Linoleic acid

Linoleic acid is a lipid of Fatty Acyls (FA) class. Linoleic acid is associated with abnormalities such as Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Obesity, Chronic Obstructive Airway Disease and Pneumonia. The involved functions are known as Insulin Resistance, Inflammation, Synthesis, Pathological accumulation of air in tissues and cytokine biosynthesis. The associated genes with Linoleic acid are TNF gene, CCL2 gene and TLR4 gene. The related lipids are palmitoleic acid, nervonic acid and Sphingolipids.

Cross Reference

Introduction

To understand associated biological information of Linoleic acid, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Linoleic acid?

Linoleic acid is suspected in Obesity, Diabetes Mellitus, Non-Insulin-Dependent, Metabolic syndrome, Chronic Obstructive Airway Disease, Pneumonia and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Linoleic acid

MeSH term MeSH ID Detail
Vitamin E Deficiency D014811 29 associated lipids
Endometrial Neoplasms D016889 30 associated lipids
Liver Diseases D008107 31 associated lipids
Heart Failure D006333 36 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Fatty Liver D005234 48 associated lipids
Precancerous Conditions D011230 48 associated lipids
Thrombosis D013927 49 associated lipids
Weight Loss D015431 56 associated lipids
Per page 10 20 50 100 | Total 75

PubChem Associated disorders and diseases

What pathways are associated with Linoleic acid

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

What functions are associated with Linoleic acid?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Linoleic acid?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Linoleic acid?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Linoleic acid?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Linoleic acid

