Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Leukemia D007938 74 associated lipids
Lactose Intolerance D007787 2 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Kidney Diseases D007674 29 associated lipids
Insulin Resistance D007333 99 associated lipids
Inflammation D007249 119 associated lipids
Hypertension, Renal D006977 9 associated lipids
Hypertension D006973 115 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hyperlipidemia, Familial Combined D006950 9 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Heart Failure D006333 36 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Glioma D005910 112 associated lipids
Fatty Liver D005234 48 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Caroprese M et al. Flaxseed supplementation improves fatty acid profile of cow milk. 2010 J. Dairy Sci. pmid:20494167
Wien M et al. Decreasing the linoleic acid to alpha-linolenic acid diet ratio increases eicosapentaenoic acid in erythrocytes in adults. 2010 Lipids pmid:20496049
Maia MR et al. Toxicity of unsaturated fatty acids to the biohydrogenating ruminal bacterium, Butyrivibrio fibrisolvens. 2010 BMC Microbiol. pmid:20167098
Hirai S et al. Loss of sense transgene-induced post-transcriptional gene silencing by sequential introduction of the same transgene sequences in tobacco. 2010 FEBS J. pmid:20180844
Gammill W et al. Comparative study of high-linoleic acid vegetable oils for the production of conjugated linoleic acid. 2010 J. Agric. Food Chem. pmid:20136082
Harris W Omega-6 and omega-3 fatty acids: partners in prevention. 2010 Curr Opin Clin Nutr Metab Care pmid:20145438
Thornhill JA et al. Pathways for the influx of molecules into cercariae of Schistosoma mansoni during skin penetration. 2010 Parasitology pmid:20128942
Dailey MJ et al. Nutrient specific feeding and endocrine effects of jejunal infusions. 2010 Obesity (Silver Spring) pmid:20134410
Combet E et al. Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation. 2010 Rapid Commun. Mass Spectrom. pmid:20112267
Castellanos P et al. Changes in fatty acid profiles in testis and spermatozoa of red deer exposed to metal pollution. 2010 Reprod. Toxicol. pmid:20096347
Coyral-Castel S et al. Effects of unsaturated fatty acids on progesterone secretion and selected protein kinases in goat granulosa cells. 2010 Domest. Anim. Endocrinol. pmid:20097509
Nakamura T et al. Excessive fat restriction might promote the recurrence of colorectal tumors. 2010 Nutr Cancer pmid:20099189
Beevi SS et al. Polyphenolics profile, antioxidant and radical scavenging activity of leaves and stem of Raphanus sativus L. 2010 Plant Foods Hum Nutr pmid:20072818
Privé F et al. Temperature and duration of heating of sunflower oil affect ruminal biohydrogenation of linoleic acid in vitro. 2010 J. Dairy Sci. pmid:20105542
Rodríguez AM et al. Time-course effects of increased fatty acid supply on the expression of genes involved in lipid/glucose metabolism in muscle cells. 2010 Cell. Physiol. Biochem. pmid:20110694
Won JC et al. Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19965780
Dimri M et al. Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells. 2010 Carcinogenesis pmid:19969553
Olveira G et al. Fatty acid supplements improve respiratory, inflammatory and nutritional parameters in adults with cystic fibrosis. 2010 Arch. Bronconeumol. pmid:20045240
Li Y et al. Bone mineral content is positively correlated to n-3 fatty acids in the femur of growing rats. 2010 Br. J. Nutr. pmid:20420751
Kubala L et al. Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation. 2010 Free Radic. Biol. Med. pmid:20156554
Gholivand MB et al. Chemical composition and antioxidant activities of the essential oil and methanol extracts of Psammogeton canescens. 2010 Food Chem. Toxicol. pmid:19748545
Kim BS et al. Effect of surfactant on the production of oxygenated unsaturated fatty acids by Bacillus megaterium ALA2. 2010 N Biotechnol pmid:19748603
Alvaro A et al. Polyunsaturated fatty acids down-regulate in vitro expression of the key intestinal cholesterol absorption protein NPC1L1: no effect of monounsaturated nor saturated fatty acids. 2010 J. Nutr. Biochem. pmid:19443194
Walloschke B et al. Enrichment of RAW264.7 macrophages with essential 18-carbon fatty acids affects both respiratory burst and production of immune modulating cytokines. 2010 J. Nutr. Biochem. pmid:19447017
