| MeSH term | MeSH ID | Detail |
|---|---|---|
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ozen T | Investigation of antioxidant properties of Nasturtium officinale (watercress) leaf extracts. | 2009 Mar-Apr | Acta Pol Pharm | pmid:19719054 |
| Torrecilla JS et al. | Self-organizing maps and learning vector quantization networks as tools to identify vegetable oils. | 2009 | J. Agric. Food Chem. | pmid:19267437 |
| Niisuke K et al. | Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesis. | 2009 | J. Lipid Res. | pmid:19244216 |
| Parnas M et al. | Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels. | 2009 | J. Neurosci. | pmid:19244513 |
| Kim MH et al. | Linoleic acid induces mouse embryonic stem cell proliferation via Ca2+/PKC, PI3K/Akt, and MAPKs. | 2009 | Cell. Physiol. Biochem. | pmid:19255500 |
| Takata Y et al. | Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers. | 2009 | Cancer Causes Control | pmid:19255861 |
| Guillén N et al. | Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver. | 2009 | Physiol. Genomics | pmid:19258494 |
| Ishitsuka Y et al. | Effects of bolus injection of soybean-based fat emulsion and fatty acids on pulmonary gas exchange function. | 2009 | Biol. Pharm. Bull. | pmid:19252304 |
| Blask DE et al. | Circadian stage-dependent inhibition of human breast cancer metabolism and growth by the nocturnal melatonin signal: consequences of its disruption by light at night in rats and women. | 2009 | Integr Cancer Ther | pmid:20042410 |
| Yang L et al. | Oxidative stability of conjugated linolenic acids. | 2009 | J. Agric. Food Chem. | pmid:19368396 |
| Angela Liou Y and Innis SM | Dietary linoleic acid has no effect on arachidonic acid, but increases n-6 eicosadienoic acid, and lowers dihomo-gamma-linolenic and eicosapentaenoic acid in plasma of adult men. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19356914 |
| Raz R et al. | The influence of short-chain essential fatty acids on children with attention-deficit/hyperactivity disorder: a double-blind placebo-controlled study. | 2009 | J Child Adolesc Psychopharmacol | pmid:19364294 |
| Inoue N et al. | Linoleic acid-menthyl ester reduces the secretion of apolipoprotein B100 in HepG2 cells. | 2009 | J Oleo Sci | pmid:19282639 |
| Santillo A et al. | Probiotic in lamb rennet paste enhances rennet lipolytic activity, and conjugated linoleic acid and linoleic acid content in Pecorino cheese. | 2009 | J. Dairy Sci. | pmid:19307614 |
| Pandey NR et al. | An induction in hepatic HDL secretion associated with reduced ATPase expression. | 2009 | Am. J. Pathol. | pmid:19717637 |
| Radunz AE et al. | Effects of dietary polyunsaturated fatty acid supplementation on fatty acid composition in muscle and subcutaneous adipose tissue of lambs. | 2009 | J. Anim. Sci. | pmid:19717771 |
| Taylor WA and Hatch GM | Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1). | 2009 | J. Biol. Chem. | pmid:19737925 |
| Iwamoto N et al. | Antioxidative capacities of durum wheat flour and its components on linoleic acid. | 2009 | J Oleo Sci | pmid:19745581 |
| Wecksler AT et al. | Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1. | 2009 | Bioorg. Med. Chem. | pmid:19716306 |
| Du YZ et al. | Preparation and characteristics of linoleic acid-grafted chitosan oligosaccharide micelles as a carrier for doxorubicin. | 2009 | Colloids Surf B Biointerfaces | pmid:19131223 |
| Plaisance V et al. | Role of the transcriptional factor C/EBPbeta in free fatty acid-elicited beta-cell failure. | 2009 | Mol. Cell. Endocrinol. | pmid:19133313 |
| Tan YL and Liu CG | Self-aggregated nanoparticles from linoleic acid modified carboxymethyl chitosan: Synthesis, characterization and application in vitro. | 2009 | Colloids Surf B Biointerfaces | pmid:19124228 |
| Sánchez-Campillo M et al. | Rosmarinic acid, a photo-protective agent against UV and other ionizing radiations. | 2009 | Food Chem. Toxicol. | pmid:19084569 |
| Marina AM et al. | Antioxidant capacity and phenolic acids of virgin coconut oil. | 2009 | Int J Food Sci Nutr | pmid:19115123 |
| Gemeinhardt A et al. | The influence of linoleic and linolenic acid on the activity and intracellular localisation of phospholipase D in COS-1 cells. | 2009 | Biol. Chem. | pmid:19090716 |
| Blask DE | Melatonin, sleep disturbance and cancer risk. | 2009 | Sleep Med Rev | pmid:19095474 |
