| MeSH term | MeSH ID | Detail |
|---|---|---|
| Heart Failure | D006333 | 36 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Hyperlipidemia, Familial Combined | D006950 | 9 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypertension, Renal | D006977 | 9 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bellini MJ et al. | Effect of simvastatin on the uptake and metabolic conversion of palmitic, dihomo-gamma-linoleic and alpha-linolenic acids in A549 cells. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14580370 |
| Nixon JB et al. | Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711249 |
| Soto-Guzman A et al. | Role of arachidonic acid metabolism in Stat5 activation induced by oleic acid in MDA-MB-231 breast cancer cells. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23332799 |
| Wenger FA et al. | Does alpha-linolenic acid in combination with linoleic acid influence liver metastasis and hepatic lipid peroxidation in BOP-induced pancreatic cancer in Syrian hamsters? | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913224 |
| Tribole E | What happened to do no harm? The issue of dietary omega-6 fatty acids. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19147337 |
| Ramsden CE et al. | Letter to the Editor re: Linoleic acid and coronary heart disease. Prostaglandins Leukot. Essent. Fatty Acids (2008), by W.S. Harris. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19147338 |
| Kuipers RS et al. | Gestational age dependent changes of the fetal brain, liver and adipose tissue fatty acid compositions in a population with high fish intakes. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22425685 |
| Sakuma S et al. | Effect of 13-hydroperoxyoctadecadienoic acid on 15-hydroxy prostaglandin dehydrogenase activity in rabbit kidney cortex. | 1993 | Prostaglandins | pmid:8210445 |
| Lewis MG et al. | Effect of essential polyunsaturated fatty acid modifications on prostaglandin production by MDCK canine kidney cells. | 1981 | Prostaglandins | pmid:6799988 |
| Bonacossa A et al. | Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. | 1982 | Prostaglandins | pmid:6278538 |
| Needleman SW et al. | Enrichment of human platelet phospholipids with linoleic acid diminishes thromboxane release. | 1982 | Prostaglandins | pmid:6819602 |
| Hashimoto A et al. | Effect of the dietary alpha-linolenate/linoleate balance on leukotriene production and histamine release in rats. | 1988 | Prostaglandins | pmid:2459732 |
| Beneytout JL et al. | Effect of isoquinoline alkaloids on soybean lipoxygenase activity in vitro. | 1986 | Prostaglandins | pmid:3086939 |
| Engels F et al. | Preferential formation of 13-hydroxylinoleic acid by human peripheral blood eosinophils. | 1996 | Prostaglandins | pmid:8880897 |
| Engels F et al. | Production of arachidonic acid and linoleic acid metabolites by human bronchoalveolar lavage cells. | 1991 | Prostaglandins | pmid:1662406 |
| Bull AW et al. | Metabolism of oxidized linoleic acid: distribution of activity for the enzymatic oxidation of 13-hydroxyoctadecadienoic acid to 13-oxooctadecadienoic acid in rat tissues. | 1991 | Prostaglandins | pmid:2020745 |
| Bronstein JC and Bull AW | The correlation between 13-hydroxyoctadecadienoate dehydrogenase (13-HODE dehydrogenase) and intestinal cell differentiation. | 1993 | Prostaglandins | pmid:8278616 |
| Andersen BR et al. | The effects of arachidonic and other fatty acids on canine neutrophil metabolism. | 1981 | Prostaglandins | pmid:6795686 |
| Hamazaki T et al. | Urinary excretion of PGI2/3-M and recent N-6/3 fatty acid intake. | 1989 | Prostaglandins | pmid:2503856 |
| Singer P et al. | Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. | 1984 | Prostaglandins | pmid:6328578 |