| MeSH term | MeSH ID | Detail |
|---|---|---|
| Kidney Diseases | D007674 | 29 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Reed S et al. | Dietary zinc deficiency affects blood linoleic acid: dihomo-γ-linolenic acid (LA:DGLA) ratio; a sensitive physiological marker of zinc status in vivo (Gallus gallus). | 2014 | Nutrients | pmid:24658588 |
| Ebrahimi M et al. | Effects of oils rich in linoleic and α-linolenic acids on fatty acid profile and gene expression in goat meat. | 2014 | Nutrients | pmid:25255382 |
| Chilton FH et al. | Diet-gene interactions and PUFA metabolism: a potential contributor to health disparities and human diseases. | 2014 | Nutrients | pmid:24853887 |
| Fekete K and Decsi T | Long-chain polyunsaturated fatty acids in inborn errors of metabolism. | 2010 | Nutrients | pmid:22254065 |
| Ueda Y et al. | Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease. | 2008 | Nutr Res | pmid:19083414 |
| Lopes PA et al. | Diet supplementation with the cis-9,trans-11 conjugated linoleic acid isomer affects the size of adipocytes in Wistar rats. | 2008 | Nutr Res | pmid:19083449 |
| Kurotani K et al. | High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance. | 2012 | Nutr Res | pmid:23084639 |
| Raatz SK et al. | Total dietary fat and fatty acid content modifies plasma phospholipid fatty acids, desaturase activity indices, and urinary prostaglandin E in women. | 2012 | Nutr Res | pmid:22260857 |
| Poudel-Tandukar K et al. | Dietary intakes of alpha-linolenic and linoleic acids are inversely associated with serum C-reactive protein levels among Japanese men. | 2009 | Nutr Res | pmid:19628101 |
| Martins SV et al. | Dietary conjugated linoleic acid isomers change the unsaturation degree of hepatic fatty acids in neutral lipids but not in polar lipids. | 2011 | Nutr Res | pmid:21481719 |
| Angell RJ et al. | Fish oil supplementation maintains adequate plasma arachidonate in cats, but similar amounts of vegetable oils lead to dietary arachidonate deficiency from nutrient dilution. | 2012 | Nutr Res | pmid:22652378 |
| Yehuda S and Mostofsky DI | The effects of an essential fatty acid compound and a cholecystokinin-8 antagonist on iron deficiency induced anorexia and learning deficits. | 2004 | Nutr Neurosci | pmid:15279494 |
| Carey AN et al. | The ability of walnut extract and fatty acids to protect against the deleterious effects of oxidative stress and inflammation in hippocampal cells. | 2013 | Nutr Neurosci | pmid:23321679 |
| Yehuda S et al. | Mixture of essential fatty acids lowers test anxiety. | 2005 | Nutr Neurosci | pmid:16491653 |
| Tsuyama S et al. | Dietary conjugated linoleic acid modifies the brain endocannabinoid system in mice. | 2009 | Nutr Neurosci | pmid:19622239 |
| Eserian JK et al. | Effects of polyunsaturated fatty acids on cocaine-conditioned place preference in mice. | 2012 | Nutr Neurosci | pmid:22390908 |
| Warensjö E et al. | Effects of saturated and unsaturated fatty acids on estimated desaturase activities during a controlled dietary intervention. | 2008 | Nutr Metab Cardiovasc Dis | pmid:18367385 |
| Wong WT et al. | Relative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aorta. | 2011 | Nutr Metab Cardiovasc Dis | pmid:20005687 |
| Beezhold BL et al. | Vegetarian diets are associated with healthy mood states: a cross-sectional study in seventh day adventist adults. | 2010 | Nutr J | pmid:20515497 |
| Griel AE et al. | An increase in dietary n-3 fatty acids decreases a marker of bone resorption in humans. | 2007 | Nutr J | pmid:17227589 |
| Kim H et al. | Association between maternal intake of n-6 to n-3 fatty acid ratio during pregnancy and infant neurodevelopment at 6 months of age: results of the MOCEH cohort study. | 2017 | Nutr J | pmid:28420388 |
| Bongers ME et al. | The clinical effect of a new infant formula in term infants with constipation: a double-blind, randomized cross-over trial. | 2007 | Nutr J | pmid:17428343 |
| McKay DL et al. | Chronic and acute effects of walnuts on antioxidant capacity and nutritional status in humans: a randomized, cross-over pilot study. | 2010 | Nutr J | pmid:20462428 |
| Lasa A et al. | The combination of resveratrol and CLA does not increase the delipidating effect of each molecule in 3T3-L1 adipocytes. | 2011 Sep-Oct | Nutr Hosp | pmid:22072344 |