Download all related citations
Per page 10 20 50 100 | Total 4513
Authors Title Published Journal PubMed Link
Palmieri-Thiers C et al. Identification of putative residues involved in the accessibility of the substrate-binding site of lipoxygenase by site-directed mutagenesis studies. 2011 Arch. Biochem. Biophys. pmid:21345329
Vedtofte MS et al. Dietary α-linolenic acid, linoleic acid, and n-3 long-chain PUFA and risk of ischemic heart disease. 2011 Am. J. Clin. Nutr. pmid:21865326
Okuyama H et al. New Cholesterol Guidelines for Longevity (2010). 2011 World Rev Nutr Diet pmid:21865826
Legrand P et al. Update of French nutritional recommendations for fatty acids. 2011 World Rev Nutr Diet pmid:21865827
Göçer H and Gülçin I Caffeic acid phenethyl ester (CAPE): correlation of structure and antioxidant properties. 2011 Int J Food Sci Nutr pmid:21631390
You Q et al. Purification, immobilization and characterization of linoleic acid isomerase on modified palygorskite. 2011 Bioprocess Biosyst Eng pmid:21340675
McCusker MM and Grant-Kels JM Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids. 2010 Jul-Aug Clin. Dermatol. pmid:20620762
Zovko Koncić M et al. Evaluation of antioxidant activities and phenolic content of Berberis vulgaris L. and Berberis croatica Horvat. 2010 Aug-Sep Food Chem. Toxicol. pmid:20488218
Hajlaoui H et al. Chemical composition and biological activities of Tunisian Cuminum cyminum L. essential oil: a high effectiveness against Vibrio spp. strains. 2010 Aug-Sep Food Chem. Toxicol. pmid:20488223
Ohmori H et al. Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and metastases via the expression of high-mobility group box 1. 2010 Pathobiology pmid:20616616
Bartók T et al. Identification of the first fumonisin mycotoxins with three acyl groups by ESI-ITMS and ESI-TOFMS following RP-HPLC separation: palmitoyl, linoleoyl and oleoyl EFB₁ fumonisin isomers from a solid culture of Fusarium verticillioides. 2010 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:21108092
Zaman MM et al. Linoleic acid supplementation results in increased arachidonic acid and eicosanoid production in CF airway cells and in cftr-/- transgenic mice. 2010 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:20656894
Frangioudakis G et al. Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors. 2010 Endocrinology pmid:20660065
Livraghi S et al. Decreasing the oxidative potential of TiO(2) nanoparticles through modification of the surface with carbon: a new strategy for the production of safe UV filters. 2010 Chem. Commun. (Camb.) pmid:20938530
Caroprese M et al. Flaxseed supplementation improves fatty acid profile of cow milk. 2010 J. Dairy Sci. pmid:20494167
Wien M et al. Decreasing the linoleic acid to alpha-linolenic acid diet ratio increases eicosapentaenoic acid in erythrocytes in adults. 2010 Lipids pmid:20496049
Can-Karabulut DC et al. Influence of experimental provisional cements containing zeolite, bone hydroxyapatite and linoleic Acid on bond strength of composite to dentin in vitro. 2010 J Adhes Dent pmid:20157651
Biro A et al. Complement protein C1q recognizes enzymatically modified low-density lipoprotein through unesterified fatty acids generated by cholesterol esterase. 2010 Biochemistry pmid:20166680
Maia MR et al. Toxicity of unsaturated fatty acids to the biohydrogenating ruminal bacterium, Butyrivibrio fibrisolvens. 2010 BMC Microbiol. pmid:20167098
Sarikurkcu C et al. Evaluation of metal concentration and antioxidant activity of three edible mushrooms from Mugla, Turkey. 2010 Food Chem. Toxicol. pmid:20167240
Vukovic N et al. An efficient synthesis and antioxidant properties of novel imino and amino derivatives of 4-hydroxy coumarins. 2010 Arch. Pharm. Res. pmid:20191339
Hirai S et al. Loss of sense transgene-induced post-transcriptional gene silencing by sequential introduction of the same transgene sequences in tobacco. 2010 FEBS J. pmid:20180844
Pauloin A et al. Oleate and linoleate stimulate degradation of β-casein in prolactin-treated HC11 mouse mammary epithelial cells. 2010 Cell Tissue Res. pmid:20182891
Gammill W et al. Comparative study of high-linoleic acid vegetable oils for the production of conjugated linoleic acid. 2010 J. Agric. Food Chem. pmid:20136082
