| MeSH term | MeSH ID | Detail |
|---|---|---|
| Kidney Diseases | D007674 | 29 associated lipids |
| Endometrial Neoplasms | D016889 | 30 associated lipids |
| Liver Diseases | D008107 | 31 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Metabolic Syndrome | D024821 | 44 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
Linoleic acid
Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.
Cross Reference
Introduction
To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Linoleic acid?
Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Linoleic acid
PubChem Associated disorders and diseases
What pathways are associated with Linoleic acid
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
What functions are associated with Linoleic acid?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Linoleic acid?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Linoleic acid?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Linoleic acid?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with Linoleic acid
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dworkin RH et al. | Linoleic acid and multiple sclerosis: a reanalysis of three double-blind trials. | 1984 | Neurology | pmid:6387534 |
| Sohal RS et al. | Relationship between lipofuscin granules and polyunsaturated fatty acids in the housefly, Musca domestica. | 1984 | Mech. Ageing Dev. | pmid:6330462 |
| Codde JP et al. | Dissociation of effects of dietary fatty acids on blood pressure and prostanoid metabolism in Goldblatt hypertensive rats. | 1984 | J. Hypertens. | pmid:6099384 |
| Frankel EN | Chemistry of free radical and singlet oxidation of lipids. | 1984 | Prog. Lipid Res. | pmid:6100997 |
| Van Alstine JM and Brooks DE | Cell membrane abnormality detected in erythrocytes from patients with multiple sclerosis by partition in two-polymer aqueous-phase systems. | 1984 | Clin. Chem. | pmid:6199135 |
| Laakso S | Inhibition of lipid peroxidation by casein. Evidence of molecular encapsulation of 1,4-pentadiene fatty acids. | 1984 | Biochim. Biophys. Acta | pmid:6419780 |
| Sanders TA et al. | The influence of a maternal diet rich in linoleic acid on brain and retinal docosahexaenoic acid in the rat. | 1984 | Br. J. Nutr. | pmid:6228249 |
| Baba A et al. | Modulation by unsaturated fatty acids of norepinephrine- and adenosine-induced formation of cyclic AMP in brain slices. | 1984 | J. Neurochem. | pmid:6315886 |
| Kitagawa S et al. | Activation of bovine platelets induced by long-chain unsaturated fatty acids at just below their lytic concentrations, and its mechanism. | 1984 | Biochim. Biophys. Acta | pmid:6435686 |
| Reeves VB et al. | Variations in plasma fatty acid concentrations during a one-year self-selected dietary intake study. | 1984 | Am. J. Clin. Nutr. | pmid:6507356 |
| Neufeld EJ et al. | A mutant HSDM1C1 fibrosarcoma line selected for defective eicosanoid precursor uptake lacks arachidonate-specific acyl-CoA synthetase. | 1984 | J. Biol. Chem. | pmid:6420417 |
| Sánchez J and Stumpf PK | The effect of hypolipidemic drugs WY14643 and DH990, and lysophospholipids on the metabolism of oleate in plants. | 1984 | Arch. Biochem. Biophys. | pmid:6696430 |
| Arslan P et al. | cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes. | 1984 | Biochem. J. | pmid:6696740 |
| Chu CH et al. | The activity of 3-hydroxyacyl-CoA epimerase is insufficient to account for the rate of linoleate oxidation in rat heart mitochondria. Evidence for a modified pathway of linoleate degradation. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6696754 |
| Cherayil GD | Sialic acid and fatty acid concentrations in lymphocytes, red blood cells and plasma from patients with multiple sclerosis. | 1984 | J. Neurol. Sci. | pmid:6699649 |
| Colard O et al. | 1-Acyl-lysolecithin acyltransferase and synthesis of biliary lecithins in rat liver. | 1984 | Biochimie | pmid:6743697 |
| Eyssen H and Verhulst A | Biotransformation of linoleic acid and bile acids by Eubacterium lentum. | 1984 | Appl. Environ. Microbiol. | pmid:6582800 |
| Cunnane SC et al. | Linoleic acid and arachidonic acid metabolism in human peripheral blood leucocytes: comparison with the rat. | 1984 | Br. J. Nutr. | pmid:6422980 |
| Chapkin RS and Ziboh VA | Inability of skin enzyme preparations to biosynthesize arachidonic acid from linoleic acid. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6439197 |
| Koo SI and Ramlet JS | Effect of dietary linoleic acid on the tissue levels of zinc and copper, and serum high density lipoprotein cholesterol. | 1984 | Atherosclerosis | pmid:6712766 |
| Harada H et al. | Enhanced suppression of myocardial slow action potentials during hypoxia by free fatty acids. | 1984 | J. Mol. Cell. Cardiol. | pmid:6716492 |
