Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Vitamin E Deficiency D014811 29 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Liver Diseases D008107 31 associated lipids
Heart Failure D006333 36 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Precancerous Conditions D011230 48 associated lipids
Fatty Liver D005234 48 associated lipids
Thrombosis D013927 49 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Stachowska E et al. Exchange of unsaturated fatty acids between adipose tissue and atherosclerotic plaque studied with artificial neural networks. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:14643180
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Crawford MA Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10991768
Cunnane SC Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10991770
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Whelan J The health implications of changing linoleic acid intakes. 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18990554
Fritsche KL Too much linoleic acid promotes inflammation-doesn't it? 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18990555
Harris WS Linoleic acid and coronary heart disease. 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18951772
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Mouradian M et al. Key roles for GRB2-associated-binding protein 1, phosphatidylinositol-3-kinase, cyclooxygenase 2, prostaglandin E2 and transforming growth factor alpha in linoleic acid-induced upregulation of lung and breast cancer cell growth. 2014 Prostaglandins Leukot. Essent. Fatty Acids pmid:24374147
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Harris MA et al. Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11487304
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Pickens CA et al. Plasma phospholipids, non-esterified plasma polyunsaturated fatty acids and oxylipids are associated with BMI. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25559239
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Strandvik B The omega-6/omega-3 ratio is of importance! 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21945460
Gibson R and Makrides M α-Linolenate reduces the dietary requirement for linoleate in the growing rat. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:22019216
Das I and Khan NS Increased arachidonic acid induced platelet chemiluminescence indicates cyclooxygenase overactivity in schizophrenic subjects. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610837
Kikuchi S et al. Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610849
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Gelderblom WC et al. Regulation of fatty acid biosynthesis as a possible mechanism for the mitoinhibitory effect of fumonisin B1 in primary rat hepatocytes. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10574646
Arun Kumar C and Das UN Lipid peroxides, nitric oxide and essential fatty acids in patients with Plasmodium falciparum malaria. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10574650
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Goodfriend TL et al. An oxidized derivative of linoleic acid affects aldosterone secretion by adrenal cells in vitro. 2002 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12324236
Okui T et al. Cis-9,trans-11-conjugated linoleic acid promotes neuronal differentiation through regulation of Hes6 mRNA and cell cycle in cultured neural stem cells. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21723718
Shapiro H et al. Beyond the classic eicosanoids: Peripherally-acting oxygenated metabolites of polyunsaturated fatty acids mediate pain associated with tissue injury and inflammation. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:27067460
Risé P et al. Different patterns characterize Omega 6 and Omega 3 long chain polyunsaturated fatty acid levels in blood from Italian infants, children, adults and elderly. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23910046
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Hover CG and Kulkarni AP A simple and efficient method for hemoglobin removal from mammalian tissue cytosol by zinc sulfate and its application to the study of lipoxygenase. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10780874
Charnock JS Gamma-linolenic acid provides additional protection against ventricular fibrillation in aged rats fed linoleic acid rich diets. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10780878
Sakuma S et al. The effects of fatty acyl CoA esters on the formation of prostaglandin and arachidonoyl-CoA formed from arachidonic acid in rabbit kidney medulla microsomes. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11161586
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Turpeinen AM et al. A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9844997
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