| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pneumonia, Viral | D011024 | 3 associated lipids |
| Exocrine Pancreatic Insufficiency | D010188 | 6 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Otitis Externa | D010032 | 8 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Melanosis | D008548 | 4 associated lipids |
| Malabsorption Syndromes | D008286 | 16 associated lipids |
| Lymphopenia | D008231 | 2 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Poirier H et al. | Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine. | 2001 | Biochem. J. | pmid:11284737 |
| MAHADEVAN S et al. | STUDIES ON METABOLISM OF VITAMIN A. 3. THE MODE OF ABSORPTION OF VITAMIN A ESTERS IN THE LIVING RAT. | 1963 | Biochem. J. | pmid:14071526 |
| MAHADEVAN S et al. | STUDIES ON METABOLISM OF VITAMIN A. 4. STUDIES ON THE MODE OF ABSORPTION OF VITAMIN A BY RAT INTESTINE IN VITRO. | 1963 | Biochem. J. | pmid:14071527 |
| HORGAN VJ et al. | Toxicity of autoxidized squalene and linoleic acid, and of simpler peroxides, in relation to toxicity of radiation. | 1957 | Biochem. J. | pmid:13488907 |
| López-Nicolás JM et al. | Use of 'soluble lipids' for biochemical processes: linoleic acid-cyclodextrin inclusion complexes in aqueous solutions. | 1995 | Biochem. J. | pmid:7755559 |
| LEAT WM | FATTY ACID COMPOSITION OF THE SERUM LIPIDS OF PIGS GIVEN DIFFERENT AMOUNTS OF LINOLEIC ACID. | 1963 | Biochem. J. | pmid:14097364 |
| Enser M and Roberts JL | The regulation of hepatic stearoyl-coenzyme A desaturase in obese-hyperglycaemic (ob/ob) mice by food intake and the fatty acid composition of the diet. | 1982 | Biochem. J. | pmid:6128973 |
| Schlame M and Rüstow B | Lysocardiolipin formation and reacylation in isolated rat liver mitochondria. | 1990 | Biochem. J. | pmid:2268287 |
| Jones AL et al. | Rapid induction of microsomal delta 12(omega 6)-desaturase activity in chilled Acanthamoeba castellanii. | 1993 | Biochem. J. | pmid:8250841 |
| Moore JP et al. | The predominant polyphenol in the leaves of the resurrection plant Myrothamnus flabellifolius, 3,4,5 tri-O-galloylquinic acid, protects membranes against desiccation and free radical-induced oxidation. | 2005 | Biochem. J. | pmid:15355309 |
| Carpenter KL et al. | Production of oxidized lipids during modification of low-density lipoprotein by macrophages or copper. | 1994 | Biochem. J. | pmid:7999000 |
| Clouet P et al. | Pathway of alpha-linolenic acid through the mitochondrial outer membrane in the rat liver and influence on the rate of oxidation. Comparison with linoleic and oleic acids. | 1989 | Biochem. J. | pmid:2597132 |
| Williams JP et al. | The role of phosphatidylcholine in fatty acid exchange and desaturation in Brassica napus L. leaves. | 2000 | Biochem. J. | pmid:10861220 |
| Stymne S and Stobart AK | Biosynthesis of gamma-linolenic acid in cotyledons and microsomal preparations of the developing seeds of common borage (Borago officinalis). | 1986 | Biochem. J. | pmid:3028375 |
| Lang I et al. | A lipoxygenase with linoleate diol synthase activity from Nostoc sp. PCC 7120. | 2008 | Biochem. J. | pmid:18031288 |
| Reid JC and Husbands DR | Oxidative metabolism of long-chain fatty acids in mitochondria from sheep and rat liver. Evidence that sheep conserve linoleate by limiting its oxidation. | 1985 | Biochem. J. | pmid:3977825 |
| Swida A et al. | Redox state of quinone affects sensitivity of Acanthamoeba castellanii mitochondrial uncoupling protein to purine nucleotides. | 2008 | Biochem. J. | pmid:18402555 |
