| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Enoki M et al. | Oxidative degradation of cis- and trans-1,4-polyisoprenes and vulcanized natural rubber with enzyme-mediator systems. | 2003 Mar-Apr | Biomacromolecules | pmid:12625726 |
| Bauman DE and Griinari JM | Nutritional regulation of milk fat synthesis. | 2003 | Annu. Rev. Nutr. | pmid:12626693 |
| Park KY et al. | Antimutagenic effects of doenjang (Korean fermented soypaste) and its active compounds. | 2003 Feb-Mar | Mutat. Res. | pmid:12628502 |
| Itoh Y et al. | Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. | 2003 | Nature | pmid:12629551 |
| Turgeon D et al. | Glucuronidation of arachidonic and linoleic acid metabolites by human UDP-glucuronosyltransferases. | 2003 | J. Lipid Res. | pmid:12639971 |
| Adlof RO and List GR | Synthesis and analysis of symmetrical and nonsymmetrical disaturated/monounsaturated triacylglycerols. | 2003 | J. Agric. Food Chem. | pmid:12643679 |
| Joo NE and Park CS | Inhibition of excitotoxicity in cultured rat cortical neurons by a mixture of conjugated linoleic acid isomers. | 2003 | Pharmacol. Res. | pmid:12644387 |
| Mackle TR et al. | Effects of abomasal infusion of conjugated linoleic acid on milk fat concentration and yield from pasture-fed dairy cows. | 2003 | J. Dairy Sci. | pmid:12647970 |
| Ramachandran S et al. | Oxidants and antioxidants affect the expression of glycodelin. | 2003 | Free Radic. Biol. Med. | pmid:12654469 |
| Chartrand R et al. | Effect of dietary fat sources on systemic and intrauterine synthesis of prostaglandins during early pregnancy in gilts. | 2003 | J. Anim. Sci. | pmid:12661653 |
| Lee C et al. | Quantitative trait loci mapping for fatty acid contents in the backfat on porcine chromosomes 1, 13, and 18. | 2003 | Mol. Cells | pmid:12661762 |
| Kark JD et al. | Adipose tissue n-6 fatty acids and acute myocardial infarction in a population consuming a diet high in polyunsaturated fatty acids. | 2003 | Am. J. Clin. Nutr. | pmid:12663274 |
| Djoussé L et al. | Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. | 2003 | Am. J. Clin. Nutr. | pmid:12663278 |
| Eitel K et al. | Protein kinase C delta activation and translocation to the nucleus are required for fatty acid-induced apoptosis of insulin-secreting cells. | 2003 | Diabetes | pmid:12663471 |
| Mitchell LA et al. | Linoleic acid metabolites act to increase contractility in isolated rat heart. | 2002 | Cardiovasc. Toxicol. | pmid:12665667 |
| Takahashi Y et al. | Activity and mRNA levels of enzymes involved in hepatic fatty acid synthesis and oxidation in mice fed conjugated linoleic acid. | 2003 | Biochim. Biophys. Acta | pmid:12668178 |
| Siddhuraju P and Becker K | Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera Lam.) leaves. | 2003 | J. Agric. Food Chem. | pmid:12670148 |
| Considine MJ et al. | Superoxide stimulates a proton leak in potato mitochondria that is related to the activity of uncoupling protein. | 2003 | J. Biol. Chem. | pmid:12672801 |
| Yang XF et al. | In vitro release and antibacterial activity of poly (oleic/linoleic acid dimer: sebacic acid)-gentamicin. | 2003 | Acta Pharmacol. Sin. | pmid:12676068 |
| Torres-Duarte AP and Vanderhoek JY | Conjugated linoleic acid exhibits stimulatory and inhibitory effects on prostanoid production in human endothelial cells and platelets. | 2003 | Biochim. Biophys. Acta | pmid:12676356 |
| Qian SY et al. | Identification of all classes of spin-trapped carbon-centered radicals in soybean lipoxygenase-dependent lipid peroxidations of omega-6 polyunsaturated fatty acids via LC/ESR, LC/MS, and tandem MS. | 2003 | Free Radic. Biol. Med. | pmid:12684086 |
| Nakanishi T et al. | Dietary conjugated linoleic acid reduces cerebral prostaglandin E(2) in mice. | 2003 | Neurosci. Lett. | pmid:12686384 |
| Bruder ED et al. | An oxidized metabolite of linoleic acid stimulates corticosterone production by rat adrenal cells. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12689852 |
| Itakura K and Uchida K | Lysine-derived fluorophores formed by autoxidation of linoleic acid. | 2003 | Chem. Phys. Lipids | pmid:12691851 |
| Nagler LG et al. | Rate of free-radical oxidation of C18 diene and triene fatty acids in aqueous micellar solutions and effectiveness of beta-carotene as an inhibitor of their oxidation. | 2003 | Biochemistry Mosc. | pmid:12693967 |
