| MeSH term | MeSH ID | Detail |
|---|---|---|
| Acute Coronary Syndrome | D054058 | 11 associated lipids |
| Polycystic Kidney Diseases | D007690 | 12 associated lipids |
| Hypertrophy, Left Ventricular | D017379 | 12 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Vitamin D Deficiency | D014808 | 13 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Malabsorption Syndromes | D008286 | 16 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Young MR et al. | Stimulation of hematopoiesis and bone marrow suppressor cells by the subcutaneous injection of linoleic acid. | 1987 | Cell. Immunol. | pmid:2953447 |
| Tilvis RS et al. | Fatty acids of plasma lipids, red cells and platelets in Alzheimer's disease and vascular dementia. | 1987 | Atherosclerosis | pmid:3619988 |
| Strauss JS et al. | The effect of 13-cis-retinoic acid on sebaceous glands. | 1987 | Arch Dermatol | pmid:2960273 |
| Melton JL et al. | Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs. | 1987 | Biochim. Biophys. Acta | pmid:3651483 |
| Dupont J | Essential fatty acids and prostaglandins. | 1987 | Prev Med | pmid:3628199 |
| Field EJ and Joyce G | Duchenne muscular dystrophy: do both parents contribute genetically to the disease? | 1987 | J. Neurol. Sci. | pmid:3126270 |
| Bjerve KS et al. | Alpha-linolenic acid deficiency in man: effect of ethyl linolenate on plasma and erythrocyte fatty acid composition and biosynthesis of prostanoids. | 1987 | Am. J. Clin. Nutr. | pmid:3310599 |
| Wertz PW et al. | Essential fatty acids and epidermal integrity. | 1987 | Arch Dermatol | pmid:3310912 |
| Levay-Young BK et al. | Linoleic acid, but not cortisol, stimulates accumulation of casein by mouse mammary epithelial cells in serum-free collagen gel culture. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3317407 |
| Funk CD et al. | Effects of selenium-deficient diets on the production of prostaglandins and other oxygenated metabolites of arachidonic acid and linoleic acid by rat and rabbit aortae. | 1987 | Biochim. Biophys. Acta | pmid:3115301 |
| Walstra P et al. | Demonstration of a 12-lipoxygenase activity in bovine polymorphonuclear leukocytes. | 1987 | Biochim. Biophys. Acta | pmid:3115302 |
| Colard O et al. | Hydrolysis of endogenous phospholipids by rat platelet phospholipase A2: ether or acyl bond and polar head group selectivity. | 1987 | Biochim. Biophys. Acta | pmid:3115303 |
| Taylor AJ et al. | An alternative explanation for the changes in erythrocyte fatty acids observed in diabetes mellitus. | 1987 | Clin. Chem. | pmid:3119255 |
| Murphy MG et al. | Effects of membrane polyunsaturated fatty acids on opiate peptide inhibition of basal and prostaglandin E1-stimulated cyclic AMP formation in intact N1E-115 neuroblastoma cells. | 1987 | Biochem. Pharmacol. | pmid:2825714 |
| Hagve TA and Christophersen BO | In vitro effects of alpha-bromopalmitate on metabolism of essential fatty acids studied in isolated rat hepatocytes: sex differences. | 1987 | Biochim. Biophys. Acta | pmid:3099848 |
| Cunnane SC and McAdoo KR | Iron intake influences essential fatty acid and lipid composition of rat plasma and erythrocytes. | 1987 | J. Nutr. | pmid:3116180 |
| Uotila P et al. | Relaxing effects of 15-lipoxygenase products of arachidonic acid on rat aorta. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3116200 |
| Bomalaski JS et al. | Alteration of uptake and distribution of eicosanoid precursor fatty acids by aspirin. | 1987 | Biochem. Pharmacol. | pmid:3117063 |
| Gibian MJ and Vandenberg P | Product yield in oxygenation of linoleate by soybean lipoxygenase: the value of the molar extinction coefficient in the spectrophotometric assay. | 1987 | Anal. Biochem. | pmid:3116881 |
| Ludwig P et al. | A kinetic model for lipoxygenases based on experimental data with the lipoxygenase of reticulocytes. | 1987 | Eur. J. Biochem. | pmid:3117544 |
| Cook HW and Spence MW | Studies of the modulation of essential fatty acid metabolism by fatty acids in cultured neuroblastoma and glioma cells. | 1987 | Biochim. Biophys. Acta | pmid:3105586 |
| Stocker R et al. | Bilirubin is an antioxidant of possible physiological importance. | 1987 | Science | pmid:3029864 |
| Griffin JF et al. | Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in biopsy material. | 1987 | Clin. Chim. Acta | pmid:3568417 |
