Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Spirochaetales Infections D013145 2 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Thrombosis D013927 49 associated lipids
Tuberculosis D014376 20 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Weight Gain D015430 101 associated lipids
Weight Loss D015431 56 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Helicobacter Infections D016481 21 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Hyperpigmentation D017495 11 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Glucose Intolerance D018149 13 associated lipids
Circoviridae Infections D018173 2 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Coronary Restenosis D023903 10 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Chen MH and Nelson EB Microbial-induced carbon competition in the spermosphere leads to pathogen and disease suppression in a municipal biosolids compost. 2012 Phytopathology pmid:22352306
Gülçin I et al. Determination of antioxidant and radical scavenging activity of Basil (Ocimum basilicum L. Family Lamiaceae) assayed by different methodologies. 2007 Phytother Res pmid:17221941
Shinohara R et al. Evaluation of antilipid peroxidative action of propolis ethanol extract. 2002 Phytother Res pmid:12112290
Pérez G RM et al. Antioxidant and free radical scavenging activities of 5,7,3'-trihydroxy-3,6,4'-trimethoxyflavone from Brickellia veronicaefolia. 2004 Phytother Res pmid:15174007
Jäger AK et al. Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. 2008 Phytother Res pmid:18389471
Chou YC et al. Bioassay-guided purification and identification of PPARalpha/gamma agonists from Chlorella sorokiniana. 2008 Phytother Res pmid:18398904
Cui Y et al. Potential biomedical properties of Pinus massoniana bark extract. 2005 Phytother Res pmid:15798999
Higashi-Okai K et al. Potent suppressive activity of fresh and dried peels from Satsuma mandarin Citrus unshiu (Marcorv.) on hydroperoxide generation from oxidized linoleic acid. 2002 Phytother Res pmid:12458489
Marongiu B et al. Antioxidant activity of supercritical extract of Melissa officinalis subsp. officinalis and Melissa officinalis subsp. inodora. 2004 Phytother Res pmid:15551397
Christensen KB et al. Identification of bioactive compounds from flowers of black elder (Sambucus nigra L.) that activate the human peroxisome proliferator-activated receptor (PPAR) gamma. 2010 Phytother Res pmid:20222152
Akeo K and Hiramitsu T Changes in lipid peroxide level in retinal pigment epithelial cells in vitro upon addition of linoleic acids or linoleic acid hydroperoxides under varying concentrations of oxygen. 1998 Pigment Cell Res. pmid:9877104
Ando H et al. Protein kinase C and linoleic acid-induced inhibition of melanogenesis. 1990 Pigment Cell Res. pmid:2077533
Akeo K et al. Effects of fluorescent light on growth of bovine retinal pigment epithelial cells in vitro incubated with linoleic acid or linoleic acid hydroperoxide. 1999 Pigment Cell Res. pmid:10385917
Hover CG and Kulkarni AP Human term placental lipoxygenase-mediated N-demethylation of phenothiazines and insecticides in the presence of linoleic acid. 2000 Placenta pmid:10985967
Huang FC and Schwab W Overexpression of hydroperoxide lyase, peroxygenase and epoxide hydrolase in tobacco for the biotechnological production of flavours and polymer precursors. 2012 Plant Biotechnol. J. pmid:22967031
Maeda H et al. Tocopherols modulate extraplastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. 2008 Plant Cell pmid:18314499
Okuley J et al. Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis. 1994 Plant Cell pmid:7907506
Ito T et al. The homeotic protein AGAMOUS controls late stamen development by regulating a jasmonate biosynthetic gene in Arabidopsis. 2007 Plant Cell pmid:17981996
Runyon JB et al. Parasitism by Cuscuta pentagona sequentially induces JA and SA defence pathways in tomato. 2010 Plant Cell Environ. pmid:19930126
Laus MN et al. Plant inner membrane anion channel (PIMAC) function in plant mitochondria. 2008 Plant Cell Physiol. pmid:18511459
Saubeau G et al. Differential induction of oxylipin pathway in potato and tobacco cells by bacterial and oomycete elicitors. 2013 Plant Cell Rep. pmid:23479199
