| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Colitis | D003092 | 69 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Harris WS | Linoleic acid and coronary heart disease. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18951772 |
| Webb AN et al. | Tolerability and safety of olive oil-based lipid emulsion in critically ill neonates: a blinded randomized trial. | 2008 Nov-Dec | Nutrition | pmid:18619813 |
| Magalhães MS et al. | Effect of a combination of medium chain triglycerides, linoleic acid, soy lecithin and vitamins A and E on wound healing in rats. | 2008 May-Jun | Acta Cir Bras | pmid:18552998 |
| Chua AC et al. | Characterization of oil bodies in jelly fig achenes. | 2008 May-Jun | Plant Physiol. Biochem. | pmid:18434174 |
| Yu IS et al. | Conversion of linoleic acid into 10-Hydroxy-12(Z)-octadecenoic acid by whole cells of Stenotrophomonas nitritireducens. | 2008 Jan-Feb | Biotechnol. Prog. | pmid:18197675 |
| Bionaz M et al. | Characterization of Madin-Darby bovine kidney cell line for peroxisome proliferator-activated receptors: temporal response and sensitivity to fatty acids. | 2008 | J. Dairy Sci. | pmid:18565938 |
| Netsu S et al. | Oral eicosapentaenoic acid supplementation as possible therapy for endometriosis. | 2008 | Fertil. Steril. | pmid:18054352 |
| Diniz YS et al. | Conjugated linoleic acid and cardiac health: oxidative stress and energetic metabolism in standard and sucrose-rich diets. | 2008 | Eur. J. Pharmacol. | pmid:18054909 |
| Vögler O et al. | Structure-effect relation of C18 long-chain fatty acids in the reduction of body weight in rats. | 2008 | Int J Obes (Lond) | pmid:18059405 |
| Ogata K et al. | Dosage plan of a flurbiprofen injection product using inhibition of protein binding by lipid emulsion in rats. | 2008 | J. Pharm. Pharmacol. | pmid:18088500 |
| Ruths M et al. | Friction of fatty acids in nanometer-sized contacts of different adhesive strength. | 2008 | Langmuir | pmid:18085802 |
| Dreisbach AW et al. | Salt loading increases urinary excretion of linoleic acid diols and triols in healthy human subjects. | 2008 | Hypertension | pmid:18227407 |
| Kim T et al. | Pharmacokinetics of formulated tenoxicam transdermal delivery systems. | 2008 | J. Pharm. Pharmacol. | pmid:18088513 |
| Jang A et al. | Comparison of hypolipidemic activity of synthetic gallic acid-linoleic acid ester with mixture of gallic acid and linoleic acid, gallic acid, and linoleic acid on high-fat diet induced obesity in C57BL/6 Cr Slc mice. | 2008 | Chem. Biol. Interact. | pmid:18571153 |
| Frenette M and Scaiano JC | Evidence for hydroxyl radical generation during lipid (linoleate) peroxidation. | 2008 | J. Am. Chem. Soc. | pmid:18597469 |
| Eder E et al. | Lipid peroxidation-related 1,N2-propanodeoxyguanosine-DNA adducts induced by endogenously formed 4-hydroxy-2-nonenal in organs of female rats fed diets supplemented with sunflower, rapeseed, olive or coconut oil. | 2008 | Mutat. Res. | pmid:18602860 |
| Meguid NA et al. | Role of polyunsaturated fatty acids in the management of Egyptian children with autism. | 2008 | Clin. Biochem. | pmid:18582451 |
| Burenjargal M and Totani N | Effects of thermally processed oil on weight loss in rats. | 2008 | J Oleo Sci | pmid:18685228 |
| Miura K et al. | Relationship of dietary linoleic acid to blood pressure. The International Study of Macro-Micronutrients and Blood Pressure Study [corrected]. | 2008 | Hypertension | pmid:18606902 |
| Ogorodnikova AV et al. | Detection of divinyl ether synthase in Lily-of-the-Valley (Convallaria majalis) roots. | 2008 | Phytochemistry | pmid:18952245 |
| Stratford JM et al. | Linoleic acid increases chorda tympani nerve responses to and behavioral preferences for monosodium glutamate by male and female rats. | 2008 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:18635450 |
| Nagelin MH et al. | 12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1. | 2008 | Arterioscler. Thromb. Vasc. Biol. | pmid:18635820 |
| Tao X et al. | GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia. | 2008 | Anal Bioanal Chem | pmid:18622754 |
| Koussoroplis AM et al. | From aquatic to terrestrial food webs: decrease of the docosahexaenoic acid/linoleic acid ratio. | 2008 | Lipids | pmid:18335265 |
| Granvogl M et al. | Development of a stable isotope dilution assay for the quantitation of glycidamide and its application to foods and model systems. | 2008 | J. Agric. Food Chem. | pmid:18624425 |
