Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Liégeois C et al. | Measuring antioxidant efficiency of wort, malt, and hops against the 2,2'-azobis(2-amidinopropane) dihydrochloride-induced oxidation of an aqueous dispersion of linoleic acid. | 2000 | J. Agric. Food Chem. | pmid:10775361 |
| Sasaki T et al. | Dietary docosahexaenoic acid can alter the surface expression of CD4 and CD8 on T cells in peripheral blood. | 2000 | J. Agric. Food Chem. | pmid:10775347 |
| Siefken W et al. | Regulation of cholesterol synthesis by oleic and palmitic acid in keratinocytes. | 2000 | Exp. Dermatol. | pmid:10772388 |
| Kritharides L | Ascorbic acid and copper in linoleate oxidation--Dunkley revisited. | 1999 | Redox Rep. | pmid:10772064 |
| Mogul R et al. | Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase. | 2000 | Biochemistry | pmid:10769137 |
| Littman ED et al. | Role of protein kinase C isoenzymes in fatty acid stimulation of insulin secretion. | 2000 | Pancreas | pmid:10766451 |
| Mohan IK and Das UN | Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical-induced diabetes mellitus. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765977 |
| Punchard NA et al. | Analysis of the intestinal absorption of essential fatty acids in vivo in the rat. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10765976 |
| Hubbard NE et al. | Reduction of murine mammary tumor metastasis by conjugated linoleic acid. | 2000 | Cancer Lett. | pmid:10755392 |
| Trimborn M et al. | Linoleic acid cytotoxicity to bovine lens epithelial cells: influence of albumin on linoleic acid uptake and cytotoxicity. | 2000 Mar-Jun | Ophthalmic Res. | pmid:10754440 |
| Rubbo H et al. | Nitric oxide reaction with lipid peroxyl radicals spares alpha-tocopherol during lipid peroxidation. Greater oxidant protection from the pair nitric oxide/alpha-tocopherol than alpha-tocopherol/ascorbate. | 2000 | J. Biol. Chem. | pmid:10753874 |
| Garcia HS et al. | Interesterification (acidolysis) of butterfat with conjugated linoleic acid in a batch reactor. | 2000 | J. Dairy Sci. | pmid:10750090 |
| Whalen MM et al. | Lysophosphatidylcholine and arachidonic acid are required in the cytotoxic response of human natural killer cells to tumor target cells. | 1999 | Cell. Physiol. Biochem. | pmid:10749996 |
| Larqué E et al. | Dietary trans fatty acids affect the essential fatty-acid concentration of rat milk. | 2000 | J. Nutr. | pmid:10736340 |
| Hudson JA et al. | Identification and enumeration of oleic acid and linoleic acid hydrating bacteria in the rumen of sheep and cows. | 2000 | J. Appl. Microbiol. | pmid:10735997 |
| Clemmesen JO et al. | Plasma phospholipid fatty acid pattern in severe liver disease. | 2000 | J. Hepatol. | pmid:10735619 |
| Hochi S et al. | Effect of linoleic acid-albumin in the culture medium on freezing sensitivity of in vitro-produced bovine morulae. | 1999 | Theriogenology | pmid:10734383 |
| Kemp B et al. | Influence of linoleic/linolenic acid ratio in the diet of periparturient cattle on plasma concentrations of PGF2 alpha metabolite and placental expulsion rate. | 1998 | Theriogenology | pmid:10732036 |
| Draper AJ and Hammock BD | Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase. | 2000 | Arch. Biochem. Biophys. | pmid:10729206 |
| Adam O | Linoleic acid - the fall of an angel? | 1999 | Ann. Nutr. Metab. | pmid:10725772 |
| Fidler N et al. | Oxidation of an oil rich in docosahexaenoic acid compared to linoleic acid in lactating women. | 1999 | Ann. Nutr. Metab. | pmid:10725767 |
| Baron CP et al. | Peroxidation of linoleate at physiological pH: hemichrome formation by substrate binding protects against metmyoglobin activation by hydrogen peroxide. | 2000 | Free Radic. Biol. Med. | pmid:10719236 |
| Chavali SR and Forse RA | Decreased production of interleukin-6 and prostaglandin E2 associated with inhibition of delta-5 desaturation of omega6 fatty acids in mice fed safflower oil diets supplemented with sesamol. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10718106 |
| Cox JE et al. | Suppression of food intake, body weight, and body fat by jejunal fatty acid infusions. | 2000 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:10712279 |