Harris W Omega-6 and omega-3 fatty acids: partners in prevention. 2010 Curr Opin Clin Nutr Metab Care pmid:20145438
Goebel AS et al. Dermal targeting using colloidal carrier systems with linoleic acid. 2010 Eur J Pharm Biopharm pmid:20170728
Thornhill JA et al. Pathways for the influx of molecules into cercariae of Schistosoma mansoni during skin penetration. 2010 Parasitology pmid:20128942
Dailey MJ et al. Nutrient specific feeding and endocrine effects of jejunal infusions. 2010 Obesity (Silver Spring) pmid:20134410
Combet E et al. Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation. 2010 Rapid Commun. Mass Spectrom. pmid:20112267
Privé F et al. Temperature and duration of heating of sunflower oil affect ruminal biohydrogenation of linoleic acid in vitro. 2010 J. Dairy Sci. pmid:20105542
Rodríguez AM et al. Time-course effects of increased fatty acid supply on the expression of genes involved in lipid/glucose metabolism in muscle cells. 2010 Cell. Physiol. Biochem. pmid:20110694
Won JC et al. Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. 2010 Arterioscler. Thromb. Vasc. Biol. pmid:19965780
Dimri M et al. Dietary omega-3 polyunsaturated fatty acids suppress expression of EZH2 in breast cancer cells. 2010 Carcinogenesis pmid:19969553
Olveira G et al. Fatty acid supplements improve respiratory, inflammatory and nutritional parameters in adults with cystic fibrosis. 2010 Arch. Bronconeumol. pmid:20045240
Esmaeili MA and Sonboli A Antioxidant, free radical scavenging activities of Salvia brachyantha and its protective effect against oxidative cardiac cell injury. 2010 Food Chem. Toxicol. pmid:20036303
Li Y et al. Bone mineral content is positively correlated to n-3 fatty acids in the femur of growing rats. 2010 Br. J. Nutr. pmid:20420751
Even P et al. Postprandial effects of a lipid-rich meal in the rat are modulated by the degree of unsaturation of 18C fatty acids. 2010 Metab. Clin. Exp. pmid:19775712
Renaville B et al. Plasma and follicular fluid fatty acid profiles in dairy cows. 2010 Reprod. Domest. Anim. pmid:19055554
Kubala L et al. Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation. 2010 Free Radic. Biol. Med. pmid:20156554
Li YF et al. Properties of synthetic homoisoflavonoids to reduce oxidants and to protect linoleic acid and dna against oxidation. 2010 J. Agric. Food Chem. pmid:20199083
Bradbury KE et al. The serum fatty acids myristic acid and linoleic acid are better predictors of serum cholesterol concentrations when measured as molecular percentages rather than as absolute concentrations. 2010 Am. J. Clin. Nutr. pmid:19955401
Gholivand MB et al. Chemical composition and antioxidant activities of the essential oil and methanol extracts of Psammogeton canescens. 2010 Food Chem. Toxicol. pmid:19748545
Kim BS et al. Effect of surfactant on the production of oxygenated unsaturated fatty acids by Bacillus megaterium ALA2. 2010 N Biotechnol pmid:19748603
Joshi SC et al. Antioxidant and antibacterial activities of the leaf essential oils of Himalayan Lauraceae species. 2010 Food Chem. Toxicol. pmid:19766161
Lábaque MC et al. Effect of age and body weight of Greater Rhea (Rhea americana) females on egg number, size and composition. 2010 Br. Poult. Sci. pmid:21161792
Fekete K and Decsi T Long-chain polyunsaturated fatty acids in inborn errors of metabolism. 2010 Nutrients pmid:22254065
Peoples GE and McLennan PL Dietary fish oil reduces skeletal muscle oxygen consumption, provides fatigue resistance and improves contractile recovery in the rat in vivo hindlimb. 2010 Br. J. Nutr. pmid:20691135
Deiana M et al. Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells. 2010 Food Chem. Toxicol. pmid:20691238
Huang CB et al. Antimicrobial activity of n-6, n-7 and n-9 fatty acids and their esters for oral microorganisms. 2010 Arch. Oral Biol. pmid:20541177
Köse EO et al. Chemical composition, antimicrobial and antioxidant activities of the essential oils of Sideritis erythrantha Boiss. and Heldr. (var. erythrantha and var. cedretorum P.H. Davis) endemic in Turkey. 2010 Food Chem. Toxicol. pmid:20670669
Strandvik B Fatty acid metabolism in cystic fibrosis. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20673710
