| MeSH term | MeSH ID | Detail |
|---|---|---|
| Tuberculosis | D014376 | 20 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Stomach Neoplasms | D013274 | 24 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Spirochaetales Infections | D013145 | 2 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Pregnancy Complications, Neoplastic | D011252 | 4 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Rosenthal MD and Whitehurst MC | Fatty acyl delta 6 desaturation activity of cultured human endothelial cells. Modulation by fetal bovine serum. | 1983 | Biochim. Biophys. Acta | pmid:6297606 |
| Herzberg GR et al. | Intestinal absorption of fish oil in rats previously adapted to diets containing fish oil or corn oil. | 1992 | Biochim. Biophys. Acta | pmid:1531932 |
| Emken EA et al. | Influence of linoleic acid on desaturation and uptake of deuterium-labeled palmitic and stearic acids in humans. | 1993 | Biochim. Biophys. Acta | pmid:8399342 |
| Haas TA et al. | Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity. | 1990 | Biochim. Biophys. Acta | pmid:2155665 |
| Borgeson CE et al. | Characterization of the delta 12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate. | 1990 | Biochim. Biophys. Acta | pmid:2248971 |
| Park HG et al. | Palmitic acid (16:0) competes with omega-6 linoleic and omega-3 ɑ-linolenic acids for FADS2 mediated Δ6-desaturation. | 2016 | Biochim. Biophys. Acta | pmid:26597785 |
| Lomnitski L et al. | The interaction between beta-carotene and lipoxygenase in plant and animal systems. | 1993 | Biochim. Biophys. Acta | pmid:8481396 |
| Parinandi NL et al. | Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. | 1990 | Biochim. Biophys. Acta | pmid:2123402 |
| Grossman S et al. | Methylmercuric iodide modification of lipoxygenase-1. Effects on the anaerobic reaction and pigment bleaching. | 1984 | Biochim. Biophys. Acta | pmid:6424722 |
| Mitranic MM et al. | The effect of linoleic acid and benzyl alcohol on the activity of glycosyltransferases of rat liver Golgi membranes and some soluble glycosyltransferases. | 1982 | Biochim. Biophys. Acta | pmid:6217837 |
| Miyashita K et al. | Preferential hydrolysis of monohydroperoxides of linoleoyl and linolenoyl triacylglycerol by pancreatic lipase. | 1990 | Biochim. Biophys. Acta | pmid:2386795 |
| Kühn H et al. | The stoichiometry of oxygen uptake and conjugated diene formation during the dioxygenation of linoleic acid by the pure reticulocyte lipoxygenase. Evidence for aerobic hydroperoxidase activity. | 1986 | Biochim. Biophys. Acta | pmid:3006782 |
| Nugteren DH et al. | Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat. | 1985 | Biochim. Biophys. Acta | pmid:3922425 |
| Jakobsson A et al. | Metabolism of fatty acids and their incorporation into phospholipids of the mitochondria and endoplasmic reticulum in isolated hepatocytes determined by isolation of fluorescence derivatives. | 1990 | Biochim. Biophys. Acta | pmid:2223867 |
| Kitagawa S et al. | Effects of four types of reagents on ADP-induced aggregation and Ca2+ mobilization of bovine blood platelets. | 1984 | Biochim. Biophys. Acta | pmid:6324876 |
| Simon I et al. | Electron-spin resonance studies of lipid-modified microsomes from Friend erythroleukemia cells. | 1984 | Biochim. Biophys. Acta | pmid:6326852 |
| Gavigan SJ and Knight BL | Catabolism of low-density lipoprotein by fibroblasts cultured in medium supplemented with saturated or unsaturated free fatty acids. | 1981 | Biochim. Biophys. Acta | pmid:6271233 |
| Cheah AM | Effect of long chain unsaturated fatty acids on the calcium transport of sarcoplasmic reticulum. | 1981 | Biochim. Biophys. Acta | pmid:6118177 |