| Huang YS et al. | Protective effect of gamma-linolenic acid on aspirin-induced gastric hemorrhage in rats. | 1987 | Digestion | pmid:3030865 |
| Tay SK et al. | Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in exfoliated cells. | 1987 | Clin. Chim. Acta | pmid:3568418 |
| Quik M | Evidence for an involvement of membrane lipids in the control of neuronal nicotinic receptor function using bungarotoxin II-S1. | 1987 | J. Neurochem. | pmid:3106571 |
| Das UN et al. | Uptake and distribution of cis-unsaturated fatty acids and their effect on free radical generation in normal and tumor cells in vitro. | 1987 | Free Radic. Biol. Med. | pmid:3040539 |
| Nilsson A et al. | Absorption and lymphatic transport of exogenous and endogenous arachidonic and linoleic acid in the rat. | 1987 | Am. J. Physiol. | pmid:3109253 |
| Fisher M et al. | Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients. | 1987 | Acta Neurol. Scand. | pmid:3687373 |
| Ashida H et al. | Effect of orally administered secondary autoxidation products of linoleic acid on carbohydrate metabolism in rat liver. | 1987 | Arch. Biochem. Biophys. | pmid:3688880 |
| del Nido PJ et al. | Evidence of myocardial free radical injury during elective repair of tetralogy of Fallot. | 1987 | Circulation | pmid:2959398 |
| Emken EA et al. | Metabolism of cis-12-octadecenoic acid and trans-9,trans-12-octadecadienoic acid and their influence on lipogenic enzyme activities in mouse liver. | 1987 | Biochim. Biophys. Acta | pmid:3580379 |
| Simpson RJ and Peters TJ | Transport of Fe2+ across lipid bilayers: possible role of free fatty acids. | 1987 | Biochim. Biophys. Acta | pmid:3828339 |
| Castańeda-Hernández G | Presence of endogenous digitalis-like activity in mammalian heart not due to fatty acids. | 1987 | Biochem. Pharmacol. | pmid:3036154 |
| Watkins BA and Kratzer FH | Effects of dietary biotin and linoleate on polyunsaturated fatty acids in tissue phospholipids. | 1987 | Poult. Sci. | pmid:3452223 |
| Stocker R et al. | Antioxidant activity of albumin-bound bilirubin. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3475708 |
| Cohen LA | Fat and endocrine-responsive cancer in animals. | 1987 | Prev Med | pmid:3476922 |
| Croft KD et al. | Differential inhibition of thromboxane B2 and leukotriene B4 biosynthesis by two naturally occurring acetylenic fatty acids. | 1987 | Biochim. Biophys. Acta | pmid:2822134 |
| Berge RK et al. | Effect of a high-fat diet with partially hydrogenated fish oil on long-chain fatty acid metabolizing enzymes in subcellular fractions of rat liver. | 1987 | Arch. Biochem. Biophys. | pmid:2880562 |
| Clementz T et al. | Membrane potential, lipid regulation and adenylate energy charge in acyl chain modified Acholeplasma laidlawii. | 1987 | Biochim. Biophys. Acta | pmid:3567184 |
| Hasegawa J et al. | Lipid requirement for mu opioid receptor binding. | 1987 | J. Neurochem. | pmid:2887631 |
| Heifets M et al. | Effect of dietary lipids on renal function in rats with subtotal nephrectomy. | 1987 | Kidney Int. | pmid:3669493 |
| Coté GG and Brody S | Circadian rhythms in Neurospora crassa: a clock mutant, prd-1, is altered in membrane fatty acid composition. | 1987 | Biochim. Biophys. Acta | pmid:2889471 |
| Hubbard NE and Erickson KL | Enhancement of metastasis from a transplantable mouse mammary tumor by dietary linoleic acid. | 1987 | Cancer Res. | pmid:3677068 |
| Hachey DL et al. | Human lactation: maternal transfer of dietary triglycerides labeled with stable isotopes. | 1987 | J. Lipid Res. | pmid:3681142 |
| Wan JM and Grimble RF | Effect of dietary linoleate content on the metabolic response of rats to Escherichia coli endotoxin. | 1987 | Clin. Sci. | pmid:3545648 |
| Bruneau C et al. | Influence of lipid environment on insulin binding in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552053 |
| Bruneau C et al. | Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells. | 1987 | Biochim. Biophys. Acta | pmid:3552054 |
| Nugteren DH and Kivits GA | Conversion of linoleic acid and arachidonic acid by skin epidermal lipoxygenases. | 1987 | Biochim. Biophys. Acta | pmid:3113487 |
| Arca M et al. | Erythrocyte fatty acid composition and gallstone disease: results of an epidemiological survey. | 1987 | Am. J. Clin. Nutr. | pmid:3604961 |