Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li Y et al. | Chemical and alpha-chymotrypsin-mediated proteolytic degradation of insulin in bile salt-unsaturated fatty acid mixed micellar systems. | 1993 | Pharm. Res. | pmid:8290478 |
| Wang Y et al. | Effects of fatty acids and iontophoresis on the delivery of midodrine hydrochloride and the structure of human skin. | 2003 | Pharm. Res. | pmid:14620516 |
| Shao Z and Mitra AK | Nasal membrane and intracellular protein and enzyme release by bile salts and bile salt-fatty acid mixed micelles: correlation with facilitated drug transport. | 1992 | Pharm. Res. | pmid:1409402 |
| Whigham LD et al. | Conjugated linoleic acid: implications for human health. | 2000 | Pharmacol. Res. | pmid:11058400 |
| Nair VB and Panchagnula R | Effect of iontophoresis and fatty acids on permeation of arginine vasopressin through rat skin. | 2003 | Pharmacol. Res. | pmid:12742012 |
| Gülçin I et al. | In vitro antioxidant properties of morphine. | 2004 | Pharmacol. Res. | pmid:14597153 |
| Büyükokuroğlu ME et al. | In vitro antioxidant properties of dantrolene sodium. | 2001 | Pharmacol. Res. | pmid:11735355 |
| Geetha T et al. | Effect of triterpenes from Crataeva nurvala stem bark on lipid peroxidation in adjuvant induced arthritis in rats. | 1998 | Pharmacol. Res. | pmid:9602466 |
| Joo NE and Park CS | Inhibition of excitotoxicity in cultured rat cortical neurons by a mixture of conjugated linoleic acid isomers. | 2003 | Pharmacol. Res. | pmid:12644387 |
| Nègre-Salvayre A et al. | Additional antilipoperoxidant activities of alpha-tocopherol and ascorbic acid on membrane-like systems are potentiated by rutin. | 1991 | Pharmacology | pmid:1652140 |
| Canudas N et al. | Photosensitizing properties of 6-methoxy-2-naphthylacetic acid, the major metabolite of the phototoxic non-steroidal anti-inflammatory and analgesic drug nabumetone. | 2005 | Pharmazie | pmid:16124404 |
| Vargas F et al. | Photodegradation and in vitro phototoxicity of aceclofenac. | 2007 | Pharmazie | pmid:17557739 |
| Vargas F et al. | Photochemistry and in vitro phototoxicity studies of levomepromazine (methotrimeprazine), a phototoxic neuroleptic drug. | 2003 | Pharmazie | pmid:12779046 |
| Hinneburg I et al. | Antioxidant and photoprotective properties of an extract from buckwheat herb (Fagopyrum esculentum MOENCH). | 2006 | Pharmazie | pmid:16599267 |
| Castell JV et al. | Photodynamic lipid peroxidation by the photosensitizing nonsteroidal antiinflammatory drugs suprofen and tiaprofenic acid. | 1994 | Photochem. Photobiol. | pmid:8127938 |
| Miolo G et al. | Photochemistry and phototoxicity of fluocinolone 16,17-acetonide. | 2005 Mar-Apr | Photochem. Photobiol. | pmid:15535735 |
| Samadi A et al. | Mechanism of lipid peroxidation photosensitized by tiaprofenic acid: product studies using linoleic acid and 1,4-cyclohexadienes as model substrates. | 2001 | Photochem. Photobiol. | pmid:11332030 |
| Vargas F et al. | Photodegradation and in vitro phototoxicity of fenofibrate, a photosensitizing anti-hyperlipoproteinemic drug. | 1993 | Photochem. Photobiol. | pmid:8248320 |
| Voigt A et al. | Polyunsaturated but not conjugated linoleic acid supplementation of leukemic U937 cells can act as an amplification factor for photofrin-mediated photodynamic therapy. | 2006 May-Jun | Photochem. Photobiol. | pmid:16468943 |
| Markovic DZ and Patterson LK | Benzophenone-sensitized lipid peroxidation in linoleate micelles. | 1993 | Photochem. Photobiol. | pmid:8234464 |
| Mujtaba SF et al. | Production of ROS by photosensitized anthracene under sunlight and UV-R at ambient environmental intensities. | 2011 Sep-Oct | Photochem. Photobiol. | pmid:21668866 |
| Anthony FA et al. | Psoralen-fatty acid adducts activate melanocyte protein kinase C: a proposed mechanism for melanogenesis induced by 8-methoxypsoralen and ultraviolet A light. | 1997 Feb-Apr | Photodermatol Photoimmunol Photomed | pmid:9361122 |
| KmonÃcková E et al. | Differences in heart phospholipids in two inbred rat strains differing in sensitivity to the development of heart lesions. | 1998 | Physiol Res | pmid:9706993 |
| Ondrias K et al. | Antioxidant and pro-oxidant effects of epinephrine and isoprenaline on peroxidation of LDL and lipid liposomes. | 1998 | Physiol Res | pmid:9706995 |