Huang CB et al. Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms. 2010 Arch. Oral Biol. pmid:20541177
Rodrigues HG et al. Dietary free oleic and linoleic acid enhances neutrophil function and modulates the inflammatory response in rats. 2010 Lipids pmid:20730605
Tel G et al. Chemical composition of the essential oil and hexane extract of Salvia chionantha and their antioxidant and anticholinesterase activities. 2010 Food Chem. Toxicol. pmid:20732375
Aziz AA et al. Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. 2010 Ann. Nutr. Metab. pmid:20714137
Gutiérrez-Correa J Trypanosoma cruzi dihydrolipoamide dehydrogenase as target of reactive metabolites generated by cytochrome c/hydrogen peroxide (or linoleic acid hydroperoxide)/phenol systems. 2010 Free Radic. Res. pmid:20815787
Serhan Z et al. Complete determination of natural site-specific enantio-isotopomeric excesses in linoleic acid using natural abundance deuterium 2D NMR in polypeptide mesophases. 2010 Chem. Commun. (Camb.) pmid:20721385
Bolton B and Halpern BP Orthonasal and retronasal but not oral-cavity-only discrimination of vapor-phase fatty acids. 2010 Chem. Senses pmid:20100787
Lu XF et al. Colorectal cancer cell growth inhibition by linoleic acid is related to fatty acid composition changes. 2010 J Zhejiang Univ Sci B pmid:21121070
Gotoh N et al. Highly unsaturated fatty acid might act as an antioxidant in emulsion system oxidized by azo compound. 2010 J Oleo Sci pmid:21099140
Wu TC et al. Fatty acid composition of Taiwanese human milk. 2010 J Chin Med Assoc pmid:21093826
West SG et al. Effects of diets high in walnuts and flax oil on hemodynamic responses to stress and vascular endothelial function. 2010 J Am Coll Nutr pmid:21677123
Tremblay-Mercier J et al. Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects. 2010 J. Pharmacol. Exp. Ther. pmid:20404010
Marei WF et al. Impact of linoleic acid on bovine oocyte maturation and embryo development. 2010 Reproduction pmid:20215338
Liu S and Han B Differential expression pattern of an acidic 9/13-lipoxygenase in flower opening and senescence and in leaf response to phloem feeders in the tea plant. 2010 BMC Plant Biol. pmid:20969806
Lu X et al. Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction. 2010 Lipids Health Dis pmid:20868498
Khiaosa-Ard R et al. Transfer of linoleic and linolenic acid from feed to milk in cows fed isoenergetic diets differing in proportion and origin of concentrates and roughages. 2010 J. Dairy Res. pmid:20482940
Sahoo PK and Behera P Synthesis and biological screening of some novel amidocarbamate derivatives of ketoprofen. 2010 Eur J Med Chem pmid:20434240
Campoy C et al. [Update of knowledge, recommendations and full consensus about the role of long chain polyunsaturated fatty acids in pregnancy, lactating period and first year of life.Asociación Española de Pediatría. Sociedad Española de Ginecología y Obstetricia. Sociedad Española de Nutrición Comunitaria. Academia Española deNutrición y Ciencias de la Alimentación]. 2010 Med Clin (Barc) pmid:20434734
Goicoechea E and Guillen MD Analysis of hydroperoxides, aldehydes and epoxides by 1H nuclear magnetic resonance in sunflower oil oxidized at 70 and 100 degrees C. 2010 J. Agric. Food Chem. pmid:20438132
Cannata S et al. Effect of visual marbling on sensory properties and quality traits of pork loin. 2010 Meat Sci. pmid:20416803
Macouzet M et al. Genetic and functional aspects of linoleate isomerase in Lactobacillus acidophilus. 2010 Appl. Microbiol. Biotechnol. pmid:20461509
Habermann N et al. Effects of fatty acids on metabolism and cell growth of human colon cell lines of different transformation state. 2009 Sep-Oct Biofactors pmid:19798733
Yu C et al. Overexpression of endoplasmic reticulum omega-3 fatty acid desaturase gene improves chilling tolerance in tomato. 2009 Nov-Dec Plant Physiol. Biochem. pmid:19648018
Kawakami Y et al. Antiproliferative activity of guava leaf extract via inhibition of prostaglandin endoperoxide H synthase isoforms. 2009 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:19457650
Parnas M et al. Linoleic acid inhibits TRP channels with intrinsic voltage sensitivity: Implications on the mechanism of linoleic acid action. 2009 May-Jun Channels (Austin) pmid:19535910
