| MeSH term | MeSH ID | Detail |
|---|---|---|
| Aortic Diseases | D001018 | 11 associated lipids |
| Polycystic Kidney Diseases | D007690 | 12 associated lipids |
| Hypertrophy, Left Ventricular | D017379 | 12 associated lipids |
| Vitamin D Deficiency | D014808 | 13 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Malabsorption Syndromes | D008286 | 16 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brush MG et al. | Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. | 1984 | Am. J. Obstet. Gynecol. | pmid:6091462 |
| Dworkin RH et al. | Linoleic acid and multiple sclerosis: a reanalysis of three double-blind trials. | 1984 | Neurology | pmid:6387534 |
| Sakaguchi M et al. | Effect of dietary unsaturated and saturated fats on azoxymethane-induced colon carcinogenesis in rats. | 1984 | Cancer Res. | pmid:6704963 |
| Van Alstine JM and Brooks DE | Cell membrane abnormality detected in erythrocytes from patients with multiple sclerosis by partition in two-polymer aqueous-phase systems. | 1984 | Clin. Chem. | pmid:6199135 |
| Simon I et al. | Electron-spin resonance studies of lipid-modified microsomes from Friend erythroleukemia cells. | 1984 | Biochim. Biophys. Acta | pmid:6326852 |
| Alarcón B et al. | Screening for new compounds with antiherpes activity. | 1984 | Antiviral Res. | pmid:6517562 |
| Schick PK et al. | Arachidonate synthesis and uptake in isolated guinea-pig megakaryocytes and platelets. | 1984 | Biochim. Biophys. Acta | pmid:6433984 |
| Furukawa M et al. | Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. | 1984 | Biochim. Biophys. Acta | pmid:6089906 |
| Becker W | Distribution of 14C after oral administration of [1-14C]linoleic acid in rats fed different levels of essential fatty acids. | 1984 | J. Nutr. | pmid:6470826 |
| Rogiers V et al. | Abnormal fatty acid turnover in the phospholipids of the red blood cell membranes of cystic fibrosis patients (in vitro study). | 1984 | Pediatr. Res. | pmid:6472942 |
| Neufeld EJ et al. | A mutant HSDM1C1 fibrosarcoma line selected for defective eicosanoid precursor uptake lacks arachidonate-specific acyl-CoA synthetase. | 1984 | J. Biol. Chem. | pmid:6420417 |
| Heine RJ et al. | The effect of dietary linoleic acid and pectin on lipoprotein and apolipoprotein A1 concentrations in rhesus monkeys. | 1984 | Ann. Nutr. Metab. | pmid:6476785 |
| Adam O and Wolfram G | Effect of different linoleic acid intakes on prostaglandin biosynthesis and kidney function in man. | 1984 | Am. J. Clin. Nutr. | pmid:6486083 |
| Jacobs JM and Jacobs NJ | Effect of unsaturated fatty acids on protoporphyrinogen oxidation, a step in heme and chlorophyll synthesis in plant organelles. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6487324 |
| Yorek MA et al. | Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells. | 1984 | Biochim. Biophys. Acta | pmid:6089899 |
| Arslan P et al. | cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes. | 1984 | Biochem. J. | pmid:6696740 |
| Stymne S and Stobart AK | The biosynthesis of triacylglycerols in microsomal preparations of developing cotyledons of sunflower (Helianthus annuus L.). | 1984 | Biochem. J. | pmid:6743281 |
| Colard O et al. | 1-Acyl-lysolecithin acyltransferase and synthesis of biliary lecithins in rat liver. | 1984 | Biochimie | pmid:6743697 |
| Margetts BM et al. | Dietary fats and blood pressure. | 1984 | Aust N Z J Med | pmid:6596055 |
| Eyssen H and Verhulst A | Biotransformation of linoleic acid and bile acids by Eubacterium lentum. | 1984 | Appl. Environ. Microbiol. | pmid:6582800 |
| Iversen SA et al. | Identification of a diene conjugated component of human lipid as octadeca-9,11-dienoic acid. | 1984 | FEBS Lett. | pmid:6723989 |
| Schafer E and Arnrich L | Effects of dietary vitamin E on serum and pulmonary fatty acids and prostaglandins in rats fed excess linoleic acid. | 1984 | J. Nutr. | pmid:6726476 |
| Wood DA et al. | Adipose tissue and platelet fatty acids and coronary heart disease in Scottish men. | 1984 | Lancet | pmid:6146032 |
| Hennig B et al. | Exposure to free fatty acid increases the transfer of albumin across cultured endothelial monolayers. | 1984 Sep-Oct | Arteriosclerosis | pmid:6477300 |
