| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Stomach Neoplasms | D013274 | 24 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Macouzet M et al. | Production of conjugated linoleic acid by probiotic Lactobacillus acidophilus La-5. | 2009 | J. Appl. Microbiol. | pmid:19228257 |
| Makyła K and Paluch M | The linoleic acid influence on molecular interactions in the model of biological membrane. | 2009 | Colloids Surf B Biointerfaces | pmid:19211229 |
| Toyosaki T and Iwabuchi M | New antioxidant protein in seaweed (Porphyra yezoensis Ueda). | 2009 | Int J Food Sci Nutr | pmid:19212859 |
| Ibrahim A et al. | Impact of maternal dietary fatty acid composition on glucose and lipid metabolism in male rat offspring aged 105 d. | 2009 | Br. J. Nutr. | pmid:19166630 |
| Kawahara S et al. | Effects of dietary supplementation with conjugated linoleic acid on fatty acid composition and lipid oxidation in chicken breast meat. | 2009 | Anim. Sci. J. | pmid:20163609 |
| Calder PC | Early life programming of immune and lung function: can we now exclude a role of arachidonic acid exposure? | 2009 | Br. J. Nutr. | pmid:19166631 |
| Oku H et al. | The effects of 2-bromopalmitate on the fatty acid composition in differentiating adipocytes of red sea bream (Pagrus major). | 2009 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:19166960 |
| Schwartz J et al. | Modification of dietary polyunsaturated fatty acids via complementary food enhances n-3 long-chain polyunsaturated fatty acid synthesis in healthy infants: a double blinded randomised controlled trial. | 2009 | Arch. Dis. Child. | pmid:19193660 |
| Uygun DA et al. | A novel support for antibody purification: fatty acid attached chitosan beads. | 2009 | Colloids Surf B Biointerfaces | pmid:19196498 |
| Carlotti ME et al. | Role of particle coating in controlling skin damage photoinduced by titania nanoparticles. | 2009 | Free Radic. Res. | pmid:19199115 |
| Devillard E et al. | Differences between human subjects in the composition of the faecal bacterial community and faecal metabolism of linoleic acid. | 2009 | Microbiology (Reading, Engl.) | pmid:19202099 |
| Torrecilla JS et al. | Self-organizing maps and learning vector quantization networks as tools to identify vegetable oils. | 2009 | J. Agric. Food Chem. | pmid:19267437 |
| Yazawa H et al. | Production of polyunsaturated fatty acids in yeast Saccharomyces cerevisiae and its relation to alkaline pH tolerance. | 2009 | Yeast | pmid:19243079 |
| Niisuke K et al. | Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesis. | 2009 | J. Lipid Res. | pmid:19244216 |
| Parnas M et al. | Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels. | 2009 | J. Neurosci. | pmid:19244513 |
| Wu D et al. | Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. | 2009 | Anal. Chim. Acta | pmid:19185115 |
| Sahoo RR and Biswas SK | Frictional response of fatty acids on steel. | 2009 | J Colloid Interface Sci | pmid:19232636 |
| MartÃnez-Force E et al. | Influence of specific fatty acids on the asymmetric distribution of saturated fatty acids in sunflower (Helianthus annuus L.) triacylglycerols. | 2009 | J. Agric. Food Chem. | pmid:19166295 |
| Zhao Z et al. | Biodegradable nanoparticles based on linoleic acid and poly(beta-malic acid) double grafted chitosan derivatives as carriers of anticancer drugs. | 2009 | Biomacromolecules | pmid:19175304 |
| Eriksson S et al. | Fatty acid pattern in serum is associated with bone mineralisation in healthy 8-year-old children. | 2009 | Br. J. Nutr. | pmid:19175947 |
| Wempe MF et al. | Investigating idebenone and idebenone linoleate metabolism: in vitro pig ear and mouse melanocyte studies. | 2009 | J Cosmet Dermatol | pmid:19250169 |
| Kim MH et al. | Linoleic acid induces mouse embryonic stem cell proliferation via Ca2+/PKC, PI3K/Akt, and MAPKs. | 2009 | Cell. Physiol. Biochem. | pmid:19255500 |
| Takata Y et al. | Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers. | 2009 | Cancer Causes Control | pmid:19255861 |
| HÃ¥versen L et al. | Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. | 2009 | Atherosclerosis | pmid:18599066 |
| Guillén N et al. | Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver. | 2009 | Physiol. Genomics | pmid:19258494 |
