| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Mammary Neoplasms, Animal | D015674 | 27 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Genetic Predisposition to Disease | D020022 | 24 associated lipids |
| Stomach Neoplasms | D013274 | 24 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Alzate A et al. | Preeclampsia prevention: a case-control study nested in a cohort. | 2015 | Colomb. Med. | pmid:26848195 |
| Frenzel E et al. | α1-Antitrypsin Combines with Plasma Fatty Acids and Induces Angiopoietin-like Protein 4 Expression. | 2015 | J. Immunol. | pmid:26363050 |
| Lee CW et al. | Structural basis for the ligand-binding specificity of fatty acid-binding proteins (pFABP4 and pFABP5) in gentoo penguin. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26206084 |
| Mizuta K et al. | Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26342087 |
| Lands B | Omega-3 PUFAs Lower the Propensity for Arachidonic Acid Cascade Overreactions. | 2015 | Biomed Res Int | pmid:26301244 |
| He J et al. | Correlation of polyunsaturated fatty acids with the cold adaptation of Rhodotorula glutinis. | 2015 | Yeast | pmid:26284451 |
| Valenzuela R et al. | Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who Received Alpha Linolenic Acid from Chia Oil during Gestation and Nursing. | 2015 | Nutrients | pmid:26247968 |
| Tucker RM et al. | No Difference in Perceived Intensity of Linoleic Acid in the Oral Cavity between Obese and Nonobese Individuals. | 2015 | Chem. Senses | pmid:26232811 |
| Evans SJ et al. | Plasma linoleic acid partially mediates the association of bipolar disorder on self-reported mental health scales. | 2015 | J Psychiatr Res | pmid:26228402 |
| Min JS et al. | Monitoring the formation of cholesterol oxidation products in model systems using response surface methodology. | 2015 | Lipids Health Dis | pmid:26201850 |
| Farvid MS et al. | Response to Letters Regarding Article, "Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies". | 2015 | Circulation | pmid:26195494 |
| Lucas M | Letter by Lucas Regarding Articles, "Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies" and "Circulating Omega-6 Polyunsaturated Fatty Acids and Total and Cause-Specific Mortality: The Cardiovascular Health Study". | 2015 | Circulation | pmid:26195492 |
| Hoenselaar R | Letter by Hoenselaar Regarding Article, "Dietary Linoleic Acid and Risk of Coronary Heart Disease: A Systematic Review and Meta-Analysis of Prospective Cohort Studies". | 2015 | Circulation | pmid:26195491 |
| Yuan T et al. | Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism. | 2015 | Int J Clin Exp Pathol | pmid:26191198 |
| Negrini R et al. | pH-responsive lyotropic liquid crystals and their potential therapeutic role in cancer treatment. | 2015 | Chem. Commun. (Camb.) | pmid:25783035 |
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| Yoshida Y et al. | Chemistry of lipid peroxidation products and their use as biomarkers in early detection of diseases. | 2015 | J Oleo Sci | pmid:25766928 |
| Ciepiela P et al. | Arachidonic and linoleic acid derivatives impact oocyte ICSI fertilization--a prospective analysis of follicular fluid and a matched oocyte in a 'one follicle--one retrieved oocyte--one resulting embryo' investigational setting. | 2015 | PLoS ONE | pmid:25763593 |
| Hernandez LR et al. | Effect of plant growth regulators on fatty acids composition in Jatropha curcas L. callus culture. | 2015 | J Oleo Sci | pmid:25757437 |
| Kotani K et al. | Enzymatic preparation of human milk fat substitutes and their oxidation stability. | 2015 | J Oleo Sci | pmid:25757431 |
| Hashim RB et al. | Fatty acid compositions of silver catfish, Pangasius sp. farmed in several rivers of Pahang, Malaysia. | 2015 | J Oleo Sci | pmid:25748380 |
| Chang TS et al. | Palm oil derived trimethylolpropane triesters synthetic lubricants and usage in industrial metalworking fluid. | 2015 | J Oleo Sci | pmid:25748374 |
| Tyurina YY et al. | LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease. | 2015 | Free Radic. Res. | pmid:25740198 |
| Wang S et al. | Plasma nutrient biomarkers are associated with waist-to-height ratio in youth with type 1 diabetes. | 2015 | J. Nutr. | pmid:25733475 |
| Nardi F et al. | Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability. | 2015 | J. Biol. Chem. | pmid:25653282 |
| Clouard C et al. | Dietary linoleic and α-linolenic acids affect anxiety-related responses and exploratory activity in growing pigs. | 2015 | J. Nutr. | pmid:25644359 |
| Liu H et al. | Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease. | 2015 | Am. J. Pathol. | pmid:25447051 |
| Reinders I et al. | Plasma phospholipid PUFAs are associated with greater muscle and knee extension strength but not with changes in muscle parameters in older adults. | 2015 | J. Nutr. | pmid:25355842 |
| Fala AM et al. | Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α. | 2015 | Sci Rep | pmid:26237540 |
| Kim SY et al. | Resveratrol exerts growth inhibitory effects on human SZ95 sebocytes through the inactivation of the PI3-K/Akt pathway. | 2015 | Int. J. Mol. Med. | pmid:25672876 |
| Beam J et al. | Excess Linoleic Acid Increases Collagen I/III Ratio and "Stiffens" the Heart Muscle Following High Fat Diets. | 2015 | J. Biol. Chem. | pmid:26240151 |
| Okazaki H et al. | Bongkrekic acid as a selective activator of the peroxisome proliferator-activated receptor γ (PPARγ) isoform. | 2015 | J Toxicol Sci | pmid:25786526 |
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| Jacob RH et al. | Phenotypic characterisation of colour stability of lamb meat. | 2014 | Meat Sci. | pmid:23415827 |
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| Purushothaman D et al. | Flaxseed oil supplementation alters the expression of inflammatory-related genes in dogs. | 2014 | Genet. Mol. Res. | pmid:25078588 |
| van Schalkwijk DB et al. | Dietary medium chain fatty acid supplementation leads to reduced VLDL lipolysis and uptake rates in comparison to linoleic acid supplementation. | 2014 | PLoS ONE | pmid:25049048 |
| Beavers WN et al. | ω-Alkynyl lipid surrogates for polyunsaturated fatty acids: free radical and enzymatic oxidations. | 2014 | J. Am. Chem. Soc. | pmid:25034362 |
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| Hellstrand S et al. | Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease. | 2014 | J. Nutr. | pmid:25008580 |
| Asselin C et al. | Circulating levels of linoleic acid and HDL-cholesterol are major determinants of 4-hydroxynonenal protein adducts in patients with heart failure. | 2014 | Redox Biol | pmid:24494189 |
| Nehdi IA et al. | Chamaerops humilis L. var. argentea André date palm seed oil: a potential dietetic plant product. | 2014 | J. Food Sci. | pmid:24666023 |
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| Chevrot M et al. | Obesity interferes with the orosensory detection of long-chain fatty acids in humans. | 2014 | Am. J. Clin. Nutr. | pmid:24522446 |
| Cho Y et al. | Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation. | 2014 | Exp. Biol. Med. (Maywood) | pmid:24495951 |
| Shen J et al. | A 13-lipoxygenase, TomloxC, is essential for synthesis of C5 flavour volatiles in tomato. | 2014 | J. Exp. Bot. | pmid:24453226 |
| Paulsen SJ et al. | Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion. | 2014 | PLoS ONE | pmid:24520357 |