| O'Brien PM et al. | The effect of dietary supplementation with linoleic and gammalinolenic acids on the pressor response to angiotensin II--a possible role in pregnancy-induced hypertension? | 1985 | Br J Clin Pharmacol | pmid:2985102 |
| Kharasch ED and Novak RF | Mitoxantrone and ametantrone inhibit hydroperoxide-dependent initiation and propagation reactions in fatty acid peroxidation. | 1985 | J. Biol. Chem. | pmid:2993283 |
| Hansen HS and Jensen B | Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate. | 1985 | Biochim. Biophys. Acta | pmid:3922424 |
| Nugteren DH et al. | Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat. | 1985 | Biochim. Biophys. Acta | pmid:3922425 |
| Ip C et al. | Requirement of essential fatty acid for mammary tumorigenesis in the rat. | 1985 | Cancer Res. | pmid:3921234 |
| Calderbank J et al. | Plasma-membrane phospholipid unsaturation affects expression of the general amino-acid permease in Saccharomyces cerevisiae Y185. | 1985 | J. Gen. Microbiol. | pmid:3886834 |
| Canfield LM et al. | Anti-oxidant/pro-oxidant reactions of vitamin K. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3985964 |
| Tsuchida M et al. | Fluorescent substances in mouse and human sera as a parameter of in vivo lipid peroxidation. | 1985 | Biochim. Biophys. Acta | pmid:3995061 |
| Bowser PA et al. | Identification, isolation and characterization of epidermal lipids containing linoleic acid. | 1985 | Biochim. Biophys. Acta | pmid:3995076 |
| Demant EJ and Wassermann K | Doxorubicin induced alterations in lipid metabolism of cultured myocardial cells. | 1985 | Biochem. Pharmacol. | pmid:4004891 |
| Robinson M et al. | Acylation of lysophospholipids by rabbit alveolar macrophages. Specificities of CoA-dependent and CoA-independent reactions. | 1985 | J. Biol. Chem. | pmid:4008481 |
| Howard-Williams J et al. | Polyunsaturated fatty acids and diabetic retinopathy. | 1985 | Br J Ophthalmol | pmid:3965024 |
| Montalto MB et al. | Nutrient intakes of formula-fed infants and infants fed cow's milk. | 1985 | Pediatrics | pmid:3969338 |
| Reid JC and Husbands DR | Oxidative metabolism of long-chain fatty acids in mitochondria from sheep and rat liver. Evidence that sheep conserve linoleate by limiting its oxidation. | 1985 | Biochem. J. | pmid:3977825 |
| Jett M et al. | Metabolic fate of liposomal phosphatidylinositol in murine tumor cells: implications for the mechanism of tumor cell cytotoxicity. | 1985 | Cancer Res. | pmid:4027970 |
| Hennig B et al. | Exposure to fatty acid increases human low density lipoprotein transfer across cultured endothelial monolayers. | 1985 | Circ. Res. | pmid:4053308 |
| Barclay LR et al. | The antioxidant activity of alpha-tocopherol-bovine serum albumin complex in micellar and liposome autoxidations. | 1985 | J. Biol. Chem. | pmid:4066696 |
| Potter LM and McCarthy JP | Varying fat and protein in diets of growing large white turkeys. | 1985 | Poult. Sci. | pmid:4070128 |
| Isseroff RR et al. | Alterations in fatty acid composition of murine keratinocytes with in vitro cultivation. | 1985 | J. Invest. Dermatol. | pmid:3926903 |
| Wertz PW et al. | The composition of the ceramides from human stratum corneum and from comedones. | 1985 | J. Invest. Dermatol. | pmid:3158712 |
| Rebello T and Watts DC | Gastrocnemius muscle lipids in relation to diet in two mouse mutants, 129Re-dy and A2G-adr, with abnormal muscle function. | 1985 | J. Neurochem. | pmid:3158720 |
| Nordøy A et al. | Effect of dietary (n--3) fatty acids on platelet function and lipid metabolism in rats. | 1985 | Biochim. Biophys. Acta | pmid:2861854 |
| Fusco AC et al. | Schistosoma mansoni: eicosanoid production by cercariae. | 1985 | Exp. Parasitol. | pmid:3917929 |
| Boberg M et al. | Platelet fatty acid composition in relation to fatty acid composition in plasma and to serum lipoprotein lipids in healthy subjects with special reference to the linoleic acid pathway. | 1985 | Clin. Sci. | pmid:3919990 |
| Erskine KJ et al. | An altered ratio of 18:2 (9,11) to 18:2 (9,12) linoleic acid in plasma phospholipids as a possible predictor of pre-eclampsia. | 1985 | Lancet | pmid:2857904 |
| Salzmann-Reinhardt U et al. | Metabolism of polyunsaturated fatty acids by rabbit reticulocytes. | 1985 | Eur. J. Biochem. | pmid:3933978 |