| Nguyen SD and Sok DE | Beneficial effect of oleoylated lipids on paraoxonase 1: protection against oxidative inactivation and stabilization. | 2003 | Biochem. J. | pmid:12871208 |
| Thuillier P et al. | Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors. | 2002 | Biochem. J. | pmid:12069687 |
| Calder PC et al. | Triacylglycerol metabolism by lymphocytes and the effect of triacylglycerols on lymphocyte proliferation. | 1994 | Biochem. J. | pmid:8141773 |
| Finn RD et al. | Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway. | 2009 | Biochem. J. | pmid:18778245 |
| Kang JX et al. | The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells. | 1992 | Biochem. J. | pmid:1323271 |
| Luévano-MartÃnez LA et al. | A critical tyrosine residue determines the uncoupling protein-like activity of the yeast mitochondrial oxaloacetate carrier. | 2012 | Biochem. J. | pmid:22236206 |
| Arslan P et al. | cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes. | 1984 | Biochem. J. | pmid:6696740 |
| Rayner BS et al. | Regio- and stereo-chemical oxidation of linoleic acid by human myoglobin and hydrogen peroxide: Tyr(103) affects rate and product distribution. | 2004 | Biochem. J. | pmid:15035657 |
| Stymne S and Stobart AK | The biosynthesis of triacylglycerols in microsomal preparations of developing cotyledons of sunflower (Helianthus annuus L.). | 1984 | Biochem. J. | pmid:6743281 |
| O'donnell VB and Kühn H | Co-oxidation of NADH and NADPH by a mammalian 15-lipoxygenase: inhibition of lipoxygenase activity at near-physiological NADH concentrations. | 1997 | Biochem. J. | pmid:9355754 |
| Haines KA et al. | The leukotriene B4 paradox: neutrophils can, but will not, respond to ligand-receptor interactions by forming leukotriene B4 or its omega-metabolites. | 1987 | Biochem. J. | pmid:3032161 |
| Louet JF et al. | Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway. | 2001 | Biochem. J. | pmid:11171094 |
| Jones AL et al. | Temperature-induced membrane-lipid adaptation in Acanthamoeba castellanii. | 1993 | Biochem. J. | pmid:8439295 |
| Fraenkel G and Blewett M | Linoleic acid and arachidonic acid in the metabolism of two insects, Ephestia kuehniella (Lep.) and Tenebrio molitor (Col.). | 1947 | Biochem. J. | pmid:16748194 |
| Ando H et al. | Intracellular composition of fatty acid affects the processing and function of tyrosinase through the ubiquitin-proteasome pathway. | 2006 | Biochem. J. | pmid:16232122 |
| Brodhun F et al. | PpoC from Aspergillus nidulans is a fusion protein with only one active haem. | 2010 | Biochem. J. | pmid:19878096 |
| Grechkin AN et al. | The lipoxygenase pathway in tulip (Tulipa gesneriana): detection of the ketol route. | 2000 | Biochem. J. | pmid:11085944 |
| Huang YS et al. | Differences in the metabolism of 18:2n-6 and 18:3n-6 by the liver and kidney may explain the anti-hypertensive effect of 18:3n-6. | 1994 | Biochem. Med. Metab. Biol. | pmid:7910749 |
| Poisson JP et al. | Effect of salt-loading and spontaneous hypertension on in vitro metabolism of [1-14C]linoleic and [2-14C]dihomo-gamma-linolenic acids. | 1993 | Biochem. Med. Metab. Biol. | pmid:8382502 |
| Jump DB et al. | Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation. | 2011 | Biochem. Pharmacol. | pmid:21184748 |