| Gülçin I | Antioxidant activity of L-adrenaline: a structure-activity insight. | 2009 | Chem. Biol. Interact. | pmid:18929549 |
| Ishitsuka Y et al. | Effects of bolus injection of soybean-based fat emulsion and fatty acids on pulmonary gas exchange function. | 2009 | Biol. Pharm. Bull. | pmid:19252304 |
| de Meijer VE et al. | Parenteral fish oil as monotherapy for patients with parenteral nutrition-associated liver disease. | 2009 | Pediatr. Surg. Int. | pmid:18828026 |
| Saitou K et al. | Contribution of gustation to the palatability of linoleic acid. | 2009 | Physiol. Behav. | pmid:18835400 |
| RodrÃguez-Cruz M et al. | Effect of dietary levels of corn oil on maternal arachidonic acid synthesis and fatty acid composition in lactating rats. | 2009 | Nutrition | pmid:18849148 |
| Bannenberg G et al. | Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana. | 2009 | Lipids | pmid:18949503 |
| Saez G et al. | Hepatic metabolism of glucose and linoleic acid varies in relation to susceptibility to fatty liver in ad libitum-fed Muscovy and Pekin ducks. | 2009 | Br. J. Nutr. | pmid:18616836 |
| Lapenna D et al. | Inhibitory activity of salicylic acid on lipoxygenase-dependent lipid peroxidation. | 2009 | Biochim. Biophys. Acta | pmid:18950686 |
| Garscha U and Oliw EH | Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activity. | 2009 | J. Biol. Chem. | pmid:19289462 |
| Leekumjorn S et al. | The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes. | 2009 | Biochim. Biophys. Acta | pmid:19371719 |
| Nayeem F et al. | Dietary beta-tocopherol and linoleic acid, serum insulin, and waist circumference predict circulating sex hormone-binding globulin in premenopausal women. | 2009 | J. Nutr. | pmid:19339706 |
| Inoue N et al. | Linoleic acid-menthyl ester reduces the secretion of apolipoprotein B100 in HepG2 cells. | 2009 | J Oleo Sci | pmid:19282639 |
| Fukuda S et al. | Evaluation and characterization of bacterial metabolic dynamics with a novel profiling technique, real-time metabolotyping. | 2009 | PLoS ONE | pmid:19287504 |
| Santillo A et al. | Probiotic in lamb rennet paste enhances rennet lipolytic activity, and conjugated linoleic acid and linoleic acid content in Pecorino cheese. | 2009 | J. Dairy Sci. | pmid:19307614 |
| Zhang D et al. | Identification and expression of a new delta-12 fatty acid desaturase (FAD2-4) gene in upland cotton and its functional expression in yeast and Arabidopsis thaliana plants. | 2009 | Plant Physiol. Biochem. | pmid:19217793 |
| Choi NJ et al. | Characterizations of environmental factors in conjugated linoleic acid production by mixed rumen bacteria. | 2009 | J. Agric. Food Chem. | pmid:19754193 |
| Chow CK | Dietary beta-tocopherol and serum concentrations of sex hormone-binding globulin. | 2009 | J. Nutr. | pmid:19710160 |
| Roche M et al. | Olive phenols efficiently inhibit the oxidation of serum albumin-bound linoleic acid and butyrylcholine esterase. | 2009 | Biochim. Biophys. Acta | pmid:19714864 |
| Pianaro A et al. | Stingless bees: chemical differences and potential functions in Nannotrigona testaceicornis and Plebeia droryana males and workers. | 2009 | J. Chem. Ecol. | pmid:19730955 |
| de Castro J et al. | Platelet linoleic acid is a potential biomarker of advanced non-small cell lung cancer. | 2009 | Exp. Mol. Pathol. | pmid:19733167 |
| Pandey NR et al. | An induction in hepatic HDL secretion associated with reduced ATPase expression. | 2009 | Am. J. Pathol. | pmid:19717637 |
| Radunz AE et al. | Effects of dietary polyunsaturated fatty acid supplementation on fatty acid composition in muscle and subcutaneous adipose tissue of lambs. | 2009 | J. Anim. Sci. | pmid:19717771 |
| Taylor WA and Hatch GM | Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1). | 2009 | J. Biol. Chem. | pmid:19737925 |
| Iwamoto N et al. | Antioxidative capacities of durum wheat flour and its components on linoleic acid. | 2009 | J Oleo Sci | pmid:19745581 |
| Queirós B et al. | In search of synergistic effects in antioxidant capacity of combined edible mushrooms. | 2009 | Int J Food Sci Nutr | pmid:19746297 |