Rodrigues HG et al. Dietary free oleic and linoleic acid enhances neutrophil function and modulates the inflammatory response in rats. 2010 Lipids pmid:20730605
Tel G et al. Chemical composition of the essential oil and hexane extract of Salvia chionantha and their antioxidant and anticholinesterase activities. 2010 Food Chem. Toxicol. pmid:20732375
Takahashi S et al. The occurrence of renin inhibitor in rice: isolation, identification, and structure-function relationship. 2010 Biosci. Biotechnol. Biochem. pmid:20699562
Vij N Linoleic acid supplement in cystic fibrosis: friend or foe? 2010 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:20709729
Aziz AA et al. Increasing Dietary alpha-linolenic acid enhances tissue levels of long-chain n-3 PUFA when linoleic acid intake is low in hamsters. 2010 Ann. Nutr. Metab. pmid:20714137
Gutiérrez-Correa J Trypanosoma cruzi dihydrolipoamide dehydrogenase as target of reactive metabolites generated by cytochrome c/hydrogen peroxide (or linoleic acid hydroperoxide)/phenol systems. 2010 Free Radic. Res. pmid:20815787
Serhan Z et al. Complete determination of natural site-specific enantio-isotopomeric excesses in linoleic acid using natural abundance deuterium 2D NMR in polypeptide mesophases. 2010 Chem. Commun. (Camb.) pmid:20721385
Noel JT et al. Specific responses of Salmonella enterica to tomato varieties and fruit ripeness identified by in vivo expression technology. 2010 PLoS ONE pmid:20824208
Macouzet M et al. Genetic and structural comparison of linoleate isomerases from selected food-grade bacteria. 2010 J. Appl. Microbiol. pmid:20825518
Collin F et al. Experimental evidence of the reciprocal oxidation of Bovine Serum Albumin and Linoleate in aqueous solution, initiated by HO* free radicals. 2010 Biochimie pmid:20685376
Calder PC The American Heart Association advisory on n-6 fatty acids: evidence based or biased evidence? 2010 Br. J. Nutr. pmid:21118616
Ramsden CE et al. n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials. 2010 Br. J. Nutr. pmid:21118617
Lu XF et al. Colorectal cancer cell growth inhibition by linoleic acid is related to fatty acid composition changes. 2010 J Zhejiang Univ Sci B pmid:21121070
Luo H et al. The In vitro antioxidant properties of chinese highland lichens. 2010 J. Microbiol. Biotechnol. pmid:21124057
Olszewska MA et al. Assessment of the content of phenolics and antioxidant action of inflorescences and leaves of selected species from the genus Sorbus sensu stricto. 2010 Molecules pmid:21127463
Gotoh N et al. Highly unsaturated fatty acid might act as an antioxidant in emulsion system oxidized by azo compound. 2010 J Oleo Sci pmid:21099140
Guo JJ and Hu CH Mechanism of chain termination in lipid peroxidation by carotenes: a theoretical study. 2010 J Phys Chem B pmid:21105679
Wu TC et al. Fatty acid composition of Taiwanese human milk. 2010 J Chin Med Assoc pmid:21093826
West SG et al. Effects of diets high in walnuts and flax oil on hemodynamic responses to stress and vascular endothelial function. 2010 J Am Coll Nutr pmid:21677123
Duckett SK and Gillis MH Effects of oil source and fish oil addition on ruminal biohydrogenation of fatty acids and conjugated linoleic acid formation in beef steers fed finishing diets. 2010 J. Anim. Sci. pmid:20348369
Aluf Y et al. Specific oxidative stress profile associated with partial striatal dopaminergic depletion by 6-hydroxydopamine as assessed by a novel multifunctional marker molecule. 2010 Free Radic. Res. pmid:20370558
Tume RK et al. Enriching M. sternomandibularis with alpha-tocopherol by dietary means does not protect against the lipid oxidation caused by high-pressure processing. 2010 Meat Sci. pmid:20374755
Berthelot V et al. Utilization of extruded linseed to modify fatty composition of intensively-reared lamb meat: effect of associated cereals (wheat vs. corn) and linoleic acid content of the diet. 2010 Meat Sci. pmid:20374762
Tremblay-Mercier J et al. Bezafibrate mildly stimulates ketogenesis and fatty acid metabolism in hypertriglyceridemic subjects. 2010 J. Pharmacol. Exp. Ther. pmid:20404010