| Pinho RS et al. | Potential oilseed crops from the semiarid region of northeastern Brazil. | 2009 | Bioresour. Technol. | pmid:19577461 |
| Finn RD et al. | Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. | 2009 | Biochem. J. | pmid:18778245 |
| Sarikurkcu C et al. | Studies on the antioxidant activity of essential oil and different solvent extracts of Vitexagnuscastus L. fruits from Turkey. | 2009 | Food Chem. Toxicol. | pmid:19595732 |
| Hernández ML et al. | Expression analysis identifies FAD2-2 as the olive oleate desaturase gene mainly responsible for the linoleic acid content in virgin olive oil. | 2009 | J. Agric. Food Chem. | pmid:19601663 |
| Deshpande GC et al. | Parenteral lipid emulsions based on olive oil compared with soybean oil in preterm (<28 weeks' gestation) neonates: a randomised controlled trial. | 2009 | J. Pediatr. Gastroenterol. Nutr. | pmid:19644398 |
| Kim JI et al. | Kinetic study of the quenching reaction of singlet oxygen by common synthetic antioxidants (tert-butylhydroxyanisol, tert-di-butylhydroxytoluene, and tert-butylhydroquinone) as compared with alpha-tocopherol. | 2009 | J. Food Sci. | pmid:19646028 |
| Tsuyama S et al. | Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice. | 2009 | Nutr Neurosci | pmid:19622239 |
| Poudel-Tandukar K et al. | Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. | 2009 | Nutr Res | pmid:19628101 |
| Lee OH et al. | Assessment of phenolics-enriched extract and fractions of olive leaves and their antioxidant activities. | 2009 | Bioresour. Technol. | pmid:19608415 |
| Tjonneland A et al. | Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case-control study within a European prospective cohort study. | 2009 | Gut | pmid:19628674 |
| de Groot RH et al. | Age dependence of plasma phospholipid fatty acid levels: potential role of linoleic acid in the age-associated increase in docosahexaenoic acid and eicosapentaenoic acid concentrations. | 2009 | Br. J. Nutr. | pmid:19402937 |
| Daly TJ et al. | Lack of genoprotective effect of phytosterols and conjugated linoleic acids on Caco-2 cells. | 2009 | Food Chem. Toxicol. | pmid:19406198 |
| Grasso EJ and Calderón RO | Urinary bladder membrane permeability differentially induced by membrane lipid composition. | 2009 | Mol. Cell. Biochem. | pmid:19412731 |
| Yasuda M et al. | Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction. | 2009 | Carcinogenesis | pmid:19414503 |
| Celia C et al. | Turbiscan lab expert analysis of the stability of ethosomes and ultradeformable liposomes containing a bilayer fluidizing agent. | 2009 | Colloids Surf B Biointerfaces | pmid:19376689 |
| Evans LM et al. | Dietary stearate reduces human breast cancer metastasis burden in athymic nude mice. | 2009 | Clin. Exp. Metastasis | pmid:19267249 |
| Venegas-Calerón M et al. | Effect of the ferredoxin electron donor on sunflower (Helianthus annuus) desaturases. | 2009 | Plant Physiol. Biochem. | pmid:19342250 |
| Lata M et al. | Whole body protection against lethal ionizing radiation in mice by REC-2001: a semi-purified fraction of Podophyllum hexandrum. | 2009 | Phytomedicine | pmid:17574826 |
| Mimoun M et al. | Increased tissue arachidonic acid and reduced linoleic acid in a mouse model of cystic fibrosis are reversed by supplemental glycerophospholipids enriched in docosahexaenoic acid. | 2009 | J. Nutr. | pmid:19828687 |
| Shimomura H et al. | Steroids mediate resistance to the bactericidal effect of phosphatidylcholines against Helicobacter pylori. | 2009 | FEMS Microbiol. Lett. | pmid:19843309 |
| Chen Q et al. | Generation of fad2 transgenic mice that produce omega-6 fatty acids. | 2009 | Sci. China, C, Life Sci. | pmid:19937203 |
| Luo J et al. | Studies on the antioxidant activity and phenolic compounds of enzyme-assisted water extracts from Du-zhong (Eucommia ulmoides Oliv.) leaves. | 2009 | J Enzyme Inhib Med Chem | pmid:19912062 |
| Higashi-Okai K et al. | Potent antioxidant and radical-scavenging activity of Chenpi--compensatory and cooperative actions of ascorbic acid and citric acid. | 2009 | J. UOEH | pmid:20000005 |
| Grossmann ME et al. | Eleostearic Acid inhibits breast cancer proliferation by means of an oxidation-dependent mechanism. | 2009 | Cancer Prev Res (Phila) | pmid:19789297 |