Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Kidney Diseases D007674 29 associated lipids
Polycystic Kidney Diseases D007690 12 associated lipids
Lactose Intolerance D007787 2 associated lipids
Leukemia D007938 74 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Liver Diseases D008107 31 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lymphopenia D008231 2 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Melanosis D008548 4 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Authors Title Published Journal PubMed Link
Randich A et al. Jejunal administration of linoleic acid increases activity of neurons in the paraventricular nucleus of the hypothalamus. 2004 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:14660477
Whigham LD et al. CLA reduces antigen-induced histamine and PGE(2) release from sensitized guinea pig tracheae. 2001 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:11171673
Matravadia S et al. LA and ALA prevent glucose intolerance in obese male rats without reducing reactive lipid content, but cause tissue-specific changes in fatty acid composition. 2016 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:26764053
Chen CS et al. Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue. 2013 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24154509
Darling RA et al. Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors. 2014 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:24760994
Zhou Y et al. UCP2 attenuates apoptosis of tubular epithelial cells in renal ischemia-reperfusion injury. 2017 Am. J. Physiol. Renal Physiol. pmid:28424210
Collett ED et al. n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes. 2001 Am. J. Physiol., Cell Physiol. pmid:11287318
Houston M et al. Oxidized linoleic acid regulates expression and shedding of syndecan-4. 2005 Am. J. Physiol., Cell Physiol. pmid:15469957
Suh HN et al. Linoleic acid stimulates gluconeogenesis via Ca2+/PLC, cPLA2, and PPAR pathways through GPR40 in primary cultured chicken hepatocytes. 2008 Am. J. Physiol., Cell Physiol. pmid:18842827
Shah BP et al. TRPM5 is critical for linoleic acid-induced CCK secretion from the enteroendocrine cell line, STC-1. 2012 Am. J. Physiol., Cell Physiol. pmid:21998136
González-Abuín N et al. Grape-seed procyanidins modulate cellular membrane potential and nutrient-induced GLP-1 secretion in STC-1 cells. 2014 Am. J. Physiol., Cell Physiol. pmid:24371039
McKay MC and Worley JF Linoleic acid both enhances activation and blocks Kv1.5 and Kv2.1 channels by two separate mechanisms. 2001 Am. J. Physiol., Cell Physiol. pmid:11546665
Reiner WB et al. Fatty acids in mountain gorilla diets: implications for primate nutrition and health. 2014 Am. J. Primatol. pmid:24243235
Kawada H et al. Improved maintenance of adult rat alveolar type II cell differentiation in vitro: effect of serum-free, hormonally defined medium and a reconstituted basement membrane. 1990 Am. J. Respir. Cell Mol. Biol. pmid:2363935
Hill EM et al. Changes in expression of 15-lipoxygenase and prostaglandin-H synthase during differentiation of human tracheobronchial epithelial cells. 1998 Am. J. Respir. Cell Mol. Biol. pmid:9569236
Cavicchioli P et al. Endogenous surfactant turnover in preterm infants with respiratory distress syndrome studied with stable isotope lipids. 2001 Am. J. Respir. Crit. Care Med. pmid:11208626
Graczyk TK and Shiff CJ Recovery of avian schistosome cercariae from water using penetration stimulant matrix with an unsaturated fatty acid. 2000 Sep-Oct Am. J. Trop. Med. Hyg. pmid:11388510
Mpagi JL et al. Hyperreactive onchocerciasis exhibits reduced arachidonate and linoleate levels in serum triglycerides. 2000 Am. J. Trop. Med. Hyg. pmid:11304059
Kim CH et al. Effects of emulsified octadecanic acids on gas production and cellulolysis by the rumen anaerobic fungus, Piromyces communis M014. 2008 Anaerobe pmid:17996466
Shen Q et al. Antioxidant activity in vitro of the selenium-contained protein from the Se-enriched Bifidobacterium animalis 01. 2010 Anaerobe pmid:20601030
Wang YL et al. LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui. 2005 Anal Bioanal Chem pmid:16132135
