Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
There are no associated biomedical information in the current reference collection.
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Alzate A et al. | Preeclampsia prevention: a case-control study nested in a cohort. | 2015 | Colomb. Med. | pmid:26848195 |
Alvarruiz A et al. | Quality and Composition of Virgin Olive Oil from Varietties Grown in Castilla-La Mancha (Spain). | 2015 | J Oleo Sci | pmid:26369595 |
Frenzel E et al. | α1-Antitrypsin Combines with Plasma Fatty Acids and Induces Angiopoietin-like Protein 4 Expression. | 2015 | J. Immunol. | pmid:26363050 |
Lee CW et al. | Structural basis for the ligand-binding specificity of fatty acid-binding proteins (pFABP4 and pFABP5) in gentoo penguin. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26206084 |
Mizuta K et al. | Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26342087 |
Lands B | Omega-3 PUFAs Lower the Propensity for Arachidonic Acid Cascade Overreactions. | 2015 | Biomed Res Int | pmid:26301244 |
He J et al. | Correlation of polyunsaturated fatty acids with the cold adaptation of Rhodotorula glutinis. | 2015 | Yeast | pmid:26284451 |
Valenzuela R et al. | Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who Received Alpha Linolenic Acid from Chia Oil during Gestation and Nursing. | 2015 | Nutrients | pmid:26247968 |
Tucker RM et al. | No Difference in Perceived Intensity of Linoleic Acid in the Oral Cavity between Obese and Nonobese Individuals. | 2015 | Chem. Senses | pmid:26232811 |
Evans SJ et al. | Plasma linoleic acid partially mediates the association of bipolar disorder on self-reported mental health scales. | 2015 | J Psychiatr Res | pmid:26228402 |
Min JS et al. | Monitoring the formation of cholesterol oxidation products in model systems using response surface methodology. | 2015 | Lipids Health Dis | pmid:26201850 |
Farvid MS et al. | Response to Letters Regarding Article, "Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies". | 2015 | Circulation | pmid:26195494 |
Lucas M | Letter by Lucas Regarding Articles, "Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies" and "Circulating Omega-6 Polyunsaturated Fatty Acids and Total and Cause-Specific Mortality: The Cardiovascular Health Study". | 2015 | Circulation | pmid:26195492 |
Negrini R et al. | pH-responsive lyotropic liquid crystals and their potential therapeutic role in cancer treatment. | 2015 | Chem. Commun. (Camb.) | pmid:25783035 |
Fajardo VA et al. | Cardiolipin linoleic acid content and mitochondrial cytochrome c oxidase activity are associated in rat skeletal muscle. | 2015 | Chem. Phys. Lipids | pmid:25727371 |
Xing J et al. | Determining antioxidant activities of lactobacilli cell-free supernatants by cellular antioxidant assay: a comparison with traditional methods. | 2015 | PLoS ONE | pmid:25789875 |
Saccenti E et al. | Strategies for individual phenotyping of linoleic and arachidonic acid metabolism using an oral glucose tolerance test. | 2015 | PLoS ONE | pmid:25786212 |
Yoshida Y et al. | Chemistry of lipid peroxidation products and their use as biomarkers in early detection of diseases. | 2015 | J Oleo Sci | pmid:25766928 |
Ciepiela P et al. | Arachidonic and linoleic acid derivatives impact oocyte ICSI fertilization--a prospective analysis of follicular fluid and a matched oocyte in a 'one follicle--one retrieved oocyte--one resulting embryo' investigational setting. | 2015 | PLoS ONE | pmid:25763593 |
Hernandez LR et al. | Effect of plant growth regulators on fatty acids composition in Jatropha curcas L. callus culture. | 2015 | J Oleo Sci | pmid:25757437 |
Kotani K et al. | Enzymatic preparation of human milk fat substitutes and their oxidation stability. | 2015 | J Oleo Sci | pmid:25757431 |
Hashim RB et al. | Fatty acid compositions of silver catfish, Pangasius sp. farmed in several rivers of Pahang, Malaysia. | 2015 | J Oleo Sci | pmid:25748380 |
Chang TS et al. | Palm oil derived trimethylolpropane triesters synthetic lubricants and usage in industrial metalworking fluid. | 2015 | J Oleo Sci | pmid:25748374 |
Askari M et al. | Tissue fatty acid composition and secretory phospholipase-A2 activity in oral squamous cell carcinoma. | 2015 | Clin Transl Oncol | pmid:25351172 |
