Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

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Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Helicobacter Infections D016481 21 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Hypertrophy, Left Ventricular D017379 12 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Hyperpigmentation D017495 11 associated lipids
Community-Acquired Infections D017714 8 associated lipids
Glucose Intolerance D018149 13 associated lipids
Circoviridae Infections D018173 2 associated lipids
Genetic Predisposition to Disease D020022 24 associated lipids
Coronary Restenosis D023903 10 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Genetic Diseases, X-Linked D040181 2 associated lipids
Atherosclerosis D050197 85 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Acute Coronary Syndrome D054058 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

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Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Yen GC and Hsieh CL Antioxidant effects of dopamine and related compounds. 1997 Biosci. Biotechnol. Biochem. pmid:10336274
Nuñez A et al. Cofactor recycling in a coupled enzyme oxidation-reduction reaction: conversion of omega-oxo-fatty acids into omega-hydroxy and dicarboxylic acids. 1999 Biotechnol. Appl. Biochem. pmid:10334949
Kapich A et al. Coupling of manganese peroxidase-mediated lipid peroxidation with destruction of nonphenolic lignin model compounds and 14C-labeled lignins. 1999 Biochem. Biophys. Res. Commun. pmid:10334942
Wei T et al. Antioxidant properties of EPC-K1: a study on mechanisms. 1999 Biophys. Chem. pmid:10326248
Haggarty P et al. Effect of maternal polyunsaturated fatty acid concentration on transport by the human placenta. 1999 Biol. Neonate pmid:10325438
Geetha T and Varalakshmi P Anticomplement activity of triterpenes from Crataeva nurvala stem bark in adjuvant arthritis in rats. 1999 Gen. Pharmacol. pmid:10323491
Burke PA et al. Conditionally essential fatty acid deficiencies in end-stage liver disease. 1999 Nutrition pmid:10319364
Iuliano L et al. Protection of low density lipoprotein oxidation by the antioxidant agent IRFI005, a new synthetic hydrophilic vitamin E analogue. 1999 Free Radic. Biol. Med. pmid:10232829
Szitanyi P et al. Metabolism of 13C-labeled linoleic acid in newborn infants during the first week of life. 1999 Pediatr. Res. pmid:10231862
Banni S et al. An increase in vitamin A status by the feeding of conjugated linoleic acid. 1999 Nutr Cancer pmid:10227044
Cortez-Pinto H et al. Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes. 1999 Gastroenterology pmid:10220511
Minich DM et al. Bile diversion in rats leads to a decreased plasma concentration of linoleic acid which is not due to decreased net intestinal absorption of dietary linoleic acid. 1999 Biochim. Biophys. Acta pmid:10216285
Spaide RF et al. Characterization of peroxidized lipids in Bruch's membrane. 1999 Retina (Philadelphia, Pa.) pmid:10213241
Bergamini S et al. Prooxidant activity of ferrioxamine in isolated rat hepatocytes and linoleic acid micelles. 1999 Chem. Res. Toxicol. pmid:10207126
DeLany JP et al. Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. 1999 Am. J. Physiol. pmid:10198400
Jayawickreme SP et al. Regulation of 15-lipoxygenase expression and mucus secretion by IL-4 in human bronchial epithelial cells. 1999 Am. J. Physiol. pmid:10198357
Augé N et al. Uptake of 13-hydroperoxylinoleic acid by cultured cells. 1999 Arterioscler. Thromb. Vasc. Biol. pmid:10195919
Stewart JM et al. Comparisons of the effects of temperature on the liver fatty acid binding proteins from hibernator and nonhibernator mammals. 1998 Biochem. Cell Biol. pmid:10099779
Galli A et al. High-level expression of rat class I alcohol dehydrogenase is sufficient for ethanol-induced fat accumulation in transduced HeLa cells. 1999 Hepatology pmid:10094961
Brodie AE et al. Conjugated linoleic acid inhibits differentiation of pre- and post- confluent 3T3-L1 preadipocytes but inhibits cell proliferation only in preconfluent cells. 1999 J. Nutr. pmid:10082762