Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Prostatic Neoplasms D011471 126 associated lipids
Kidney Diseases D007674 29 associated lipids
Weight Gain D015430 101 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Bjerve KS et al. Alpha-linolenic acid deficiency in man: effect of ethyl linolenate on plasma and erythrocyte fatty acid composition and biosynthesis of prostanoids. 1987 Am. J. Clin. Nutr. pmid:3310599
KRAUSE RF LIVER LIPIDS IN A CASE OF HYPERVITAMINOSIS A. 1965 Am. J. Clin. Nutr. pmid:14301352
Turpeinen AM et al. Bioconversion of vaccenic acid to conjugated linoleic acid in humans. 2002 Am. J. Clin. Nutr. pmid:12197992
DeLany JP et al. Differential oxidation of individual dietary fatty acids in humans. 2000 Am. J. Clin. Nutr. pmid:11010930
Martin JC et al. Essential fatty acid composition of human colostrum triglycerides: its relationship with adipose tissue composition. 1991 Am. J. Clin. Nutr. pmid:1951153
HOLMAN RT et al. ESTIMATION OF LINOLEATE INTAKE OF MEN FROM SERUM LIPID ANALYSIS. 1964 Am. J. Clin. Nutr. pmid:14142377
Rudel LL et al. Dietary polyunsaturated fat modifies low-density lipoproteins and reduces atherosclerosis of nonhuman primates with high and low diet responsiveness. 1995 Am. J. Clin. Nutr. pmid:7625361
Reeves VB et al. Variations in plasma fatty acid concentrations during a one-year self-selected dietary intake study. 1984 Am. J. Clin. Nutr. pmid:6507356
Gibson RA and Makrides M n-3 polyunsaturated fatty acid requirements of term infants. 2000 Am. J. Clin. Nutr. pmid:10617980
Crawford M Placental delivery of arachidonic and docosahexaenoic acids: implications for the lipid nutrition of preterm infants. 2000 Am. J. Clin. Nutr. pmid:10617983
Dutta-Roy AK Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. 2000 Am. J. Clin. Nutr. pmid:10617989
Blair IA et al. Dietary modification of omega 6 fatty acid intake and its effect on urinary eicosanoid excretion. 1993 Am. J. Clin. Nutr. pmid:8424383
Ziboh VA et al. Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. 2000 Am. J. Clin. Nutr. pmid:10617998
Kalivianakis M et al. Fat malabsorption in cystic fibrosis patients receiving enzyme replacement therapy is due to impaired intestinal uptake of long-chain fatty acids. 1999 Am. J. Clin. Nutr. pmid:9925134
Andersen LF et al. Evaluation of a food frequency questionnaire with weighed records, fatty acids, and alpha-tocopherol in adipose tissue and serum. 1999 Am. J. Epidemiol. pmid:10400557
Brosnan MJ and Carkner RD Hepatic effects of a fructose diet in the stroke-prone spontaneously hypertensive rat. 2008 Am. J. Hypertens. pmid:18437120
Taylor EN et al. Fatty acid intake and incident nephrolithiasis. 2005 Am. J. Kidney Dis. pmid:15685503
Ascherio A Epidemiologic studies on dietary fats and coronary heart disease. 2002 Am. J. Med. pmid:12566133
Weiss LA et al. The omega-6 fatty acid linoleic acid is associated with risk of gastroschisis: a novel dietary risk factor. 2012 Am. J. Med. Genet. A pmid:22315197
SCHWARTZ S et al. LIPID THROMBOPLASTINS AND MYOCARDIAL INFARCTION. 1965 Am. J. Med. Sci. pmid:14254823
Brush MG et al. Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. 1984 Am. J. Obstet. Gynecol. pmid:6091462
Kääpä P et al. Dietary fatty acids and platelet thromboxane production in puerperal women and their offspring. 1986 Am. J. Obstet. Gynecol. pmid:3089014
MacKenzie LW et al. Prostacyclin biosynthesis by cultured human myometrial smooth muscle cells: dependency on arachidonic or linoleic acid in the culture medium. 1988 Am. J. Obstet. Gynecol. pmid:3144917
