Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Dermatitis, Allergic Contact D017449 20 associated lipids
Tuberculosis D014376 20 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Helicobacter Infections D016481 21 associated lipids
Birth Weight D001724 23 associated lipids
Stomach Neoplasms D013274 24 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Mammary Neoplasms, Animal D015674 27 associated lipids
Kidney Diseases D007674 29 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Rosenthal MD and Whitehurst MC Selective effects of isomeric cis and trans fatty acids on fatty acyl delta 9 and delta 6 desaturation by human skin fibroblasts. 1983 Biochim. Biophys. Acta pmid:6615875
Girón MD et al. Changes in lipid composition and desaturase activities of duodenal mucosa induced by dietary fat. 1990 Biochim. Biophys. Acta pmid:2369586
Melton JL et al. Effects of essential fatty acid deficiency on epidermal O-acylsphingolipids and transepidermal water loss in young pigs. 1987 Biochim. Biophys. Acta pmid:3651483
Claeys M et al. Metabolic profile of linoleic acid in porcine leukocytes through the lipoxygenase pathway. 1985 Biochim. Biophys. Acta pmid:2996610
Lam YY et al. Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21570480
DeWille JW and Farmer SJ Linoleic acid controls neonatal tissue-specific stearoyl-CoA desaturase mRNA levels. 1993 Biochim. Biophys. Acta pmid:8105893
Park HG et al. Palmitic acid (16:0) competes with omega-6 linoleic and omega-3 ɑ-linolenic acids for FADS2 mediated Δ6-desaturation. 2016 Biochim. Biophys. Acta pmid:26597785
Haycock JC and Evers AS Altered phosphoinositide fatty acid composition, mass and metabolism in brain essential fatty acid deficiency. 1988 Biochim. Biophys. Acta pmid:2833931
Villasuso AL et al. Culture age and carbamoylcholine increase the incorporation of endogenously synthesized linoleic acid in lipids of Trypanosoma cruzi epimastigotes. 2005 Biochim. Biophys. Acta pmid:16024291
Yang XB et al. Sulfation of a polysaccharide produced by a marine filamentous fungus Phoma herbarum YS4108 alters its antioxidant properties in vitro. 2005 Biochim. Biophys. Acta pmid:16054758
Dutta-Roy AK et al. Purification and characterization of fatty acid-binding proteins from brown adipose tissue of the rat. 1993 Biochim. Biophys. Acta pmid:8334153
Yamamoto T et al. Purification of the two forms of the high-molecular-weight neutral proteinase ingensin from rat liver. 1986 Biochim. Biophys. Acta pmid:3015226
Funk CD et al. Effects of selenium-deficient diets on the production of prostaglandins and other oxygenated metabolites of arachidonic acid and linoleic acid by rat and rabbit aortae. 1987 Biochim. Biophys. Acta pmid:3115301
Walstra P et al. Demonstration of a 12-lipoxygenase activity in bovine polymorphonuclear leukocytes. 1987 Biochim. Biophys. Acta pmid:3115302
Colard O et al. Hydrolysis of endogenous phospholipids by rat platelet phospholipase A2: ether or acyl bond and polar head group selectivity. 1987 Biochim. Biophys. Acta pmid:3115303
SHAW R THE OCCURRENCE OF GAMMA-LINOLENIC ACID IN FUNGI. 1965 Biochim. Biophys. Acta pmid:14320219
Bernbäck S et al. Fatty acids generated by gastric lipase promote human milk triacylglycerol digestion by pancreatic colipase-dependent lipase. 1989 Biochim. Biophys. Acta pmid:2917153
Greenspan MD et al. Studies on the in vivo synthesis of triacylglycerol in mouse liver. 1982 Biochim. Biophys. Acta pmid:7055591
