Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Tracy RE and Walia P | A method to fix lipids for staining fat embolism in paraffin sections. | 2002 | Histopathology | pmid:12121240 |
Kim EJ et al. | Trans-10,cis-12-conjugated linoleic acid inhibits Caco-2 colon cancer cell growth. | 2002 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12121883 |
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Ghebremeskel K et al. | Liver triacylglycerols and free fatty acids in streptozotocin-induced diabetic rats have atypical n-6 and n-3 pattern. | 2002 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:12161168 |
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Lee MH et al. | Therapeutic effect of topical application of linoleic acid and lincomycin in combination with betamethasone valerate in melasma patients. | 2002 | J. Korean Med. Sci. | pmid:12172049 |
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Kuo TM et al. | Conversion of fatty acids by Bacillus sphaericus-like organisms. | 2002 | Curr. Microbiol. | pmid:12192524 |
Risérus U et al. | Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. | 2002 | Diabetes Care | pmid:12196420 |
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Yang H et al. | Sex-specific induction of mutations by PhIP in the kidney of male and female rats and its modulation by conjugated linoleic acid. | 2002 | Environ. Mol. Mutagen. | pmid:12203404 |
Tithof PK et al. | Polycyclic aromatic hydrocarbons present in cigarette smoke cause endothelial cell apoptosis by a phospholipase A2-dependent mechanism. | 2002 | FASEB J. | pmid:12205049 |
Ko TF et al. | Squalene content and antioxidant activity of Terminalia catappa leaves and seeds. | 2002 | J. Agric. Food Chem. | pmid:12207472 |
Nuchi CD et al. | Ability of lipid hydroperoxides to partition into surfactant micelles and alter lipid oxidation rates in emulsions. | 2002 | J. Agric. Food Chem. | pmid:12207489 |
Noone EJ et al. | The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. | 2002 | Br. J. Nutr. | pmid:12207834 |
Bottger JD et al. | Effects of supplementation with high linoleic or oleic cracked safflower seeds on postpartum reproduction and calf performance of primiparous beef heifers. | 2002 | J. Anim. Sci. | pmid:12211368 |
Smith SB et al. | Conjugated linoleic acid depresses the delta9 desaturase index and stearoyl coenzyme A desaturase enzyme activity in porcine subcutaneous adipose tissue. | 2002 | J. Anim. Sci. | pmid:12211379 |
Göbel C et al. | Oxylipin profiling in pathogen-infected potato leaves. | 2002 | Biochim. Biophys. Acta | pmid:12213493 |
Giesy JG et al. | Effect of dose of calcium salts of conjugated linoleic acid (CLA) on percentage and fatty acid content of milk fat in midlactation holstein cows. | 2002 | J. Dairy Sci. | pmid:12214995 |
Freedman JE | Nitrated lipids: defining their bioactivity. | 2002 | Circ. Res. | pmid:12215483 |
Coles B et al. | Nitrolinoleate inhibits superoxide generation, degranulation, and integrin expression by human neutrophils: novel antiinflammatory properties of nitric oxide-derived reactive species in vascular cells. | 2002 | Circ. Res. | pmid:12215485 |
Gulcin I et al. | On the in vitro antioxidative properties of melatonin. | 2002 | J. Pineal Res. | pmid:12220332 |
Bouthegourd JC et al. | A CLA mixture prevents body triglyceride accumulation without affecting energy expenditure in Syrian hamsters. | 2002 | J. Nutr. | pmid:12221229 |
Clément L et al. | Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. | 2002 | J. Lipid Res. | pmid:12235171 |
Blank C et al. | Optimizing DHA levels in piglets by lowering the linoleic acid to alpha-linolenic acid ratio. | 2002 | J. Lipid Res. | pmid:12235186 |
Newman JW et al. | The simultaneous quantification of cytochrome P450 dependent linoleate and arachidonate metabolites in urine by HPLC-MS/MS. | 2002 | J. Lipid Res. | pmid:12235189 |
Harrell MD and Stimers JR | Differential effects of linoleic Acid metabolites on cardiac sodium current. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12235270 |
Du M et al. | Quality characteristics of irradiated ready-to-eat breast rolls from turkeys fed conjugated linoleic acid. | 2002 | Poult. Sci. | pmid:12269620 |
Yang L et al. | Production of conjugated linoleic acids through KOH-catalyzed dehydration of ricinoleic acid. | 2002 | Chem. Phys. Lipids | pmid:12270670 |
Fang JG et al. | Antioxidant effects of resveratrol and its analogues against the free-radical-induced peroxidation of linoleic acid in micelles. | 2002 | Chemistry | pmid:12298009 |
Goodfriend TL et al. | An oxidized derivative of linoleic acid affects aldosterone secretion by adrenal cells in vitro. | 2002 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12324236 |
Baylin A et al. | Adipose tissue biomarkers of fatty acid intake. | 2002 | Am. J. Clin. Nutr. | pmid:12324287 |
Voorrips LE et al. | Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands Cohort Study on Diet and Cancer. | 2002 | Am. J. Clin. Nutr. | pmid:12324303 |
Itoh A et al. | Identification of a jasmonate-regulated allene oxide synthase that metabolizes 9-hydroperoxides of linoleic and linolenic acids. | 2002 | J. Biol. Chem. | pmid:12351632 |