| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperpigmentation | D017495 | 11 associated lipids |
| Hypertrophy, Left Ventricular | D017379 | 12 associated lipids |
| Polycystic Kidney Diseases | D007690 | 12 associated lipids |
| Vitamin D Deficiency | D014808 | 13 associated lipids |
| Glucose Intolerance | D018149 | 13 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Alopecia | D000505 | 14 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Malabsorption Syndromes | D008286 | 16 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Politis I et al. | Effects of dietary conjugated linoleic acid isomers on several functional properties of macrophages and heterophils in laying hens. | 2003 | Br. Poult. Sci. | pmid:12828205 |
| Sehanputri PS and Hill CG | Lipase-mediated acidolysis of butteroil with free conjugated linoleic acid in a packed bed reactor. | 2003 | Biotechnol. Bioeng. | pmid:12827703 |
| Tamura K et al. | Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants. | 2003 | J. Med. Chem. | pmid:12825946 |
| Kamphuis MM et al. | The effect of conjugated linoleic acid supplementation after weight loss on body weight regain, body composition, and resting metabolic rate in overweight subjects. | 2003 | Int. J. Obes. Relat. Metab. Disord. | pmid:12821971 |
| Kim JY and Chung BH | Effects of combination dietary conjugated linoleic acid with vitamin A (retinol) and selenium on the response of the immunoglobulin production in mice. | 2003 | J. Vet. Sci. | pmid:12819373 |
| Hutley LJ et al. | Effects of rosiglitazone and linoleic acid on human preadipocyte differentiation. | 2003 | Eur. J. Clin. Invest. | pmid:12814394 |
| Chajes V et al. | Conjugated linoleic acid content in breast adipose tissue of breast cancer patients and the risk of metastasis. | 2003 | Nutr Cancer | pmid:12791500 |
| pmid:12790685 | ||||
| Nagao K et al. | The 10trans,12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima fatty rats. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12788078 |
| Shimada Y et al. | Increased response of liver microsomal delta 6-desaturase activity to dietary methionine in rats. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12784613 |
| Beck S et al. | Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation. | 2003 | J. Biol. Chem. | pmid:12782627 |
| Barceló-Coblijn G et al. | Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. | 2003 | Biochim. Biophys. Acta | pmid:12782153 |
| Cho H et al. | Nonradiometric HPLC measurement of 13(S)-hydroxyoctadecadienoic acid from rat tissues. | 2003 | Anal. Biochem. | pmid:12782030 |
| Vargas F et al. | Photochemistry and in vitro phototoxicity studies of levomepromazine (methotrimeprazine), a phototoxic neuroleptic drug. | 2003 | Pharmazie | pmid:12779046 |
| Ward AT et al. | Fresh forage and solin supplementation on conjugated linoleic acid levels in plasma and milk. | 2003 | J. Dairy Sci. | pmid:12778585 |
| Macrì A et al. | Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy. | 2003 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:12768289 |
| Aletor VA et al. | The effects of conjugated linoleic acids or an alpha-glucosidase inhibitor on tissue lipid concentrations and fatty acid composition of broiler chicks fed a low-protein diet. | 2003 | Poult. Sci. | pmid:12762403 |
| Buckner JS and Hagen MM | Triacylglycerol and phospholipid fatty acids of the silverleaf whitefly: composition and biosynthesis. | 2003 | Arch. Insect Biochem. Physiol. | pmid:12761874 |
| Rotta AT et al. | Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems. | 2003 | Pediatr Crit Care Med | pmid:12749658 |
| Gorinstein S et al. | Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determined by four different radical scavenging tests. | 2003 | J. Nutr. Biochem. | pmid:12742543 |
| Nair VB and Panchagnula R | Effect of iontophoresis and fatty acids on permeation of arginine vasopressin through rat skin. | 2003 | Pharmacol. Res. | pmid:12742012 |
| Mashek DG and Grummer RR | Short communication: Net uptake of nonesterified long chain fatty acids by the perfused caudate lobe of the caprine liver. | 2003 | J. Dairy Sci. | pmid:12741546 |