WILLS ED MECHANISMS OF LIPID PEROXIDE FORMATION IN TISSUES. ROLE OF METALS AND HAEMATIN PROTEINS IN THE CATALYSIS OF THE OXIDATION UNSATURATED FATTY ACIDS. 1965 Biochim. Biophys. Acta pmid:14325327
Okano G and Shimojo T Utilization of long-chain free fatty acids in white and red muscle of rats. 1982 Biochim. Biophys. Acta pmid:7066350
Zhou L et al. Tissue uptake and interconversion of plasma unesterified 14C linoleic acid in the guinea pig. 1997 Biochim. Biophys. Acta pmid:9434134
Bauldry SA et al. Activation of cytosolic phospholipase A2 in permeabilized human neutrophils. 1996 Biochim. Biophys. Acta pmid:8555268
Hagve TA and Christophersen BO In vitro effects of alpha-bromopalmitate on metabolism of essential fatty acids studied in isolated rat hepatocytes: sex differences. 1987 Biochim. Biophys. Acta pmid:3099848
Kanazawa K and Ashida H Catabolic fate of dietary trilinoleoylglycerol hydroperoxides in rat gastrointestines. 1998 Biochim. Biophys. Acta pmid:9748647
Kanazawa K and Ashida H Dietary hydroperoxides of linoleic acid decompose to aldehydes in stomach before being absorbed into the body. 1998 Biochim. Biophys. Acta pmid:9748650
Nilsson A and Landin B Metabolism of chylomicron arachidonic and linoleic acid in the rat. 1988 Biochim. Biophys. Acta pmid:3128335
Jernerén F et al. Reaction mechanism of 5,8-linoleate diol synthase, 10R-dioxygenase, and 8,11-hydroperoxide isomerase of Aspergillus clavatus. 2010 Biochim. Biophys. Acta pmid:20045744
Daoud G et al. Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation. 2005 Biochim. Biophys. Acta pmid:15708366
Deva R et al. Arachidonic acid stimulates cell growth and forms a novel oxygenated metabolite in Candida albicans. 2000 Biochim. Biophys. Acta pmid:10903481
Quoc KP and Dubacq JP Effect of growth temperature on the biosynthesis of eukaryotic lipid molecular species by the cyanobacterium Spirulina platensis. 1997 Biochim. Biophys. Acta pmid:9219908
Callaghan R et al. Increased accumulation of drugs in a multidrug resistant cell line by alteration of membrane biophysical properties. 1993 Biochim. Biophys. Acta pmid:8435444
Figueroa V et al. Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca(2+)-dependent pathway. 2013 Biochim. Biophys. Acta pmid:23261389
Venkatraman JT and Clandinin MT Ribonucleic acid efflux from isolated mouse liver nuclei is altered by diet and genotypically determined change in nuclear envelope composition. 1988 Biochim. Biophys. Acta pmid:2452656
Cook HW and Spence MW Studies of the modulation of essential fatty acid metabolism by fatty acids in cultured neuroblastoma and glioma cells. 1987 Biochim. Biophys. Acta pmid:3105586
Gardner HW Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism. 1989 Biochim. Biophys. Acta pmid:2492826
Leekumjorn S et al. The role of fatty acid unsaturation in minimizing biophysical changes on the structure and local effects of bilayer membranes. 2009 Biochim. Biophys. Acta pmid:19371719
Park Y and Pariza MW The effects of dietary conjugated nonadecadienoic acid on body composition in mice. 2001 Biochim. Biophys. Acta pmid:11731328
Peters JM et al. Influence of conjugated linoleic acid on body composition and target gene expression in peroxisome proliferator-activated receptor alpha-null mice. 2001 Biochim. Biophys. Acta pmid:11731333
Memoli S et al. Diffusible melanin-related metabolites are potent inhibitors of lipid peroxidation. 1997 Biochim. Biophys. Acta pmid:9187303
