| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Qian SY et al. | EPR detection of lipid-derived free radicals from PUFA, LDL, and cell oxidations. | 2000 | Free Radic. Biol. Med. | pmid:11025200 |
| Meaney CM and O'Driscoll CM | A comparison of the permeation enhancement potential of simple bile salt and mixed bile salt:fatty acid micellar systems using the CaCo-2 cell culture model. | 2000 | Int J Pharm | pmid:11036226 |
| Smith HL et al. | Development of a serum-free system for the in vitro cultivation of Brugia malayi infective-stage larvae. | 2000 | Exp. Parasitol. | pmid:11038308 |
| French SJ et al. | The effects of intestinal infusion of long-chain fatty acids on food intake in humans. | 2000 | Gastroenterology | pmid:11040181 |
| Moran JH et al. | Analysis of the cytotoxic properties of linoleic acid metabolites produced by renal and hepatic P450s. | 2000 | Toxicol. Appl. Pharmacol. | pmid:11042099 |
| Soriano CR et al. | Cutaneous application of vegetable oil as a coadjutant in the nutritional management of preterm infants. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:11045835 |
| Steinkamp G et al. | Energy supplements rich in linoleic acid improve body weight and essential fatty acid status of cystic fibrosis patients. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:11045840 |
| Whigham LD et al. | Conjugated linoleic acid: implications for human health. | 2000 | Pharmacol. Res. | pmid:11058400 |
| Surai PF et al. | Effect of long-term supplementation with arachidonic or docosahexaenoic acids on sperm production in the broiler chicken. | 2000 | J. Reprod. Fertil. | pmid:11058441 |
| Cunnane SC et al. | Specific linoleate deficiency in the rat does not prevent substantial carbon recycling from [(14)C]linoleate into sterols. | 2000 | J. Lipid Res. | pmid:11060350 |
| Ferry DR et al. | A phase II study of the 5-lipoxygenase inhibitor, CV6504, in advanced pancreatic cancer: correlation of clinical data with pharmacokinetic and pharmacodynamic endpoints. | 2000 | Ann. Oncol. | pmid:11061613 |
| French P et al. | Fatty acid composition, including conjugated linoleic acid, of intramuscular fat from steers offered grazed grass, grass silage, or concentrate-based diets. | 2000 | J. Anim. Sci. | pmid:11063308 |
| Brynes AE et al. | Diet-induced change in fatty acid composition of plasma triacylglycerols is not associated with change in glucagon-like peptide 1 or insulin sensitivity in people with type 2 diabetes. | 2000 | Am. J. Clin. Nutr. | pmid:11063437 |
| Granot E et al. | Breast-fed and formula-fed infants do not differ in immunocompetent cell cytokine production despite differences in cell membrane fatty acid composition. | 2000 | Am. J. Clin. Nutr. | pmid:11063450 |
| Cahoon EB et al. | Formation of conjugated delta8,delta10-double bonds by delta12-oleic-acid desaturase-related enzymes: biosynthetic origin of calendic acid. | 2001 | J. Biol. Chem. | pmid:11067856 |
| Hochi S et al. | Nuclear transfer in cattle : effect of linoleic acid-albumin on freezing sensitivity of enucleated oocytes. | 2000 | J. Vet. Med. Sci. | pmid:11073086 |
| Grechkin AN et al. | The lipoxygenase pathway in tulip (Tulipa gesneriana): detection of the ketol route. | 2000 | Biochem. J. | pmid:11085944 |
| Lehtinen P and Laakso S | Inhibition of linoleic acid oxidation by interaction with a protein-rich oat fraction. | 2000 | J. Agric. Food Chem. | pmid:11087534 |
| Louw L and Dannhauser A | Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090250 |
| Louw L | Keloids in rural black South Africans. Part 3: a lipid model for the prevention and treatment of keloid formations. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090251 |
| Mizushina Y et al. | Structural homology between DNA binding sites of DNA polymerase beta and DNA topoisomerase II. | 2000 | J. Mol. Biol. | pmid:11090281 |
| Ueno S et al. | Polymorphism of linoleic acid (cis-9, cis-12-octadecadienoic acid) and alpha-linolenic acid (cis-9, cis-12, cis-15-octadecatrienoic acid). | 2000 | Chem. Phys. Lipids | pmid:11090846 |
| Kwok CF et al. | Linoleic acid and oleic acid increase the endothelin-1 binding and action in cultured rat aortic smooth muscle cells. | 2000 | Metab. Clin. Exp. | pmid:11092498 |
| Minich DM et al. | Intestinal absorption and postabsorptive metabolism of linoleic acid in rats with short-term bile duct ligation. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:11093947 |
