Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Iwamoto S et al. | Effects of fatty acids on liver metastasis of ACL-15 rat colon cancer cells. | 1998 | Nutr Cancer | pmid:9770727 |
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Ip C et al. | Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. | 1995 | Nutr Cancer | pmid:8610043 |
Methy N et al. | Dietary fatty acids and recurrence of colorectal adenomas in a European intervention trial. | 2008 | Nutr Cancer | pmid:18791918 |
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Connolly JM et al. | Dietary linoleic acid-stimulated human breast cancer cell growth and metastasis in nude mice and their suppression by indomethacin, a cyclooxygenase inhibitor. | 1996 | Nutr Cancer | pmid:8771566 |
Ma DW et al. | An enriched mixture of trans-10,cis-12-CLA inhibits linoleic acid metabolism and PGE2 synthesis in MDA-MB-231 cells. | 2002 | Nutr Cancer | pmid:12734056 |
Yamasaki M et al. | Effect of dietary conjugated linoleic acid on the in vivo growth of rat hepatoma dRLh-84. | 2001 | Nutr Cancer | pmid:11962249 |
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Banni S et al. | An increase in vitamin A status by the feeding of conjugated linoleic acid. | 1999 | Nutr Cancer | pmid:10227044 |
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Park HJ et al. | Linoleic acid-induced VCAM-1 expression in human microvascular endothelial cells is mediated by the NF-kappa B-dependent pathway. | 2001 | Nutr Cancer | pmid:12094615 |
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Ip C et al. | Control of rat mammary epithelium proliferation by conjugated linoleic acid. | 2001 | Nutr Cancer | pmid:11759286 |
Yang H et al. | Modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutation in the cecum and colon of big blue rats by conjugated linoleic acid and 1,2-dithiole-3-thione. | 2001 | Nutr Cancer | pmid:11759290 |
Mackie BS et al. | Melanoma and dietary lipids. | 1987 | Nutr Cancer | pmid:3110746 |
Chajes V et al. | Conjugated linoleic acid content in breast adipose tissue of breast cancer patients and the risk of metastasis. | 2003 | Nutr Cancer | pmid:12791500 |
Aro A et al. | Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women. | 2000 | Nutr Cancer | pmid:11525591 |
Kavanaugh CJ et al. | Effect of dietary conjugated linoleic acid on phorbol ester-induced PGE2 production and hyperplasia in mouse epidermis. | 1999 | Nutr Cancer | pmid:10368807 |
De Stefani E et al. | Nutrient intake and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay. | 2006 | Nutr Cancer | pmid:17474860 |
Ip C and Scimeca JA | Conjugated linoleic acid and linoleic acid are distinctive modulators of mammary carcinogenesis. | 1997 | Nutr Cancer | pmid:9121939 |
Berry EM et al. | Dietary fat, plasma lipoproteins, and immune function in middle-aged American men. | 1987 | Nutr Cancer | pmid:3562291 |
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Golfetto I et al. | Fatty acid composition of milk of refugee Karen and urban Korean mothers. Is the level of DHA in breast milk of Western women compromised by high intake of saturated fat and linoleic acid? | 2007 | Nutr Health | pmid:18087864 |
Lasa A et al. | The combination of resveratrol and CLA does not increase the delipidating effect of each molecule in 3T3-L1 adipocytes. | 2011 Sep-Oct | Nutr Hosp | pmid:22072344 |
Scalerandi MV et al. | Effect of conjugated linoleic acid mixtures and different edible oils in body composition and lipid regulation in mice. | 2014 | Nutr Hosp | pmid:24559004 |
de Luis DA et al. | Double blind randomized clinical trial controlled by placebo with an alpha linoleic acid and prebiotic enriched cookie on risk cardiovascular factor in obese patients. | 2011 Jul-Aug | Nutr Hosp | pmid:22470031 |
Beezhold BL et al. | Vegetarian diets are associated with healthy mood states: a cross-sectional study in seventh day adventist adults. | 2010 | Nutr J | pmid:20515497 |
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McKay DL et al. | Chronic and acute effects of walnuts on antioxidant capacity and nutritional status in humans: a randomized, cross-over pilot study. | 2010 | Nutr J | pmid:20462428 |
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Yehuda S and Mostofsky DI | The effects of an essential fatty acid compound and a cholecystokinin-8 antagonist on iron deficiency induced anorexia and learning deficits. | 2004 | Nutr Neurosci | pmid:15279494 |
Yehuda S et al. | Mixture of essential fatty acids lowers test anxiety. | 2005 | Nutr Neurosci | pmid:16491653 |
Eserian JK et al. | Effects of polyunsaturated fatty acids on cocaine-conditioned place preference in mice. | 2012 | Nutr Neurosci | pmid:22390908 |