| Zhang Y and Wang ZZ | Phenolic composition and antioxidant activities of two Phlomis species: A correlation study. | 2009 | C. R. Biol. | pmid:19748456 |
| Simopoulos AP | Evolutionary aspects of the dietary omega-6:omega-3 fatty acid ratio: medical implications. | 2009 | World Rev Nutr Diet | pmid:19696523 |
| Wecksler AT et al. | Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1. | 2009 | Bioorg. Med. Chem. | pmid:19716306 |
| Takasuka N et al. | Promotion of mouse two-stage skin carcinogenesis by diacylglycerol-rich edible oil. | 2009 | Cancer Lett. | pmid:19028010 |
| Malhotra S et al. | Antioxidant activity of citrus cultivars and chemical composition of Citrus karna essential oil. | 2009 | Planta Med. | pmid:19031367 |
| Hodson L et al. | Differences in partitioning of meal fatty acids into blood lipid fractions: a comparison of linoleate, oleate, and palmitate. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:18940935 |
| Tribole E | What happened to do no harm? The issue of dietary omega-6 fatty acids. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19147337 |
| Ramsden CE et al. | Letter to the Editor re: Linoleic acid and coronary heart disease. Prostaglandins Leukot. Essent. Fatty Acids (2008), by W.S. Harris. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19147338 |
| Yuan X et al. | Identification of an endogenous ligand bound to a native orphan nuclear receptor. | 2009 | PLoS ONE | pmid:19440305 |
| Robinson NJ et al. | A potential role for free fatty acids in the pathogenesis of preeclampsia. | 2009 | J. Hypertens. | pmid:19462499 |
| Adiguzel A et al. | Antimicrobial and antioxidant activity of the essential oil and methanol extract of Nepeta cataria. | 2009 | Pol. J. Microbiol. | pmid:19469289 |
| Wecksler AT et al. | Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. | 2009 | Biochemistry | pmid:19469483 |
| Dauchy RT et al. | Antineoplastic effects of melatonin on a rare malignancy of mesenchymal origin: melatonin receptor-mediated inhibition of signal transduction, linoleic acid metabolism and growth in tissue-isolated human leiomyosarcoma xenografts. | 2009 | J. Pineal Res. | pmid:19486272 |
| Yano M et al. | Oxidative stress induces anti-hepatitis C virus status via the activation of extracellular signal-regulated kinase. | 2009 | Hepatology | pmid:19492433 |
| Tanaka N et al. | Dietary olive oil prevents carbon tetrachloride-induced hepatic fibrosis in mice. | 2009 | J. Gastroenterol. | pmid:19506795 |
| Cho CW et al. | Enhanced transdermal delivery of loratadine from the EVA matrix. | 2009 | Drug Deliv | pmid:19514983 |
| Khalili M et al. | Influence of exogenous salicylic acid on flavonolignans and lipoxygenase activity in the hairy root cultures of Silybum marianum. | 2009 | Cell Biol. Int. | pmid:19524695 |
| Damsgaard CT et al. | Reduced ex vivo interleukin-6 production by dietary fish oil is not modified by linoleic acid intake in healthy men. | 2009 | J. Nutr. | pmid:19494025 |
| Zhang M et al. | Cytotoxic aggregates of alpha-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells. | 2009 | Chem. Biol. Interact. | pmid:19497410 |
| Villa PM et al. | Free fatty acid profiles in preeclampsia. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19497719 |
| Jeng JY et al. | Linoleic acid promotes mitochondrial biogenesis and maintains mitochondrial structure for prevention of streptozotocin damage in RIN-m5F cells. | 2009 | Biosci. Biotechnol. Biochem. | pmid:19502730 |
| Pinho RS et al. | Potential oilseed crops from the semiarid region of northeastern Brazil. | 2009 | Bioresour. Technol. | pmid:19577461 |
| Finn RD et al. | Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. | 2009 | Biochem. J. | pmid:18778245 |
| Sarikurkcu C et al. | Studies on the antioxidant activity of essential oil and different solvent extracts of Vitexagnuscastus L. fruits from Turkey. | 2009 | Food Chem. Toxicol. | pmid:19595732 |
| Hernández ML et al. | Expression analysis identifies FAD2-2 as the olive oleate desaturase gene mainly responsible for the linoleic acid content in virgin olive oil. | 2009 | J. Agric. Food Chem. | pmid:19601663 |
| Marosvölgyi T et al. | Trans isomeric and LCPUFA are inversely correlated in erythrocyte membrane lipids at mid-gestation. | 2009 | Adv. Exp. Med. Biol. | pmid:19536675 |
