Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Pneumonia, Viral D011024 3 associated lipids
Exocrine Pancreatic Insufficiency D010188 6 associated lipids
Pain D010146 64 associated lipids
Otitis Externa D010032 8 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Melanosis D008548 4 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Lymphopenia D008231 2 associated lipids
Lung Neoplasms D008175 171 associated lipids
Liver Diseases D008107 31 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Downie MM et al. Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. 2004 Br. J. Dermatol. pmid:15491415
Manku MS et al. Essential fatty acids in the plasma phospholipids of patients with atopic eczema. 1984 Br. J. Dermatol. pmid:6329254
Zouboulis CC et al. Regulation of stearoyl-coenzyme A desaturase and fatty acid delta-6 desaturase-2 expression by linoleic acid and arachidonic acid in human sebocytes leads to enhancement of proinflammatory activity but does not affect lipogenesis. 2011 Br. J. Dermatol. pmid:21457203
WATSON WC The morphology and lipid composition of the erythrocytes in normal and essential-fatty-acid-deficient rats. 1963 Br. J. Haematol. pmid:13999227
Bellavite P et al. Correlations between the intensity of fMLP-dependent respiratory burst and cellular fatty acid composition in human neutrophils. 1995 Br. J. Haematol. pmid:7873377
Ivan M et al. Rumen fermentation and microbial population in lactating dairy cows receiving diets containing oilseeds rich in C-18 fatty acids. 2013 Br. J. Nutr. pmid:22850225
Alvheim AR et al. Dietary linoleic acid elevates endogenous 2-arachidonoylglycerol and anandamide in Atlantic salmon (Salmo salar L.) and mice, and induces weight gain and inflammation in mice. 2013 Br. J. Nutr. pmid:22883314
Thomas Yeung CH et al. Dietary conjugated linoleic acid mixture affects the activity of intestinal acyl coenzyme A: cholesterol acyltransferase in hamsters. 2000 Br. J. Nutr. pmid:11177212
Yepuri G et al. Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. 2011 Br. J. Nutr. pmid:21281526
Czernichow S et al. n-6 Fatty acids and cardiovascular health: a review of the evidence for dietary intake recommendations. 2010 Br. J. Nutr. pmid:20522273
Kelly O et al. The effect of polyunsaturated fatty acids, including conjugated linoleic acid, on calcium absorption and bone metabolism and composition in young growing rats. 2003 Br. J. Nutr. pmid:13129442
Han KH et al. Anthocyanin-rich purple potato flake extract has antioxidant capacity and improves antioxidant potential in rats. 2006 Br. J. Nutr. pmid:17181888
Hsu JM and Ding ST Effect of polyunsaturated fatty acids on the expression of transcription factor adipocyte determination and differentiation-dependent factor 1 and of lipogenic and fatty acid oxidation enzymes in porcine differentiating adipocytes. 2003 Br. J. Nutr. pmid:13129455
Loor JJ et al. Effects of dietary cis 9, trans 11-18:2, trans 10, cis 12-18:2, or vaccenic acid (trans 11-18:1) during lactation on body composition, tissue fatty acid profiles, and litter growth in mice. 2003 Br. J. Nutr. pmid:14641963
Sanders TA et al. The influence of a maternal diet rich in linoleic acid on brain and retinal docosahexaenoic acid in the rat. 1984 Br. J. Nutr. pmid:6228249
Zuo R et al. Effects of conjugated linoleic acid on growth, non-specific immunity, antioxidant capacity, lipid deposition and related gene expression in juvenile large yellow croaker (Larmichthys crocea) fed soyabean oil-based diets. 2013 Br. J. Nutr. pmid:23452520
García-de-Lorenzo A et al. Parenteral nutrition providing a restricted amount of linoleic acid in severely burned patients: a randomised double-blind study of an olive oil-based lipid emulsion v. medium/long-chain triacylglycerols. 2005 Br. J. Nutr. pmid:16115356
Oikawa D et al. Modification of skin composition by conjugated linoleic acid alone or with combination of other fatty acids in mice. 2005 Br. J. Nutr. pmid:16115363
Ibrahim A et al. Impact of maternal dietary fatty acid composition on glucose and lipid metabolism in male rat offspring aged 105 d. 2009 Br. J. Nutr. pmid:19166630
Calder PC Early life programming of immune and lung function: can we now exclude a role of arachidonic acid exposure? 2009 Br. J. Nutr. pmid:19166631
