| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brynes AE et al. | Diet-induced change in fatty acid composition of plasma triacylglycerols is not associated with change in glucagon-like peptide 1 or insulin sensitivity in people with type 2 diabetes. | 2000 | Am. J. Clin. Nutr. | pmid:11063437 |
| Hennig B et al. | Linoleic acid activates nuclear transcription factor-kappa B (NF-kappa B) and induces NF-kappa B-dependent transcription in cultured endothelial cells. | 1996 | Am. J. Clin. Nutr. | pmid:8602587 |
| Routi T et al. | Effects of prospective, randomized cholesterol-lowering dietary intervention and apolipoprotein E phenotype on serum lipoprotein(a) concentrations of infants aged 7-24 mo. | 1996 | Am. J. Clin. Nutr. | pmid:8602597 |
| Anderson RL | Quantitation of the effects of trans isomers of linoleic acid on the metabolism of linoleic acid. | 1982 | Am. J. Clin. Nutr. | pmid:7081132 |
| Innis SM and Elias SL | Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. | 2003 | Am. J. Clin. Nutr. | pmid:12540410 |
| Vos E and Cunnane SC | Alpha-linolenic acid, linoleic acid, coronary artery disease, and overall mortality. | 2003 | Am. J. Clin. Nutr. | pmid:12540417 |
| Anderson GJ and Connor WE | On the demonstration of omega-3 essential-fatty-acid deficiency in humans. | 1989 | Am. J. Clin. Nutr. | pmid:2494878 |
| Vedtofte MS et al. | Dietary α-linolenic acid, linoleic acid, and n-3 long-chain PUFA and risk of ischemic heart disease. | 2011 | Am. J. Clin. Nutr. | pmid:21865326 |
| Herbel BK et al. | Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. | 1998 | Am. J. Clin. Nutr. | pmid:9459383 |
| Meerarani P et al. | Zinc protects against apoptosis of endothelial cells induced by linoleic acid and tumor necrosis factor alpha. | 2000 | Am. J. Clin. Nutr. | pmid:10617950 |
| Horrobin DF | Essential fatty acid metabolism and its modification in atopic eczema. | 2000 | Am. J. Clin. Nutr. | pmid:10617999 |
| Abbey M et al. | Oxidation of low-density lipoproteins: intraindividual variability and the effect of dietary linoleate supplementation. | 1993 | Am. J. Clin. Nutr. | pmid:8438773 |
| Elias SL and Innis SM | Infant plasma trans, n-6, and n-3 fatty acids and conjugated linoleic acids are related to maternal plasma fatty acids, length of gestation, and birth weight and length. | 2001 | Am. J. Clin. Nutr. | pmid:11273857 |
| Freeman VL et al. | Assessing the effect of fatty acids on prostate carcinogenesis in humans: does self-reported dietary intake rank prostatic exposure correctly? | 2001 | Am. J. Clin. Nutr. | pmid:11273858 |
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| Ascherio A | Epidemiologic studies on dietary fats and coronary heart disease. | 2002 | Am. J. Med. | pmid:12566133 |
| Weiss LA et al. | The omega-6 fatty acid linoleic acid is associated with risk of gastroschisis: a novel dietary risk factor. | 2012 | Am. J. Med. Genet. A | pmid:22315197 |
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| MacKenzie LW et al. | Prostacyclin biosynthesis by cultured human myometrial smooth muscle cells: dependency on arachidonic or linoleic acid in the culture medium. | 1988 | Am. J. Obstet. Gynecol. | pmid:3144917 |
| Vaughan JE and Walsh SW | Neutrophils from pregnant women produce thromboxane and tumor necrosis factor-alpha in response to linoleic acid and oxidative stress. | 2005 | Am. J. Obstet. Gynecol. | pmid:16150282 |
| Liu H et al. | Transient receptor potential vanilloid 1 gene deficiency ameliorates hepatic injury in a mouse model of chronic binge alcohol-induced alcoholic liver disease. | 2015 | Am. J. Pathol. | pmid:25447051 |
| McEntee MF et al. | Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer. | 2008 | Am. J. Pathol. | pmid:18556778 |
| Pandey NR et al. | An induction in hepatic HDL secretion associated with reduced ATPase expression. | 2009 | Am. J. Pathol. | pmid:19717637 |
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| Murray MJ et al. | Effects of endotoxin on pigs prefed omega-3 vs. omega-6 fatty acid-enriched diets. | 1993 | Am. J. Physiol. | pmid:8279548 |
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| Emmison N et al. | Linoleic and linolenic acids are selectively secreted in triacylglycerol by hepatocytes from neonatal rats. | 1995 | Am. J. Physiol. | pmid:7631907 |
| Thomas ME et al. | Metabolic effects of fatty acid-bearing albumin on a proximal tubule cell line. | 1995 | Am. J. Physiol. | pmid:7611458 |
| Chen ZY et al. | Depletion of linoleate induced by weight cycling is independent of extent of calorie restriction. | 1997 | Am. J. Physiol. | pmid:9038989 |
| WILSON JD | Relation between dietary cholesterol and bile acid excretion in the rat. | 1962 | Am. J. Physiol. | pmid:14001040 |
| Nilsson A et al. | Absorption and lymphatic transport of exogenous and endogenous arachidonic and linoleic acid in the rat. | 1987 | Am. J. Physiol. | pmid:3109253 |
| Reddy SR et al. | Effect of linoleic acid infusion on blood pressure in normotensive and hypertensive rats. | 1989 | Am. J. Physiol. | pmid:2764141 |
| Le Petit-Thevenin J et al. | Changes in pattern of phospholipid acylation during in vivo aging of rat red blood cells. | 1991 | Am. J. Physiol. | pmid:1887869 |
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| Devor DC and Frizzell RA | Modulation of K+ channels by arachidonic acid in T84 cells. II. Activation of a Ca(2+)-independent K+ channel. | 1998 | Am. J. Physiol. | pmid:9458723 |
| Chen ZY et al. | Moderate, selective depletion of linoleate and alpha-linolenate in weight-cycled rats. | 1995 | Am. J. Physiol. | pmid:7864247 |
| Hjelte L et al. | Absorption and metabolism of [3H]arachidonic and [14C]linoleic acid in essential fatty acid-deficient rats. | 1990 | Am. J. Physiol. | pmid:2115302 |
| Phifer CB and Berthoud HR | Duodenal nutrient infusions differentially affect sham feeding and Fos expression in rat brain stem. | 1998 | Am. J. Physiol. | pmid:9841547 |
| Meyer C et al. | Human kidney free fatty acid and glucose uptake: evidence for a renal glucose-fatty acid cycle. | 1997 | Am. J. Physiol. | pmid:9316458 |
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