Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brush MG et al. | Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. | 1984 | Am. J. Obstet. Gynecol. | pmid:6091462 |
| Dworkin RH et al. | Linoleic acid and multiple sclerosis: a reanalysis of three double-blind trials. | 1984 | Neurology | pmid:6387534 |
| Sohal RS et al. | Relationship between lipofuscin granules and polyunsaturated fatty acids in the housefly, Musca domestica. | 1984 | Mech. Ageing Dev. | pmid:6330462 |
| Sakaguchi M et al. | Effect of dietary unsaturated and saturated fats on azoxymethane-induced colon carcinogenesis in rats. | 1984 | Cancer Res. | pmid:6704963 |
| Chen TC et al. | Modulation of 1,25-dihydroxyvitamin D3 receptor by phospholipids and fatty acids. | 1984 | J. Lipid Res. | pmid:6099395 |
| Frankel EN | Chemistry of free radical and singlet oxidation of lipids. | 1984 | Prog. Lipid Res. | pmid:6100997 |
| Van Alstine JM and Brooks DE | Cell membrane abnormality detected in erythrocytes from patients with multiple sclerosis by partition in two-polymer aqueous-phase systems. | 1984 | Clin. Chem. | pmid:6199135 |
| Benaim G et al. | Different conformational states of the purified Ca2+-ATPase of the erythrocyte plasma membrane revealed by controlled trypsin proteolysis. | 1984 | J. Biol. Chem. | pmid:6234313 |
| Sanders TA et al. | The influence of a maternal diet rich in linoleic acid on brain and retinal docosahexaenoic acid in the rat. | 1984 | Br. J. Nutr. | pmid:6228249 |
| Baba A et al. | Modulation by unsaturated fatty acids of norepinephrine- and adenosine-induced formation of cyclic AMP in brain slices. | 1984 | J. Neurochem. | pmid:6315886 |
| Simon I et al. | Electron-spin resonance studies of lipid-modified microsomes from Friend erythroleukemia cells. | 1984 | Biochim. Biophys. Acta | pmid:6326852 |
| Manku MS et al. | Essential fatty acids in the plasma phospholipids of patients with atopic eczema. | 1984 | Br. J. Dermatol. | pmid:6329254 |
| Alarcón B et al. | Screening for new compounds with antiherpes activity. | 1984 | Antiviral Res. | pmid:6517562 |
| Schick PK et al. | Arachidonate synthesis and uptake in isolated guinea-pig megakaryocytes and platelets. | 1984 | Biochim. Biophys. Acta | pmid:6433984 |
| Furukawa M et al. | Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. | 1984 | Biochim. Biophys. Acta | pmid:6089906 |
| Inouye S | Site-specific cleavage of double-strand DNA by hydroperoxide of linoleic acid. | 1984 | FEBS Lett. | pmid:6430718 |
| Ramesha CS and Thompson GA | The mechanism of membrane response to chilling. Effect of temperature on phospholipid deacylation and reacylation reactions in the cell surface membrane. | 1984 | J. Biol. Chem. | pmid:6430890 |
| Kitagawa S et al. | Activation of bovine platelets induced by long-chain unsaturated fatty acids at just below their lytic concentrations, and its mechanism. | 1984 | Biochim. Biophys. Acta | pmid:6435686 |
| Reeves VB et al. | Variations in plasma fatty acid concentrations during a one-year self-selected dietary intake study. | 1984 | Am. J. Clin. Nutr. | pmid:6507356 |
| Becker W | Distribution of 14C after oral administration of [1-14C]linoleic acid in rats fed different levels of essential fatty acids. | 1984 | J. Nutr. | pmid:6470826 |
| Rogiers V et al. | Abnormal fatty acid turnover in the phospholipids of the red blood cell membranes of cystic fibrosis patients (in vitro study). | 1984 | Pediatr. Res. | pmid:6472942 |
| Neufeld EJ et al. | A mutant HSDM1C1 fibrosarcoma line selected for defective eicosanoid precursor uptake lacks arachidonate-specific acyl-CoA synthetase. | 1984 | J. Biol. Chem. | pmid:6420417 |
| Heine RJ et al. | The effect of dietary linoleic acid and pectin on lipoprotein and apolipoprotein A1 concentrations in rhesus monkeys. | 1984 | Ann. Nutr. Metab. | pmid:6476785 |
| Adam O and Wolfram G | Effect of different linoleic acid intakes on prostaglandin biosynthesis and kidney function in man. | 1984 | Am. J. Clin. Nutr. | pmid:6486083 |
| Badwey JA et al. | Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin. | 1984 | J. Biol. Chem. | pmid:6330088 |
