Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| VIOQUE E and HOLMAN RT | Characterization of the ketodienes formed in the oxidation of linoleate by lipoxidase. | 1962 | Arch. Biochem. Biophys. | pmid:13997422 |
| YUAN C and BLOCH K | Conversion of oleic acid to linoleic acid. | 1961 | J. Biol. Chem. | pmid:13787544 |
| PEIFER JJ et al. | Studies on the distribution of lipides in hypercholesteremic rats. I. The effect of feeding palmitate, oleate, linoleate, linolenate, menhaden and tuna oils. | 1960 | Arch. Biochem. Biophys. | pmid:14431396 |
| HAUGE JG and NICOLAYSEN R | The serum cholesterol depressive effect of linoleic, linolenic acids and of cod liver oil in experimental hypercholesterolaemic rats. | 1959 | Acta Physiol. Scand. | pmid:13626601 |
| KLEIN PD | Linoleic acid and cholesterol metabolism in the rat. II. Effects of dietary cholesterol on plasma and liver ester composition. | 1959 | Arch. Biochem. Biophys. | pmid:13638000 |
| FULD H and HORWICH L | Xanthomatous biliary cirrhosis treated with ethyl linoleate. | 1959 | Lancet | pmid:13655619 |
| OLSON FE et al. | The use of diets containing large amounts of linoleic acid. | 1958 Nov-Dec | Am. J. Clin. Nutr. | pmid:13594895 |
| TOOKEY HL et al. | Coupled oxidation of carotene and linoleate catalyzed by lipoxidase. | 1958 | J. Biol. Chem. | pmid:13502374 |
| KLEIN PD | Linoleic acid and cholesterol metabolism in the rat. I. The effect of dietary fat and linoleic acid levels on the content and composition of cholesterol esters in liver and plasma. | 1958 | Arch. Biochem. Biophys. | pmid:13560012 |
| WIESE HF et al. | Essential fatty acids in infant nutrition. I. Linoleic acid requirement in terms of serum di-, tri- and tetraenoic acid levels. | 1958 | J. Nutr. | pmid:13611579 |
| HANSEN AE et al. | Essential fatty acids in infant nutrition. III. Clinical manifestations of linoleic acid deficiency. | 1958 | J. Nutr. | pmid:13621281 |
| KOCH RB et al. | Linoleic acid and trilinolein as substrates for soybean lipoxidase (s). | 1958 | Arch. Biochem. Biophys. | pmid:13595914 |
| HAINING JL and AXELROD B | Induction period in the lipoxidase-catalyzed oxidation of linoleic acid and its abolition by substrate peroxide. | 1958 | J. Biol. Chem. | pmid:13549410 |
| FISHER H and LEVEILLE GA | Observations on the cholesterol, linoleic and linolenic acid content of eggs as influenced by dietary fats. | 1957 | J. Nutr. | pmid:13476240 |
| HORGAN VJ et al. | Toxicity of autoxidized squalene and linoleic acid, and of simpler peroxides, in relation to toxicity of radiation. | 1957 | Biochem. J. | pmid:13488907 |
| MEAD JF et al. | Metabolism of the essential fatty acids. II. The metabolism of stearate, oleate, and linoleate by fat-deficient and normal mice. | 1956 | J. Biol. Chem. | pmid:13278347 |
| STEINBERG G et al. | Metabolism of essential fatty acids. IV. Incorporation of linoleate into arachidonic acid. | 1956 | J. Biol. Chem. | pmid:13319343 |
| SIDDIQI AM and TAPPEL AL | Catalysis of linoleate oxidation by pea lipoxidase. | 1956 | Arch. Biochem. Biophys. | pmid:13283592 |
| KHAN NA | Infrared studies on initiation of the autoxidation of some fatty acid esters with and without light-sensitized chlorophyll, ultraviolet light and lipoxidase. | 1955 | Biochim. Biophys. Acta | pmid:14363243 |
| CHENG AL et al. | The effect of fat level of the diet on general nutrition. XV. Comparison of the protective effect of linoleic acid and linolenic acid against multiple sublethal doses of x-irradiation in the rat. | 1955 | J. Nutr. | pmid:14368364 |
| PRIVETT OS et al. | Polyethenoid fatty acid metabolism. VIII. Nonpotency of cis-9, trans-12-linoleate as essential fatty acid. | 1955 | Arch. Biochem. Biophys. | pmid:13239196 |
| BLOMSTRAND R | The intestinal absorption of linoleic-1-14C acid. | 1954 | Acta Physiol. Scand. | pmid:13228101 |
| TAPPEL AL et al. | Effect of temperature and antioxidants upon the lipoxidase-catalyzed oxidation of sodium linoleate. | 1953 | Arch. Biochem. Biophys. | pmid:13031632 |
| KHAN NA | Biological oxidation. I. The infrared studies on the lipoxidasecatalyzed oxidation of linoleic acid. | 1953 | Arch. Biochem. Biophys. | pmid:13058378 |
| TAPPEL AL | The mechanism of the oxidation of unsaturated fatty acids catalyzed by hematin compounds. | 1953 | Arch. Biochem. Biophys. | pmid:13058395 |
| BUTCHER EO | The penetration of fat and fatty acid into the skin of the rat. | 1953 | J. Invest. Dermatol. | pmid:13069840 |
| Mead JF | The Irradiation-Induced Autoxidation of Linoleic Acid. | 1952 | Science | pmid:17749056 |
| MEDES G et al. | Dienoic acid contents of rats with linoleic acid and pyridoxine deficiencies. | 1951 | Arch. Biochem. Biophys. | pmid:14847665 |
| Fraenkel G and Blewett M | Linoleic acid and arachidonic acid in the metabolism of two insects, Ephestia kuehniella (Lep.) and Tenebrio molitor (Col.). | 1947 | Biochem. J. | pmid:16748194 |
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