| Saitou K et al. | Contribution of gustation to the palatability of linoleic acid. | 2009 | Physiol. Behav. | pmid:18835400 |
| Smith JC et al. | Orosensory factors in the ingestion of corn oil/sucrose mixtures by the rat. | 2000 Apr 1-15 | Physiol. Behav. | pmid:10854925 |
| Cox JE et al. | Truncal and hepatic vagotomy reduce suppression of feeding by jejunal lipid infusions. | 2004 | Physiol. Behav. | pmid:15059681 |
| Ebba S et al. | The examination of fatty acid taste with edible strips. | 2012 | Physiol. Behav. | pmid:22521910 |
| Stratford JM et al. | Chorda tympani nerve transection alters linoleic acid taste discrimination by male and female rats. | 2006 | Physiol. Behav. | pmid:16963089 |
| McCormack DN et al. | Detection of free fatty acids following a conditioned taste aversion in rats. | 2006 | Physiol. Behav. | pmid:16448678 |
| Gilbertson TA et al. | Fatty acid responses in taste cells from obesity-prone and -resistant rats. | 2005 | Physiol. Behav. | pmid:16249010 |
| Yoneda T et al. | The palatability of corn oil and linoleic acid to mice as measured by short-term two-bottle choice and licking tests. | 2007 | Physiol. Behav. | pmid:17459430 |
| Greenberg D et al. | Differential satiating effects of fats in the small intestine of obesity-resistant and obesity-prone rats. | 1999 | Physiol. Behav. | pmid:10386906 |
| Guillén N et al. | Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver. | 2009 | Physiol. Genomics | pmid:19258494 |
| LaRosa PC et al. | Trans-10, cis-12 conjugated linoleic acid activates the integrated stress response pathway in adipocytes. | 2007 | Physiol. Genomics | pmid:17878318 |
| Georgiadi A et al. | Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. | 2012 | Physiol. Genomics | pmid:22274564 |
| Salazar MO et al. | A thin-layer chromatography autographic method for the detection of inhibitors of the Salmonella PhoP-PhoQ regulatory system. | 2014 Mar-Apr | Phytochem Anal | pmid:24185747 |
| Qu WX et al. | Analysis of fatty acids in A. szechenyianum Gay. by microwave-assisted extraction and gas chromatography-mass spectrometry. | 2011 May-Jun | Phytochem Anal | pmid:20848395 |
| Ogorodnikova AV et al. | Detection of divinyl ether synthase in Lily-of-the-Valley (Convallaria majalis) roots. | 2008 | Phytochemistry | pmid:18952245 |
| Williams M and Harwood JL | Characterisation of lipoxygenase isoforms from olive callus cultures. | 2008 | Phytochemistry | pmid:18790508 |
| DoÄŸru-Koca A et al. | Chemotaxonomic perspectives of the Paracaryum (Cynoglosseae, Boraginaceae) taxa based on fruit fatty acid composition. | 2016 | Phytochemistry | pmid:27600716 |
| Bergman M et al. | Scavenging of reactive oxygen species by a novel glucurinated flavonoid antioxidant isolated and purified from spinach. | 2003 | Phytochemistry | pmid:12620328 |
| Ohnishi M et al. | Inhibition in vitro linoleic acid peroxidation and haemolysis by caffeoyltryptophan. | 1998 | Phytochemistry | pmid:9611825 |
| Hatano T et al. | Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects. | 2002 | Phytochemistry | pmid:11909632 |
| Padilla MN et al. | Molecular cloning, functional characterization and transcriptional regulation of a 9-lipoxygenase gene from olive. | 2012 | Phytochemistry | pmid:22169502 |
| Bryant D et al. | Cloning and characterization of a theta class glutathione transferase from the potato pathogen Phytophthora infestans. | 2006 | Phytochemistry | pmid:16797619 |
| Jablonická V et al. | Identification of a secretory phospholipase A2 from Papaver somniferum L. that transforms membrane phospholipids. | 2016 | Phytochemistry | pmid:27473012 |
| Reininger EA and Bauer R | Prostaglandin-H-synthase (PGHS)-1 and -2 microtiter assays for the testing of herbal drugs and in vitro inhibition of PGHS-isoenzyms by polyunsaturated fatty acids from Platycodi radix. | 2006 | Phytomedicine | pmid:16428023 |
| Liu J et al. | Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry). | 2004 | Phytomedicine | pmid:14974442 |
| Lata M et al. | Whole body protection against lethal ionizing radiation in mice by REC-2001: a semi-purified fraction of Podophyllum hexandrum. | 2009 | Phytomedicine | pmid:17574826 |