| Takahashi Y et al. | Activity and mRNA levels of enzymes involved in hepatic fatty acid synthesis and oxidation in mice fed conjugated linoleic acid. | 2003 | Biochim. Biophys. Acta | pmid:12668178 |
| Hagve TA and Christophersen BO | In vitro effects of alpha-bromopalmitate on metabolism of essential fatty acids studied in isolated rat hepatocytes: sex differences. | 1987 | Biochim. Biophys. Acta | pmid:3099848 |
| López-Nicolás JM et al. | Kinetic characteristics of the enzymatic conversion in presence of cyclodextrins: study of the oxidation of polyunsaturated fatty acids by lipoxygenase. | 1997 | Biochim. Biophys. Acta | pmid:9295158 |
| Brasitus TA and Dudeja PK | Effect of hypothyroidism on the lipid composition and fluidity of rat colonic apical plasma membranes. | 1988 | Biochim. Biophys. Acta | pmid:3128322 |
| Nilsson A and Landin B | Metabolism of chylomicron arachidonic and linoleic acid in the rat. | 1988 | Biochim. Biophys. Acta | pmid:3128335 |
| Liffmann SM and Lynch RD | Incorporation of [3H]acetate into L-cell lipids. Dependence on method of linoleate administration and timing of the pulse label. | 1981 | Biochim. Biophys. Acta | pmid:7295748 |
| Lapenna D et al. | Inhibitory activity of salicylic acid on lipoxygenase-dependent lipid peroxidation. | 2009 | Biochim. Biophys. Acta | pmid:18950686 |
| Seeley SK et al. | Metabolism of oxidized linoleic acid by glutathione transferases: peroxidase activity toward 13-hydroperoxyoctadecadienoic acid. | 2006 | Biochim. Biophys. Acta | pmid:16624487 |
| Figueroa V et al. | Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca(2+)-dependent pathway. | 2013 | Biochim. Biophys. Acta | pmid:23261389 |
| Fitch CD et al. | A role for linoleic acid in erythrocytes infected with Plasmodium berghei. | 2000 | Biochim. Biophys. Acta | pmid:11113630 |
| Leekumjorn S et al. | The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes. | 2009 | Biochim. Biophys. Acta | pmid:19371719 |
| Bowser PA et al. | Identification, isolation and characterization of epidermal lipids containing linoleic acid. | 1985 | Biochim. Biophys. Acta | pmid:3995076 |
| Mizushina Y et al. | Fatty acids selectively inhibit eukaryotic DNA polymerase activities in vitro. | 1996 | Biochim. Biophys. Acta | pmid:8809118 |
| Memoli S et al. | Diffusible melanin-related metabolites are potent inhibitors of lipid peroxidation. | 1997 | Biochim. Biophys. Acta | pmid:9187303 |
| De Villiers M and Lochner A | Mitochondrial Ca2+ fluxes: role of free fatty acids, acyl-CoA and acylcarnitine. | 1986 | Biochim. Biophys. Acta | pmid:3955069 |
| Artmann A et al. | Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine. | 2008 | Biochim. Biophys. Acta | pmid:18316044 |
| Gurvitz A et al. | Degradation of conjugated linoleic acid isomers in the yeast Saccharomyces cerevisiae. | 2001 | Biochim. Biophys. Acta | pmid:11566445 |
| van Kuiken BA and Behnke WD | The activation of porcine pancreatic lipase by cis-unsaturated fatty acids. | 1994 | Biochim. Biophys. Acta | pmid:7918595 |
| Roy P et al. | Superoxide generation by lipoxygenase in the presence of NADH and NADPH. | 1994 | Biochim. Biophys. Acta | pmid:7918597 |
| Bakken AM et al. | The activities of acyl-CoA hydrolase in lysate and subcellular fractions of human blood platelets in relation to activities of acyl-CoA:1-acyl-lysophospholipid acyltransferase. | 1994 | Biochim. Biophys. Acta | pmid:7918598 |
| del Carmen Boyano-Adánez M et al. | Protein kinase C-mediated phospholipase D activity is increased by linolenic acid supplementation in NG 108-15 cells. | 1994 | Biochim. Biophys. Acta | pmid:7918608 |
| Hrboticky N et al. | Linoleic acid esterified in low density lipoprotein serves as substrate for increased arachidonic acid synthesis in differentiating monocytic cells. | 1996 | Biochim. Biophys. Acta | pmid:8765140 |
