Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Prostatic Neoplasms D011471 126 associated lipids
Kidney Diseases D007674 29 associated lipids
Weight Gain D015430 101 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Thrombosis D013927 49 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Nanji AA and Narod S Multiple sclerosis, latitude and dietary fat: is pork the missing link? 1986 Med. Hypotheses pmid:3638477
Melton JL et al. Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs. 1987 Biochim. Biophys. Acta pmid:3651483
Kaneko T et al. Lethal effects of a linoleic acid hydroperoxide and its autoxidation products, unsaturated aliphatic aldehydes, on human diploid fibroblasts. 1987 Chem. Biol. Interact. pmid:3664790
Heifets M et al. Effect of dietary lipids on renal function in rats with subtotal nephrectomy. 1987 Kidney Int. pmid:3669493
Loscalzo J et al. Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. 1987 Sep-Oct Arteriosclerosis pmid:3675304
Hubbard NE and Erickson KL Enhancement of metastasis from a transplantable mouse mammary tumor by dietary linoleic acid. 1987 Cancer Res. pmid:3677068
Hachey DL et al. Human lactation: maternal transfer of dietary triglycerides labeled with stable isotopes. 1987 J. Lipid Res. pmid:3681142
Fisher M et al. Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients. 1987 Acta Neurol. Scand. pmid:3687373
Ashida H et al. Effect of orally administered secondary autoxidation products of linoleic acid on carbohydrate metabolism in rat liver. 1987 Arch. Biochem. Biophys. pmid:3688880
Okabe H et al. Effects of anti-convulsants on fatty acid metabolism in human serum. 1986 Tohoku J. Exp. Med. pmid:3705068
Wertz PW and Downing DT Linoleate content of epidermal acylglucosylceramide in newborn, growing and mature mice. 1986 Biochim. Biophys. Acta pmid:3707979
Hajarine M and Lagarde M Studies on polyenoic acid incorporation into human platelet lipid stores: interactions with linoleic and arachidonic acids. 1986 Biochim. Biophys. Acta pmid:3719006
Awad AB and Chattopadhyay JP Effect of dietary saturated fatty acids on intracellular free fatty acids and kinetic properties of hormone-sensitive lipase of rat adipocytes. 1986 J. Nutr. pmid:3723204
Hennig B et al. Linoleic acid hydroperoxide increases the transfer of albumin across cultured endothelial monolayers. 1986 Arch. Biochem. Biophys. pmid:3729421
Parsons HG et al. Modulation of human erythrocyte shape and fatty acids by diet. 1986 Biochim. Biophys. Acta pmid:3741859
Kanazawa K et al. The effect of orally administered secondary autoxidation products of linoleic acid on the activity of detoxifying enzymes in the rat liver. 1986 Biochim. Biophys. Acta pmid:3768385
Feingold KR et al. Effect of essential fatty acid deficiency on cutaneous sterol synthesis. 1986 J. Invest. Dermatol. pmid:3772153
Jensen GE and Clausen J Glutathione peroxidase activity, associated enzymes and substrates in blood cells from patients with multiple sclerosis--effects of antioxidant supplementation. 1986 Acta Pharmacol Toxicol (Copenh) pmid:3776606
Willett WC et al. Dietary fat and the risk of breast cancer. 1987 N. Engl. J. Med. pmid:3785347
Jensen E et al. Cell-density-dependent uptake of chylomicron remnants in rat hepatocyte monolayers. Effects of compactin and mevalonic acid. 1987 Biochim. Biophys. Acta pmid:3790613
Lee SH and Clandinin MT Effect of dietary fat on the utilization of fatty acids by myocardial tissue in the rat. 1986 J. Nutr. pmid:3794820
Utermohlen V and Tucker MA Possible effects of dietary n-6 series polyunsaturated fatty acids on the development of immune dysfunction and infection. 1986 Proc Nutr Soc pmid:3797410
Tilvis RS et al. Serum lipids and fatty acids in ischemic strokes. 1987 Am. Heart J. pmid:3812213
Thomson AB et al. A high linoleic acid diet diminishes enhanced intestinal uptake of sugars in diabetic rats. 1987 Am. J. Physiol. pmid:3826353