| Jacobs JM and Jacobs NJ | Effect of unsaturated fatty acids on protoporphyrinogen oxidation, a step in heme and chlorophyll synthesis in plant organelles. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6487324 |
| Yorek MA et al. | Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells. | 1984 | Biochim. Biophys. Acta | pmid:6089899 |
| Sánchez J and Stumpf PK | The effect of hypolipidemic drugs WY14643 and DH990, and lysophospholipids on the metabolism of oleate in plants. | 1984 | Arch. Biochem. Biophys. | pmid:6696430 |
| Arslan P et al. | cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes. | 1984 | Biochem. J. | pmid:6696740 |
| Cherayil GD | Sialic acid and fatty acid concentrations in lymphocytes, red blood cells and plasma from patients with multiple sclerosis. | 1984 | J. Neurol. Sci. | pmid:6699649 |
| Stymne S and Stobart AK | The biosynthesis of triacylglycerols in microsomal preparations of developing cotyledons of sunflower (Helianthus annuus L.). | 1984 | Biochem. J. | pmid:6743281 |
| Colard O et al. | 1-Acyl-lysolecithin acyltransferase and synthesis of biliary lecithins in rat liver. | 1984 | Biochimie | pmid:6743697 |
| Margetts BM et al. | Dietary fats and blood pressure. | 1984 | Aust N Z J Med | pmid:6596055 |
| Eyssen H and Verhulst A | Biotransformation of linoleic acid and bile acids by Eubacterium lentum. | 1984 | Appl. Environ. Microbiol. | pmid:6582800 |
| Curnutte JT et al. | Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate. | 1984 | J. Biol. Chem. | pmid:6090448 |
| Chapkin RS and Ziboh VA | Inability of skin enzyme preparations to biosynthesize arachidonic acid from linoleic acid. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6439197 |
| McMurchie EJ et al. | Dietary-induced changes in the fatty acid composition of human cheek cell phospholipids: correlation with changes in the dietary polyunsaturated/saturated fat ratio. | 1984 | Am. J. Clin. Nutr. | pmid:6720626 |
| Iversen SA et al. | Identification of a diene conjugated component of human lipid as octadeca-9,11-dienoic acid. | 1984 | FEBS Lett. | pmid:6723989 |
| Schafer E and Arnrich L | Effects of dietary vitamin E on serum and pulmonary fatty acids and prostaglandins in rats fed excess linoleic acid. | 1984 | J. Nutr. | pmid:6726476 |
| Hagve TA and Christophersen BO | Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells. | 1984 | Biochim. Biophys. Acta | pmid:6093889 |
| Wood DA et al. | Adipose tissue and platelet fatty acids and coronary heart disease in Scottish men. | 1984 | Lancet | pmid:6146032 |
| Hoffmann P et al. | Impaired catecholamine inactivation. A prohypertensive stimulus after dietary linoleate deficiency in salt-loaded rats? | 1983 Nov-Dec | Hypertension | pmid:6581124 |
| Rosenthal MD and Whitehurst MC | Selective effects of isomeric cis and trans fatty acids on fatty acyl delta 9 and delta 6 desaturation by human skin fibroblasts. | 1983 | Biochim. Biophys. Acta | pmid:6615875 |
| Yoshida M et al. | Linoleate and fatty acid compositions in the serum lipids of Japanese patients with multiple sclerosis. | 1983 | Acta Neurol. Scand. | pmid:6364685 |
| Rustin P et al. | Oxidative interactions between fatty acid peroxy radicals and quinones: possible involvement in cyanide-resistant electron transport in plant mitochondria. | 1983 | Arch. Biochem. Biophys. | pmid:6414377 |
| Campbell TB and Lueking DR | Long-chain fatty acid assimilation By rhodopseudomonas sphaeroides. | 1983 | J. Bacteriol. | pmid:6600450 |
| Kirstein D et al. | Effect of dietary fats on the delta 6- and delta 5-desaturation of fatty acids in rat liver microsomes. | 1983 | Br. J. Nutr. | pmid:6315055 |
| Sanders TA | Dietary fat and platelet function. | 1983 | Clin. Sci. | pmid:6309463 |
| Breton M et al. | Linoleate incorporation into rat liver membranes phospholipids: effect on plasma membrane ATPase activities and physical properties. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6230079 |
| Arudi RL et al. | Purification of oleic acid and linoleic acid. | 1983 | J. Lipid Res. | pmid:6854155 |