| Scalerandi MV et al. | Effect of conjugated linoleic acid mixtures and different edible oils in body composition and lipid regulation in mice. | 2014 | Nutr Hosp | pmid:24559004 |
| de Luis DA et al. | Double blind randomized clinical trial controlled by placebo with an alpha linoleic acid and prebiotic enriched cookie on risk cardiovascular factor in obese patients. | 2011 Jul-Aug | Nutr Hosp | pmid:22470031 |
| Golfetto I et al. | Fatty acid composition of milk of refugee Karen and urban Korean mothers. Is the level of DHA in breast milk of Western women compromised by high intake of saturated fat and linoleic acid? | 2007 | Nutr Health | pmid:18087864 |
| Vasudevan C et al. | The effect of parenteral lipid emulsions on pulmonary hemodynamics and eicosanoid metabolites in preterm infants: a pilot study. | 2013 | Nutr Clin Pract | pmid:24177284 |
| Vanek VW et al. | A.S.P.E.N. position paper: Clinical role for alternative intravenous fat emulsions. | 2012 | Nutr Clin Pract | pmid:22378798 |
| Nakamura T et al. | Excessive fat restriction might promote the recurrence of colorectal tumors. | 2010 | Nutr Cancer | pmid:20099189 |
| Banni S et al. | Vaccenic acid feeding increases tissue levels of conjugated linoleic acid and suppresses development of premalignant lesions in rat mammary gland. | 2001 | Nutr Cancer | pmid:12094634 |
| Iwamoto S et al. | Effects of fatty acids on liver metastasis of ACL-15 rat colon cancer cells. | 1998 | Nutr Cancer | pmid:9770727 |
| Ip C et al. | Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. | 1995 | Nutr Cancer | pmid:8610043 |
| Groscolas R et al. | Developing Yoshida sarcoma does not influence the fatty acid composition of adipose tissues in the rat. | 1995 | Nutr Cancer | pmid:7491300 |
| Ma DW et al. | An enriched mixture of trans-10,cis-12-CLA inhibits linoleic acid metabolism and PGE2 synthesis in MDA-MB-231 cells. | 2002 | Nutr Cancer | pmid:12734056 |
| Banni S et al. | An increase in vitamin A status by the feeding of conjugated linoleic acid. | 1999 | Nutr Cancer | pmid:10227044 |
| Ealey KN et al. | Conjugated linoleic acid does not inhibit development of aberrant crypt foci in colons of male Sprague-Dawley rats. | 2001 | Nutr Cancer | pmid:12094611 |
| Park HJ et al. | Linoleic acid-induced VCAM-1 expression in human microvascular endothelial cells is mediated by the NF-kappa B-dependent pathway. | 2001 | Nutr Cancer | pmid:12094615 |
| Lasekan JB et al. | Dietary olive and safflower oils in promotion of DMBA-induced mammary tumorigenesis in rats. | 1990 | Nutr Cancer | pmid:2106675 |
| Wang J et al. | Dietary fat, cooking fat, and breast cancer risk in a multiethnic population. | 2008 | Nutr Cancer | pmid:18584483 |
| Pink RC et al. | Molecular basis for maize as a risk factor for esophageal cancer in a South African population via a prostaglandin E2 positive feedback mechanism. | 2011 | Nutr Cancer | pmid:21667399 |
| Degner SC et al. | Cyclooxygenase-2 promoter activation by the aromatic hydrocarbon receptor in breast cancer mcf-7 cells: repressive effects of conjugated linoleic acid. | 2007 | Nutr Cancer | pmid:18001219 |
| Ip C et al. | Control of rat mammary epithelium proliferation by conjugated linoleic acid. | 2001 | Nutr Cancer | pmid:11759286 |
| Yang H et al. | Modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutation in the cecum and colon of big blue rats by conjugated linoleic acid and 1,2-dithiole-3-thione. | 2001 | Nutr Cancer | pmid:11759290 |
| Mackie BS et al. | Melanoma and dietary lipids. | 1987 | Nutr Cancer | pmid:3110746 |
| Chajes V et al. | Conjugated linoleic acid content in breast adipose tissue of breast cancer patients and the risk of metastasis. | 2003 | Nutr Cancer | pmid:12791500 |
| Aro A et al. | Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women. | 2000 | Nutr Cancer | pmid:11525591 |
| Kavanaugh CJ et al. | Effect of dietary conjugated linoleic acid on phorbol ester-induced PGE2 production and hyperplasia in mouse epidermis. | 1999 | Nutr Cancer | pmid:10368807 |
| De Stefani E et al. | Nutrient intake and risk of squamous cell carcinoma of the esophagus: a case-control study in Uruguay. | 2006 | Nutr Cancer | pmid:17474860 |
| Berry EM et al. | Dietary fat, plasma lipoproteins, and immune function in middle-aged American men. | 1987 | Nutr Cancer | pmid:3562291 |