| Foti MC and Ingold KU | Mechanism of inhibition of lipid peroxidation by gamma-terpinene, an unusual and potentially useful hydrocarbon antioxidant. | 2003 | J. Agric. Food Chem. | pmid:12696969 |
| Albers R et al. | Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men. | 2003 | Eur J Clin Nutr | pmid:12700622 |
| Meerarani P et al. | Cholesterol attenuates linoleic acid-induced endothelial cell activation. | 2003 | Metab. Clin. Exp. | pmid:12701065 |
| AbuGhazaleh AA et al. | Milk conjugated linoleic acid response to fish oil supplementation of diets differing in fatty acid profiles. | 2003 | J. Dairy Sci. | pmid:12703631 |
| Zhang WH et al. | Model studies on protein side chain modification by 4-oxo-2-nonenal. | 2003 | Chem. Res. Toxicol. | pmid:12703968 |
| Risé P et al. | Relative potencies of statins in reducing cholesterol synthesis and enhancing linoleic acid metabolism. | 2003 | Eur. J. Pharmacol. | pmid:12706457 |
| Gueck T et al. | Effects of essential fatty acids on mediators of mast cells in culture. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711248 |
| Nixon JB et al. | Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711249 |
| Chen XG et al. | O/W emulsification for the self-aggregation and nanoparticle formation of linoleic acid-modified chitosan in the aqueous system. | 2003 | J. Agric. Food Chem. | pmid:12720404 |
| Ju JW and Jung MY | Formation of conjugated linoleic acids in soybean oil during hydrogenation with a nickel catalyst as affected by sulfur addition. | 2003 | J. Agric. Food Chem. | pmid:12720406 |
| Mattos R et al. | Polyunsaturated fatty acids and bovine interferon-tau modify phorbol ester-induced secretion of prostaglandin F2 alpha and expression of prostaglandin endoperoxide synthase-2 and phospholipase-A2 in bovine endometrial cells. | 2003 | Biol. Reprod. | pmid:12724278 |
| Mun'im A et al. | Antioxidative compounds from Crotalaria sessiliflora. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12729010 |
| Inagaki K et al. | Evidence of isozymes for delta6 fatty acid desaturase in rat hepatocytes. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12729021 |
| Ma DW et al. | An enriched mixture of trans-10,cis-12-CLA inhibits linoleic acid metabolism and PGE2 synthesis in MDA-MB-231 cells. | 2002 | Nutr Cancer | pmid:12734056 |
| Wiesenfeld PW et al. | Flaxseed increased alpha-linolenic and eicosapentaenoic acid and decreased arachidonic acid in serum and tissues of rat dams and offspring. | 2003 | Food Chem. Toxicol. | pmid:12738189 |
| Babu US et al. | Impact of high flaxseed diet on mitogen-induced proliferation, IL-2 production, cell subsets and fatty acid composition of spleen cells from pregnant and F1 generation Sprague-Dawley rats. | 2003 | Food Chem. Toxicol. | pmid:12738196 |
| Mashek DG and Grummer RR | Short communication: Net uptake of nonesterified long chain fatty acids by the perfused caudate lobe of the caprine liver. | 2003 | J. Dairy Sci. | pmid:12741546 |
| Nair VB and Panchagnula R | Effect of iontophoresis and fatty acids on permeation of arginine vasopressin through rat skin. | 2003 | Pharmacol. Res. | pmid:12742012 |
| Gorinstein S et al. | Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determined by four different radical scavenging tests. | 2003 | J. Nutr. Biochem. | pmid:12742543 |
| Rotta AT et al. | Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems. | 2003 | Pediatr Crit Care Med | pmid:12749658 |
| Buckner JS and Hagen MM | Triacylglycerol and phospholipid fatty acids of the silverleaf whitefly: composition and biosynthesis. | 2003 | Arch. Insect Biochem. Physiol. | pmid:12761874 |
| Aletor VA et al. | The effects of conjugated linoleic acids or an alpha-glucosidase inhibitor on tissue lipid concentrations and fatty acid composition of broiler chicks fed a low-protein diet. | 2003 | Poult. Sci. | pmid:12762403 |
| Macrì A et al. | Effect of linoleic acid and gamma-linolenic acid on tear production, tear clearance and on the ocular surface after photorefractive keratectomy. | 2003 | Graefes Arch. Clin. Exp. Ophthalmol. | pmid:12768289 |
| Ward AT et al. | Fresh forage and solin supplementation on conjugated linoleic acid levels in plasma and milk. | 2003 | J. Dairy Sci. | pmid:12778585 |
| Vargas F et al. | Photochemistry and in vitro phototoxicity studies of levomepromazine (methotrimeprazine), a phototoxic neuroleptic drug. | 2003 | Pharmazie | pmid:12779046 |