:23575905 |
Mujtaba SF et al. | Singlet oxygen mediated apoptosis by anthrone involving lysosomes and mitochondria at ambient UV exposure. | 2013 | J. Hazard. Mater. | pmid:23542321 |
Wardhani DH et al. | Inhibition kinetics of lipid oxidation of model foods by using antioxidant extract of fermented soybeans. | 2013 | Food Chem | pmid:23561179 |
Garofalo JM et al. | Mouse mammary gland is refractory to the effects of ethanol after natural lactation. | 2013 | Comp. Med. | pmid:23561936 |
Hein LK et al. | Selective reduction of bis(monoacylglycero)phosphate ameliorates the storage burden in a THP-1 macrophage model of Gaucher disease. | 2013 | J. Lipid Res. | pmid:23564732 |
Zhao Y et al. | Linoleic acid stimulates [Ca2+]i increase in rat pancreatic beta-cells through both membrane receptor- and intracellular metabolite-mediated pathways. | 2013 | PLoS ONE | pmid:23565210 |
Høstmark AT and Haug A | Percentage oleic acid is inversely related to percentage arachidonic acid in total lipids of rat serum. | 2013 | Lipids Health Dis | pmid:23521743 |
Franco-Pons N et al. | Fat necrosis generates proinflammatory halogenated lipids during acute pancreatitis. | 2013 | Ann. Surg. | pmid:22964727 |
Al-Bishri WM | Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive Wistar rats. | 2013 | J Oleo Sci | pmid:24005015 |
Han L et al. | Hydroxyl radical induced by lipid in Maillard reaction model system promotes diet-derived N(ε)-carboxymethyllysine formation. | 2013 | Food Chem. Toxicol. | pmid:23959106 |
Luo C et al. | Vegetable oil thermosets reinforced by tannin-lipid formulations. | 2013 | Acta Biomater | pmid:22975626 |
Ramirez AM et al. | A trichome-specific linoleate lipoxygenase expressed during pyrethrin biosynthesis in pyrethrum. | 2013 | Lipids | pmid:23893337 |
Kummerow FA et al. | Effects of trans fats on prostacyclin production. | 2013 | Scand. Cardiovasc. J. | pmid:24228623 |
Herrera-Meza MS et al. | Dietary anhydrous milk fat naturally enriched with conjugated linoleic acid and vaccenic acid modify cardiovascular risk biomarkers in spontaneously hypertensive rats. | 2013 | Int J Food Sci Nutr | pmid:23360131 |
Satoh K | Linoleic acid. A novel mechanism of endothelial cell dysfunction. | 2013 | Circ. J. | pmid:24077059 |
Hashim A et al. | Antioxidant and α -amylase inhibitory property of phyllanthus virgatus L.: an in vitro and molecular interaction study. | 2013 | Biomed Res Int | pmid:23957001 |
Risé P et al. | Different patterns characterize Omega 6 and Omega 3 long chain polyunsaturated fatty acid levels in blood from Italian infants, children, adults and elderly. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23910046 |
Xia Q et al. | Fatty acid profile, oxidative stability and toxicological safety of bayberry kernel oil. | 2013 | Food Chem. Toxicol. | pmid:23867545 |
Le Maux S et al. | Complexes between linoleate and native or aggregated β-lactoglobulin: interaction parameters and in vitro cytotoxic effect. | 2013 | Food Chem | pmid:23870962 |
Aladedunye F and Przybylski R | Frying stability of high oleic sunflower oils as affected by composition of tocopherol isomers and linoleic acid content. | 2013 | Food Chem | pmid:23870970 |
Chen CS et al. | Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue. | 2013 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24154509 |
Chen HW et al. | Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. | 2013 | Arch. Toxicol. | pmid:23288142 |
Steffen BT et al. | n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. | 2013 | Br. J. Nutr. | pmid:23551952 |
Shinjyo N et al. | Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system. | 2013 | J. Neurosci. Res. | pmid:23633391 |
Ngakegni-Limbili AC et al. | Aframomum stipulatum (Gagnep) K. Schum and Aframomum giganteum (Oliv. & Hanb) K. Schum as Aroma Tincto Oleo Crops resources: essential oil, fatty acids, sterols, tocopherols, and tocotrienols composition of different fruit parts of Congo varieties. | 2013 | J. Sci. Food Agric. | pmid:22692978 |
De Weirdt R et al. | A simulated mucus layer protects Lactobacillus reuteri from the inhibitory effects of linoleic acid. | 2013 | Benef Microbes | pmid:24311313 |
Li XP et al. | Linolelaidic acid induces a stronger proliferative effect on human umbilical vein smooth muscle cells compared to elaidic acid. | 2013 | Lipids | pmid:23341188 |
Okada Y et al. | Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization. | 2013 | Clin. Exp. Immunol. | pmid:24028683 |
Ramsden CE et al. | Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22959954 |
Alinezhad H et al. | Biochemical activities of acetone extracts of Hyssopus angustifolius. | 2012 Jul-Aug | Acta Pol Pharm | pmid:22876603 |
Moghaddam AH et al. | Antioxidant, antihemolytic and nephroprotective activity of aqueous extract of Diospyros lotus seeds. | 2012 Jul-Aug | Acta Pol Pharm | pmid:22876611 |
Kuipers RS et al. | Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22115845 |
Brenna T | Tissue-specific LCPUFA accretion in fetal humans. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22078006 |