| Murphy MG et al. | Effects of membrane polyunsaturated fatty acids on opiate peptide inhibition of basal and prostaglandin E1-stimulated cyclic AMP formation in intact N1E-115 neuroblastoma cells. | 1987 | Biochem. Pharmacol. | pmid:2825714 |
| Bomalaski JS et al. | Alteration of uptake and distribution of eicosanoid precursor fatty acids by aspirin. | 1987 | Biochem. Pharmacol. | pmid:3117063 |
| Medini L et al. | Diets rich in n-9, n-6 and n-3 fatty acids differentially affect the generation of inositol phosphates and of thromboxane by stimulated platelets, in the rabbit. | 1990 | Biochem. Pharmacol. | pmid:2105092 |
| Demant EJ and Wassermann K | Doxorubicin induced alterations in lipid metabolism of cultured myocardial cells. | 1985 | Biochem. Pharmacol. | pmid:4004891 |
| Kashfi K and Rigas B | Non-COX-2 targets and cancer: expanding the molecular target repertoire of chemoprevention. | 2005 | Biochem. Pharmacol. | pmid:15949789 |
| Clark DL and Queener SF | Effects of diabetes mellitus on renal fatty acid activation and desaturation. | 1985 | Biochem. Pharmacol. | pmid:4074391 |
| Kawashima Y et al. | Reduction by clofibric acid of serum arachidonic acid in rats. Effect on the acyl composition of renal phospholipids. | 1992 | Biochem. Pharmacol. | pmid:1610396 |
| Blond JP et al. | Effect of fenofibrate treatment on linoleic acid desaturation in liver of obese Zucker rats. | 1989 | Biochem. Pharmacol. | pmid:2764996 |
| Hudson EA et al. | Kinetics of the inhibition of tumour growth in mice by eicosapentaenoic acid-reversal by linoleic acid. | 1993 | Biochem. Pharmacol. | pmid:8517859 |
| Sauer LA et al. | Polyunsaturated fatty acids, melatonin, and cancer prevention. | 2001 | Biochem. Pharmacol. | pmid:11377374 |
| Allgayer H et al. | Superoxide, hydroxyl and fatty acid radical scavenging by aminosalicylates. Direct evaluation with electron spin resonance spectroscopy. | 1992 | Biochem. Pharmacol. | pmid:1310851 |
| Larsen LN et al. | Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. | 1998 | Biochem. Pharmacol. | pmid:9514074 |
| Goldmacher VS | Immobilization of protein molecules on liposomes. Anchorage by artificially bound unsaturated hydrocarbon tails. | 1983 | Biochem. Pharmacol. | pmid:6189496 |
| Masini E et al. | Histamine release from rat mast cells induced by metabolic activation of polyunsaturated fatty acids into free radicals. | 1990 | Biochem. Pharmacol. | pmid:1690007 |
| Vaughan PF and Ball SG | The effect of unsaturated fatty acids on sodium nitroprusside stimulation of guanylate cyclase in the human astrocytoma clone, D384, and the human neuroblastoma clone, NB1-G. | 1990 | Biochem. Pharmacol. | pmid:1968340 |
| Castańeda-Hernández G | Presence of endogenous digitalis-like activity in mammalian heart not due to fatty acids. | 1987 | Biochem. Pharmacol. | pmid:3036154 |
| Reynolds CH | Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic acid. | 1988 | Biochem. Pharmacol. | pmid:3144281 |
| Murakami A et al. | New class of linoleic acid metabolites biosynthesized by corn and rice lipoxygenases: suppression of proinflammatory mediator expression via attenuation of MAPK- and Akt-, but not PPARgamma-, dependent pathways in stimulated macrophages. | 2005 | Biochem. Pharmacol. | pmid:16143312 |
| Altmann R et al. | 13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells. | 2007 | Biochem. Pharmacol. | pmid:17604003 |
| Verwoert I et al. | The molecular basis of the high linoleic acid content in Petunia seed oil: analysis of a seed-specific linoleic acid mutant. | 2000 | Biochem. Soc. Trans. | pmid:11171150 |
