Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cho H et al. | Nonradiometric HPLC measurement of 13(S)-hydroxyoctadecadienoic acid from rat tissues. | 2003 | Anal. Biochem. | pmid:12782030 |
| Barceló-Coblijn G et al. | Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. | 2003 | Biochim. Biophys. Acta | pmid:12782153 |
| Beck S et al. | Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation. | 2003 | J. Biol. Chem. | pmid:12782627 |
| Shimada Y et al. | Increased response of liver microsomal delta 6-desaturase activity to dietary methionine in rats. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12784613 |
| Nagao K et al. | The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima fatty rats. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12788078 |
| pmid:12790685 | ||||
| Chajes V et al. | Conjugated linoleic acid content in breast adipose tissue of breast cancer patients and the risk of metastasis. | 2003 | Nutr Cancer | pmid:12791500 |
| Hutley LJ et al. | Effects of rosiglitazone and linoleic acid on human preadipocyte differentiation. | 2003 | Eur. J. Clin. Invest. | pmid:12814394 |
| Kim JY and Chung BH | Effects of combination dietary conjugated linoleic acid with vitamin A (retinol) and selenium on the response of the immunoglobulin production in mice. | 2003 | J. Vet. Sci. | pmid:12819373 |
| Kamphuis MM et al. | The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects. | 2003 | Int. J. Obes. Relat. Metab. Disord. | pmid:12821971 |
| Tamura K et al. | Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants. | 2003 | J. Med. Chem. | pmid:12825946 |
| Sehanputri PS and Hill CG | Lipase-mediated acidolysis of butteroil with free conjugated linoleic acid in a packed bed reactor. | 2003 | Biotechnol. Bioeng. | pmid:12827703 |
| Politis I et al. | Effects of dietary conjugated linoleic acid isomers on several functional properties of macrophages and heterophils in laying hens. | 2003 | Br. Poult. Sci. | pmid:12828205 |
| Mittendorfer B et al. | What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean? | 2003 | Diabetes | pmid:12829627 |
| Nagao K et al. | The 10trans, 12cis isomer of conjugated linoleic acid promotes energy metabolism in OLETF rats. | 2003 Jul-Aug | Nutrition | pmid:12831953 |
| McNeel RL and Mersmann HJ | Effects of isomers of conjugated linoleic acid on porcine adipocyte growth and differentiation. | 2003 | J. Nutr. Biochem. | pmid:12832030 |
| Degrace P et al. | Association of liver steatosis with lipid oversecretion and hypotriglyceridaemia in C57BL/6j mice fed trans-10,cis-12-linoleic acid. | 2003 | FEBS Lett. | pmid:12832064 |
| Domergue F et al. | Acyl carriers used as substrates by the desaturases and elongases involved in very long-chain polyunsaturated fatty acids biosynthesis reconstituted in yeast. | 2003 | J. Biol. Chem. | pmid:12835316 |
| Alonso L et al. | Production of free conjugated linoleic acid by Lactobacillus acidophilus and Lactobacillus casei of human intestinal origin. | 2003 | J. Dairy Sci. | pmid:12836928 |
| Lima ES et al. | Cholesteryl nitrolinoleate, a nitrated lipid present in human blood plasma and lipoproteins. | 2003 | J. Lipid Res. | pmid:12837858 |
| Nagao T et al. | Purification of conjugated linoleic acid isomers through a process including lipase-catalyzed selective esterification. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12843679 |
| Szymczyk B and Pisulewski PM | Effects of dietary conjugated linoleic acid on fatty acid composition and cholesterol content of hen egg yolks. | 2003 | Br. J. Nutr. | pmid:12844380 |
| Kamphuis MM et al. | The effect of addition of linoleic acid on food intake regulation in linoleic acid tasters and linoleic acid non-tasters. | 2003 | Br. J. Nutr. | pmid:12844392 |
| Blask DE et al. | Growth and fatty acid metabolism of human breast cancer (MCF-7) xenografts in nude rats: impact of constant light-induced nocturnal melatonin suppression. | 2003 | Breast Cancer Res. Treat. | pmid:12846415 |
| Salvatori G et al. | Control of dietary energy level and dl-alpha-tocopheryl acetate treatment can improve the lipid composition of lamb meat. | 2003 | Int J Vitam Nutr Res | pmid:12847993 |
| Kim YJ | Partial inhibition of biohydrogenation of linoleic acid can increase the conjugated linoleic acid production of Butyrivibrio fibrisolvens A38. | 2003 | J. Agric. Food Chem. | pmid:12848494 |