French S Effects of dietary fat and carbohydrate on appetite vary depending upon site and structure. 2004 Br. J. Nutr. pmid:15384318
MEGHAL SK and NATH MC ACTION OF FATS AND LINOLEIC ACID ON INTESTINAL SYNTHESIS OF THIAMINE IN THIAMINE-DEFICIENT RATS. 1965 Br. J. Nutr. pmid:14290858
Eriksson S et al. Fatty acid pattern in serum is associated with bone mineralisation in healthy 8-year-old children. 2009 Br. J. Nutr. pmid:19175947
Kritchevsky D Antimutagenic and some other effects of conjugated linoleic acid. 2000 Br. J. Nutr. pmid:10953669
Costarelli V and Sanders TA Acute effects of dietary fat composition on postprandial plasma bile acid and cholecystokinin concentrations in healthy premenopausal women. 2001 Br. J. Nutr. pmid:11591234
Kirstein D et al. Effect of dietary fats on the delta 6- and delta 5-desaturation of fatty acids in rat liver microsomes. 1983 Br. J. Nutr. pmid:6315055
MOORE JH and WILLIAMS DL THE EFFECT OF DIET ON THE LEVEL OF PLASMA CHOLESTEROL AND THE DEGREE OF ATHEROMATOUS DEGENERATION IN THE RABBIT. 1964 Br. J. Nutr. pmid:14154252
Li Y et al. Bone mineral content is positively correlated to n-3 fatty acids in the femur of growing rats. 2010 Br. J. Nutr. pmid:20420751
Saez G et al. Hepatic metabolism of glucose and linoleic acid varies in relation to susceptibility to fatty liver in ad libitum-fed Muscovy and Pekin ducks. 2009 Br. J. Nutr. pmid:18616836
Moussa M et al. Relationship between the fatty acid composition of rat lymphocytes and immune functions. 2000 Br. J. Nutr. pmid:10884721
Ostrowska E et al. Conjugated linoleic acid decreases fat accretion in pigs: evaluation by dual-energy X-ray absorptiometry. 2003 Br. J. Nutr. pmid:12575906
Noone EJ et al. The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. 2002 Br. J. Nutr. pmid:12207834
MacIntosh BA et al. Low-n-6 and low-n-6 plus high-n-3 diets for use in clinical research. 2013 Br. J. Nutr. pmid:23328113
Wang S et al. In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation. 2009 Br. J. Nutr. pmid:19660150
Javadi M et al. The effect of six different C18 fatty acids on body fat and energy metabolism in mice. 2004 Br. J. Nutr. pmid:15469642
Burdge GC et al. Effect of reduced maternal protein intake in pregnancy in the rat on the fatty acid composition of brain, liver, plasma, heart and lung phospholipids of the offspring after weaning. 2003 Br. J. Nutr. pmid:12908895
Zhang M and Fritsche KL Fatty acid-mediated inhibition of IL-12 production by murine macrophages is independent of PPARgamma. 2004 Br. J. Nutr. pmid:15137925
Ostrowska E et al. Effects of dietary fat and conjugated linoleic acid on plasma metabolite concentrations and metabolic responses to homeostatic signals in pigs. 2002 Br. J. Nutr. pmid:12493084
Wachira AM et al. Effects of dietary fat source and breed on the carcass composition, n-3 polyunsaturated fatty acid and conjugated linoleic acid content of sheep meat and adipose tissue. 2002 Br. J. Nutr. pmid:12493092
Chen ZY et al. Accumulation of polyunsaturates is decreased by weight-cycling: whole-body analysis in young, growing rats. 1996 Br. J. Nutr. pmid:8672410
Strandvik B Mediterranean diet and cystic fibrosis. 2006 Br. J. Nutr. pmid:16923213
Burdge GC et al. Lack of effect of meal fatty acid composition on postprandial lipid, glucose and insulin responses in men and women aged 50-65 years consuming their habitual diets. 2006 Br. J. Nutr. pmid:16925854
Chen ZY et al. Accumulation and apparent oxidation of cis,trans-18 : 2 isomers relative to linoleic acid in rats. 2001 Br. J. Nutr. pmid:11502239
Mitoulas LR et al. Infant intake of fatty acids from human milk over the first year of lactation. 2003 Br. J. Nutr. pmid:14667191
Turpeinen AM et al. Effects of conjugated linoleic acid on linoleic and linolenic acid metabolism in man. 2006 Br. J. Nutr. pmid:16571152
Smeets AJ and Westerterp-Plantenga MS Satiety and substrate mobilization after oral fat stimulation. 2006 Br. J. Nutr. pmid:16571160
Tyagi A et al. Attenuation of colonic inflammation by partial replacement of dietary linoleic acid with α-linolenic acid in a rat model of inflammatory bowel disease. 2012 Br. J. Nutr. pmid:22243775
Lee S et al. Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1. 2012 Br. J. Nutr. pmid:21846428