| Babu US et al. | Impact of high flaxseed diet on mitogen-induced proliferation, IL-2 production, cell subsets and fatty acid composition of spleen cells from pregnant and F1 generation Sprague-Dawley rats. | 2003 | Food Chem. Toxicol. | pmid:12738196 |
| Wiesenfeld PW et al. | Flaxseed increased alpha-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring. | 2003 | Food Chem. Toxicol. | pmid:12738189 |
| Ma DW et al. | An enriched mixture of trans-10,cis-12-CLA inhibits linoleic acid metabolism and PGE2 synthesis in MDA-MB-231 cells. | 2002 | Nutr Cancer | pmid:12734056 |
| Inagaki K et al. | Evidence of isozymes for delta6 fatty acid desaturase in rat hepatocytes. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12729021 |
| Mun'im A et al. | Antioxidative compounds from Crotalaria sessiliflora. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12729010 |
| Mattos R et al. | Polyunsaturated fatty acids and bovine interferon-tau modify phorbol ester-induced secretion of prostaglandin F2 alpha and expression of prostaglandin endoperoxide synthase-2 and phospholipase-A2 in bovine endometrial cells. | 2003 | Biol. Reprod. | pmid:12724278 |
| Ju JW and Jung MY | Formation of conjugated linoleic acids in soybean oil during hydrogenation with a nickel catalyst as affected by sulfur addition. | 2003 | J. Agric. Food Chem. | pmid:12720406 |
| Chen XG et al. | O/W emulsification for the self-aggregation and nanoparticle formation of linoleic acid-modified chitosan in the aqueous system. | 2003 | J. Agric. Food Chem. | pmid:12720404 |
| Nixon JB et al. | Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711249 |
| Gueck T et al. | Effects of essential fatty acids on mediators of mast cells in culture. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711248 |
| Risé P et al. | Relative potencies of statins in reducing cholesterol synthesis and enhancing linoleic acid metabolism. | 2003 | Eur. J. Pharmacol. | pmid:12706457 |
| Zhang WH et al. | Model studies on protein side chain modification by 4-oxo-2-nonenal. | 2003 | Chem. Res. Toxicol. | pmid:12703968 |
| AbuGhazaleh AA et al. | Milk conjugated linoleic acid response to fish oil supplementation of diets differing in fatty acid profiles. | 2003 | J. Dairy Sci. | pmid:12703631 |
| Meerarani P et al. | Cholesterol attenuates linoleic acid-induced endothelial cell activation. | 2003 | Metab. Clin. Exp. | pmid:12701065 |
| Albers R et al. | Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men. | 2003 | Eur J Clin Nutr | pmid:12700622 |
| Foti MC and Ingold KU | Mechanism of inhibition of lipid peroxidation by gamma-terpinene, an unusual and potentially useful hydrocarbon antioxidant. | 2003 | J. Agric. Food Chem. | pmid:12696969 |
| Nagler LG et al. | Rate of free-radical oxidation of C18 diene and triene fatty acids in aqueous micellar solutions and effectiveness of beta-carotene as an inhibitor of their oxidation. | 2003 | Biochemistry Mosc. | pmid:12693967 |
| Itakura K and Uchida K | Lysine-derived fluorophores formed by autoxidation of linoleic acid. | 2003 | Chem. Phys. Lipids | pmid:12691851 |
| Bruder ED et al. | An oxidized metabolite of linoleic acid stimulates corticosterone production by rat adrenal cells. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12689852 |
| Nakanishi T et al. | Dietary conjugated linoleic acid reduces cerebral prostaglandin E(2) in mice. | 2003 | Neurosci. Lett. | pmid:12686384 |
| Qian SY et al. | Identification of all classes of spin-trapped carbon-centered radicals in soybean lipoxygenase-dependent lipid peroxidations of omega-6 polyunsaturated fatty acids via LC/ESR, LC/MS, and tandem MS. | 2003 | Free Radic. Biol. Med. | pmid:12684086 |
| Torres-Duarte AP and Vanderhoek JY | Conjugated linoleic acid exhibits stimulatory and inhibitory effects on prostanoid production in human endothelial cells and platelets. | 2003 | Biochim. Biophys. Acta | pmid:12676356 |
| Yang XF et al. | In vitro release and antibacterial activity of poly (oleic/linoleic acid dimer: sebacic acid)-gentamicin. | 2003 | Acta Pharmacol. Sin. | pmid:12676068 |
| Considine MJ et al. | Superoxide stimulates a proton leak in potato mitochondria that is related to the activity of uncoupling protein. | 2003 | J. Biol. Chem. | pmid:12672801 |
| Siddhuraju P and Becker K | Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera Lam.) leaves. | 2003 | J. Agric. Food Chem. | pmid:12670148 |