Simpson RJ and Peters TJ Transport of Fe2+ across lipid bilayers: possible role of free fatty acids. 1987 Biochim. Biophys. Acta pmid:3828339
Burton AF and Anderson FH Increased cholesteryl ester content in liver of mice fed lipid emulsion diets high in polyunsaturated fats. 1985 Jul-Aug JPEN J Parenter Enteral Nutr pmid:3839859
Calderbank J et al. Plasma-membrane phospholipid unsaturation affects expression of the general amino-acid permease in Saccharomyces cerevisiae Y185. 1985 J. Gen. Microbiol. pmid:3886834
Margetts BM et al. Blood pressure and dietary polyunsaturated and saturated fats: a controlled trial. 1985 Clin. Sci. pmid:3905211
Fusco AC et al. Schistosoma mansoni: eicosanoid production by cercariae. 1985 Exp. Parasitol. pmid:3917929
Farrell PM et al. Fatty acid abnormalities in cystic fibrosis. 1985 Pediatr. Res. pmid:3918287
Boberg M et al. Platelet fatty acid composition in relation to fatty acid composition in plasma and to serum lipoprotein lipids in healthy subjects with special reference to the linoleic acid pathway. 1985 Clin. Sci. pmid:3919990
Ip C et al. Requirement of essential fatty acid for mammary tumorigenesis in the rat. 1985 Cancer Res. pmid:3921234
Charnock JS et al. Changes in fatty acid composition of the cardiac phospholipids of the cotton-eared marmoset (Callithrix jacchus) after feeding different lipid supplements. 1985 Ann. Nutr. Metab. pmid:3922279
Hansen HS and Jensen B Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate. 1985 Biochim. Biophys. Acta pmid:3922424
Nugteren DH et al. Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat. 1985 Biochim. Biophys. Acta pmid:3922425
Isseroff RR et al. Alterations in fatty acid composition of murine keratinocytes with in vitro cultivation. 1985 J. Invest. Dermatol. pmid:3926903
Cooke RJ et al. Safflower oil emulsion administration during parenteral nutrition in the preterm infant. 1. Effect on essential fatty acid status. 1985 J. Pediatr. Gastroenterol. Nutr. pmid:3930688
Jones PJ et al. Whole body oxidation of dietary fatty acids: implications for energy utilization. 1985 Am. J. Clin. Nutr. pmid:3933323
Salzmann-Reinhardt U et al. Metabolism of polyunsaturated fatty acids by rabbit reticulocytes. 1985 Eur. J. Biochem. pmid:3933978
Buchanan MR et al. 13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX. 1985 J. Biol. Chem. pmid:3934168
Andersen GE et al. Fatty acid changes in plasma lipids and lymphocyte phospholipids after infusion of intralipid to newborn infants. 1985 Nov-Dec JPEN J Parenter Enteral Nutr pmid:3934403
Youyou A et al. Recovery of altered fatty acid composition induced by a diet devoid of n-3 fatty acids in myelin, synaptosomes, mitochondria, and microsomes of developing rat brain. 1986 J. Neurochem. pmid:3940283
Nijssen JG and van den Bosch H Cytosol-stimulated remodeling of phosphatidylcholine in rat lung microsomes. 1986 Biochim. Biophys. Acta pmid:3947653
Kryvi H et al. Effects of essential fatty acid deficiency on mitochondria and peroxisomes in rat hepatocytes with special reference to a partially hydrogenated fish oil diet. 1986 Biochim. Biophys. Acta pmid:3947675
De Villiers M and Lochner A Mitochondrial Ca2+ fluxes: role of free fatty acids, acyl-CoA and acylcarnitine. 1986 Biochim. Biophys. Acta pmid:3955069
Fressinaud C et al. Fatty acid composition of endoneurium and perineurium from adult rat sciatic nerve. 1986 J. Neurochem. pmid:3958717
Kort WJ et al. Influence of the linoleic acid content of the diet on tumor growth in transplantable rat tumor models. 1986 Ann. Nutr. Metab. pmid:3963748
Howard-Williams J et al. Polyunsaturated fatty acids and diabetic retinopathy. 1985 Br J Ophthalmol pmid:3965024
Montalto MB et al. Nutrient intakes of formula-fed infants and infants fed cow's milk. 1985 Pediatrics pmid:3969338
Reid JC and Husbands DR Oxidative metabolism of long-chain fatty acids in mitochondria from sheep and rat liver. Evidence that sheep conserve linoleate by limiting its oxidation. 1985 Biochem. J. pmid:3977825