| van Haaster CM et al. | Formation of prostanoids and hydroxy fatty acids by stimulated peritoneal mast cells: role of the dietary fat type in rat. | 1993 | Biochim. Biophys. Acta | pmid:8466942 |
| Wenli Y and Yaping Z | Chemiluminescence evaluation of oxidative damage to biomolecules induced by singlet oxygen and the protective effects of antioxidants. | 2005 | Biochim. Biophys. Acta | pmid:15936152 |
| Schick PK et al. | Arachidonate synthesis and uptake in isolated guinea-pig megakaryocytes and platelets. | 1984 | Biochim. Biophys. Acta | pmid:6433984 |
| Garg ML et al. | Fish oil reduces cholesterol and arachidonic acid content more efficiently in rats fed diets containing low linoleic acid to saturated fatty acid ratios. | 1988 | Biochim. Biophys. Acta | pmid:2844278 |
| Ek BA et al. | Fatty acid binding proteins reduce 15-lipoxygenase-induced oxygenation of linoleic acid and arachidonic acid. | 1997 | Biochim. Biophys. Acta | pmid:9187305 |
| Beyers EC and Emken EA | Metabolites of cis,trans, and trans,cis isomers of linoleic acid in mice and incorporation into tissue lipids. | 1991 | Biochim. Biophys. Acta | pmid:2029547 |
| Lester DS | In vitro linoleic acid activation of protein kinase C. | 1990 | Biochim. Biophys. Acta | pmid:2207179 |
| Hulea SA et al. | Bilirubin sensitized photooxidation of human plasma low density lipoprotein. | 1996 | Biochim. Biophys. Acta | pmid:8982266 |
| Kitagawa S et al. | Inhibitory mechanism of cis-polyunsaturated fatty acids on platelet aggregation: the relation with their effects on Ca2+ mobilization, cyclic AMP levels and membrane fluidity. | 1990 | Biochim. Biophys. Acta | pmid:2166588 |
| Schürer NY et al. | Evidence for a novel keratinocyte fatty acid uptake mechanism with preference for linoleic acid: comparison of oleic and linoleic acid uptake by cultured human keratinocytes, fibroblasts and a human hepatoma cell line. | 1994 | Biochim. Biophys. Acta | pmid:8123682 |
| Stein Y et al. | Metabolism of 3-[3H]sphingosine sphingomyelin labeled with [14C]palmitic or [14C]linoleic acid by Hep G2 cells and rat liver in vivo. | 1991 | Biochim. Biophys. Acta | pmid:2054378 |
| Konrad SD et al. | Use of deuterium oxide to measure de novo fatty acid synthesis in normal subjects consuming different dietary fatty acid composition1. | 1998 | Biochim. Biophys. Acta | pmid:9714781 |
| Ryu SB and Wang X | Increase in free linolenic and linoleic acids associated with phospholipase D-mediated hydrolysis of phospholipids in wounded castor bean leaves. | 1998 | Biochim. Biophys. Acta | pmid:9714802 |
| Zevenbergen JL and Houtsmuller UM | Effect of dietary fats on linoleic acid metabolism. A radiolabel study in rats. | 1989 | Biochim. Biophys. Acta | pmid:2713382 |
| Hu ZY et al. | cAMP inhibits linoleic acid-induced growth by antagonizing p27(kip1) depletion, but not interfering with the extracellular signal-regulated kinase or AP-1 activities. | 1998 | Biochim. Biophys. Acta | pmid:9784625 |
| Stein O et al. | Modification of cellular fatty acid composition of Hep-G2 cells: effect of antioxidants on cholesterol esterification and secretion. | 1989 | Biochim. Biophys. Acta | pmid:2730885 |
| Nordøy A et al. | Effect of dietary (n--3) fatty acids on platelet function and lipid metabolism in rats. | 1985 | Biochim. Biophys. Acta | pmid:2861854 |
| Loidl-Stahlhofen A and Spiteller G | alpha-Hydroxyaldehydes, products of lipid peroxidation. | 1994 | Biochim. Biophys. Acta | pmid:8117742 |
| Vrignaud P and Robert J | Free fatty acid uptake is increased in doxorubicin-resistant rat glioblastoma cells. | 1987 | Biochim. Biophys. Acta | pmid:2886153 |