| Takahashi Y et al. | Activity and mRNA levels of enzymes involved in hepatic fatty acid synthesis and oxidation in mice fed conjugated linoleic acid. | 2003 | Biochim. Biophys. Acta | pmid:12668178 |
| Mitchell LA et al. | Linoleic acid metabolites act to increase contractility in isolated rat heart. | 2002 | Cardiovasc. Toxicol. | pmid:12665667 |
| Eitel K et al. | Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. | 2003 | Diabetes | pmid:12663471 |
| Djoussé L et al. | Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. | 2003 | Am. J. Clin. Nutr. | pmid:12663278 |
| Kark JD et al. | Adipose tissue n-6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids. | 2003 | Am. J. Clin. Nutr. | pmid:12663274 |
| Lee C et al. | Quantitative trait loci mapping for fatty acid contents in the backfat on porcine chromosomes 1, 13, and 18. | 2003 | Mol. Cells | pmid:12661762 |
| Chartrand R et al. | Effect of dietary fat sources on systemic and intrauterine synthesis of prostaglandins during early pregnancy in gilts. | 2003 | J. Anim. Sci. | pmid:12661653 |
| Ramachandran S et al. | Oxidants and antioxidants affect the expression of glycodelin. | 2003 | Free Radic. Biol. Med. | pmid:12654469 |
| Mackle TR et al. | Effects of abomasal infusion of conjugated linoleic acid on milk fat concentration and yield from pasture-fed dairy cows. | 2003 | J. Dairy Sci. | pmid:12647970 |
| Joo NE and Park CS | Inhibition of excitotoxicity in cultured rat cortical neurons by a mixture of conjugated linoleic acid isomers. | 2003 | Pharmacol. Res. | pmid:12644387 |
| Adlof RO and List GR | Synthesis and analysis of symmetrical and nonsymmetrical disaturated/monounsaturated triacylglycerols. | 2003 | J. Agric. Food Chem. | pmid:12643679 |
| Turgeon D et al. | Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases. | 2003 | J. Lipid Res. | pmid:12639971 |
| Itoh Y et al. | Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. | 2003 | Nature | pmid:12629551 |
| Park KY et al. | Antimutagenic effects of doenjang (Korean fermented soypaste) and its active compounds. | 2003 Feb-Mar | Mutat. Res. | pmid:12628502 |
| Bauman DE and Griinari JM | Nutritional regulation of milk fat synthesis. | 2003 | Annu. Rev. Nutr. | pmid:12626693 |
| Enoki M et al. | Oxidative degradation of cis- and trans-1,4-polyisoprenes and vulcanized natural rubber with enzyme-mediator systems. | 2003 Mar-Apr | Biomacromolecules | pmid:12625726 |
| Fernández-Moya V et al. | Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds. | 2003 | Planta | pmid:12624771 |
| Adam O et al. | Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers. | 2003 | Ann. Nutr. Metab. | pmid:12624485 |
| Yang H et al. | Conjugated linoleic acid inhibits mutagenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the prostate of Big Blue rats. | 2003 | Mutagenesis | pmid:12621076 |
| Bergman M et al. | Scavenging of reactive oxygen species by a novel glucurinated flavonoid antioxidant isolated and purified from spinach. | 2003 | Phytochemistry | pmid:12620328 |
| Kishino S et al. | Structural analysis of conjugated linoleic acid produced by Lactobacillus plantarum, and factors affecting isomer production. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12619692 |
| Koba K et al. | Effect of phytate in soy protein on the serum and liver cholesterol levels and liver fatty acid profile in rats. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12619668 |
| Henriksen EJ et al. | Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat. | 2003 | Am. J. Physiol. Endocrinol. Metab. | pmid:12618357 |
| Waddington EI et al. | Fatty acid oxidation products in human atherosclerotic plaque: an analysis of clinical and histopathological correlates. | 2003 | Atherosclerosis | pmid:12618275 |
| Cui YF et al. | Effect of unsaturated fatty acid on muscarinic current in guinea pig gastric antral circular myocytes. | 2003 | Acta Pharmacol. Sin. | pmid:12617780 |
| Gonzalez S et al. | Oxidation and textural characteristics of butter and ice cream with modified fatty acid profiles. | 2003 | J. Dairy Sci. | pmid:12613850 |
| Campbell W et al. | The impact of fortification with conjugated linoleic acid (CLA) on the quality of fluid milk. | 2003 | J. Dairy Sci. | pmid:12613847 |