Stammers JP et al. High arachidonic acid levels in the cord blood of infants of mothers on vegetarian diets. 1989 Br. J. Nutr. pmid:2493804
de Goede J et al. Linoleic acid intake, plasma cholesterol and 10-year incidence of CHD in 20,000 middle-aged men and women in the Netherlands. 2012 Br. J. Nutr. pmid:21816117
Peoples GE and McLennan PL Dietary fish oil reduces skeletal muscle oxygen consumption, provides fatigue resistance and improves contractile recovery in the rat in vivo hindlimb. 2010 Br. J. Nutr. pmid:20691135
Sergeant S et al. Impact of methods used to express levels of circulating fatty acids on the degree and direction of associations with blood lipids in humans. 2016 Br. J. Nutr. pmid:26615716
Ghusain-Choueiri AA and Rath EA Effect of carbohydrate source on lipid metabolism in lactating mice and on pup development. 1995 Br. J. Nutr. pmid:8562569
Torres AG et al. Polyunsaturated fatty acids and conjugated linoleic acid isomers in breast milk are associated with plasma non-esterified and erythrocyte membrane fatty acid composition in lactating women. 2006 Br. J. Nutr. pmid:16512938
Hurley MS et al. Effects of fatty acids on skeletal muscle cell differentiation in vitro. 2006 Br. J. Nutr. pmid:16512949
Ghebremeskel K et al. Maternal diet high in fat reduces docosahexaenoic acid in liver lipids of newborn and sucking rat pups. 1999 Br. J. Nutr. pmid:10615212
MOORE JH and WILLIAMS D THE RELATIONSHIP BETWEEN THE LINOLEIC ACID CONTENT OF THE DIET, THE FATTY ACID COMPOSITION OF THE PLASMA PHOSPHOLIPIDS AND THE DEGREE OF AORTIC ATHEROSIS IN EXPERIMENTAL RABBITS. 1964 Br. J. Nutr. pmid:14241591
Odabasoglu F et al. α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations. 2011 Br. J. Nutr. pmid:21073761
Levitan EB et al. α-Linolenic acid, linoleic acid and heart failure in women. 2012 Br. J. Nutr. pmid:22172525
Calder PC The American Heart Association advisory on n-6 fatty acids: evidence based or biased evidence? 2010 Br. J. Nutr. pmid:21118616
Ramsden CE et al. n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. 2010 Br. J. Nutr. pmid:21118617
Mateu-de Antonio J et al. Comparative effects of olive oil-based and soyabean oil-based emulsions on infection rate and leucocyte count in critically ill patients receiving parenteral nutrition. 2008 Br. J. Nutr. pmid:17916276
de Deckere EA et al. Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster. 1999 Br. J. Nutr. pmid:10655980
Szymczyk B and Pisulewski PM Effects of dietary conjugated linoleic acid on fatty acid composition and cholesterol content of hen egg yolks. 2003 Br. J. Nutr. pmid:12844380
Kamphuis MM et al. The effect of addition of linoleic acid on food intake regulation in linoleic acid tasters and linoleic acid non-tasters. 2003 Br. J. Nutr. pmid:12844392
Sato M et al. Linoleic acid-rich fats reduce atherosclerosis development beyond its oxidative and inflammatory stress-increasing effect in apolipoprotein E-deficient mice in comparison with saturated fatty acid-rich fats. 2005 Br. J. Nutr. pmid:16351765
de Groot RH et al. Age dependence of plasma phospholipid fatty acid levels: potential role of linoleic acid in the age-associated increase in docosahexaenoic acid and eicosapentaenoic acid concentrations. 2009 Br. J. Nutr. pmid:19402937
Scislowski V et al. Linoleate supplementation in steers modifies lipid composition of plasma lipoproteins but does not alter their fluidity. 2004 Br. J. Nutr. pmid:15035684
Forsythe CE et al. Cholesterolaemic influence of palmitic acid in the sn-1, 3 v. the sn-2 position with high or low dietary linoleic acid in healthy young men. 2007 Br. J. Nutr. pmid:17391563
Steffen BT et al. n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. 2013 Br. J. Nutr. pmid:23551952
Rudel LL Atherosclerosis and conjugated linoleic acid. 1999 Br. J. Nutr. pmid:10434843
Cunnane SC et al. Linoleic acid and arachidonic acid metabolism in human peripheral blood leucocytes: comparison with the rat. 1984 Br. J. Nutr. pmid:6422980
Devillard E et al. Rumen ciliate protozoa contain high concentrations of conjugated linoleic acids and vaccenic acid, yet do not hydrogenate linoleic acid or desaturate stearic acid. 2006 Br. J. Nutr. pmid:17010229