Nijssen JG and van den Bosch H Cytosol-stimulated remodeling of phosphatidylcholine in rat lung microsomes. 1986 Biochim. Biophys. Acta pmid:3947653
Imaizumi K et al. Effect of phosphatidylethanolamine and its constituent base on the metabolism of linoleic acid in rat liver. 1989 Biochim. Biophys. Acta pmid:2508745
Minich DM et al. Bile diversion in rats leads to a decreased plasma concentration of linoleic acid which is not due to decreased net intestinal absorption of dietary linoleic acid. 1999 Biochim. Biophys. Acta pmid:10216285
Roche M et al. Olive phenols efficiently inhibit the oxidation of serum albumin-bound linoleic acid and butyrylcholine esterase. 2009 Biochim. Biophys. Acta pmid:19714864
Saddik M and Lopaschuk GD The fate of arachidonic acid and linoleic acid in isolated working rat hearts containing normal or elevated levels of coenzyme A. 1991 Biochim. Biophys. Acta pmid:1932104
Luthria DL and Sprecher H A comparison of the specific activities of linoleate and arachidonate in liver, heart and kidney phospholipids after feeding rats ethyl linoleate-9,10,12,13-d4. 1994 Biochim. Biophys. Acta pmid:8011670
Woldseth B and Christophersen BO Biosynthesis of phospholipid molecular species in isolated liver cells studied by combining fatty acid substrates esterified in the sn-1 and sn-2 positions. 1994 Biochim. Biophys. Acta pmid:8011678
Yu Y et al. Conjugated linoleic acid decreases production of pro-inflammatory products in macrophages: evidence for a PPAR gamma-dependent mechanism. 2002 Biochim. Biophys. Acta pmid:12020636
Earles SM et al. Metabolism of oxidized linoleic acid: characterization of 13-hydroxyoctadecadienoic acid dehydrogenase activity from rat colonic tissue. 1991 Biochim. Biophys. Acta pmid:1998735
Garg ML et al. Desaturation of linoleic acid in the small bowel is increased by short-term fasting and by dietary content of linoleic acid. 1992 Biochim. Biophys. Acta pmid:1606171
Ek BA et al. Fatty acid binding proteins reduce 15-lipoxygenase-induced oxygenation of linoleic acid and arachidonic acid. 1997 Biochim. Biophys. Acta pmid:9187305
Hansen O Characterization of fatty acid interaction with ouabain and vanadate binding to (Na+ + K+)-activated ATPase. 1989 Biochim. Biophys. Acta pmid:2554979
Furukawa M et al. Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. 1984 Biochim. Biophys. Acta pmid:6089906
Mahmmoud YA and Christensen SB Oleic and linoleic acids are active principles in Nigella sativa and stabilize an E(2)P conformation of the Na,K-ATPase. Fatty acids differentially regulate cardiac glycoside interaction with the pump. 2011 Biochim. Biophys. Acta pmid:21767529
Ghafoorunissa A et al. Substituting dietary linoleic acid with alpha-linolenic acid improves insulin sensitivity in sucrose fed rats. 2005 Biochim. Biophys. Acta pmid:15801047
Hulea SA et al. Bilirubin sensitized photooxidation of human plasma low density lipoprotein. 1996 Biochim. Biophys. Acta pmid:8982266
Bull AW et al. Conjugation of the linoleic acid oxidation product, 13-oxooctadeca-9,11-dienoic acid, a bioactive endogenous substrate for mammalian glutathione transferase. 2002 Biochim. Biophys. Acta pmid:12031293
Anel A et al. Fatty acid metabolism in human lymphocytes. II. Activation of fatty acid desaturase-elongase systems during blastic transformation. 1990 Biochim. Biophys. Acta pmid:2114179
Rich MR Conformational analysis of arachidonic and related fatty acids using molecular dynamics simulations. 1993 Biochim. Biophys. Acta pmid:8329458