| Kamisaka Y and Noda N | Intracellular transport of phosphatidic acid and phosphatidylcholine into lipid bodies: use of fluorescent lipids to study lipid-body formation in an oleaginous fungus. | 2000 | Biochem. Soc. Trans. | pmid:11171185 |
| Bailey JM et al. | Dietary linoleic acid in alcohol-induced liver cirrhosis. | 1995 | Biochem. Soc. Trans. | pmid:7672270 |
| Grechkin AN et al. | Lipoxygenase pathway in tulip: biosynthesis of ketols. | 2000 | Biochem. Soc. Trans. | pmid:11171230 |
| Kashulin PA et al. | Extremely rapid effects of polyunsaturated fatty acids and N-acetylglucosamine on free-radical metabolism in cultured potato plant cells. | 2000 | Biochem. Soc. Trans. | pmid:11171236 |
| Nuñez A et al. | Anaerobic lipoxygenase activity from Chlorella pyrenoidosa. | 2000 | Biochem. Soc. Trans. | pmid:11171268 |
| Kaushik N and Agnihotri A | GLC analysis of Indian rapeseed-mustard to study the variability of fatty acid composition. | 2000 | Biochem. Soc. Trans. | pmid:11171132 |
| Bates D | Lipids and multiple sclerosis. | 1989 | Biochem. Soc. Trans. | pmid:2546837 |
| Avery SV et al. | Low temperature-induced adaptations in lipid metabolism and physiological function in Acanthamoeba castellanii cultures of different ages. | 1994 | Biochem. Soc. Trans. | pmid:7821519 |
| O'Shea M et al. | The effect of a conjugated dienoic derivative of linoleic acid on the in vitro growth of MCF-7 and SW480 human cancer cell lines. | 1998 | Biochem. Soc. Trans. | pmid:10909819 |
| Cantwell H et al. | The effect of a conjugated linoleic acid on superoxide dismutase, catalase and glutathione peroxidase in oxidatively-challenged liver cells. | 1998 | Biochem. Soc. Trans. | pmid:10909820 |
| Peres CM et al. | Transference of fatty acids from macrophages to lymphocytes in culture. | 1997 | Biochem. Soc. Trans. | pmid:9191389 |
| Sanderson P et al. | Dietary fish oil diminishes the antigen presentation activity of rat dendritic cells. | 1997 | Biochem. Soc. Trans. | pmid:9191396 |
| Campbell FM and Dutta-Roy AK | Asymmetric distribution of the plasma membrane fatty acid-binding protein (FABPpm) in the human placenta. | 1996 | Biochem. Soc. Trans. | pmid:8736907 |
| Oliver MF | Linoleic acid, antioxidants and coronary heart disease. | 1990 | Biochem. Soc. Trans. | pmid:2088801 |
| Chaloner C et al. | Effect of oral supplementation with micronutrient antioxidants on trans fatty acid content of lipoproteins in healthy humans. | 1996 | Biochem. Soc. Trans. | pmid:8736849 |
| Das I et al. | Effects of aspirin and garlic on cyclooxygenase-induced chemiluminescence in human term placenta. | 1997 | Biochem. Soc. Trans. | pmid:9056997 |
| Colquhoun A and Curi R | Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. | 1997 | Biochem. Soc. Trans. | pmid:9450108 |
| Lloyd D et al. | Adaptive changes in yeast membranes: catabolite repression and oxygen. | 1983 | Biochem. Soc. Trans. | pmid:6617968 |
| Kaushik N and Vir S | Variations in fatty acid composition of neem seeds collected from the Rajasthan state of India. | 2000 | Biochem. Soc. Trans. | pmid:11171243 |
| Clouet P et al. | Mitochondrial respiration on rumenic and linoleic acids. | 2001 | Biochem. Soc. Trans. | pmid:11356175 |
| Emken EA et al. | Metabolism in vivo of deuterium-labelled linolenic and linoleic acids in humans. | 1990 | Biochem. Soc. Trans. | pmid:2083671 |