| McNamara S et al. | Effect of offering rumen-protected fat supplements on fertility and performance in spring-calving Holstein-Friesian cows. | 2003 | Anim. Reprod. Sci. | pmid:12853178 |
| Griswold KE et al. | Effectiveness of short-term feeding strategies for altering conjugated linoleic acid content of beef. | 2003 | J. Anim. Sci. | pmid:12854825 |
| Yamasaki M et al. | Alleviation of the cytotoxic activity induced by trans10, cis12-conjugated linoleic acid in rat hepatoma dRLh-84 cells by oleic or palmitoleic acid. | 2003 | Cancer Lett. | pmid:12860277 |
| Nguyen SD and Sok DE | Beneficial effect of oleoylated lipids on paraoxonase 1: protection against oxidative inactivation and stabilization. | 2003 | Biochem. J. | pmid:12871208 |
| Kilian M et al. | Influence of conjugated and conventional linoleic acid on tumor growth and lipid peroxidation in pancreatic adenocarcinoma in hamster. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878453 |
| Lee KW and Lip GY | The role of omega-3 fatty acids in the secondary prevention of cardiovascular disease. | 2003 | QJM | pmid:12881589 |
| Gollnick H | Current concepts of the pathogenesis of acne: implications for drug treatment. | 2003 | Drugs | pmid:12887264 |
| Kim EJ et al. | Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. | 2003 | J. Nutr. | pmid:12888657 |
| Lee SO et al. | Bioconversion of linoleic acid into conjugated linoleic acid during fermentation and by washed cells of Lactobacillus reuteri. | 2003 | Biotechnol. Lett. | pmid:12889826 |
| Torres CF et al. | Lipase-catalyzed esterification of conjugated linoleic acid with sorbitol: a kinetic study. | 2003 Jul-Aug | Biotechnol. Prog. | pmid:12892488 |
| Miyazawa D et al. | Dietary alpha-linolenic acid suppresses the formation of lysophosphatidic acid, a lipid mediator, in rat platelets compared with linoleic acid. | 2003 | Life Sci. | pmid:12899931 |
| Thibault C et al. | Effect of feeding prepubertal heifers with a high oil diet on mammary development and milk production. | 2003 | J. Dairy Sci. | pmid:12906048 |
| Mashek DG and Grummer RR | Effects of long chain fatty acids on lipid and glucose metabolism in monolayer cultures of bovine hepatocytes. | 2003 | J. Dairy Sci. | pmid:12906057 |
| Burdge GC et al. | Effect of reduced maternal protein intake in pregnancy in the rat on the fatty acid composition of brain, liver, plasma, heart and lung phospholipids of the offspring after weaning. | 2003 | Br. J. Nutr. | pmid:12908895 |
| Hiramoto K et al. | Suppression of free radical-induced DNA strand breaks by linoleic acid and low density lipoprotein in vitro. | 2003 | Biol. Pharm. Bull. | pmid:12913264 |
| Kim KH and Park HS | Dietary supplementation of conjugated linoleic acid reduces colon tumor incidence in DMH-treated rats by increasing apoptosis with modulation of biomarkers. | 2003 | Nutrition | pmid:12921888 |
| Metz TO et al. | Pyridoxamine traps intermediates in lipid peroxidation reactions in vivo: evidence on the role of lipids in chemical modification of protein and development of diabetic complications. | 2003 | J. Biol. Chem. | pmid:12923193 |
| Reissig D et al. | Effect of fatty acids on expression of endothelial leukocyte adhesion molecules. | 2003 | Eur J Nutr | pmid:12923654 |
| Kelsey JA et al. | The effect of breed, parity, and stage of lactation on conjugated linoleic acid (CLA) in milk fat from dairy cows. | 2003 | J. Dairy Sci. | pmid:12939083 |
| Sirri F et al. | Fatty acid composition and productive traits of broiler fed diets containing conjugated linoleic acid. | 2003 | Poult. Sci. | pmid:12943310 |
| Pilitsis JG et al. | Free fatty acids in cerebrospinal fluids from patients with traumatic brain injury. | 2003 | Neurosci. Lett. | pmid:12946571 |
| Bull AW et al. | Activation of PPAR gamma in colon tumor cell lines by oxidized metabolites of linoleic acid, endogenous ligands for PPAR gamma. | 2003 | Carcinogenesis | pmid:12949056 |
| Yang L et al. | Isomeric distribution of conjugated linoleic acids (CLA) in the tissues of layer hens fed a CLA diet. | 2003 | J. Agric. Food Chem. | pmid:12952415 |
| Seibold SA et al. | Histidine 386 and its role in cyclooxygenase and peroxidase catalysis by prostaglandin-endoperoxide H synthases. | 2003 | J. Biol. Chem. | pmid:12952981 |