Vaughan JE and Walsh SW Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-alpha in response to linoleic acid and oxidative stress. 2005 Am. J. Obstet. Gynecol. pmid:16150282
Liu H et al. Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease. 2015 Am. J. Pathol. pmid:25447051
McEntee MF et al. Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer. 2008 Am. J. Pathol. pmid:18556778
Pandey NR et al. An induction in hepatic HDL secretion associated with reduced ATPase expression. 2009 Am. J. Pathol. pmid:19717637
Thomson AB et al. A high linoleic acid diet diminishes enhanced intestinal uptake of sugars in diabetic rats. 1987 Am. J. Physiol. pmid:3826353
Düsing R et al. Dietary linoleic acid deprivation: effects on blood pressure and PGI2 synthesis. 1983 Am. J. Physiol. pmid:6337507
Murray MJ et al. Effects of endotoxin on pigs prefed omega-3 vs. omega-6 fatty acid-enriched diets. 1993 Am. J. Physiol. pmid:8279548
Sarel I and Widmaier EP Stimulation of steroidogenesis in cultured rat adrenocortical cells by unsaturated fatty acids. 1995 Am. J. Physiol. pmid:7611525
West DB et al. Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. 1998 Am. J. Physiol. pmid:9728060
GOLD M and SPITZER JJ METABOLISM OF FREE FATTY ACIDS BY MYOCARDIUM AND KIDNEY. 1964 Am. J. Physiol. pmid:14111431
SPITZER JJ and GOLD M FREE FATTY ACID METABOLISM BY SKELETAL MUSCLE. 1964 Am. J. Physiol. pmid:14111432
ERWIN ES and STERNER W DIETARY LIPIDS AND FATTY ACID DEPOSITION IN VARIOUS CALF TISSUES. 1963 Am. J. Physiol. pmid:14084975
Emmison N et al. Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. 1995 Am. J. Physiol. pmid:7631907
Thomas ME et al. Metabolic effects of fatty acid-bearing albumin on a proximal tubule cell line. 1995 Am. J. Physiol. pmid:7611458
Spalinger JH et al. Uptake and metabolism of structured triglyceride by Caco-2 cells: reversal of essential fatty acid deficiency. 1998 Am. J. Physiol. pmid:9756493
Chen ZY et al. Depletion of linoleate induced by weight cycling is independent of extent of calorie restriction. 1997 Am. J. Physiol. pmid:9038989
Reddy SR et al. Effect of linoleic acid infusion on blood pressure in normotensive and hypertensive rats. 1989 Am. J. Physiol. pmid:2764141
Le Petit-Thevenin J et al. Changes in pattern of phospholipid acylation during in vivo aging of rat red blood cells. 1991 Am. J. Physiol. pmid:1887869
Bogdanov KY et al. Modulation of the transient outward current in adult rat ventricular myocytes by polyunsaturated fatty acids. 1998 Am. J. Physiol. pmid:9486261
Aw TY et al. Absorption and lymphatic transport of peroxidized lipids by rat small intestine in vivo: role of mucosal GSH. 1992 Am. J. Physiol. pmid:1733274
Liu F et al. Permeability properties of monolayers of the human trophoblast cell line BeWo. 1997 Am. J. Physiol. pmid:9374645
Guidot DM et al. Modulating phosphatidic acid metabolism decreases oxidative injury in rat lungs. 1997 Am. J. Physiol. pmid:9374722
Devor DC and Frizzell RA Modulation of K+ channels by arachidonic acid in T84 cells. II. Activation of a Ca(2+)-independent K+ channel. 1998 Am. J. Physiol. pmid:9458723
Shasby DM et al. Oxidants and conductance of cultured epithelial cell monolayers: inositol phospholipid hydrolysis. 1988 Am. J. Physiol. pmid:3144179
Meyer C et al. Human kidney free fatty acid and glucose uptake: evidence for a renal glucose-fatty acid cycle. 1997 Am. J. Physiol. pmid:9316458
Sebokova E et al. Modulation of receptor-mediated gonadotropin action in rat testes by dietary fat. 1988 Am. J. Physiol. pmid:2897795
Ookhtens M and Baker N Incomplete free fatty acid oxidation by ascites tumor cells under low oxygen tension. 1983 Am. J. Physiol. pmid:6295191