Zeng Z et al. Identification of lactic acid bacterial strains with high conjugated linoleic acid-producing ability from natural sauerkraut fermentations. 2009 May-Jul J. Food Sci. pmid:19490332
Ozen T Investigation of antioxidant properties of Nasturtium officinale (watercress) leaf extracts. 2009 Mar-Apr Acta Pol Pharm pmid:19719054
Parnas M et al. Membrane lipid modulations remove divalent open channel block from TRP-like and NMDA channels. 2009 J. Neurosci. pmid:19244513
Kim MH et al. Linoleic acid induces mouse embryonic stem cell proliferation via Ca2+/PKC, PI3K/Akt, and MAPKs. 2009 Cell. Physiol. Biochem. pmid:19255500
Takata Y et al. Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers. 2009 Cancer Causes Control pmid:19255861
Guillén N et al. Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver. 2009 Physiol. Genomics pmid:19258494
Ishitsuka Y et al. Effects of bolus injection of soybean-based fat emulsion and fatty acids on pulmonary gas exchange function. 2009 Biol. Pharm. Bull. pmid:19252304
Blask DE et al. Circadian stage-dependent inhibition of human breast cancer metabolism and growth by the nocturnal melatonin signal: consequences of its disruption by light at night in rats and women. 2009 Integr Cancer Ther pmid:20042410
Garscha U and Oliw EH Leucine/valine residues direct oxygenation of linoleic acid by (10R)- and (8R)-dioxygenases: expression and site-directed mutagenesis oF (10R)-dioxygenase with epoxyalcohol synthase activity. 2009 J. Biol. Chem. pmid:19289462
Yang L et al. Oxidative stability of conjugated linolenic acids. 2009 J. Agric. Food Chem. pmid:19368396
Angela Liou Y and Innis SM Dietary linoleic acid has no effect on arachidonic acid, but increases n-6 eicosadienoic acid, and lowers dihomo-gamma-linolenic and eicosapentaenoic acid in plasma of adult men. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19356914
Raz R et al. The influence of short-chain essential fatty acids on children with attention-deficit/hyperactivity disorder: a double-blind placebo-controlled study. 2009 J Child Adolesc Psychopharmacol pmid:19364294
Inoue N et al. Linoleic acid-menthyl ester reduces the secretion of apolipoprotein B100 in HepG2 cells. 2009 J Oleo Sci pmid:19282639
Fukuda S et al. Evaluation and characterization of bacterial metabolic dynamics with a novel profiling technique, real-time metabolotyping. 2009 PLoS ONE pmid:19287504
Radunz AE et al. Effects of dietary polyunsaturated fatty acid supplementation on fatty acid composition in muscle and subcutaneous adipose tissue of lambs. 2009 J. Anim. Sci. pmid:19717771
Taylor WA and Hatch GM Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1). 2009 J. Biol. Chem. pmid:19737925
Iwamoto N et al. Antioxidative capacities of durum wheat flour and its components on linoleic acid. 2009 J Oleo Sci pmid:19745581
Li Z et al. Synthesis and biological activity of hydroxylated derivatives of linoleic acid and conjugated linoleic acids. 2009 Chem. Phys. Lipids pmid:19146841
Du YZ et al. Preparation and characteristics of linoleic acid-grafted chitosan oligosaccharide micelles as a carrier for doxorubicin. 2009 Colloids Surf B Biointerfaces pmid:19131223
Plaisance V et al. Role of the transcriptional factor C/EBPbeta in free fatty acid-elicited beta-cell failure. 2009 Mol. Cell. Endocrinol. pmid:19133313
Lee CM et al. SPION-loaded chitosan-linoleic acid nanoparticles to target hepatocytes. 2009 Int J Pharm pmid:19138733
Tan YL and Liu CG Self-aggregated nanoparticles from linoleic acid modified carboxymethyl chitosan: Synthesis, characterization and application in vitro. 2009 Colloids Surf B Biointerfaces pmid:19124228
Sánchez-Campillo M et al. Rosmarinic acid, a photo-protective agent against UV and other ionizing radiations. 2009 Food Chem. Toxicol. pmid:19084569
Marina AM et al. Antioxidant capacity and phenolic acids of virgin coconut oil. 2009 Int J Food Sci Nutr pmid:19115123
Gemeinhardt A et al. The influence of linoleic and linolenic acid on the activity and intracellular localisation of phospholipase D in COS-1 cells. 2009 Biol. Chem. pmid:19090716
Blask DE Melatonin, sleep disturbance and cancer risk. 2009 Sleep Med Rev pmid:19095474
