Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Emmison N et al. | Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. | 1995 | Am. J. Physiol. | pmid:7631907 |
| Leichsenring M et al. | Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. | 1995 | Acta Paediatr. | pmid:7633146 |
| Appel MJ and Woutersen RA | Effects of dietary fish oil (MaxEPA) on N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic carcinogenesis in hamsters. | 1995 | Cancer Lett. | pmid:7634246 |
| Rao GN et al. | Linoleic acid and its metabolites, hydroperoxyoctadecadienoic acids, stimulate c-Fos, c-Jun, and c-Myc mRNA expression, mitogen-activated protein kinase activation, and growth in rat aortic smooth muscle cells. | 1995 | J. Clin. Invest. | pmid:7635978 |
| Laneuville O et al. | Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid. | 1995 | J. Biol. Chem. | pmid:7642610 |
| Tezabwala BU et al. | Immunotoxicity of polyunsaturated fatty acids in serum-free medium. | 1995 | Immunopharmacol Immunotoxicol | pmid:7650296 |
| Khan MF et al. | Hematopoietic toxicity of linoleic acid anilide: importance of aniline. | 1995 | Fundam Appl Toxicol | pmid:7665006 |
| Mize CE et al. | Lipoprotein-cholesterol responses in healthy infants fed defined diets from ages 1 to 12 months: comparison of diets predominant in oleic acid versus linoleic acid, with parallel observations in infants fed a human milk-based diet. | 1995 | J. Lipid Res. | pmid:7665996 |
| Abdel-Fattah G et al. | Regulation of guinea pig very low density lipoprotein secretion rates by dietary fat saturation. | 1995 | J. Lipid Res. | pmid:7665997 |
| Romon M et al. | Comparison between fat intake assessed by a 3-day food record and phospholipid fatty acid composition of red blood cells: results from the Monitoring of Cardiovascular Disease-Lille Study. | 1995 | Metab. Clin. Exp. | pmid:7666786 |
| van Tol A et al. | Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man. | 1995 | Atherosclerosis | pmid:7669083 |
| Sakai T et al. | A lipid peroxidation-derived aldehyde, 4-hydroxy-2-nonenal and omega 6 fatty acids contents in meats. | 1995 | Biosci. Biotechnol. Biochem. | pmid:7670203 |
| Grechkin AN et al. | The lipoxygenase pathway in garlic (Allium sativum L.) bulbs: detection of the novel divinyl ether oxylipins. | 1995 | FEBS Lett. | pmid:7672118 |
| Bailey JM et al. | Dietary linoleic acid in alcohol-induced liver cirrhosis. | 1995 | Biochem. Soc. Trans. | pmid:7672270 |
| Sud'ina GF et al. | Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. | 1993 | FEBS Lett. | pmid:7689063 |
| Shi X et al. | Silica radical-induced DNA damage and lipid peroxidation. | 1994 | Environ. Health Perspect. | pmid:7705289 |
| van Greevenbroek MM et al. | Palmitic acid and linoleic acid metabolism in Caco-2 cells: different triglyceride synthesis and lipoprotein secretion. | 1995 | J. Lipid Res. | pmid:7706938 |
| Bayon Y et al. | Effect of specific phospholipid molecular species incorporated in human platelet membranes on thromboxane A2/prostaglandin H2 receptors. | 1995 | J. Lipid Res. | pmid:7706947 |
| Jiang WG et al. | Inhibition of hepatocyte growth factor-induced motility and in vitro invasion of human colon cancer cells by gamma-linolenic acid. | 1995 | Br. J. Cancer | pmid:7710939 |
| Umezawa M et al. | Dietary alpha-linolenate/linoleate balance influences learning and memory in the senescence-accelerated mouse (SAM). | 1995 | Brain Res. | pmid:7712178 |
| Kang JX et al. | Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. | 1995 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7732020 |
| Degousée N et al. | Measurement of thermally produced volatile alkanes: an assay for plant hydroperoxy fatty acid evaluation. | 1995 | Anal. Biochem. | pmid:7733454 |
| Angerman-Stewart JA et al. | Prostaglandin H synthase-2 is induced in Syrian hamster embryo cells in response to basic fibroblast growth factor. | 1995 | Arch. Biochem. Biophys. | pmid:7733666 |
| Campbell FM et al. | Plasma membrane fatty-acid-binding protein in human placenta: identification and characterization. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7733952 |
