Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| TOOKEY HL et al. | Coupled oxidation of carotene and linoleate catalyzed by lipoxidase. | 1958 | J. Biol. Chem. | pmid:13502374 |
| KLEIN PD | Linoleic acid and cholesterol metabolism in the rat. I. The effect of dietary fat and linoleic acid levels on the content and composition of cholesterol esters in liver and plasma. | 1958 | Arch. Biochem. Biophys. | pmid:13560012 |
| WIESE HF et al. | Essential fatty acids in infant nutrition. I. Linoleic acid requirement in terms of serum di-, tri- and tetraenoic acid levels. | 1958 | J. Nutr. | pmid:13611579 |
| HANSEN AE et al. | Essential fatty acids in infant nutrition. III. Clinical manifestations of linoleic acid deficiency. | 1958 | J. Nutr. | pmid:13621281 |
| KOCH RB et al. | Linoleic acid and trilinolein as substrates for soybean lipoxidase (s). | 1958 | Arch. Biochem. Biophys. | pmid:13595914 |
| HAINING JL and AXELROD B | Induction period in the lipoxidase-catalyzed oxidation of linoleic acid and its abolition by substrate peroxide. | 1958 | J. Biol. Chem. | pmid:13549410 |
| OLSON FE et al. | The use of diets containing large amounts of linoleic acid. | 1958 Nov-Dec | Am. J. Clin. Nutr. | pmid:13594895 |
| HAUGE JG and NICOLAYSEN R | The serum cholesterol depressive effect of linoleic, linolenic acids and of cod liver oil in experimental hypercholesterolaemic rats. | 1959 | Acta Physiol. Scand. | pmid:13626601 |
| KLEIN PD | Linoleic acid and cholesterol metabolism in the rat. II. Effects of dietary cholesterol on plasma and liver ester composition. | 1959 | Arch. Biochem. Biophys. | pmid:13638000 |
| FULD H and HORWICH L | Xanthomatous biliary cirrhosis treated with ethyl linoleate. | 1959 | Lancet | pmid:13655619 |
| PEIFER JJ et al. | Studies on the distribution of lipides in hypercholesteremic rats. I. The effect of feeding palmitate, oleate, linoleate, linolenate, menhaden and tuna oils. | 1960 | Arch. Biochem. Biophys. | pmid:14431396 |
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| JAGANNATHAN SN | Effect of feeding different fat mixtures providing the same amount of linoleic acid, on serum cholesterol levels in monkeys and liver cholesterol concentration in cholesterol-fed rats. | 1962 | J. Nutr. | pmid:14450883 |
| JAGANNATHAN SN | Effect of feeding fat blends of hydrogenated groundnut (peanut) fat and cottonseed oil containing different levels of linoleic acid on serum choles terol levels in monkeys (Macaca radiata) and liver cholesterol concentration in cholesterol-fed rats. | 1962 | J. Nutr. | pmid:14450884 |
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| WILSON JD | Relation between dietary cholesterol and bile acid excretion in the rat. | 1962 | Am. J. Physiol. | pmid:14001040 |
| CASTER WO et al. | Determination of linoleate requirement of swine by a new method of estimating nutritional requirement. | 1962 | J. Nutr. | pmid:14019220 |
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| STEIN O and STEIN Y | METABOLISM OF FATTY ACIDS IN THE ISOLATED PERFUSED RAT HEART. | 1963 | Biochim. Biophys. Acta | pmid:14085937 |
| LEAT WM | FATTY ACID COMPOSITION OF THE SERUM LIPIDS OF PIGS GIVEN DIFFERENT AMOUNTS OF LINOLEIC ACID. | 1963 | Biochem. J. | pmid:14097364 |
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| WATSON WC | The morphology and lipid composition of the erythrocytes in normal and essential-fatty-acid-deficient rats. | 1963 | Br. J. Haematol. | pmid:13999227 |
| WOOD RD et al. | Metabolism of labeled linoleic-1-C-14 acid in the sheep rumen. | 1963 | J. Nutr. | pmid:14001756 |
| STEIN Y et al. | Enzymic pathways of glyceride and phospholipid synthesis in aortic homogenates. | 1963 | Biochim. Biophys. Acta | pmid:13983700 |
| HOMBURGER F et al. | Serum lipid changes accompanying the inclusion of canned fish in the diet. | 1963 | J Am Geriatr Soc | pmid:13961527 |
| BEELER DA and QUACKENBUSH FW | Effect of linoleate and dietary fat level on plasma and liver cholesterol and vascular lesions of the cholesterol-fed rat. | 1963 | J. Nutr. | pmid:13970237 |
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