Canfield LM et al. Anti-oxidant/pro-oxidant reactions of vitamin K. 1985 Biochem. Biophys. Res. Commun. pmid:3985964
Válek J et al. Serum linoleic acid and cardiovascular death in postinfarction middle-aged men. 1985 Atherosclerosis pmid:3994777
Tsuchida M et al. Fluorescent substances in mouse and human sera as a parameter of in vivo lipid peroxidation. 1985 Biochim. Biophys. Acta pmid:3995061
Bowser PA et al. Identification, isolation and characterization of epidermal lipids containing linoleic acid. 1985 Biochim. Biophys. Acta pmid:3995076
Demant EJ and Wassermann K Doxorubicin induced alterations in lipid metabolism of cultured myocardial cells. 1985 Biochem. Pharmacol. pmid:4004891
Robinson M et al. Acylation of lysophospholipids by rabbit alveolar macrophages. Specificities of CoA-dependent and CoA-independent reactions. 1985 J. Biol. Chem. pmid:4008481
Jett M et al. Metabolic fate of liposomal phosphatidylinositol in murine tumor cells: implications for the mechanism of tumor cell cytotoxicity. 1985 Cancer Res. pmid:4027970
Roshanai F and Sanders TA Influence of different supplements of N-3 polyunsaturated fatty acids on blood and tissue lipids in rats receiving high intakes of linoleic acid. 1985 Ann. Nutr. Metab. pmid:4037727
Becker W and MÃ¥nsson JE Incorporation of 14C into tissue lipids after oral administration of [1-14C]linoleic acid in rats fed different levels of essential fatty acids. 1985 J. Nutr. pmid:4045568
Charnock JS et al. Altered levels of n-6/n-3 fatty acids in rat heart and storage fat following variable dietary intake of linoleic acid. 1985 Ann. Nutr. Metab. pmid:4051450
Charnock JS et al. Diet and cardiac arrhythmia: effects of lipids on age-related changes in myocardial function in the rat. 1985 Ann. Nutr. Metab. pmid:4051452
Takahashi K et al. Ester-exchange catalyzed by lipase modified with polyethylene glycol. 1985 Biochem. Biophys. Res. Commun. pmid:4052065
Hennig B et al. Exposure to fatty acid increases human low density lipoprotein transfer across cultured endothelial monolayers. 1985 Circ. Res. pmid:4053308
Barclay LR et al. The antioxidant activity of alpha-tocopherol-bovine serum albumin complex in micellar and liposome autoxidations. 1985 J. Biol. Chem. pmid:4066696
Potter LM and McCarthy JP Varying fat and protein in diets of growing large white turkeys. 1985 Poult. Sci. pmid:4070128
Clark DL and Queener SF Effects of diabetes mellitus on renal fatty acid activation and desaturation. 1985 Biochem. Pharmacol. pmid:4074391
Giamalva D et al. A comparison of the rates of ozonation of biological antioxidants and oleate and linoleate esters. 1985 Biochem. Biophys. Res. Commun. pmid:4084297
Kabara JJ et al. Fatty acids and derivatives as antimicrobial agents. 1972 Antimicrob. Agents Chemother. pmid:4670656
Yorek MA et al. Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells. 1984 Biochim. Biophys. Acta pmid:6089899
Furukawa M et al. Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. 1984 Biochim. Biophys. Acta pmid:6089906
Curnutte JT et al. Studies on the mechanism of superoxide release from human neutrophils stimulated with arachidonate. 1984 J. Biol. Chem. pmid:6090448
Brush MG et al. Abnormal essential fatty acid levels in plasma of women with premenstrual syndrome. 1984 Am. J. Obstet. Gynecol. pmid:6091462
Hagve TA and Christophersen BO Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells. 1984 Biochim. Biophys. Acta pmid:6093889
Codde JP et al. Dissociation of effects of dietary fatty acids on blood pressure and prostanoid metabolism in Goldblatt hypertensive rats. 1984 J. Hypertens. pmid:6099384
Chen TC et al. Modulation of 1,25-dihydroxyvitamin D3 receptor by phospholipids and fatty acids. 1984 J. Lipid Res. pmid:6099395
Frankel EN Chemistry of free radical and singlet oxidation of lipids. 1984 Prog. Lipid Res. pmid:6100997
Volpe JJ and Obert KA Coordinate regulation of cholesterol synthesis and 3-hydroxy-3-methylglutaryl coenzyme A synthase but not 3-hydroxy-3-methylglutaryl coenzyme A reductase in C-6 glia. 1981 Arch. Biochem. Biophys. pmid:6118099