Ito J et al. A novel chiral stationary phase HPLC-MS/MS method to discriminate between enzymatic oxidation and auto-oxidation of phosphatidylcholine. 2016 Anal Bioanal Chem pmid:27549797
Tao X et al. GC-MS with ethyl chloroformate derivatization for comprehensive analysis of metabolites in serum and its application to human uremia. 2008 Anal Bioanal Chem pmid:18622754
Billault I et al. Probing substrate-product relationships by natural abundance deuterium 2D NMR spectroscopy in liquid-crystalline solvents: epoxidation of linoleate to vernoleate by two different plant enzymes. 2012 Anal Bioanal Chem pmid:22349323
Wejnerowska G et al. Determination of linoleic acid in toothpaste by gas chromatography with flame ionization detection. 2008 Anal Sci pmid:18544865
Degousée N et al. Measurement of thermally produced volatile alkanes: an assay for plant hydroperoxy fatty acid evaluation. 1995 Anal. Biochem. pmid:7733454
KOKATNUR MG et al. A RAPID METHOD FOR THE PREPARATION OF PEROXIDES FROM AUTOXIDIZED METHYL ESTERS OF FATTY ACIDS. 1965 Anal. Biochem. pmid:14340025
López-Nicolás JM et al. An octaethylene glycol monododecyl ether-based mixed micellar assay for lipoxygenase acting at neutral pH. 1994 Anal. Biochem. pmid:7810887
Gibian MJ and Vandenberg P Product yield in oxygenation of linoleate by soybean lipoxygenase: the value of the molar extinction coefficient in the spectrophotometric assay. 1987 Anal. Biochem. pmid:3116881
Kotani A et al. Determination of plasma free fatty acids by high-performance liquid chromatography with electrochemical detection. 2000 Anal. Biochem. pmid:10933857
Liu X et al. Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation. 2013 Anal. Biochem. pmid:23850559
KOEHLER WR et al. A METHOD FOR SEPARATING SATURATED FATTY ACID ESTERS FROM UNSATURATED ESTERS FOR GAS CHROMATOGRAPHIC ANALYSIS. 1964 Anal. Biochem. pmid:14213999
Pourplanche C et al. Comparison of polarographic and chemical measurements of oxygen uptake in complex media: the example of lipoxygenase reaction. 1991 Anal. Biochem. pmid:1789419
Andre JC and Funk MO Determination of stereochemistry in the fatty acid hydroperoxide products of lipoxygenase catalysis. 1986 Anal. Biochem. pmid:3101541
Oliw EH et al. Payne rearrangement during analysis of epoxyalcohols of linoleic and alpha-linolenic acids by normal phase liquid chromatography with tandem mass spectrometry. 2006 Anal. Biochem. pmid:16712763
Cho H et al. Nonradiometric HPLC measurement of 13(S)-hydroxyoctadecadienoic acid from rat tissues. 2003 Anal. Biochem. pmid:12782030
Auerbach BJ et al. A spectrophotometric microtiter-based assay for the detection of hydroperoxy derivatives of linoleic acid. 1992 Anal. Biochem. pmid:1632527
PINTER KG et al. QUANTITATIVE DETERMINATION OF SERUM TRIGLYCERIDES BY GLASS-FIBER PAPER CHROMATOGRAPHY. 1964 Anal. Biochem. pmid:14186669
Waddington E et al. Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatography. 2001 Anal. Biochem. pmid:11355856
Wu D et al. Determination of alpha-linolenic acid and linoleic acid in edible oils using near-infrared spectroscopy improved by wavelet transform and uninformative variable elimination. 2009 Anal. Chim. Acta pmid:19185115
Moodley R et al. Elemental composition and fatty acid profile of the edible fruits of Amatungula (Carissa macrocarpa) and impact of soil quality on chemical characteristics. 2012 Anal. Chim. Acta pmid:22632042
Zeng YX et al. Comparative analysis of volatile components from Clematis species growing in China. 2007 Anal. Chim. Acta pmid:17606017
P Wrobel T et al. Imaging of lipids in atherosclerotic lesion in aorta from ApoE/LDLR-/- mice by FT-IR spectroscopy and Hierarchical Cluster Analysis. 2011 Analyst pmid:22007352
Tavilani H et al. Decreased polyunsaturated and increased saturated fatty acid concentration in spermatozoa from asthenozoospermic males as compared with normozoospermic males. 2006 Andrologia pmid:16961570
Kreich M and Claus P Direct conversion of linoleic acid over silver catalysts in the presence of H2: an unusual way towards conjugated linoleic acids. 2005 Angew. Chem. Int. Ed. Engl. pmid:16315163
