| MeSH term | MeSH ID | Detail |
|---|---|---|
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Olfaction Disorders | D000857 | 17 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Staphylococcal Skin Infections | D013207 | 9 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Birth Weight | D001724 | 23 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Moran JH et al. | Defining mechanisms of toxicity for linoleic acid monoepoxides and diols in Sf-21 cells. | 2001 | Chem. Res. Toxicol. | pmid:11304132 |
| Yamasaki M et al. | Effect of dietary conjugated linoleic acid on lipid peroxidation and histological change in rat liver tissues. | 2000 | J. Agric. Food Chem. | pmid:11312809 |
| Park Y et al. | Comparison of methylation procedures for conjugated linoleic acid and artifact formation by commercial (trimethylsilyl) diazomethane. | 2001 | J. Agric. Food Chem. | pmid:11312828 |
| Hurst WJ et al. | Determination of conjugated linoleic acid (CLA) concentrations in milk chocolate. | 2001 | J. Agric. Food Chem. | pmid:11312847 |
| Yen GC et al. | Isolation and characterization of antioxidant compounds from Aspergillus candidus broth filtrate. | 2001 | J. Agric. Food Chem. | pmid:11312875 |
| Duh PD et al. | Antioxidant effects of water extracts from barley (Hordeum vulgare L.) prepared under different roasting temperatures. | 2001 | J. Agric. Food Chem. | pmid:11312880 |
| Miner JL et al. | Conjugated linoleic acid (CLA), body fat, and apoptosis. | 2001 | Obes. Res. | pmid:11316347 |
| Burczynski JM et al. | Changes in mitochondrial and microsomal lipid peroxidation and fatty acid profiles in adrenal glands, testes, and livers from alpha-tocopherol-deficient rats. | 2001 | Free Radic. Biol. Med. | pmid:11316583 |
| Spiteller G | Peroxidation of linoleic acid and its relation to aging and age dependent diseases. | 2001 | Mech. Ageing Dev. | pmid:11322990 |
| Spiteller P et al. | Aldehydic lipid peroxidation products derived from linoleic acid. | 2001 | Biochim. Biophys. Acta | pmid:11325611 |
| Samadi A et al. | Mechanism of lipid peroxidation photosensitized by tiaprofenic acid: product studies using linoleic acid and 1,4-cyclohexadienes as model substrates. | 2001 | Photochem. Photobiol. | pmid:11332030 |
| Cox JE et al. | Celiac vagotomy reduces suppression of feeding by jejunal fatty acid infusions. | 2001 | Neuroreport | pmid:11338171 |
| Orihara T et al. | Effect of Helicobacter pylori eradication on gastric mucosal phospholipid content and its fatty acid composition. | 2001 | J. Gastroenterol. Hepatol. | pmid:11339417 |
| Mattes RD | Oral exposure to butter, but not fat replacers elevates postprandial triacylglycerol concentration in humans. | 2001 | J. Nutr. | pmid:11340105 |
| Ritzenthaler KL et al. | Estimation of conjugated linoleic acid intake by written dietary assessment methodologies underestimates actual intake evaluated by food duplicate methodology. | 2001 | J. Nutr. | pmid:11340114 |
| Murase T et al. | Abundant expression of uncoupling protein-2 in the small intestine: up-regulation by dietary fish oil and fibrates. | 2001 | Biochim. Biophys. Acta | pmid:11341955 |
| Szymczyk B et al. | Effects of conjugated linoleic acid on growth performance, feed conversion efficiency, and subsequent carcass quality in broiler chickens. | 2001 | Br. J. Nutr. | pmid:11348561 |
| Pruzanski W et al. | Mitogenic effect of lipoproteins on human vascular smooth muscle cells: the impact of hydrolysis by gr II A phospholipase A(2). | 2001 | Lab. Invest. | pmid:11351047 |
| Kelder B et al. | Expression of fungal desaturase genes in cultured mammalian cells. | 2001 | Mol. Cell. Biochem. | pmid:11354256 |
| Waddington E et al. | Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatography. | 2001 | Anal. Biochem. | pmid:11355856 |
| Clouet P et al. | Mitochondrial respiration on rumenic and linoleic acids. | 2001 | Biochem. Soc. Trans. | pmid:11356175 |
| Devery R et al. | Conjugated linoleic acid and oxidative behaviour in cancer cells. | 2001 | Biochem. Soc. Trans. | pmid:11356179 |
| Fuller MA et al. | Activity of soybean lipoxygenase isoforms against esterified fatty acids indicates functional specificity. | 2001 | Arch. Biochem. Biophys. | pmid:11361131 |
| Tijet N et al. | Biogenesis of volatile aldehydes from fatty acid hydroperoxides: molecular cloning of a hydroperoxide lyase (CYP74C) with specificity for both the 9- and 13-hydroperoxides of linoleic and linolenic acids. | 2001 | Arch. Biochem. Biophys. | pmid:11368353 |