| Kitts DD et al. | Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. | 1999 | Mol. Cell. Biochem. | pmid:10705999 |
| Shimada A et al. | Phytotoxicity of indole-3-acetic acid produced by the fungus, Pythium aphanidermatum. | 2000 | Biosci. Biotechnol. Biochem. | pmid:10705467 |
| Kim D and Pleumsamran A | Cytoplasmic unsaturated free fatty acids inhibit ATP-dependent gating of the G protein-gated K(+) channel. | 2000 | J. Gen. Physiol. | pmid:10694258 |
| Sekiwa Y et al. | Isolation of novel glucosides related to gingerdiol from ginger and their antioxidative activities. | 2000 | J. Agric. Food Chem. | pmid:10691642 |
| López-Nicolás JM et al. | Effect of calcium on the oxidation of linoleic acid by potato (Solanum tuberosum var. Desiree) tuber 5-lipoxygenase. | 2000 | J. Agric. Food Chem. | pmid:10691630 |
| Saito A et al. | Effects of capsaicin on biliary free fatty acids in rats. | 2000 | Int J Vitam Nutr Res | pmid:10683757 |
| Sébédio JL et al. | Recent advances in conjugated linoleic acid research. | 1999 | Curr Opin Clin Nutr Metab Care | pmid:10678680 |
| Rüttinger HH and Radschuweit A | Determination of peroxides by capillary zone electrophoresis with amperometric detection. | 2000 | J Chromatogr A | pmid:10677087 |
| Jarmuszkiewicz W et al. | First evidence and characterization of an uncoupling protein in fungi kingdom: CpUCP of Candida parapsilosis. | 2000 | FEBS Lett. | pmid:10675527 |
| Larqué E et al. | Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats. | 2000 | Pediatr. Res. | pmid:10674359 |
| Grobas S et al. | Influence of dietary energy, supplemental fat and linoleic acid concentration on performance of laying hens at two ages. | 1999 | Br. Poult. Sci. | pmid:10670682 |
| Heeley EL et al. | Phospholipid molecular species of bronchoalveolar lavage fluid after local allergen challenge in asthma. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10666114 |
| Rukkwamsuk T et al. | Interrelation of fatty acid composition in adipose tissue, serum, and liver of dairy cows during the development of fatty liver postpartum. | 2000 | J. Dairy Sci. | pmid:10659963 |
| Berghaus TM et al. | Essential fatty acids and their long-chain polyunsaturated metabolites in maternal and cord plasma triglycerides during late gestation. | 2000 | Biol. Neonate | pmid:10657686 |
| de Deckere EA et al. | Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster. | 1999 | Br. J. Nutr. | pmid:10655980 |
| Oriani G et al. | Effects of intramuscular injection of alpha-tocopheryl acetate on fatty acid profile in lamb liver. | 1999 | Int J Vitam Nutr Res | pmid:10642895 |
| Salo P et al. | Low-saturated fat, low-cholesterol diet in 3-year-old children: effect on intake and composition of trans fatty acids and other fatty acids in serum phospholipid fraction-The STRIP study. Special Turku coronary Risk factor Intervention Project for children. | 2000 | J. Pediatr. | pmid:10636973 |
| Connolly JM et al. | Effects of reduced dietary linoleic acid intake, alone or combined with an algal source of docosahexaenoic acid, on MDA-MB-231 breast cancer cell growth and apoptosis in nude mice. | 1999 | Nutr Cancer | pmid:10624705 |
| Horrobin DF | Essential fatty acid metabolism and its modification in atopic eczema. | 2000 | Am. J. Clin. Nutr. | pmid:10617999 |
| Ziboh VA et al. | Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. | 2000 | Am. J. Clin. Nutr. | pmid:10617998 |
| Dutta-Roy AK | Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. | 2000 | Am. J. Clin. Nutr. | pmid:10617989 |
| Crawford M | Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617983 |
| Gibson RA and Makrides M | n-3 polyunsaturated fatty acid requirements of term infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617980 |
| Uauy R and Hoffman DR | Essential fat requirements of preterm infants. | 2000 | Am. J. Clin. Nutr. | pmid:10617979 |
| Sanders TA | Polyunsaturated fatty acids in the food chain in Europe. | 2000 | Am. J. Clin. Nutr. | pmid:10617968 |
| Meerarani P et al. | Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. | 2000 | Am. J. Clin. Nutr. | pmid:10617950 |