| Arab L | Biomarkers of fat and fatty acid intake. | 2003 | J. Nutr. | pmid:12612178 |
| Yamasaki M et al. | Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid. | 2003 | J. Nutr. | pmid:12612153 |
| Xu X et al. | Short-term intake of conjugated linoleic acid inhibits lipoprotein lipase and glucose metabolism but does not enhance lipolysis in mouse adipose tissue. | 2003 | J. Nutr. | pmid:12612134 |
| Barabino S et al. | Systemic linoleic and gamma-linolenic acid therapy in dry eye syndrome with an inflammatory component. | 2003 | Cornea | pmid:12605039 |
| Tsydendambaev VD and Vereshchagin AG | Changes in triacylglycerol composition during ripening of sea buckthorn (Hippophaë rhamnoides L.) seeds. | 2003 | J. Agric. Food Chem. | pmid:12590468 |
| Liang CF et al. | Effects of epidermal growth factor and linoleic acid on lipid contents in human intestinal C2BBe1 cells. | 2002 | IUBMB Life | pmid:12587978 |
| Badinga L et al. | Dietary conjugated linoleic acid alters hepatic lipid content and fatty acid composition in broiler chickens. | 2003 | Poult. Sci. | pmid:12580252 |
| Bazinet RP et al. | Whole-body beta-oxidation of 18:2omega6 and 18:3omega3 in the pig varies markedly with weaning strategy and dietary 18:3omega3. | 2003 | J. Lipid Res. | pmid:12576513 |
| Hellemans K et al. | PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation. | 2003 | J. Lipid Res. | pmid:12576510 |
| Ostrowska E et al. | Conjugated linoleic acid decreases fat accretion in pigs: evaluation by dual-energy X-ray absorptiometry. | 2003 | Br. J. Nutr. | pmid:12575906 |
| Cho HJ et al. | Conjugated linoleic acid inhibits cell proliferation and ErbB3 signaling in HT-29 human colon cell line. | 2003 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:12571082 |
| Rollin X et al. | The effects of dietary lipid and strain difference on polyunsaturated fatty acid composition and conversion in anadromous and landlocked salmon (Salmo salar L.) parr. | 2003 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:12568812 |
| Sher J et al. | Dietary conjugated linoleic acid lowers plasma cholesterol during cholesterol supplementation, but accentuates the atherogenic lipid profile during the acute phase response in hamsters. | 2003 | J. Nutr. | pmid:12566483 |
| Ascherio A | Epidemiologic studies on dietary fats and coronary heart disease. | 2002 | Am. J. Med. | pmid:12566133 |
| Kotarsky K et al. | A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12565875 |
| Lee JY et al. | Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. | 2003 | J. Lipid Res. | pmid:12562875 |
| Valianpour F et al. | Linoleic acid supplementation of Barth syndrome fibroblasts restores cardiolipin levels: implications for treatment. | 2003 | J. Lipid Res. | pmid:12562862 |
| Gorard DA | Enteral nutrition in Crohn's disease: fat in the formula. | 2003 | Eur J Gastroenterol Hepatol | pmid:12560753 |
| Llor X et al. | The effects of fish oil, olive oil, oleic acid and linoleic acid on colorectal neoplastic processes. | 2003 | Clin Nutr | pmid:12553953 |
| Duckett SK et al. | Effect of high-oil corn or added corn oil on ruminal biohydrogenation of fatty acids and conjugated linoleic acid formation in beef steers fed finishing diets. | 2002 | J. Anim. Sci. | pmid:12542177 |
| Martin SA and Jenkins TC | Factors affecting conjugated linoleic acid and trans-C18:1 fatty acid production by mixed ruminal bacteria. | 2002 | J. Anim. Sci. | pmid:12542176 |
| Vos E and Cunnane SC | Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality. | 2003 | Am. J. Clin. Nutr. | pmid:12540417 |
| Innis SM and Elias SL | Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. | 2003 | Am. J. Clin. Nutr. | pmid:12540410 |
| Pasqualini ME et al. | Association between E-cadherin expression by human colon, bladder and breast cancer cells and the 13-HODE:15-HETE ratio. A possible role of their metastatic potential. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12538085 |
| Hubbard NE et al. | Effect of separate conjugated linoleic acid isomers on murine mammary tumorigenesis. | 2003 | Cancer Lett. | pmid:12536072 |
| Cohen LA et al. | Effect of soy protein isolate and conjugated linoleic acid on the growth of Dunning R-3327-AT-1 rat prostate tumors. | 2003 | Prostate | pmid:12518321 |