O'Quinn PR et al. Conjugated linoleic acid. 2000 Anim Health Res Rev pmid:11706843
McNamara S et al. Effect of offering rumen-protected fat supplements on fertility and performance in spring-calving Holstein-Friesian cows. 2003 Anim. Reprod. Sci. pmid:12853178
Kawahara S et al. Effects of dietary supplementation with conjugated linoleic acid on fatty acid composition and lipid oxidation in chicken breast meat. 2009 Anim. Sci. J. pmid:20163609
Shibata H et al. Effect of supplementation of soy sauce oil and Ca salts of fatty acids on rumen fermentation, milk production and conjugated linoleic acid in milk of dairy cows. 2011 Anim. Sci. J. pmid:21794014
Guo J et al. Selective transport of long-chain fatty acids by FAT/CD36 in skeletal muscle of broilers. 2013 Animal pmid:23031491
Men XM et al. Age-related changes and nutritional regulation of myosin heavy-chain composition in longissimus dorsi of commercial pigs. 2013 Animal pmid:23764195
Smink W et al. Linoleic and α-linolenic acid as precursor and inhibitor for the synthesis of long-chain polyunsaturated fatty acids in liver and brain of growing pigs. 2012 Animal pmid:22436184
Zened A et al. In vitro study of dietary factors affecting the biohydrogenation shift from trans-11 to trans-10 fatty acids in the rumen of dairy cows. 2012 Animal pmid:22436225
Yen CH et al. Linoleic acid metabolite levels and transepidermal water loss in children with atopic dermatitis. 2008 Ann. Allergy Asthma Immunol. pmid:18254485
Ranganath LR et al. Increased mean platelet volume after oestrogen replacement therapy. 1996 Ann. Clin. Biochem. pmid:8937589
Taylor AJ Erythrocyte membrane fatty acid composition in hypercholesterolaemia. 1994 Ann. Clin. Biochem. pmid:7979101
Fairfield K ACP Journal Club. Review: replacing dietary saturated fatty acids with n-6 polyunsaturated fatty acids does not reduce mortality. 2013 Ann. Intern. Med. pmid:23689785
Davis PA et al. A linoleate-enriched cheese product reduces low-density lipoprotein in moderately hypercholesterolemic adults. 1993 Ann. Intern. Med. pmid:8363165
Kankaanpää P et al. Dietary fatty acids and allergy. 1999 Ann. Med. pmid:10480759
Chopra M et al. Free radical scavenging of lutein in vitro. 1993 Ann. N. Y. Acad. Sci. pmid:8129303
Thompson RL et al. Cigarette smoking, polyunsaturated fats, and coronary heart disease. 1993 Ann. N. Y. Acad. Sci. pmid:8512244
Sugano M and Koba K Dietary protein and lipid metabolism: a multifunctional effect. 1993 Ann. N. Y. Acad. Sci. pmid:8489133
Merendino N et al. Induction of apoptosis in human pancreatic cancer cells by docosahexaenoic acid. 2003 Ann. N. Y. Acad. Sci. pmid:15033753
Schlame M et al. Deficiency of tetralinoleoyl-cardiolipin in Barth syndrome. 2002 Ann. Neurol. pmid:12112112
Sakai T et al. Chorea-acanthocytosis: abnormal composition of covalently bound fatty acids of erythrocyte membrane proteins. 1991 Ann. Neurol. pmid:1832532
Charnock JS et al. Changes in fatty acid composition of the cardiac phospholipids of the cotton-eared marmoset (Callithrix jacchus) after feeding different lipid supplements. 1985 Ann. Nutr. Metab. pmid:3922279
Babin F et al. Plasma fatty acid composition and lipid peroxide levels in children with paucity of interlobular bile ducts. 1988 Ann. Nutr. Metab. pmid:3195990
Carreau JP et al. Cholesterol synthesis in the liver, kidneys and brain after injection of uniformly 14C-labeled oleic or linoleic acid to developing rats. 1982 Ann. Nutr. Metab. pmid:6814348
Romijn D et al. A linoleic acid enriched diet increases serum cholesterol esterification by lecithin:cholesterol acyltransferase in meal-fed rats. 1998 Ann. Nutr. Metab. pmid:9745111
Choi YS and Sugano M Effects of dietary alpha- and gamma-linolenic acid on lipid metabolism in young and adult rats. 1988 Ann. Nutr. Metab. pmid:2903713
Mogenson GJ and Box BM Physiological effects of varying dietary linoleic acid in spontaneously hypertensive rats. 1982 Ann. Nutr. Metab. pmid:7137945
Adam O et al. Prostaglandin formation in man during intake of different amounts of linoleic acid in formula diets. 1982 Ann. Nutr. Metab. pmid:7137955