| Masuda T et al. | Chemical studies on antioxidant mechanism of curcumin: analysis of oxidative coupling products from curcumin and linoleate. | 2001 | J. Agric. Food Chem. | pmid:11368633 |
| Kimoto N et al. | Site-dependent modulating effects of conjugated fatty acids from safflower oil in a rat two-stage carcinogenesis model in female Sprague-Dawley rats. | 2001 | Cancer Lett. | pmid:11368872 |
| Bretillon L et al. | Isomerization increases the postprandial oxidation of linoleic acid but not alpha-linolenic acid in men. | 2001 | J. Lipid Res. | pmid:11369808 |
| Nakagawa H et al. | Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines. | 2001 | Carcinogenesis | pmid:11375895 |
| Rahman SM et al. | Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats. | 2001 | Nutrition | pmid:11377131 |
| Sauer LA et al. | Polyunsaturated fatty acids, melatonin, and cancer prevention. | 2001 | Biochem. Pharmacol. | pmid:11377374 |
| Vermunt SH et al. | The metabolism of linoleic acid in healthy subjects after intake of a single dose of (13)C-linoleic acid. | 2001 | Eur J Clin Nutr | pmid:11378804 |
| Sisk MB et al. | Dietary conjugated linoleic acid reduces adiposity in lean but not obese Zucker rats. | 2001 | J. Nutr. | pmid:11385051 |
| Misikangas M et al. | High linoleic acid, low vegetable, and high oleic acid, high vegetable diets affect platelet activation similarly in healthy women and men. | 2001 | J. Nutr. | pmid:11385056 |
| Baumgard LH et al. | Milk fat synthesis in dairy cows is progressively reduced by increasing supplemental amounts of trans-10, cis-12 conjugated linoleic acid (CLA). | 2001 | J. Nutr. | pmid:11385065 |
| Graczyk TK and Shiff CJ | Recovery of avian schistosome cercariae from water using penetration stimulant matrix with an unsaturated fatty acid. | 2000 Sep-Oct | Am. J. Trop. Med. Hyg. | pmid:11388510 |
| Saija A et al. | In vitro evaluation of the antioxidant activity and biomembrane interaction of the lazaroid U-74389G. | 2001 | Life Sci. | pmid:11388688 |
| Thomas MJ et al. | Isoprostane levels in lipids extracted from atherosclerotic arteries of nonhuman primates. | 2001 | Free Radic. Biol. Med. | pmid:11390178 |
| Amet Y et al. | Adaptation to chronic ethanol administration emphasized by fatty acid hydroxylations in rat liver and kidney microsomes. | 2000 | Eur J Nutr | pmid:11395987 |
| Jung MO et al. | Effects of temperature and agitation rate on the formation of conjugated linoleic acids in soybean oil during hydrogenation process. | 2001 | J. Agric. Food Chem. | pmid:11410002 |
| Hsi LC et al. | Evaluation of the activity and localization of 15-lipoxygenase-1 after introduction into human colorectal carcinoma Caco-2 cells. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418015 |
| Okita M et al. | Effect of arachidonic acid-rich oil on lipids and arachidonate metabolites in ethanol- treated rats. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418023 |
| Abeywardena MY et al. | Dietary n-3 and n-6 polyunsaturated oils and airway contractility. | 2001 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11418024 |
| Iwase H et al. | Thiol-oxidizing agent diamide and acidic pH enhance lipid peroxidation of rat heart mitochondria and cardiolipin-cytochrome c complex. | 2001 | IUBMB Life | pmid:11419694 |
| Kamphuis MM et al. | Fat-specific satiety in humans for fat high in linoleic acid vs fat high in oleic acid. | 2001 | Eur J Clin Nutr | pmid:11423927 |
| Swan JE et al. | Total body electrical conductivity (TOBEC) measurement of compositional differences in hams, loins, and bellies from conjugated linoleic acid (CLA)-fed stress-genotype pigs. | 2001 | J. Anim. Sci. | pmid:11424684 |
| McCarty MF | Current prospects for controlling cancer growth with non-cytotoxic agents--nutrients, phytochemicals, herbal extracts, and available drugs. | 2001 | Med. Hypotheses | pmid:11425277 |
| McCarty MF | The chlorophyll metabolite phytanic acid is a natural rexinoid--potential for treatment and prevention of diabetes. | 2001 | Med. Hypotheses | pmid:11425290 |
| Kim JY et al. | Lipid and fatty acid analysis of fresh and frozen-thawed immature and in vitro matured bovine oocytes. | 2001 | Reproduction | pmid:11425337 |
| Sauer LA et al. | Melatonin inhibits fatty acid transport in inguinal fat pads of hepatoma 7288CTC-bearing and normal Buffalo rats via receptor-mediated signal transduction. | 2001 | Life Sci. | pmid:11432449 |
| Nomura T et al. | A long-lasting facilitation of hippocampal neurotransmission via a phospholipase A2 signaling pathway. | 2001 | Life Sci. | pmid:11432454 |