Cheah AM Effect of long chain unsaturated fatty acids on the calcium transport of sarcoplasmic reticulum. 1981 Biochim. Biophys. Acta pmid:6118177
Hoelgaard A and Møllgaard B Permeation of linoleic acid through skin in vitro. 1982 J. Pharm. Pharmacol. pmid:6127396
Enser M and Roberts JL The regulation of hepatic stearoyl-coenzyme A desaturase in obese-hyperglycaemic (ob/ob) mice by food intake and the fatty acid composition of the diet. 1982 Biochem. J. pmid:6128973
Gerzer R et al. Calcium-induced release from platelet membranes of fatty acids that modulate soluble guanylate cyclase. 1983 J. Pharmacol. Exp. Ther. pmid:6134818
Wood DA et al. Adipose tissue and platelet fatty acids and coronary heart disease in Scottish men. 1984 Lancet pmid:6146032
Goldmacher VS Immobilization of protein molecules on liposomes. Anchorage by artificially bound unsaturated hydrocarbon tails. 1983 Biochem. Pharmacol. pmid:6189496
Van Alstine JM and Brooks DE Cell membrane abnormality detected in erythrocytes from patients with multiple sclerosis by partition in two-polymer aqueous-phase systems. 1984 Clin. Chem. pmid:6199135
Mitranic MM et al. The effect of linoleic acid and benzyl alcohol on the activity of glycosyltransferases of rat liver Golgi membranes and some soluble glycosyltransferases. 1982 Biochim. Biophys. Acta pmid:6217837
Hoover RL et al. Role of cholesterol in the capping of surface immunoglobulin receptors on murine lymphocytes. 1983 J. Cell Biol. pmid:6223042
Sanders TA et al. The influence of a maternal diet rich in linoleic acid on brain and retinal docosahexaenoic acid in the rat. 1984 Br. J. Nutr. pmid:6228249
Breton M et al. Linoleate incorporation into rat liver membranes phospholipids: effect on plasma membrane ATPase activities and physical properties. 1983 Biochem. Biophys. Res. Commun. pmid:6230079
Benaim G et al. Different conformational states of the purified Ca2+-ATPase of the erythrocyte plasma membrane revealed by controlled trypsin proteolysis. 1984 J. Biol. Chem. pmid:6234313
Gavigan SJ and Knight BL Catabolism of low-density lipoprotein by fibroblasts cultured in medium supplemented with saturated or unsaturated free fatty acids. 1981 Biochim. Biophys. Acta pmid:6271233
Bonacossa A et al. Effect of corticosterone, hydrocortisone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats. 1982 Prostaglandins pmid:6278538
Huang YS et al. Most biological effects of zinc deficiency corrected by gamma-linolenic acid (18: 3 omega 6) but not by linoleic acid (18: 2 omega 6). 1982 Atherosclerosis pmid:6279122
De Schrijver R and Privett OS Effects of dietary long-chain fatty acids on the rat biosynthesis of unsaturated fatty acids in the rat. 1982 J. Nutr. pmid:6279803
Sutherland MW and Gebicki JM A reaction between the superoxide free radical and lipid hydroperoxide in sodium linoleate micelles. 1982 Arch. Biochem. Biophys. pmid:6282219
Thomas MJ et al. The role of superoxide in xanthine oxidase-induced autooxidation of linoleic acid. 1982 J. Biol. Chem. pmid:6282880
Rosenthal MD and Whitehurst MC Selective utilization of omega 6 and omega 3 polyunsaturated fatty acids by human skin fibroblasts. 1982 J. Cell. Physiol. pmid:6294123
Ookhtens M and Baker N Incomplete free fatty acid oxidation by ascites tumor cells under low oxygen tension. 1983 Am. J. Physiol. pmid:6295191
Shechter Y et al. Evaluation of factors responsible for the inability of insulin to antagonize lipolysis due to high concentrations of catecholamines. 1982 Biochem. Biophys. Res. Commun. pmid:6297490
Rosenthal MD and Whitehurst MC Fatty acyl delta 6 desaturation activity of cultured human endothelial cells. Modulation by fetal bovine serum. 1983 Biochim. Biophys. Acta pmid:6297606
Oliw EH Oxygenation of linolenic and linoleic acid to novel vicinal dihydroxy acids by hepatic microsomes of the rabbit. 1983 Biochem. Biophys. Res. Commun. pmid:6301473