Fuhrmann H and Sallmann HP Alpha-tocopherol and phospholipase A2 in liver and brain of chicks posthatching: the influence of dietary fat and vitamin E. 1995 Ann. Nutr. Metab. pmid:8585700
Saito M and Yamaguchi M Liver microsomal mixed-function oxidases in response to dietary n-3 fatty acid levels in rats. 1994 Ann. Nutr. Metab. pmid:7832581
Saín J et al. Effects of trans-fatty acids on liver lipid metabolism in mice fed on diets showing different fatty acid composition. 2013 Ann. Nutr. Metab. pmid:23594856
Boissonneault GA et al. Oxidized low-density lipoproteins delay endothelial wound healing: lack of effect of vitamin E. 1995 Ann. Nutr. Metab. pmid:7872651
Santos MJ et al. Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. 1995 Ann. Nutr. Metab. pmid:7872656
Lohner S et al. Gender differences in the long-chain polyunsaturated fatty acid status: systematic review of 51 publications. 2013 Ann. Nutr. Metab. pmid:23327902
Kort WJ et al. Influence of the linoleic acid content of the diet on tumor growth in transplantable rat tumor models. 1986 Ann. Nutr. Metab. pmid:3963748
Roshanai F and Sanders TA Influence of different supplements of N-3 polyunsaturated fatty acids on blood and tissue lipids in rats receiving high intakes of linoleic acid. 1985 Ann. Nutr. Metab. pmid:4037727
Fidler N et al. Oxidation of an oil rich in docosahexaenoic acid compared to linoleic acid in lactating women. 1999 Ann. Nutr. Metab. pmid:10725767
Charnock JS et al. Altered levels of n-6/n-3 fatty acids in rat heart and storage fat following variable dietary intake of linoleic acid. 1985 Ann. Nutr. Metab. pmid:4051450
Adam O Linoleic acid - the fall of an angel? 1999 Ann. Nutr. Metab. pmid:10725772
Charnock JS et al. Diet and cardiac arrhythmia: effects of lipids on age-related changes in myocardial function in the rat. 1985 Ann. Nutr. Metab. pmid:4051452
Soltysova T and Bellisle F Nutrition in ten-year-old children of the Liberec area (Czech Republic). 1994 Ann. Nutr. Metab. pmid:7979168
Pascaud M and Strouve-Vallet C Desaturation of 14C linoleic acid by the rat fetus. 1985 Ann. Nutr. Metab. pmid:2983600
Roth HP and Kirchgessner M [Effect of various unsaturated fatty acids on the stability of the erythrocyte membrane in the rat]. 1992 Ann. Nutr. Metab. pmid:1354951
Aziz AA et al. Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. 2010 Ann. Nutr. Metab. pmid:20714137
Jensen MM et al. Intestinal absorption of octanoic, decanoic, and linoleic acids: effect of triglyceride structure. 1994 Ann. Nutr. Metab. pmid:8067685
Heine RJ et al. The effect of dietary linoleic acid and pectin on lipoprotein and apolipoprotein A1 concentrations in rhesus monkeys. 1984 Ann. Nutr. Metab. pmid:6476785
de Deckere EA et al. Hepatic de novo fatty acid synthesis in the rat. 1993 Ann. Nutr. Metab. pmid:8215236
Katan MB et al. Biological markers of dietary intake, with emphasis on fatty acids. 1991 Ann. Nutr. Metab. pmid:1776820
Xiang M et al. Diet and gene expression: delta-5 and delta-6 desaturases in healthy Chinese and European subjects. 2006 Ann. Nutr. Metab. pmid:16988497
Decsi T and Koletzko B Do trans fatty acids impair linoleic acid metabolism in children? 1995 Ann. Nutr. Metab. pmid:7872654
De Vriese SR et al. Estimation of dietary fat intake of Belgian pregnant women. Comparison of two methods. 2001 Ann. Nutr. Metab. pmid:11786650
Black JM and Kinsella JE Dietary n-3 fatty acids alter murine peritoneal macrophage cytotoxicity. 1993 Ann. Nutr. Metab. pmid:8373135
Adam O et al. Influence of dietary linoleic acid intake with different fat intakes on arachidonic acid concentrations in plasma and platelet lipids and eicosanoid biosynthesis in female volunteers. 2003 Ann. Nutr. Metab. pmid:12624485
Leat WM et al. Retinal function in rats and guinea-pigs reared on diets low in essential fatty acids and supplemented with linoleic or linolenic acids. 1986 Ann. Nutr. Metab. pmid:2872851
Sanders TA and Rana SK Comparison of the metabolism of linoleic and linolenic acids in the fetal rat. 1987 Ann. Nutr. Metab. pmid:2892461
Jakobsen K et al. Heat production and quantitative oxidation of nutrients by physical activity in pigs. 1994 Ann. Nutr. Metab. pmid:8185282