Della Casa G et al. Performance and fat quality of heavy pigs fed maize differing in linoleic acid content. 2010 Meat Sci. pmid:20374768
Aldai N et al. Double-muscling character influences the trans-18:1 and conjugated linoleic acid profiles in concentrate-fed yearling bulls. 2010 Meat Sci. pmid:20374865
Christensen KB et al. Identification of bioactive compounds from flowers of black elder (Sambucus nigra L.) that activate the human peroxisome proliferator-activated receptor (PPAR) gamma. 2010 Phytother Res pmid:20222152
Xiao C et al. Synthesis of methyl-substituted xanthotoxol to clarify prooxidant effect of methyl on radical-induced oxidation of DNA. 2010 Eur J Med Chem pmid:20332056
Georgiadi A et al. Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress. 2010 Circ. Res. pmid:20378851
Marei WF et al. Impact of linoleic acid on bovine oocyte maturation and embryo development. 2010 Reproduction pmid:20215338
Litvinov D et al. Anti-atherosclerotic actions of azelaic acid, an end product of linoleic acid peroxidation, in mice. 2010 Atherosclerosis pmid:19880116
Wan ZX et al. Lipid content and fatty acids composition of mature human milk in rural North China. 2010 Br. J. Nutr. pmid:19825220
Li Z et al. Dual response surface-optimized synthesis of L-menthyl conjugated linoleate in solvent-free system by Candida rugosa lipase. 2010 Bioresour. Technol. pmid:19833506
Friesen RW and Innis SM Linoleic acid is associated with lower long-chain n-6 and n-3 fatty acids in red blood cell lipids of Canadian pregnant women. 2010 Am. J. Clin. Nutr. pmid:19923368
Runyon JB et al. Parasitism by Cuscuta pentagona sequentially induces JA and SA defence pathways in tomato. 2010 Plant Cell Environ. pmid:19930126
Matsuoka T et al. Elevated dietary linoleic acid increases gastric carcinoma cell invasion and metastasis in mice. 2010 Br. J. Cancer pmid:20842125
Lau BY et al. Influence of high-fat diet from differential dietary sources on bone mineral density, bone strength, and bone fatty acid composition in rats. 2010 Appl Physiol Nutr Metab pmid:20962915
Schwartz J et al. Dietary intake and plasma concentrations of PUFA and LC-PUFA in breastfed and formula fed infants under real-life conditions. 2010 Eur J Nutr pmid:19851802
Liu S and Han B Differential expression pattern of an acidic 9/13-lipoxygenase in flower opening and senescence and in leaf response to phloem feeders in the tea plant. 2010 BMC Plant Biol. pmid:20969806
Benammar C et al. Zizyphus lotus L. (Desf.) modulates antioxidant activity and human T-cell proliferation. 2010 BMC Complement Altern Med pmid:20868496
Lu X et al. Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction. 2010 Lipids Health Dis pmid:20868498
Brodhun F et al. PpoC from Aspergillus nidulans is a fusion protein with only one active haem. 2010 Biochem. J. pmid:19878096
Khiaosa-Ard R et al. Transfer of linoleic and linolenic acid from feed to milk in cows fed isoenergetic diets differing in proportion and origin of concentrates and roughages. 2010 J. Dairy Res. pmid:20482940
Sahoo PK and Behera P Synthesis and biological screening of some novel amidocarbamate derivatives of ketoprofen. 2010 Eur J Med Chem pmid:20434240
Campoy C et al. [Update of knowledge, recommendations and full consensus about the role of long chain polyunsaturated fatty acids in pregnancy, lactating period and first year of life.Asociación Española de Pediatría. Sociedad Española de Ginecología y Obstetricia. Sociedad Española de Nutrición Comunitaria. Academia Española deNutrición y Ciencias de la Alimentación]. 2010 Med Clin (Barc) pmid:20434734
Goicoechea E and Guillen MD Analysis of hydroperoxides, aldehydes and epoxides by 1H nuclear magnetic resonance in sunflower oil oxidized at 70 and 100 degrees C. 2010 J. Agric. Food Chem. pmid:20438132
Cannata S et al. Effect of visual marbling on sensory properties and quality traits of pork loin. 2010 Meat Sci. pmid:20416803
Macouzet M et al. Genetic and functional aspects of linoleate isomerase in Lactobacillus acidophilus. 2010 Appl. Microbiol. Biotechnol. pmid:20461509
Rodrigues AS et al. Proton leak modulation in testicular mitochondria affects reactive oxygen species production and lipid peroxidation. 2010 Cell Biochem. Funct. pmid:20235330