Finn RD et al. Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. 2009 Biochem. J. pmid:18778245
Hernández ML et al. Expression analysis identifies FAD2-2 as the olive oleate desaturase gene mainly responsible for the linoleic acid content in virgin olive oil. 2009 J. Agric. Food Chem. pmid:19601663
Deshpande GC et al. Parenteral lipid emulsions based on olive oil compared with soybean oil in preterm (<28 weeks' gestation) neonates: a randomised controlled trial. 2009 J. Pediatr. Gastroenterol. Nutr. pmid:19644398
Kim JI et al. Kinetic study of the quenching reaction of singlet oxygen by common synthetic antioxidants (tert-butylhydroxyanisol, tert-di-butylhydroxytoluene, and tert-butylhydroquinone) as compared with alpha-tocopherol. 2009 J. Food Sci. pmid:19646028
Tsuyama S et al. Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice. 2009 Nutr Neurosci pmid:19622239
Poudel-Tandukar K et al. Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. 2009 Nutr Res pmid:19628101
Guillén MD and Uriarte PS Contribution to further understanding of the evolution of sunflower oil submitted to frying temperature in a domestic fryer: study by 1H nuclear magnetic resonance. 2009 J. Agric. Food Chem. pmid:19663427
Lee OH et al. Assessment of phenolics-enriched extract and fractions of olive leaves and their antioxidant activities. 2009 Bioresour. Technol. pmid:19608415
Tjonneland A et al. Linoleic acid, a dietary n-6 polyunsaturated fatty acid, and the aetiology of ulcerative colitis: a nested case-control study within a European prospective cohort study. 2009 Gut pmid:19628674
de Groot RH et al. Age dependence of plasma phospholipid fatty acid levels: potential role of linoleic acid in the age-associated increase in docosahexaenoic acid and eicosapentaenoic acid concentrations. 2009 Br. J. Nutr. pmid:19402937
Daly TJ et al. Lack of genoprotective effect of phytosterols and conjugated linoleic acids on Caco-2 cells. 2009 Food Chem. Toxicol. pmid:19406198
Lux CA et al. Hypersusceptibility of neutrophil granulocytes towards lethal action of free fatty acids contained in enzyme-modified atherogenic low density lipoprotein. 2009 Atherosclerosis pmid:19423111
Hamel FG Preliminary report: inhibition of cellular proteasome activity by free fatty acids. 2009 Metab. Clin. Exp. pmid:19423142
Grasso EJ and Calderón RO Urinary bladder membrane permeability differentially induced by membrane lipid composition. 2009 Mol. Cell. Biochem. pmid:19412731
Yasuda M et al. Linoleic acid metabolite suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction. 2009 Carcinogenesis pmid:19414503
Celia C et al. Turbiscan lab expert analysis of the stability of ethosomes and ultradeformable liposomes containing a bilayer fluidizing agent. 2009 Colloids Surf B Biointerfaces pmid:19376689
Evans LM et al. Dietary stearate reduces human breast cancer metastasis burden in athymic nude mice. 2009 Clin. Exp. Metastasis pmid:19267249
Venegas-Calerón M et al. Effect of the ferredoxin electron donor on sunflower (Helianthus annuus) desaturases. 2009 Plant Physiol. Biochem. pmid:19342250
Lata M et al. Whole body protection against lethal ionizing radiation in mice by REC-2001: a semi-purified fraction of Podophyllum hexandrum. 2009 Phytomedicine pmid:17574826
Mimoun M et al. Increased tissue arachidonic acid and reduced linoleic acid in a mouse model of cystic fibrosis are reversed by supplemental glycerophospholipids enriched in docosahexaenoic acid. 2009 J. Nutr. pmid:19828687
Shimomura H et al. Steroids mediate resistance to the bactericidal effect of phosphatidylcholines against Helicobacter pylori. 2009 FEMS Microbiol. Lett. pmid:19843309
Chen Q et al. Generation of fad2 transgenic mice that produce omega-6 fatty acids. 2009 Sci. China, C, Life Sci. pmid:19937203
Luo J et al. Studies on the antioxidant activity and phenolic compounds of enzyme-assisted water extracts from Du-zhong (Eucommia ulmoides Oliv.) leaves. 2009 J Enzyme Inhib Med Chem pmid:19912062
Higashi-Okai K et al. Potent antioxidant and radical-scavenging activity of Chenpi--compensatory and cooperative actions of ascorbic acid and citric acid. 2009 J. UOEH pmid:20000005
Grossmann ME et al. Eleostearic Acid inhibits breast cancer proliferation by means of an oxidation-dependent mechanism. 2009 Cancer Prev Res (Phila) pmid:19789297