| Alghazeer R et al. | Cytotoxicity of oxidised lipids in cultured colonal human intestinal cancer cells (caco-2 cells). | 2008 | Toxicol. Lett. | pmid:18625293 |
| Lukovac S et al. | Essential fatty acid deficiency in mice impairs lactose digestion. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18653724 |
| Fagali N and Catalá A | Antioxidant activity of conjugated linoleic acid isomers, linoleic acid and its methyl ester determined by photoemission and DPPH techniques. | 2008 | Biophys. Chem. | pmid:18656302 |
| Gülçin I | In vitro prooxidant effect of caffeine. | 2008 | J Enzyme Inhib Med Chem | pmid:18341268 |
| Minami Y et al. | Occurrence of singlet oxygen oxygenation of oleic acid and linoleic acid in the skin of live mice. | 2008 | Free Radic. Res. | pmid:18344113 |
| Horowitz Brown S et al. | Morphological transitions governed by density dependence and lipoxygenase activity in Aspergillus flavus. | 2008 | Appl. Environ. Microbiol. | pmid:18658287 |
| Sasaki N et al. | Down-regulation of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase by polyunsaturated fatty acids in hepatocytes is not mediated by PPARalpha. | 2008 | Eur J Nutr | pmid:18320257 |
| Chicco AJ et al. | Linoleate-rich high-fat diet decreases mortality in hypertensive heart failure rats compared with lard and low-fat diets. | 2008 | Hypertension | pmid:18663155 |
| Zhao ZY et al. | Influence of dietary conjugated linoleic acid on growth, fatty acid composition and hepatic lipogenesis in large yellow croaker (Pseudosciaena crocea R.). | 2008 | J Zhejiang Univ Sci B | pmid:18763301 |
| Chavarro JE et al. | A prospective study of trans-fatty acid levels in blood and risk of prostate cancer. | 2008 | Cancer Epidemiol. Biomarkers Prev. | pmid:18199715 |
| Yara A et al. | Enhancement of disease resistance to Magnaporthe grisea in rice by accumulation of hydroxy linoleic acid. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18373976 |
| Jäger AK et al. | Isolation of linoleic and alpha-linolenic acids as COX-1 and -2 inhibitors in rose hip. | 2008 | Phytother Res | pmid:18389471 |
| Chou YC et al. | Bioassay-guided purification and identification of PPARalpha/gamma agonists from Chlorella sorokiniana. | 2008 | Phytother Res | pmid:18398904 |
| Gallardo E et al. | Influence of lipids in the generation of phenylacetaldehyde in wort-related model systems. | 2008 | J. Agric. Food Chem. | pmid:18386901 |
| Morawicki RO and Beelman RB | Study of the biosynthesis of 1-octen-3-ol using a crude homogenate of Agaricus bisporus in a bioreactor. | 2008 | J. Food Sci. | pmid:18387089 |
| Kwon JI et al. | Induction of apoptosis by linoleic acid is associated with the modulation of Bcl-2 family and Fas/FasL system and activation of caspases in AGS human gastric adenocarcinoma cells. | 2008 | J Med Food | pmid:18361731 |
| Tian Z et al. | Preparation and evaluation of a linoleic-acid-modified amphiphilic polypeptide copolymer as a carrier for controlled drug release. | 2008 | Biomed Mater | pmid:19029601 |
| Warensjö E et al. | Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. | 2008 | Nutr Metab Cardiovasc Dis | pmid:18367385 |
| Ueda Y et al. | Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease. | 2008 | Nutr Res | pmid:19083414 |
| Lopes PA et al. | Diet supplementation with the cis-9,trans-11 conjugated linoleic acid isomer affects the size of adipocytes in Wistar rats. | 2008 | Nutr Res | pmid:19083449 |
| Hoashi S et al. | Association between fatty acid compositions and genotypes of FABP4 and LXR-alpha in Japanese black cattle. | 2008 | BMC Genet. | pmid:19077218 |
| Safaa HM et al. | Effects of the levels of methionine, linoleic Acid, and added fat in the diet on productive performance and egg quality of brown laying hens in the late phase of production. | 2008 | Poult. Sci. | pmid:18648054 |
| Bueno AA et al. | Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue. | 2008 | Pflugers Arch. | pmid:17717684 |
| Tepe B | Antioxidant potentials and rosmarinic acid levels of the methanolic extracts of Salvia virgata (Jacq), Salvia staminea (Montbret & Aucher ex Bentham) and Salvia verbenaca (L.) from Turkey. | 2008 | Bioresour. Technol. | pmid:17531471 |
| Xanthopoulou MN et al. | Biological studies of new organotin(IV) complexes of thioamide ligands. | 2008 | Eur J Med Chem | pmid:17509733 |