Gibson RA et al. Incorporation of dietary oleate, linoleate, alpha-linolenate and eicosapentaenoate into the plasma lipid fractions of four strains of rat. 1992 Biochim. Biophys. Acta pmid:1351403
Hansen HS et al. Apparent in vivo retroconversion of dietary arachidonic to linoleic acid in essential fatty acid-deficient rats. 1986 Biochim. Biophys. Acta pmid:3092868
Bolton-Smith C et al. The effect of dietary linoleic acid on rat platelet sialic acid. 1989 Biochim. Biophys. Acta pmid:2775771
Chambaz J et al. Essential fatty acid uptake and esterification in primary culture of rat hepatocytes. 1986 Biochim. Biophys. Acta pmid:3092869
Kitagawa S et al. Activation of bovine platelets induced by long-chain unsaturated fatty acids at just below their lytic concentrations, and its mechanism. 1984 Biochim. Biophys. Acta pmid:6435686
Ivanetich KM et al. Delta 6-desaturase: improved methodology and analysis of the kinetics in a multi-enzyme system. 1996 Biochim. Biophys. Acta pmid:8547334
Mahfouz MM et al. Changes of linoleic acid metabolism and cellular phospholipid fatty acid composition in LLC-PK cells cultured at low magnesium concentrations. 1989 Biochim. Biophys. Acta pmid:2804072
Sprinz H et al. Mechanism of thiyl radical-catalyzed isomerization of unsaturated fatty acid residues in homogeneous solution and in liposomes. 2000 Biochim. Biophys. Acta pmid:10601698
Byczkowski JZ and Kulkarni AP Vanadium redox cycling, lipid peroxidation and co-oxygenation of benzo(a)pyrene-7,8-dihydrodiol. 1992 Biochim. Biophys. Acta pmid:1315157
Parsons HG et al. Modulation of human erythrocyte shape and fatty acids by diet. 1986 Biochim. Biophys. Acta pmid:3741859
Hirabara SM et al. Acute effect of fatty acids on metabolism and mitochondrial coupling in skeletal muscle. 2006 Biochim. Biophys. Acta pmid:16375848
DeMar JC et al. Brain elongation of linoleic acid is a negligible source of the arachidonate in brain phospholipids of adult rats. 2006 Biochim. Biophys. Acta pmid:16920015
Bedotti R et al. Stimulatory effect of serum albumin on the proliferation of serum-free SV40-transformed Balb/c 3T3 cells. 1990 Biochim. Biophys. Acta pmid:2163687
Urquhart P et al. The effect of conjugated linoleic acid on arachidonic acid metabolism and eicosanoid production in human saphenous vein endothelial cells. 2002 Biochim. Biophys. Acta pmid:11880240
Loidl-Stahlhofen A et al. Generation of alpha-hydroxyaldehydic compounds in the course of lipid peroxidation. 1994 Biochim. Biophys. Acta pmid:8025124
Brinkmeier H et al. Specific modifications of the membrane fatty acid composition of human myotubes and their effects on the muscular sodium channels. 1993 Biochim. Biophys. Acta pmid:8380720
Macrì F et al. Lipoxygenase activity associated to isolated soybean plasma membranes. 1994 Biochim. Biophys. Acta pmid:7947991
Simpson RJ and Peters TJ Transport of Fe2+ across lipid bilayers: possible role of free fatty acids. 1987 Biochim. Biophys. Acta pmid:3828339
Bester R and Lochner A Sarcolemmal phospholipid fatty acid composition and permeability. 1988 Biochim. Biophys. Acta pmid:3382645
Shires SE et al. Effects of linoleic acid and mitogenic stimulation on the fatty acid composition of human lymphocytes. 1989 Biochim. Biophys. Acta pmid:2493807
Ulmann L et al. Incorporation into liver microsomal lipids of linoleic and stearic acids and of their respective products of delta 6 and delta 9 desaturation, gamma-linolenic and oleic acids: effect of age and of blackcurrant seed oil. 1991 Biochim. Biophys. Acta pmid:1657182