Girgih AT et al. Reverse-phase HPLC separation of hemp seed (Cannabis sativa L.) protein hydrolysate produced peptide fractions with enhanced antioxidant capacity. 2013 Plant Foods Hum Nutr pmid:23417711
Beevi SS et al. Polyphenolics profile, antioxidant and radical scavenging activity of leaves and stem of Raphanus sativus L. 2010 Plant Foods Hum Nutr pmid:20072818
Freiberger CE et al. Nutrient content of the edible leaves of seven wild plants from Niger. 1998 Plant Foods Hum Nutr pmid:10890758
Valdez-Morales M et al. Phenolic Compounds, Antioxidant Activity and Lipid Profile of Huitlacoche Mushroom (Ustilago maydis) Produced in Several Maize Genotypes at Different Stages of Development. 2016 Plant Foods Hum Nutr pmid:27605221
Rahamatalla AB et al. Changes in fatty acids composition during seed growth and physicochemical characteristics of oil extracted from four safflower cultivars. 2001 Plant Foods Hum Nutr pmid:11678443
Rao MS et al. Yield, protein, and oil quality of soybean genotypes selected for tofu production. 1998 Plant Foods Hum Nutr pmid:9950085
Forster C et al. Molecular analysis of a null mutant for pea (Pisum sativum L.) seed lipoxygenase-2. 1999 Plant Mol. Biol. pmid:10380807
Fraser TC et al. Expression of the Isochrysis C18-delta9 polyunsaturated fatty acid specific elongase component alters Arabidopsis glycerolipid profiles. 2004 Plant Physiol. pmid:15173563
Woodfield HK et al. Spatial and Temporal Mapping of Key Lipid Species in Brassica napus Seeds. 2017 Plant Physiol. pmid:28188274
Cahoon EB et al. Transgenic production of epoxy fatty acids by expression of a cytochrome P450 enzyme from Euphorbia lagascae seed. 2002 Plant Physiol. pmid:11842164
Domínguez T et al. Increasing omega-3 desaturase expression in tomato results in altered aroma profile and enhanced resistance to cold stress. 2010 Plant Physiol. pmid:20382895
Kang J et al. Identification of three genes encoding microsomal oleate desaturases (FAD2) from the oilseed crop Camelina sativa. 2011 Plant Physiol. Biochem. pmid:21215650
Hofmann E and Pollmann S Molecular mechanism of enzymatic allene oxide cyclization in plants. 2008 Plant Physiol. Biochem. pmid:18272375
Zhang D et al. Identification and expression of a new delta-12 fatty acid desaturase (FAD2-4) gene in upland cotton and its functional expression in yeast and Arabidopsis thaliana plants. 2009 Plant Physiol. Biochem. pmid:19217793
Chua AC et al. Characterization of oil bodies in jelly fig achenes. 2008 May-Jun Plant Physiol. Biochem. pmid:18434174
Lorenzi V et al. Purification, product characterization and kinetic properties of lipoxygenase from olive fruit (Olea europaea L.). 2006 Jul-Sep Plant Physiol. Biochem. pmid:17011785
Yu C et al. Overexpression of endoplasmic reticulum omega-3 fatty acid desaturase gene improves chilling tolerance in tomato. 2009 Nov-Dec Plant Physiol. Biochem. pmid:19648018
Venegas-Calerón M et al. Effect of the ferredoxin electron donor on sunflower (Helianthus annuus) desaturases. 2009 Plant Physiol. Biochem. pmid:19342250
Quintana N et al. Phytotoxic compounds from roots of Centaurea diffusa Lam. 2009 Plant Signal Behav pmid:19568334
Fernández-Moya V et al. Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds. 2003 Planta pmid:12624771
de Virville JD et al. Changes in electron transport pathways in endoplasmic reticulum of rapeseed in response to cold. 2008 Planta pmid:18663470
Smith MA et al. Heterologous expression of a fatty acid hydroxylase gene in developing seeds of Arabidopsis thaliana. 2003 Planta pmid:14520576
Liu JH et al. Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase. 1998 Planta Med. pmid:9741298
Haraguchi H et al. Antioxidative action of diterpenoids from Podocarpus nagi. 1997 Planta Med. pmid:9225601
Su BN et al. Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay. 2002 Planta Med. pmid:12494342
Sewram V et al. Supercritical fluid extraction and analysis of compounds from Clivia miniata for uterotonic activity. 2001 Planta Med. pmid:11488461
Hou WC et al. Yam (Dioscorea batatas) tuber mucilage exhibited antioxidant activities in vitro. 2002 Planta Med. pmid:12494332
AbouZid S and Orihara Y Biosynthesis of polyacetylenes in Ambrosia maritima hairy roots. 2007 Planta Med. pmid:17973205
Hong CY et al. Linoleate-rich triacylglycerol in Panax pseudo-ginseng improves erythrocyte deformability in vitro. 1993 Planta Med. pmid:8372148