| Kim YJ et al. | Effect of linoleic acid concentration on conjugated linoleic acid production by Butyrivibrio fibrisolvens A38. | 2000 | Appl. Environ. Microbiol. | pmid:11097894 |
| van Dijk K and Nelson EB | Fatty acid competition as a mechanism by which Enterobacter cloacae suppresses Pythium ultimum sporangium germination and damping-off. | 2000 | Appl. Environ. Microbiol. | pmid:11097912 |
| Bauman DE et al. | Technical note: production of butter with enhanced conjugated linoleic acid for use in biomedical studies with animal models. | 2000 | J. Dairy Sci. | pmid:11104258 |
| Thuillier P et al. | Activators of peroxisome proliferator-activated receptor-alpha partially inhibit mouse skin tumor promotion. | 2000 | Mol. Carcinog. | pmid:11108658 |
| Blankson H et al. | Conjugated linoleic acid reduces body fat mass in overweight and obese humans. | 2000 | J. Nutr. | pmid:11110851 |
| Bee G | Dietary conjugated linoleic acid consumption during pregnancy and lactation influences growth and tissue composition in weaned pigs. | 2000 | J. Nutr. | pmid:11110857 |
| Innis SM | The role of dietary n-6 and n-3 fatty acids in the developing brain. | 2000 Sep-Dec | Dev. Neurosci. | pmid:11111165 |
| Fitch CD et al. | A role for linoleic acid in erythrocytes infected with Plasmodium berghei. | 2000 | Biochim. Biophys. Acta | pmid:11113630 |
| Yamasaki M et al. | Dietary conjugated linoleic acid increases immunoglobulin productivity of Sprague-Dawley rat spleen lymphocytes. | 2000 | Biosci. Biotechnol. Biochem. | pmid:11129589 |
| Masuda A et al. | Study of lipid in the ear canal in canine otitis externa with Malassezia pachydermatis. | 2000 | J. Vet. Med. Sci. | pmid:11129861 |
| MarÃn MC et al. | Dietary long-chain fatty acids and visual response in malnourished nursing infants. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11133176 |
| Kontush A et al. | Amyloid-beta is an antioxidant for lipoproteins in cerebrospinal fluid and plasma. | 2001 | Free Radic. Biol. Med. | pmid:11134902 |
| Kawai T et al. | Chronic effects of different fatty acids and leptin in INS-1 cells. | 2001 | Diabetes Res. Clin. Pract. | pmid:11137176 |
| Shureiqi I et al. | 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells. | 2000 | Cancer Res. | pmid:11156377 |
| Sakuma S et al. | The effects of fatty acyl CoA esters on the formation of prostaglandin and arachidonoyl-CoA formed from arachidonic acid in rabbit kidney medulla microsomes. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161586 |
| Soppela P and Nieminen M | The effect of wintertime undernutrition on the fatty acid composition of leg bone marrow fats in reindeer (Rangifer tarandus tarandus L.). | 2001 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:11163305 |
| Dikalov SI and Mason RP | Spin trapping of polyunsaturated fatty acid-derived peroxyl radicals: reassignment to alkoxyl radical adducts. | 2001 | Free Radic. Biol. Med. | pmid:11163536 |
| RamÃrez-Expósito MJ et al. | Oleate, linoleate and cholesterol differently modify aspartyl- and glutamyl-aminopeptidase activities in primary cultures of rat astrocytes. | 2001 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:11166679 |
| Widstrom RL et al. | Binding of cytochrome P450 monooxygenase and lipoxygenase pathway products by heart fatty acid-binding protein. | 2001 | Biochemistry | pmid:11170430 |
| Rival SG et al. | Caseins and casein hydrolysates. 2. Antioxidative properties and relevance to lipoxygenase inhibition. | 2001 | J. Agric. Food Chem. | pmid:11170591 |
| López-Nicolás JM et al. | Eggplant lipoxygenase (Solanum melongena): product characterization and effect of physicochemical properties of linoleic acid on the enzymatic activity. | 2001 | J. Agric. Food Chem. | pmid:11170610 |
| Louet JF et al. | Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway. | 2001 | Biochem. J. | pmid:11171094 |
| Kaushik N and Agnihotri A | GLC analysis of Indian rapeseed-mustard to study the variability of fatty acid composition. | 2000 | Biochem. Soc. Trans. | pmid:11171132 |
| Verwoert I et al. | The molecular basis of the high linoleic acid content in Petunia seed oil: analysis of a seed-specific linoleic acid mutant. | 2000 | Biochem. Soc. Trans. | pmid:11171150 |
| Kamisaka Y and Noda N | Intracellular transport of phosphatidic acid and phosphatidylcholine into lipid bodies: use of fluorescent lipids to study lipid-body formation in an oleaginous fungus. | 2000 | Biochem. Soc. Trans. | pmid:11171185 |
| Grechkin AN et al. | Lipoxygenase pathway in tulip: biosynthesis of ketols. | 2000 | Biochem. Soc. Trans. | pmid:11171230 |