| Leis HJ et al. | On the inhibition of prostanoid formation by SK&F 96365, a blocker of receptor-operated calcium entry. | 1995 | Br. J. Pharmacol. | pmid:7735686 |
| Welsch CW | Review of the effects of dietary fat on experimental mammary gland tumorigenesis: role of lipid peroxidation. | 1995 | Free Radic. Biol. Med. | pmid:7750800 |
| López-Nicolás JM et al. | Use of 'soluble lipids' for biochemical processes: linoleic acid-cyclodextrin inclusion complexes in aqueous solutions. | 1995 | Biochem. J. | pmid:7755559 |
| Lodge JK et al. | Copper-induced LDL peroxidation investigated by 1H-NMR spectroscopy. | 1995 | Biochim. Biophys. Acta | pmid:7766690 |
| Santanam N and Parthasarathy S | Paradoxical actions of antioxidants in the oxidation of low density lipoprotein by peroxidases. | 1995 | J. Clin. Invest. | pmid:7769102 |
| Jones RE | A common factor for cardiac or respiratory failure in SIDS. | 1995 | Clin Pediatr (Phila) | pmid:7774147 |
| Noguchi M et al. | The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. | 1995 Jul-Aug | Oncology | pmid:7777237 |
| Schmitt A et al. | Phospholipid hydrolysis of mildly oxidized LDL reduces their cytotoxicity to cultured endothelial cells. Potential protective role against atherogenesis. | 1995 | Biochim. Biophys. Acta | pmid:7786889 |
| Ghosh D et al. | Structure of uncomplexed and linoleate-bound Candida cylindracea cholesterol esterase. | 1995 | Structure | pmid:7788294 |
| Livrea MA and Tesoriere L | Lipoperoxyl radical-scavenging activity of vitamin A and analogs in homogeneous solution. | 1994 | Meth. Enzymol. | pmid:7808312 |
| López-Nicolás JM et al. | An octaethylene glycol monododecyl ether-based mixed micellar assay for lipoxygenase acting at neutral pH. | 1994 | Anal. Biochem. | pmid:7810887 |
| Jones RE | A hypothesis for early intervention in SIDS. | 1994 | Clin Pediatr (Phila) | pmid:7813148 |
| Avery SV et al. | Low temperature-induced adaptations in lipid metabolism and physiological function in Acanthamoeba castellanii cultures of different ages. | 1994 | Biochem. Soc. Trans. | pmid:7821519 |
| Nada MA et al. | Evidence for intermediate channeling in mitochondrial beta-oxidation. | 1995 | J. Biol. Chem. | pmid:7822275 |
| Thompson L et al. | Inhibitory effect of polyunsaturated fatty acids on the growth of Helicobacter pylori: a possible explanation of the effect of diet on peptic ulceration. | 1994 | Gut | pmid:7828972 |
| Saito M and Yamaguchi M | Liver microsomal mixed-function oxidases in response to dietary n-3 fatty acid levels in rats. | 1994 | Ann. Nutr. Metab. | pmid:7832581 |
| Roberts TL et al. | trans isomers of oleic and linoleic acids in adipose tissue and sudden cardiac death. | 1995 | Lancet | pmid:7837861 |
| Mantzioris E et al. | Differences exist in the relationships between dietary linoleic and alpha-linolenic acids and their respective long-chain metabolites. | 1995 | Am. J. Clin. Nutr. | pmid:7840069 |
| Siguel E | Does linoleic acid contribute to coronary artery disease? | 1995 | Am. J. Clin. Nutr. | pmid:7840081 |
| Fuhrman B et al. | Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties. | 1994 | Atherosclerosis | pmid:7840815 |
| Kvilekval K et al. | Fatty acids as determinants of triglyceride and cholesteryl ester synthesis by isolated hepatocytes: kinetics as a function of various fatty acids. | 1994 | J. Lipid Res. | pmid:7852855 |
| Siguel EN and Ratnayake WM | Trans-fatty acid patterns in patients with demonstrated coronary artery disease. | 1995 | Am. J. Cardiol. | pmid:7856548 |
| Croft KD et al. | Oxidation of low-density lipoproteins: effect of antioxidant content, fatty acid composition and intrinsic phospholipase activity on susceptibility to metal ion-induced oxidation. | 1995 | Biochim. Biophys. Acta | pmid:7857965 |
| Chen ZY et al. | Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats. | 1995 | Am. J. Physiol. | pmid:7864247 |
| Lawrence JF et al. | An incident of elevated levels of unsaturated free fatty acids in mussels from Nova Scotia and their toxic effect in mice after intraperitoneal injection. | 1994 | Nat. Toxins | pmid:7866668 |
| Bulan EJ et al. | Immature maxi-K channels exhibit heterogeneous properties in the embryonic rat telencephalon. | 1994 | Dev. Neurosci. | pmid:7867514 |