| Zhu X et al. | Mass spectrometric characterization of protein modification by the products of nonenzymatic oxidation of linoleic acid. | 2009 | Chem. Res. Toxicol. | pmid:19537826 |
| Gursoy N et al. | Antioxidant activities, metal contents, total phenolics and flavonoids of seven Morchella species. | 2009 | Food Chem. Toxicol. | pmid:19563856 |
| Goupy P et al. | Antioxidant activity of wine pigments derived from anthocyanins: hydrogen transfer reactions to the dpph radical and inhibition of the heme-induced peroxidation of linoleic acid. | 2009 | J. Agric. Food Chem. | pmid:19566083 |
| Silva-Queiroz SR et al. | PHA(MCL) biosynthesis systems in Pseudomonas aeruginosa and Pseudomonas putida strains show differences on monomer specificities. | 2009 | J. Biotechnol. | pmid:19540884 |
| Lausada N et al. | Effect of cyclosporine and sirolimus on fatty acid desaturase activities in cultured HEPG2 cells. | 2009 | Transplant. Proc. | pmid:19545746 |
| Tesoriere L et al. | Betacyanins as phenol antioxidants. Chemistry and mechanistic aspects of the lipoperoxyl radical-scavenging activity in solution and liposomes. | 2009 | Free Radic. Res. | pmid:19548153 |
| Cheong SJ et al. | Superparamagnetic iron oxide nanoparticles-loaded chitosan-linoleic acid nanoparticles as an effective hepatocyte-targeted gene delivery system. | 2009 | Int J Pharm | pmid:19429277 |
| Fukasawa R et al. | Anti-oxidative effects of rooibos tea extract on autoxidation and thermal oxidation of lipids. | 2009 | J Oleo Sci | pmid:19430189 |
| Fang IM et al. | Comparative effects of fatty acids on proinflammatory gene cyclooxygenase 2 and inducible nitric oxide synthase expression in retinal pigment epithelial cells. | 2009 | Mol Nutr Food Res | pmid:19437483 |
| Evans LM et al. | Dietary stearate reduces human breast cancer metastasis burden in athymic nude mice. | 2009 | Clin. Exp. Metastasis | pmid:19267249 |
| Venegas-Calerón M et al. | Effect of the ferredoxin electron donor on sunflower (Helianthus annuus) desaturases. | 2009 | Plant Physiol. Biochem. | pmid:19342250 |
| Mimoun M et al. | Increased tissue arachidonic acid and reduced linoleic acid in a mouse model of cystic fibrosis are reversed by supplemental glycerophospholipids enriched in docosahexaenoic acid. | 2009 | J. Nutr. | pmid:19828687 |
| Artwohl M et al. | Fatty acids induce apoptosis in human smooth muscle cells depending on chain length, saturation, and duration of exposure. | 2009 | Atherosclerosis | pmid:18597758 |
| Watanabe A et al. | In vitro free radical scavenging activity of platinum nanoparticles. | 2009 | Nanotechnology | pmid:19834242 |
| Hernández-Ledesma B et al. | Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19836349 |
| Shimomura H et al. | Steroids mediate resistance to the bactericidal effect of phosphatidylcholines against Helicobacter pylori. | 2009 | FEMS Microbiol. Lett. | pmid:19843309 |
| Yang J et al. | Study of the inhibitory effect of fatty acids on the interaction between DNA and polymerase beta. | 2009 | Biochemistry Mosc. | pmid:19747104 |
| Detsi A et al. | Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. | 2009 | Bioorg. Med. Chem. | pmid:19853459 |
| Luo J et al. | Studies on the antioxidant activity and phenolic compounds of enzyme-assisted water extracts from Du-zhong (Eucommia ulmoides Oliv.) leaves. | 2009 | J Enzyme Inhib Med Chem | pmid:19912062 |
| Chechetkin IR et al. | Specificity of oxidation of linoleic acid homologs by plant lipoxygenases. | 2009 | Biochemistry Mosc. | pmid:19817685 |
| Grossmann ME et al. | Eleostearic Acid inhibits breast cancer proliferation by means of an oxidation-dependent mechanism. | 2009 | Cancer Prev Res (Phila) | pmid:19789297 |
| Whelan J | The health implications of changing linoleic acid intakes. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18990554 |
| Fritsche KL | Too much linoleic acid promotes inflammation-doesn't it? | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18990555 |
| Adam O et al. | Impact of linoleic acid intake on arachidonic acid formation and eicosanoid biosynthesis in humans. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18973995 |