Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
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Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yoo TJ et al. | Effect of fatty acid modification of cultured hepatoma cells on susceptibility to natural killer cells. | 1982 | Cancer Res. | pmid:7105033 |
| Letts V et al. | Synthesis and utilization of fatty acids by wild-type and fatty acid auxotrophs of Caulobacter crescentus. | 1982 | J. Bacteriol. | pmid:7107555 |
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| Mogenson GJ and Box BM | Physiological effects of varying dietary linoleic acid in spontaneously hypertensive rats. | 1982 | Ann. Nutr. Metab. | pmid:7137945 |
| Adam O et al. | Prostaglandin formation in man during intake of different amounts of linoleic acid in formula diets. | 1982 | Ann. Nutr. Metab. | pmid:7137955 |
| Cuebas D and Schulz H | Evidence for a modified pathway of linoleate degradation. Metabolism of 2,4-decadienoyl coenzyme A. | 1982 | J. Biol. Chem. | pmid:7142199 |
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| Campbell FM and Dutta-Roy AK | Plasma membrane fatty acid-binding protein (FABPpm) is exclusively located in the maternal facing membranes of the human placenta. | 1995 | FEBS Lett. | pmid:7498505 |
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| Norman HA et al. | Licorice-derived compounds inhibit linoleic acid (C:18:2 omega 6) desaturation in soybean chloroplasts. | 1995 | FEBS Lett. | pmid:7615067 |
| Camacho M et al. | Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. | 1995 | J. Biol. Chem. | pmid:7615528 |
| Chu S et al. | Transformation of mammalian cells by overexpressing H2O2-generating peroxisomal fatty acyl-CoA oxidase. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7624373 |
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| van der Heijdt LM et al. | Changes in the iron coordination sphere of Fe(II) lipoxygenase-1 from soybeans upon binding of linoleate or oleate. | 1995 | Eur. J. Biochem. | pmid:7628469 |
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| Guo L et al. | Preferential formation of the hydroperoxide of linoleic acid in choline glycerophospholipids in human erythrocytes membrane during peroxidation with an azo initiator. | 1995 | Free Radic. Biol. Med. | pmid:7628726 |