| Hirabara SM et al. | Acute effect of fatty acids on metabolism and mitochondrial coupling in skeletal muscle. | 2006 | Biochim. Biophys. Acta | pmid:16375848 |
| Jensen E et al. | Cell-density-dependent uptake of chylomicron remnants in rat hepatocyte monolayers. Effects of compactin and mevalonic acid. | 1987 | Biochim. Biophys. Acta | pmid:3790613 |
| Ringseis R et al. | LDL receptor gene transcription is selectively induced by t10c12-CLA but not by c9t11-CLA in the human hepatoma cell line HepG2. | 2006 | Biochim. Biophys. Acta | pmid:16982210 |
| Yorek MA et al. | Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells. | 1984 | Biochim. Biophys. Acta | pmid:6089899 |
| Ramanadham S et al. | Delta6-, Stearoyl CoA-, and Delta5-desaturase enzymes are expressed in beta-cells and are altered by increases in exogenous PUFA concentrations. | 2002 | Biochim. Biophys. Acta | pmid:11923099 |
| Jyothirmayi N and Ramadoss CS | Soybean lipoxygenase catalysed oxygenation of unsaturated fatty acid encapsulated in cyclodextrin. | 1991 | Biochim. Biophys. Acta | pmid:1903659 |
| Wertz PW and Downing DT | Linoleate content of epidermal acylglucosylceramide in newborn, growing and mature mice. | 1986 | Biochim. Biophys. Acta | pmid:3707979 |
| Macrì F et al. | Lipoxygenase activity associated to isolated soybean plasma membranes. | 1994 | Biochim. Biophys. Acta | pmid:7947991 |
| Hajarine M and Lagarde M | Studies on polyenoic acid incorporation into human platelet lipid stores: interactions with linoleic and arachidonic acids. | 1986 | Biochim. Biophys. Acta | pmid:3719006 |
| Park Y and Pariza MW | Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid. | 2001 | Biochim. Biophys. Acta | pmid:11750884 |
| Chen Q et al. | Hydrolysis of triacylglycerol arachidonic and linoleic acid ester bonds by human pancreatic lipase and carboxyl ester lipase. | 1989 | Biochim. Biophys. Acta | pmid:2503032 |
| Thomson AB et al. | Feeding rats a diet enriched with saturated fatty acids prevents the inhibitory effects of acute and chronic ethanol exposure on the in vitro uptake of hexoses and lipids. | 1991 | Biochim. Biophys. Acta | pmid:1854796 |
| Raederstorff D and Moser U | Influence of an increased intake of linoleic acid on the incorporation of dietary (n-3) fatty acids in phospholipids and on prostanoid synthesis in rat tissues. | 1992 | Biochim. Biophys. Acta | pmid:1450214 |
| Paiement J et al. | Modulation of GTP-dependent fusion by linoleic and arachidonic acid in derivatives of rough endoplasmic reticulum from rat liver. | 1994 | Biochim. Biophys. Acta | pmid:8142417 |
| Hayakawa F et al. | DNA cleavage reaction and linoleic acid peroxidation induced by tea catechins in the presence of cupric ion. | 1997 | Biochim. Biophys. Acta | pmid:9305782 |
| Hagve TA and Christophersen BO | Sex-related differences in desaturation and chain elongation of essential fatty acids studied in isolated rat hepatocytes. | 1987 | Biochim. Biophys. Acta | pmid:3607076 |
| Mizushina Y et al. | The inhibitory action of fatty acids on DNA polymerase beta. | 1997 | Biochim. Biophys. Acta | pmid:9367179 |
| Schieberle P et al. | A study of oxygen isotope scrambling in the enzymic and non-enzymic oxidation of linoleic acid. | 1981 | Biochim. Biophys. Acta | pmid:6798993 |
| Mizushina Y et al. | Mode analysis of binding of fatty acids to mammalian DNA polymerases. | 2000 | Biochim. Biophys. Acta | pmid:10903472 |
| Doderer A et al. | Purification and characterization of two lipoxygenase isoenzymes from germinating barley. | 1992 | Biochim. Biophys. Acta | pmid:1554746 |
| DESAI ID et al. | PEROXIDATIVE AND RADIATION DAMAGE TO ISOLATED LYSOSOMES. | 1964 | Biochim. Biophys. Acta | pmid:14171002 |