Nijssen JG and van den Bosch H Coenzyme A-mediated transacylation of sn-2 fatty acids from phosphatidylcholine in rat lung microsomes. 1986 Biochim. Biophys. Acta pmid:3081034
Mizushina Y et al. Mode analysis of binding of fatty acids to mammalian DNA polymerases. 2000 Biochim. Biophys. Acta pmid:10903472
Schmitt A et al. Phospholipid hydrolysis of mildly oxidized LDL reduces their cytotoxicity to cultured endothelial cells. Potential protective role against atherogenesis. 1995 Biochim. Biophys. Acta pmid:7786889
Croft KD et al. Differential inhibition of thromboxane B2 and leukotriene B4 biosynthesis by two naturally occurring acetylenic fatty acids. 1987 Biochim. Biophys. Acta pmid:2822134
Dufour C and Loonis M Flavonoids and their oxidation products protect efficiently albumin-bound linoleic acid in a model of plasma oxidation. 2007 Biochim. Biophys. Acta pmid:17428609
Batna A et al. The occurrence of furan fatty acids in Isochrysis sp. and Phaeodactylum tricornutum. 1993 Biochim. Biophys. Acta pmid:8443233
Gaquerel E et al. Evidence for oxylipin synthesis and induction of a new polyunsaturated fatty acid hydroxylase activity in Chondrus crispus in response to methyljasmonate. 2007 Biochim. Biophys. Acta pmid:17428728
Murase T et al. Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates. 2001 Biochim. Biophys. Acta pmid:11341955
Subbaiah PV et al. Incorporation profiles of conjugated linoleic acid isomers in cell membranes and their positional distribution in phospholipids. 2011 Biochim. Biophys. Acta pmid:20920595
Clementz T et al. Membrane potential, lipid regulation and adenylate energy charge in acyl chain modified Acholeplasma laidlawii. 1987 Biochim. Biophys. Acta pmid:3567184
Kühn H et al. Overexpression, purification and characterization of human recombinant 15-lipoxygenase. 1993 Biochim. Biophys. Acta pmid:8334154
Hagve TA and Christophersen BO Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells. 1984 Biochim. Biophys. Acta pmid:6093889
Spiteller P et al. Aldehydic lipid peroxidation products derived from linoleic acid. 2001 Biochim. Biophys. Acta pmid:11325611
Torres-Duarte AP and Vanderhoek JY Conjugated linoleic acid exhibits stimulatory and inhibitory effects on prostanoid production in human endothelial cells and platelets. 2003 Biochim. Biophys. Acta pmid:12676356
Kwon B et al. Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. 2014 Biochim. Biophys. Acta pmid:24732014
Mojumdar EH et al. Stratum corneum lipid matrix: Location of acyl ceramide and cholesterol in the unit cell of the long periodicity phase. 2016 Biochim. Biophys. Acta pmid:27169629
Jaudszus A et al. Cis-9,trans-11-CLA exerts anti-inflammatory effects in human bronchial epithelial cells and eosinophils: comparison to trans-10,cis-12-CLA and to linoleic acid. 2005 Biochim. Biophys. Acta pmid:16303327
Cominacini L et al. Determination of lipid hydroperoxides in native low-density lipoprotein by a chemiluminescent flow-injection assay. 1993 Biochim. Biophys. Acta pmid:8418885
Bruneau C et al. Influence of lipid environment on insulin binding in cultured hepatoma cells. 1987 Biochim. Biophys. Acta pmid:3552053
Bruneau C et al. Modifications of cellular lipids induce insulin resistance in cultured hepatoma cells. 1987 Biochim. Biophys. Acta pmid:3552054
Nugteren DH and Kivits GA Conversion of linoleic acid and arachidonic acid by skin epidermal lipoxygenases. 1987 Biochim. Biophys. Acta pmid:3113487