| Hagve TA and Christophersen BO | Effect of dietary fats on arachidonic acid and eicosapentaenoic acid biosynthesis and conversion to C22 fatty acids in isolated rat liver cells. | 1984 | Biochim. Biophys. Acta | pmid:6093889 |
| Singer P et al. | Age-dependent alterations of linoleic, arachidonic and eicosapentaenoic acids in renal cortex and medulla of spontaneously hypertensive rats. | 1984 | Prostaglandins | pmid:6328578 |
| Hennig B et al. | Exposure to free fatty acid increases the transfer of albumin across cultured endothelial monolayers. | 1984 Sep-Oct | Arteriosclerosis | pmid:6477300 |
| O'Brien PM et al. | The effect of dietary supplementation with linoleic and gammalinolenic acids on the pressor response to angiotensin II--a possible role in pregnancy-induced hypertension? | 1985 | Br J Clin Pharmacol | pmid:2985102 |
| Salafsky B and Fusco AC | Schistosoma mansoni: cercarial eicosanoid production and penetration response inhibited by esculetin and ibuprofen. | 1985 | Exp. Parasitol. | pmid:2990990 |
| Claeys M et al. | Metabolic profile of linoleic acid in porcine leukocytes through the lipoxygenase pathway. | 1985 | Biochim. Biophys. Acta | pmid:2996610 |
| Hansen HS and Jensen B | Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate. | 1985 | Biochim. Biophys. Acta | pmid:3922424 |
| Nugteren DH et al. | Metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat. | 1985 | Biochim. Biophys. Acta | pmid:3922425 |
| Margetts BM et al. | Blood pressure and dietary polyunsaturated and saturated fats: a controlled trial. | 1985 | Clin. Sci. | pmid:3905211 |
| Ip C et al. | Requirement of essential fatty acid for mammary tumorigenesis in the rat. | 1985 | Cancer Res. | pmid:3921234 |
| Calderbank J et al. | Plasma-membrane phospholipid unsaturation affects expression of the general amino-acid permease in Saccharomyces cerevisiae Y185. | 1985 | J. Gen. Microbiol. | pmid:3886834 |
| Canfield LM et al. | Anti-oxidant/pro-oxidant reactions of vitamin K. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3985964 |
| Tsuchida M et al. | Fluorescent substances in mouse and human sera as a parameter of in vivo lipid peroxidation. | 1985 | Biochim. Biophys. Acta | pmid:3995061 |
| Bowser PA et al. | Identification, isolation and characterization of epidermal lipids containing linoleic acid. | 1985 | Biochim. Biophys. Acta | pmid:3995076 |
| Robinson M et al. | Acylation of lysophospholipids by rabbit alveolar macrophages. Specificities of CoA-dependent and CoA-independent reactions. | 1985 | J. Biol. Chem. | pmid:4008481 |
| Howard-Williams J et al. | Polyunsaturated fatty acids and diabetic retinopathy. | 1985 | Br J Ophthalmol | pmid:3965024 |
| Reid JC and Husbands DR | Oxidative metabolism of long-chain fatty acids in mitochondria from sheep and rat liver. Evidence that sheep conserve linoleate by limiting its oxidation. | 1985 | Biochem. J. | pmid:3977825 |
| Becker W and MÃ¥nsson JE | Incorporation of 14C into tissue lipids after oral administration of [1-14C]linoleic acid in rats fed different levels of essential fatty acids. | 1985 | J. Nutr. | pmid:4045568 |
| Takahashi K et al. | Ester-exchange catalyzed by lipase modified with polyethylene glycol. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4052065 |
| Wertz PW et al. | The composition of the ceramides from human stratum corneum and from comedones. | 1985 | J. Invest. Dermatol. | pmid:3158712 |
| Rebello T and Watts DC | Gastrocnemius muscle lipids in relation to diet in two mouse mutants, 129Re-dy and A2G-adr, with abnormal muscle function. | 1985 | J. Neurochem. | pmid:3158720 |
| Nordøy A et al. | Effect of dietary (n--3) fatty acids on platelet function and lipid metabolism in rats. | 1985 | Biochim. Biophys. Acta | pmid:2861854 |
| Jones PJ et al. | Whole body oxidation of dietary fatty acids: implications for energy utilization. | 1985 | Am. J. Clin. Nutr. | pmid:3933323 |
| Cooke RJ et al. | Safflower oil emulsion administration during parenteral nutrition in the preterm infant. 1. Effect on essential fatty acid status. | 1985 | J. Pediatr. Gastroenterol. Nutr. | pmid:3930688 |
| Smith MT and Thompson S | Free radicals and alcoholics. | 1985 | Lancet | pmid:2864501 |
| Boberg M et al. | Platelet fatty acid composition in relation to fatty acid composition in plasma and to serum lipoprotein lipids in healthy subjects with special reference to the linoleic acid pathway. | 1985 | Clin. Sci. | pmid:3919990 |
| Fink R et al. | Increased free-radical activity in alcoholics. | 1985 | Lancet | pmid:2862465 |
| Banerjee N and Rosenthal MD | High-affinity incorporation of 20-carbon polyunsaturated fatty acids by human skin fibroblasts. | 1985 | Biochim. Biophys. Acta | pmid:2990563 |
| Crutchley DJ | Hydroxyeicosatetraenoic acids and other unsaturated fatty acids inhibit endotoxin-induced thromboplastin activity in human monocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2865954 |