| Dufour C and Loonis M | Flavonoids and their oxidation products protect efficiently albumin-bound linoleic acid in a model of plasma oxidation. | 2007 | Biochim. Biophys. Acta | pmid:17428609 |
| Stimers JR et al. | Effects of linoleic acid metabolites on electrical activity in adult rat ventricular myocytes. | 1999 | Biochim. Biophys. Acta | pmid:10366778 |
| Gaquerel E et al. | Evidence for oxylipin synthesis and induction of a new polyunsaturated fatty acid hydroxylase activity in Chondrus crispus in response to methyljasmonate. | 2007 | Biochim. Biophys. Acta | pmid:17428728 |
| Murase T et al. | Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates. | 2001 | Biochim. Biophys. Acta | pmid:11341955 |
| Subbaiah PV et al. | Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids. | 2011 | Biochim. Biophys. Acta | pmid:20920595 |
| Zhou L and Nilsson A | Fasting increases tissue uptake and interconversion of plasma unesterified linoleic acid in guinea pigs. | 1999 | Biochim. Biophys. Acta | pmid:9989279 |
| Barceló-Coblijn G et al. | Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. | 2003 | Biochim. Biophys. Acta | pmid:12782153 |
| Sasaki T et al. | Effects of dietary docosahexaenoic acid on surface molecules involved in T cell proliferation. | 1999 | Biochim. Biophys. Acta | pmid:9989281 |
| Lodge JK et al. | Copper-induced LDL peroxidation investigated by 1H-NMR spectroscopy. | 1995 | Biochim. Biophys. Acta | pmid:7766690 |
| Brightman AO et al. | A growth factor- and hormone-stimulated NADH oxidase from rat liver plasma membrane. | 1992 | Biochim. Biophys. Acta | pmid:1567890 |
| Kwon B et al. | Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. | 2014 | Biochim. Biophys. Acta | pmid:24732014 |
| Mojumdar EH et al. | Stratum corneum lipid matrix: Location of acyl ceramide and cholesterol in the unit cell of the long periodicity phase. | 2016 | Biochim. Biophys. Acta | pmid:27169629 |
| Banerjee N and Rosenthal MD | High-affinity incorporation of 20-carbon polyunsaturated fatty acids by human skin fibroblasts. | 1985 | Biochim. Biophys. Acta | pmid:2990563 |
| Breiden B and Sandhoff K | The role of sphingolipid metabolism in cutaneous permeability barrier formation. | 2014 | Biochim. Biophys. Acta | pmid:23954553 |
| Chander A and Fisher AB | Choline-phosphate cytidyltransferase activity and phosphatidylcholine synthesis in rat granular pneumocytes are increased with exogenous fatty acids. | 1988 | Biochim. Biophys. Acta | pmid:2893643 |
| de Athayde Moncorvo Collado A et al. | Cholesterol induces surface localization of polyphenols in model membranes thus enhancing vesicle stability against lysozyme, but reduces protection of distant double bonds from reactive-oxygen species. | 2016 | Biochim. Biophys. Acta | pmid:27063609 |
| Bordet JC et al. | Hydroperoxides produced by n-6 lipoxygenation of arachidonic and linoleic acids potentiate synthesis of prostacyclin related compounds. | 1988 | Biochim. Biophys. Acta | pmid:3124885 |
| Biagi PL et al. | Gamma-linolenic acid dietary supplementation can reverse the aging influence on rat liver microsome delta 6-desaturase activity. | 1991 | Biochim. Biophys. Acta | pmid:1674661 |
| Egashira Y et al. | Differential effects of dietary fatty acids on rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase activity and gene expression. | 2004 | Biochim. Biophys. Acta | pmid:15522828 |
| Elmes M et al. | The effect of dietary supplementation with linoleic acid to late gestation ewes on the fatty acid composition of maternal and fetal plasma and tissues and the synthetic capacity of the placenta for 2-series prostaglandins. | 2004 | Biochim. Biophys. Acta | pmid:15522830 |