| James SR et al. | Linoleic acid increases cytosolic Ca2+ in lymphocytes. | 1990 | Biochem. Soc. Trans. | pmid:2083720 |
| Toomey S et al. | Regression of pre-established atherosclerosis in the apoE-/- mouse by conjugated linoleic acid. | 2003 | Biochem. Soc. Trans. | pmid:14505483 |
| Bell JG and Raynard RS | Effects of a high linoleic acid diet on the fatty acid composition of leucocytes from Atlantic salmon (Salmo salar). | 1990 | Biochem. Soc. Trans. | pmid:2083726 |
| Liu Q et al. | Genetic modification of cotton seed oil using inverted-repeat gene-silencing techniques. | 2000 | Biochem. Soc. Trans. | pmid:11288706 |
| Devery R et al. | Conjugated linoleic acid and oxidative behaviour in cancer cells. | 2001 | Biochem. Soc. Trans. | pmid:11356179 |
| Mogul R and Holman TR | Inhibition studies of soybean and human 15-lipoxygenases with long-chain alkenyl sulfate substrates. | 2001 | Biochemistry | pmid:11284695 |
| Kleinfeld AM et al. | Transport of long-chain native fatty acids across lipid bilayer membranes indicates that transbilayer flip-flop is rate limiting. | 1997 | Biochemistry | pmid:9369487 |
| Surette ME et al. | Relationship between arachidonate--phospholipid remodeling and apoptosis. | 1996 | Biochemistry | pmid:8703924 |
| Glickman MH and Klinman JP | Lipoxygenase reaction mechanism: demonstration that hydrogen abstraction from substrate precedes dioxygen binding during catalytic turnover. | 1996 | Biochemistry | pmid:8841132 |
| Biro A et al. | Complement protein C1q recognizes enzymatically modified low-density lipoprotein through unesterified fatty acids generated by cholesterol esterase. | 2010 | Biochemistry | pmid:20166680 |
| Pandey NR et al. | Linoleic acid-enriched phospholipids act through peroxisome proliferator-activated receptors alpha to stimulate hepatic apolipoprotein A-I secretion. | 2008 | Biochemistry | pmid:18189424 |
| Lima ES et al. | Characterization of linoleic acid nitration in human blood plasma by mass spectrometry. | 2002 | Biochemistry | pmid:12186558 |
| Richieri GV et al. | Fatty acid binding proteins from different tissues show distinct patterns of fatty acid interactions. | 2000 | Biochemistry | pmid:10852718 |
| Nieuwenhuizen WF et al. | Lipoxygenase is irreversibly inactivated by the hydroperoxides formed from the enynoic analogues of linoleic acid. | 1997 | Biochemistry | pmid:9109655 |
| Jones GD et al. | Role of lipid hydroperoxides in the activation of 15-lipoxygenase. | 1996 | Biochemistry | pmid:8679548 |
| Wecksler AT et al. | Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. | 2009 | Biochemistry | pmid:19469483 |
| Rickert KW and Klinman JP | Nature of hydrogen transfer in soybean lipoxygenase 1: separation of primary and secondary isotope effects. | 1999 | Biochemistry | pmid:10493789 |
| Mukherjee A et al. | Molecular oxygen dependent steps in fatty acid oxidation by cyclooxygenase-1. | 2007 | Biochemistry | pmid:17355126 |
| Mogul R et al. | Oleyl sulfate reveals allosteric inhibition of soybean lipoxygenase-1 and human 15-lipoxygenase. | 2000 | Biochemistry | pmid:10769137 |
| Widstrom RL et al. | Fatty acid-binding proteins inhibit hydration of epoxyeicosatrienoic acids by soluble epoxide hydrolase. | 2003 | Biochemistry | pmid:14529287 |
| Arnold WR et al. | Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase. | 2016 | Biochemistry | pmid:27992998 |
| Widstrom RL et al. | Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. | 2001 | Biochemistry | pmid:11170430 |