Chivandi E et al. | Suppression of Caco-2 and HEK-293 cell proliferation by Kigelia africana, Mimusops zeyheri and Ximenia caffra seed oils. | 2012 Jan-Feb | In Vivo | pmid:22210722 |
Chiou TY et al. | Extraction of defatted rice bran with subcritical aqueous acetone. | 2012 | Biosci. Biotechnol. Biochem. | pmid:22878207 |
Järvinen R et al. | Associations of dietary polyunsaturated fatty acids with bone mineral density in elderly women. | 2012 | Eur J Clin Nutr | pmid:22113249 |
Nandi S et al. | Effect of prostaglandin producing modulators on in vitro growth of buffalo uterine epithelial cells. | 2012 | Theriogenology | pmid:22115808 |
Xue C et al. | Differences in lipid characteristics among populations: low-temperature adaptability of ayu, Plecoglossus altivelis. | 2012 | Lipids | pmid:22120618 |
Msika O et al. | NGF blocks polyunsaturated fatty acids biosynthesis in n-3 fatty acid-supplemented PC12 cells. | 2012 | Biochim. Biophys. Acta | pmid:22564256 |
Moodley R et al. | Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. | 2012 | Anal. Chim. Acta | pmid:22632042 |
Jung CH et al. | The role of Rho/Rho-kinase pathway in the expression of ICAM-1 by linoleic acid in human aortic endothelial cells. | 2012 | Inflammation | pmid:22124782 |
Macaluso F et al. | Effect of conjugated linoleic acid on testosterone levels in vitro and in vivo after an acute bout of resistance exercise. | 2012 | J Strength Cond Res | pmid:22614148 |
Saracoglu HT et al. | Evaluation of oil content and fatty acid composition of five endemic Bupleurum species growing in the Central Anatolia region of Turkey. | 2012 | Nat. Prod. Res. | pmid:21870933 |
Lee S et al. | Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1. | 2012 | Br. J. Nutr. | pmid:21846428 |
Gu L et al. | Chemical and cellular antioxidant activity of two novel peptides designed based on glutathione structure. | 2012 | Food Chem. Toxicol. | pmid:22940538 |
Rodrigues HG et al. | Oral administration of oleic or linoleic acid accelerates the inflammatory phase of wound healing. | 2012 | J. Invest. Dermatol. | pmid:21881592 |
Nurachman Z et al. | Oil from the tropical marine benthic-diatom Navicula sp. | 2012 | Appl. Biochem. Biotechnol. | pmid:22926527 |
Osuji GO et al. | Molecular modeling of metabolism for allergen-free low linoleic acid peanuts. | 2012 | Appl. Biochem. Biotechnol. | pmid:22918723 |
Mukherjee S et al. | NAD(P)H cytochrome b5 oxidoreductase deficiency in Leishmania major results in impaired linoleate synthesis followed by increased oxidative stress and cell death. | 2012 | J. Biol. Chem. | pmid:22923617 |
Le Maux S et al. | β-Lactoglobulin as a molecular carrier of linoleate: characterization and effects on intestinal epithelial cells in vitro. | 2012 | J. Agric. Food Chem. | pmid:22924475 |
Sajid ZI et al. | Antioxidant, antimicrobial properties and phenolics of different solvent extracts from bark, leaves and seeds of Pongamia pinnata (L.) Pierre. | 2012 | Molecules | pmid:22466852 |
Gören AC et al. | Fatty acid composition and chemotaxonomic evaluation of species of Stachys. | 2012 | Nat. Prod. Res. | pmid:21859257 |
Takahashi T et al. | Effect of linoleic acid albumin in a dilution solution and long-term equilibration for freezing of bovine spermatozoa with poor freezability. | 2012 | Reprod. Domest. Anim. | pmid:21635578 |
Liu X et al. | Method for screening of bacterial strains biosynthesizing specific conjugated linoleic acid isomers. | 2012 | J. Agric. Food Chem. | pmid:22946615 |
Eserian JK et al. | Effects of polyunsaturated fatty acids on cocaine-conditioned place preference in mice. | 2012 | Nutr Neurosci | pmid:22390908 |
Fei J et al. | ω-6 lipids regulate PPAR turnover via reciprocal switch between PGC-1 alpha and ubiquitination. | 2012 | Atherosclerosis | pmid:22464285 |
Burrows T et al. | A comparative validation of a child food frequency questionnaire using red blood cell membrane fatty acids. | 2012 | Eur J Clin Nutr | pmid:22378224 |
Vanek VW et al. | A.S.P.E.N. position paper: Clinical role for alternative intravenous fat emulsions. | 2012 | Nutr Clin Pract | pmid:22378798 |
Shin D et al. | Effects of dietary combination of n-3 and n-9 fatty acids on the deposition of linoleic and arachidonic acid in broiler chicken meats. | 2012 | Poult. Sci. | pmid:22399741 |
He M et al. | Effect of dietary fat blend enriched in oleic or linoleic acid and monensin supplementation on dairy cattle performance, milk fatty acid profiles, and milk fat depression. | 2012 | J. Dairy Sci. | pmid:22365227 |
Castro LF et al. | Functional desaturase Fads1 (Δ5) and Fads2 (Δ6) orthologues evolved before the origin of jawed vertebrates. | 2012 | PLoS ONE | pmid:22384110 |
Li KL et al. | Characterization of cumulus expansion-inhibiting factor (CEIF) in goat follicles. | 2012 | Biol. Reprod. | pmid:22402961 |
Mulligan CM et al. | Dietary linoleate preserves cardiolipin and attenuates mitochondrial dysfunction in the failing rat heart. | 2012 | Cardiovasc. Res. | pmid:22411972 |
Gull J et al. | Variation in antioxidant attributes at three ripening stages of guava (Psidium guajava L.) fruit from different geographical regions of Pakistan. | 2012 | Molecules | pmid:22418924 |