Wan ZX et al. Lipid content and fatty acids composition of mature human milk in rural North China. 2010 Br. J. Nutr. pmid:19825220
Watkins BA Influences of biotin deficiency and dietary trans-fatty acids on tissue lipids in chickens. 1989 Br. J. Nutr. pmid:2923859
Naughton SS et al. Australia's nutrition transition 1961-2009: a focus on fats. 2015 Br. J. Nutr. pmid:26123446
Damsgaard CT et al. The effects of fish oil and high or low linoleic acid intake on fatty acid composition of human peripheral blood mononuclear cells. 2008 Br. J. Nutr. pmid:17663804
Szymczyk B et al. Effects of conjugated linoleic acid on growth performance, feed conversion efficiency, and subsequent carcass quality in broiler chickens. 2001 Br. J. Nutr. pmid:11348561
Nadtochiy SM et al. Mitochondrially targeted nitro-linoleate: a new tool for the study of cardioprotection. 2014 Br. J. Pharmacol. pmid:24102583
Briscoe CP et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. 2006 Br. J. Pharmacol. pmid:16702987
Leis HJ et al. On the inhibition of prostanoid formation by SK&F 96365, a blocker of receptor-operated calcium entry. 1995 Br. J. Pharmacol. pmid:7735686
Whitehead CC and Herron KM Fatty acid requirements of breeding turkeys. 1988 Br. Poult. Sci. pmid:3233502
Murai A et al. Role of dietary gamma-linolenic acid in liver lipid metabolism in Japanese quail. 1995 Br. Poult. Sci. pmid:8746984
Grobas S et al. Influence of dietary energy, supplemental fat and linoleic acid concentration on performance of laying hens at two ages. 1999 Br. Poult. Sci. pmid:10670682
Lábaque MC et al. Effect of age and body weight of Greater Rhea (Rhea americana) females on egg number, size and composition. 2010 Br. Poult. Sci. pmid:21161792
Sijben JW et al. Interactions of dietary polyunsaturated fatty acids and vitamin E with regard to vitamin E status, fat composition and antibody responsiveness in layer hens. 2002 Br. Poult. Sci. pmid:12047096
Parmentier HK et al. Different sources of dietary n-6 polyunsaturated fatty acids and their effects on antibody responses in chickens. 2002 Br. Poult. Sci. pmid:12365510
Dänicke S et al. Interactions between dietary fat type and xylanase supplementation when rye-based diets are fed to broiler chickens 2. Performance, nutrient digestibility and the fat-soluble vitamin status of livers. 1997 Br. Poult. Sci. pmid:9511000
Alao SJ and Balnave D Growth and carcass composition of broilers fed sunflower oil and olive oil. 1984 Br. Poult. Sci. pmid:6733552
Politis I et al. Effects of dietary conjugated linoleic acid isomers on several functional properties of macrophages and heterophils in laying hens. 2003 Br. Poult. Sci. pmid:12828205
Umezawa M et al. Dietary alpha-linolenate/linoleate balance influences learning and memory in the senescence-accelerated mouse (SAM). 1995 Brain Res. pmid:7712178
Cao AH et al. Composition of long chain polyunsaturated fatty acids (LC-PUFAs) in different encephalic regions and its association with behavior in spontaneous hypertensive rat (SHR). 2013 Brain Res. pmid:23811335
Sikorski AM et al. Conjugated Linoleic Acid (CLA) inhibits new vessel growth in the mammalian brain. 2008 Brain Res. pmid:18456247
Berthoud HR et al. Food-related gastrointestinal signals activate caudal brainstem neurons expressing both NMDA and AMPA receptors. 2001 Brain Res. pmid:11595203
Nishizaki T et al. Short-term depression and long-term enhancement of ACh-gated channel currents induced by linoleic and linolenic acid. 1997 Brain Res. pmid:9099812
Itokazu N et al. Bidirectional actions of docosahexaenoic acid on hippocampal neurotransmissions in vivo. 2000 Brain Res. pmid:10799687
Pittman D et al. Chorda tympani nerve transection impairs the gustatory detection of free fatty acids in male and female rats. 2007 Brain Res. pmid:17428454
Yaguchi T et al. Effects of cis-unsaturated free fatty acids on PKC-epsilon activation and nicotinic ACh receptor responses. 2005 Brain Res. Mol. Brain Res. pmid:15710250
Gregório SM et al. Effect of dietary linoleic acid on the progression of chronic renal failure in rats. 2002 Braz. J. Med. Biol. Res. pmid:12011943
McGowan MM et al. A proof of principle clinical trial to determine whether conjugated linoleic acid modulates the lipogenic pathway in human breast cancer tissue. 2013 Breast Cancer Res. Treat. pmid:23417336