Tyurina YY et al. | LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease. | 2015 | Free Radic. Res. | pmid:25740198 |
Wang S et al. | Plasma nutrient biomarkers are associated with waist-to-height ratio in youth with type 1 diabetes. | 2015 | J. Nutr. | pmid:25733475 |
Nardi F et al. | Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability. | 2015 | J. Biol. Chem. | pmid:25653282 |
Clouard C et al. | Dietary linoleic and α-linolenic acids affect anxiety-related responses and exploratory activity in growing pigs. | 2015 | J. Nutr. | pmid:25644359 |
Fala AM et al. | Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α. | 2015 | Sci Rep | pmid:26237540 |
Kim SY et al. | Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K/Akt pathway. | 2015 | Int. J. Mol. Med. | pmid:25672876 |
Beam J et al. | Excess Linoleic Acid Increases Collagen I/III Ratio and "Stiffens" the Heart Muscle Following High Fat Diets. | 2015 | J. Biol. Chem. | pmid:26240151 |
Okazaki H et al. | Bongkrekic acid as a selective activator of the peroxisome proliferator-activated receptor γ (PPARγ) isoform. | 2015 | J Toxicol Sci | pmid:25786526 |
Salazar MO et al. | A thin-layer chromatography autographic method for the detection of inhibitors of the Salmonella PhoP-PhoQ regulatory system. | 2014 Mar-Apr | Phytochem Anal | pmid:24185747 |
Petrogianni M et al. | Additional benefit in CVD risk indices derived from the consumption of fortified milk when combined with a lifestyle intervention. | 2014 | Public Health Nutr | pmid:23249766 |
Huang X et al. | Serum and adipose tissue fatty acid composition as biomarkers of habitual dietary fat intake in elderly men with chronic kidney disease. | 2014 | Nephrol. Dial. Transplant. | pmid:23229929 |
Bagai S et al. | Lipid-modified polyethylenimine-mediated DNA attraction evaluated by molecular dynamics simulations. | 2014 | J Phys Chem B | pmid:24918771 |
Hellstrand S et al. | Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease. | 2014 | J. Nutr. | pmid:25008580 |
Hester AG et al. | Relationship between a common variant in the fatty acid desaturase (FADS) cluster and eicosanoid generation in humans. | 2014 | J. Biol. Chem. | pmid:24962583 |
Evans SJ et al. | Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism. | 2014 | J Psychiatr Res | pmid:24953860 |
Verlotta A and Trono D | Expression, purification and refolding of active durum wheat (Triticum durum Desf.) secretory phospholipase A2 from inclusion bodies of Escherichia coli. | 2014 | Protein Expr. Purif. | pmid:24925645 |
Kim JY et al. | Role of moisture on the lipid oxidation determined by D(2)O in a linoleic acid model system. | 2014 | Food Chem | pmid:24176324 |
Sponton OE et al. | Effect of limited enzymatic hydrolysis on linoleic acid binding properties of β-lactoglobulin. | 2014 | Food Chem | pmid:24176383 |
Su MH et al. | Chemical composition of seed oils in native Taiwanese Camellia species. | 2014 | Food Chem | pmid:24629982 |
Bakır T et al. | Antioxidant/prooxidant effects of α-tocopherol, quercetin and isorhamnetin on linoleic acid peroxidation induced by Cu(II) and H2O2. | 2014 | Int J Food Sci Nutr | pmid:24152374 |
Yang Y et al. | Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species. | 2014 | Lipids | pmid:24777581 |
Dailey MJ et al. | Nutrient-specific feeding and endocrine effects of jejunal infusions in obese animals. | 2014 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:24452547 |
Shen J et al. | A 13-lipoxygenase, TomloxC, is essential for synthesis of C5 flavour volatiles in tomato. | 2014 | J. Exp. Bot. | pmid:24453226 |
Mulligan CM et al. | Inhibition of delta-6 desaturase reverses cardiolipin remodeling and prevents contractile dysfunction in the aged mouse heart without altering mitochondrial respiratory function. | 2014 | J. Gerontol. A Biol. Sci. Med. Sci. | pmid:24418793 |
Oh YT et al. | Regulation of hypothalamic-pituitary-adrenal axis by circulating free fatty acids in male Wistar rats: role of individual free fatty acids. | 2014 | Endocrinology | pmid:24424035 |
Hall TD et al. | Changes during leaf expansion of ΦPSII temperature optima in Gossypium hirsutum are associated with the degree of fatty acid lipid saturation. | 2014 | J. Plant Physiol. | pmid:24594393 |